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Entry version 127 (29 Sep 2021)
Sequence version 1 (01 Jun 2001)
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Protein

Mediator of RNA polymerase II transcription subunit 24

Gene

Med24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).

Required for basal and activator-dependent transcription.

By similarity2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-212436, Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 24
Alternative name(s):
Mediator complex subunit 24
Thyroid hormone receptor-associated protein 4
Thyroid hormone receptor-associated protein complex 100 kDa component
Short name:
Trap100
Short name:
mTRAP100
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Med24
Synonyms:D11Ertd307e, Thrap4, Trap100
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1344385, Med24

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000017210

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003059121 – 987Mediator of RNA polymerase II transcription subunit 24Add BLAST987

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei860PhosphoserineCombined sources1
Modified residuei871PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99K74

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99K74

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99K74

PeptideAtlas

More...
PeptideAtlasi
Q99K74

PRoteomics IDEntifications database

More...
PRIDEi
Q99K74

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
295917 [Q99K74-1]
295918 [Q99K74-2]
295919 [Q99K74-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99K74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99K74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the adrenal gland, brain, epididymis, heart, kidney, liver, ovary, pancreas, prostate, skeletal muscle, small intestine, spleen, stomach, testis and thymus.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout development; expression levels drop immediately after birth. Strongly expressed throughout the primitive nervous system, the hepatic primoridium and the earliest limb buds.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000017210, Expressed in cerebral cortex and 284 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99K74, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.

Interacts with AR (By similarity).

Interacts with MED1 and MED10.

By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
204840, 4 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...
ComplexPortali
CPX-3264, Core mediator complex

CORUM comprehensive resource of mammalian protein complexes

More...
CORUMi
Q99K74

Protein interaction database and analysis system

More...
IntActi
Q99K74, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000017354

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99K74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99K74

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi128 – 132LXXLL motif 15
Motifi344 – 348LXXLL motif 25
Motifi446 – 450LXXLL motif 35
Motifi555 – 559LXXLL motif 45
Motifi786 – 790LXXLL motif 55
Motifi855 – 859LXXLL motif 65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the Mediator complex subunit 24 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QPJD, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000016438

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_007484_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99K74

Identification of Orthologs from Complete Genome Data

More...
OMAi
RWSDSQW

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99K74

TreeFam database of animal gene trees

More...
TreeFami
TF323565

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021429, Mediator_Med24

The PANTHER Classification System

More...
PANTHERi
PTHR12898, PTHR12898, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11277, Med24_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99K74-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKVVNLKQAI LQAWKERWSD YQWAINMKKF FPKGATWDIL NLAEALLEQA
60 70 80 90 100
MIGPSPNPLI LSYLKYAISS QMVSCSSVLT AISKFDDFSR DLCVQALLDI
110 120 130 140 150
MDMFCDRLSC HGKAEECIGL CRALLSALHW LLRCTAASAE RLQEGLEAGT
160 170 180 190 200
PAPGEKQLAL CLQCLEKTLS STKNRALLHI AKLEEASSWT AIEHSLLKLG
210 220 230 240 250
EILANLSNPQ LRSQAERCGT LIRSIPSMLS VHSEQLHKTG FPTIHALILL
260 270 280 290 300
EGTMNLTGEM QPLVEQLMMV KRMQHIPTPL FVLEIWKACF VGLIESPEGT
310 320 330 340 350
QELKWTAFTY LKIPQVLVKL KKYFHGEKDF TEDVNCAFEF LLKLTPLLDK
360 370 380 390 400
ADQRCNCDCT NFLLQECNKQ GLLSEVNFAS LVGKRTADRD PQLKSSENAN
410 420 430 440 450
IQPNPGLILR AEPTVTNILK TMDADHSKSP EGLLGVLGHM LSGKSLDLLL
460 470 480 490 500
AAAAATGKLK SFARKFINLN EFTTHGSGES TKTASVRALL FDISFLMLCH
510 520 530 540 550
VAQTYGSEVI LSESSSGEEV PFFETWMQTC MPEEGKILNP DHPCFRPDST
560 570 580 590 600
KVESLVALLN NSSEMKLVQM KWHEACLSIS AAILEILNAW ENGVLAFESI
610 620 630 640 650
QKITDNIKGK VCSLAVCAVA WLVAHVRMLG LDEREKSLQM IRQLAGPLYS
660 670 680 690 700
ENTLQFYNER VVIMNSILEH MCADVLQQTA TQIKFPSTGV DTMPYWNLLP
710 720 730 740 750
PKRPIKEVLT DIFAKVLEKG WVDSRSIHIL DTLLHMGGVY WFCNNLIKEL
760 770 780 790 800
LKETRKEHTL RAVQLLYSIF CLDMQQVTLV LLGHILPGLL TDSSKWHSLM
810 820 830 840 850
DPPGTALAKL AVWCALSSYS SHKGQASSRQ KKRHREDIED YVSLFPVEDM
860 870 880 890 900
QPSKLMRLLS SSDDDANILS SPTDRSMNSS LSASQLHTVN MRDPLNRVLA
910 920 930 940 950
NLFLLISSIL GSRTAGPHTQ FVQWFMEECV GCLEQDSRGS ILQFMPFTTV
960 970 980
SELVKVSAMS SPKVVLAITD LSLPLGRQVA AKAIAAL
Length:987
Mass (Da):109,985
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i713C6A02C3C0B294
GO
Isoform 2 (identifier: Q99K74-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-50: Missing.
     187-187: S → SLHTSQGLGQGGTRANQPTA

Show »
Length:956
Mass (Da):105,942
Checksum:i41FC6F4D850D6540
GO
Isoform 3 (identifier: Q99K74-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     661-758: VVIMNSILEH...ELLKETRKEH → SVPRPRQVCG...LVCVSVSRGF
     759-987: Missing.

Show »
Length:758
Mass (Da):83,879
Checksum:iF09A51692BE1598B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6PW47A6PW47_MOUSE
Mediator complex subunit 24
Med24
1,006Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A6PW46A6PW46_MOUSE
Mediator complex subunit 24
Med24
90Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6XX22F6XX22_MOUSE
Mediator complex subunit 24
Med24
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti26N → K in BAB32051 (PubMed:16141072).Curated1
Sequence conflicti503Q → H in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti541D → E in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti566K → N in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti608K → N in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti699L → F in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti888T → R in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti940S → T in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti963K → E in AAD42776 (PubMed:10406464).Curated1
Sequence conflicti970D → H in AAD42776 (PubMed:10406464).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0283551 – 50Missing in isoform 2. 2 PublicationsAdd BLAST50
Alternative sequenceiVSP_028356187S → SLHTSQGLGQGGTRANQPTA in isoform 2. 2 Publications1
Alternative sequenceiVSP_028357661 – 758VVIMN…TRKEH → SVPRPRQVCGRESAPPGTNI PPHALGLRFPGSRSATTSSS IQAPTSPPCLAAEAVHIQGS WTLAPSFAFPYHSLAFLVTH SLSWLSRCLVCVSVSRGF in isoform 3. 1 PublicationAdd BLAST98
Alternative sequenceiVSP_028358759 – 987Missing in isoform 3. 1 PublicationAdd BLAST229

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF126543 mRNA Translation: AAD42776.1
AF483498 mRNA Translation: AAL90772.1
AF483499 mRNA Translation: AAL90773.1
AK020269 mRNA Translation: BAB32051.1
AK154618 mRNA Translation: BAE32717.1
AL590963 Genomic DNA No translation available.
BC005409 mRNA Translation: AAH05409.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS25361.2 [Q99K74-1]

NCBI Reference Sequences

More...
RefSeqi
NP_035999.2, NM_011869.2 [Q99K74-1]
XP_006533368.1, XM_006533305.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000017354; ENSMUSP00000017354; ENSMUSG00000017210 [Q99K74-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
23989

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:23989

UCSC genome browser

More...
UCSCi
uc007lgz.1, mouse [Q99K74-2]
uc007lha.1, mouse [Q99K74-1]
uc007lhc.1, mouse [Q99K74-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126543 mRNA Translation: AAD42776.1
AF483498 mRNA Translation: AAL90772.1
AF483499 mRNA Translation: AAL90773.1
AK020269 mRNA Translation: BAB32051.1
AK154618 mRNA Translation: BAE32717.1
AL590963 Genomic DNA No translation available.
BC005409 mRNA Translation: AAH05409.1
CCDSiCCDS25361.2 [Q99K74-1]
RefSeqiNP_035999.2, NM_011869.2 [Q99K74-1]
XP_006533368.1, XM_006533305.2

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6W1Selectron microscopy4.02S4-985[»]
SMRiQ99K74
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi204840, 4 interactors
ComplexPortaliCPX-3264, Core mediator complex
CORUMiQ99K74
IntActiQ99K74, 4 interactors
STRINGi10090.ENSMUSP00000017354

PTM databases

iPTMnetiQ99K74
PhosphoSitePlusiQ99K74

Proteomic databases

EPDiQ99K74
jPOSTiQ99K74
PaxDbiQ99K74
PeptideAtlasiQ99K74
PRIDEiQ99K74
ProteomicsDBi295917 [Q99K74-1]
295918 [Q99K74-2]
295919 [Q99K74-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
28479, 152 antibodies

The DNASU plasmid repository

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DNASUi
23989

Genome annotation databases

EnsembliENSMUST00000017354; ENSMUSP00000017354; ENSMUSG00000017210 [Q99K74-1]
GeneIDi23989
KEGGimmu:23989
UCSCiuc007lgz.1, mouse [Q99K74-2]
uc007lha.1, mouse [Q99K74-1]
uc007lhc.1, mouse [Q99K74-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9862
MGIiMGI:1344385, Med24
VEuPathDBiHostDB:ENSMUSG00000017210

Phylogenomic databases

eggNOGiENOG502QPJD, Eukaryota
GeneTreeiENSGT00390000016438
HOGENOMiCLU_007484_0_0_1
InParanoidiQ99K74
OMAiRWSDSQW
PhylomeDBiQ99K74
TreeFamiTF323565

Enzyme and pathway databases

ReactomeiR-MMU-212436, Generic Transcription Pathway

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
23989, 23 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Med24, mouse

Protein Ontology

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PROi
PR:Q99K74
RNActiQ99K74, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000017210, Expressed in cerebral cortex and 284 other tissues
ExpressionAtlasiQ99K74, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR021429, Mediator_Med24
PANTHERiPTHR12898, PTHR12898, 1 hit
PfamiView protein in Pfam
PF11277, Med24_N, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMED24_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99K74
Secondary accession number(s): A3KFP0
, Q8R004, Q9D277, Q9WVF1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: June 1, 2001
Last modified: September 29, 2021
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
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