Nono

Functionⁱ

DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double-stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as a heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. Together with PSPC1, required for the formation of nuclear paraspeckles. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. NONO is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional activity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription. Regulates the circadian clock by repressing the transcriptional activator activity of the CLOCK-ARNTL/BMAL1 heterodimer. Important for the functional organization of GABAergic synapses. Plays a specific and important role in the regulation of synaptic RNAs and GPHN/gephyrin scaffold structure, through the regulation of GABRA2 transcript (PubMed:26571461).Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.By similarity4 Publications

GO - Molecular functionⁱ

chromatin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19389484
E-box binding
Source: UniProtKB
Inferred from direct assayⁱ
- 22966205
identical protein binding Source: MGI
RNA binding Source: UniProtKB-KW
RNA polymerase II distal enhancer sequence-specific DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 19389484

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of innate immune response Source: MGI
circadian rhythm Source: UniProtKB
DNA recombination Source: UniProtKB-KW
DNA repair Source: UniProtKB-KW
innate immune response Source: UniProtKB-KW
mRNA splicing, via spliceosome Source: GO_Central
negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway Source: MGI
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 22966205
regulation of circadian rhythm
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 22966205
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Repressor, RNA-binding
Biological process	Biological rhythms, DNA damage, DNA recombination, DNA repair, Immunity, Innate immunity, mRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Non-POU domain-containing octamer-binding protein Short name: NonO protein
Gene namesⁱ	Name:Nono
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome X

Organism-specific databases

MGIⁱ	MGI:1855692 Nono

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mutant mice display flattened nose and a smaller cerebellum. Behaviorally, mice show impaired spatial memory, as well as a marked anxiety phenotype and increased risk aversion.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000081684	1 – 473	Non-POU domain-containing octamer-binding proteinAdd BLAST		473

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineCombined sources	1
Modified residueⁱ	5	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	5	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	11	N6-acetyllysineCombined sources	1
Cross-linkⁱ	62	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	98	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	101	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	128	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	149	PhosphoserineBy similarity	1
Cross-linkⁱ	192	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	200	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	200	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Cross-linkⁱ	245	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linkⁱ	251	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	264	PhosphoserineBy similarity	1
Modified residueⁱ	297	N6-acetyllysineCombined sources	1
Modified residueⁱ	373	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	373	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	430	PhosphothreonineBy similarity	1
Modified residueⁱ	442	PhosphothreonineBy similarity	1
Modified residueⁱ	452	PhosphothreonineCombined sources	1
Modified residueⁱ	458	Omega-N-methylarginineBy similarity	1
Cross-linkⁱ	469	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q99K48
PaxDbⁱ	Q99K48
PeptideAtlas More...PeptideAtlasⁱ	Q99K48
PRIDEⁱ	Q99K48
TopDownProteomicsⁱ	Q99K48-1 [Q99K48-1]

PTM databases

iPTMnetⁱ	Q99K48
PhosphoSitePlusⁱ	Q99K48
SwissPalmⁱ	Q99K48

Expressionⁱ

Tissue specificityⁱ

Expressed in liver and suprachiasmatic nuclei, hippocampus and neocortex (at protein level). Expression is strongest in neurons in CA1 and CA3 pyramidal regions and granule cells of the dentate gyrus. Detected in testis and kidney.3 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000031311 Expressed in 227 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q99K48 baseline and differential
Genevisibleⁱ	Q99K48 MM

Interactionⁱ

Subunit structureⁱ

Interacts with CPNE4 (via VWFA domain) (PubMed:12522145). Monomer and component of the SFPQ-NONO complex, which is probably a heterotetramer of two 52 kDa (NONO) and two 100 kDa (SFPQ) subunits. NONO is a component of spliceosome and U5.4/6 snRNP complexes. Forms heterodimers with PSPC1; this involves formation of a coiled coil domain by helices from both proteins. Interacts with PSPC1 and SNRPA/U1A. Part of complex consisting of SFPQ, NONO and MATR3. Part of a complex consisting of SFPQ, NONO and NR5A1. Part of a complex consisting of SFPQ, NONO and TOP1. Interacts with SPI1. Interacts with RNF43. Interacts with PER1 and PER2. Part of the HDP-RNP complex composed of at least HEXIM1, PRKDC, XRCC5, XRCC6, paraspeckle proteins (SFPQ, NONO, PSPC1, RBM14, and MATR3) and NEAT1 RNA.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Spi1	P17433	3	EBI-607499,EBI-607588

With

Entry

#Exp.

IntAct

Notes

Spi1

P17433

3

EBI-607499,EBI-607588

GO - Molecular functionⁱ

identical protein binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	207330, 19 interactors
Database of interacting proteins More...DIPⁱ	DIP-34308N
ELMⁱ	Q99K48
IntActⁱ	Q99K48, 6 interactors
Molecular INTeraction database More...MINTⁱ	Q99K48
STRINGⁱ	10090.ENSMUSP00000033673

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	77 – 82	Combined sources	6
Helixⁱ	89 – 95	Combined sources	7
Helixⁱ	97 – 99	Combined sources	3
Beta strandⁱ	103 – 108	Combined sources	6
Turnⁱ	109 – 112	Combined sources	4
Beta strandⁱ	113 – 117	Combined sources	5
Beta strandⁱ	119 – 121	Combined sources	3
Helixⁱ	122 – 131	Combined sources	10
Beta strandⁱ	142 – 147	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99K48
SMRⁱ	Q99K48
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99K48

EvolutionaryTraceⁱ

Q99K48

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	76 – 143	RRM 1PROSITE-ProRule annotationAdd BLAST		68
Domainⁱ	150 – 231	RRM 2PROSITE-ProRule annotationAdd BLAST		82

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	56 – 375	DBHSBy similarityAdd BLAST		320

Coiled coil

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Coiled coilⁱ	270 – 374	Sequence analysisAdd BLAST		105

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	29 – 38	Poly-Gln	10
Compositional biasⁱ	39 – 44	Poly-Pro	6
Compositional biasⁱ	350 – 353	Poly-Arg	4

Keywords - Domainⁱ

Coiled coil, Repeat

Phylogenomic databases

eggNOGⁱ	KOG0115 Eukaryota ENOG410XQA0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000005004
HOVERGENⁱ	HBG009801
InParanoidⁱ	Q99K48
KEGG Orthology (KO) More...KOⁱ	K13214
OMAⁱ	NQQYHKE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G09T7
TreeFamⁱ	TF315795

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd12588 RRM1_p54nrb, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012975 NOPS IPR012677 Nucleotide-bd_a/b_plait_sf IPR034552 p54nrb_RRM1 IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF08075 NOPS, 1 hit PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: Q99K48-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQSNKAFNLE KQNHTPRKHH QHHHQQHHQQ QQQQQQQQPP PPIPANGQQA 
        60         70         80         90        100
SSQNEGLTID LKNFRKPGEK TFTQRSRLFV GNLPPDITEE EMRKLFEKYG 
       110        120        130        140        150
KAGEVFIHKD KGFGFIRLET RTLAEIAKVE LDNMPLRGKQ LRVRFACHSA 
       160        170        180        190        200
SLTVRNLPQY VSNELLEEAF SVFGQVERAV VIVDDRGRPS GKGIVEFSGK 
       210        220        230        240        250
PAARKALDRC SEGSFLLTTF PRPVTVEPMD QLDDEEGLPE KLVIKNQQFH 
       260        270        280        290        300
KEREQPPRFA QPGSFEYEYA MRWKALIEME KQQQDQVDRN IKEAREKLEM 
       310        320        330        340        350
EMEAARHEHQ VMLMRQDLMR RQEELRRMEE LHNQEVQKRK QLELRQEEER 
       360        370        380        390        400
RRREEEMRRQ QEEMMRRQQE GFKGTFPDAR EQEIRMGQMA MGGAMGINNR 
       410        420        430        440        450
GAMPPAPVPP GTPAPPGPAT MMPDGTLGLT PPTTERFGQA ATMEGIGAIG 
       460        470 
GTPPAFNRPA PGAEFAPNKR RRY

Length:473

Mass (Da):54,541

Last modified:July 5, 2005 - v3

Checksum:ⁱF65E6AE25D471A38

GO

Isoform 2 (identifier: Q99K48-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
220-473: Missing.

« Hide

        10         20         30         40         50
MQSNKAFNLE KQNHTPRKHH QHHHQQHHQQ QQQQQQQQPP PPIPANGQQA 
        60         70         80         90        100
SSQNEGLTID LKNFRKPGEK TFTQRSRLFV GNLPPDITEE EMRKLFEKYG 
       110        120        130        140        150
KAGEVFIHKD KGFGFIRLET RTLAEIAKVE LDNMPLRGKQ LRVRFACHSA 
       160        170        180        190        200
SLTVRNLPQY VSNELLEEAF SVFGQVERAV VIVDDRGRPS GKGIVEFSGK 
       210 
PAARKALDRC SEGSFLLTT

Note: No experimental confirmation available.

Show »

Length:219

Mass (Da):24,969

Checksum:ⁱCFF17042BD1E721E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	B1AXT0	B1AXT0_MOUSE		Non-POU domain-containing octamer-b... Non-POU domain-containing octamer-binding protein	Nono	98	Annotation score:

Sequence cautionⁱ

The sequence BAB23598 differs from that shown. Reason: Erroneous termination at position 258. Translated as Arg.Curated

The sequence BAB28857 differs from that shown. Reason: Frameshift at position 187.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	76	S → T in BAB28857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	117	R → N in BAB28857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	127	A → V in AAB27887 (PubMed:8355702).Curated	1
Sequence conflictⁱ	153	T → K in BAB28857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	167	E → G in BAB28857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	183	V → E in BAB28857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	188	R → W in BAB28857 (PubMed:16141072).Curated	1
Sequence conflictⁱ	203 – 204	AR → VL in BAB28857 (PubMed:16141072).Curated	2
Sequence conflictⁱ	222	R → W in AAB27887 (PubMed:8355702).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_013981	220 – 473	Missing in isoform 2. 1 PublicationAdd BLAST		254

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S64860 mRNA Translation: AAB27887.1 AK004830 mRNA Translation: BAB23598.1 Sequence problems. AK013444 mRNA Translation: BAB28857.1 Sequence problems. AK028338 mRNA Translation: BAC25890.1 BC005465 mRNA Translation: AAH05465.1 BC083074 mRNA Translation: AAH83074.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS30316.1 [Q99K48-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001239447.1, NM_001252518.1 [Q99K48-1] NP_075633.2, NM_023144.2 [Q99K48-1]
UniGeneⁱ	Mm.280069 Mm.475350

Genome annotation databases

Ensemblⁱ	ENSMUST00000033673; ENSMUSP00000033673; ENSMUSG00000031311 [Q99K48-1]
GeneIDⁱ	53610
KEGGⁱ	mmu:53610
UCSC genome browser More...UCSCⁱ	uc009txr.2 mouse [Q99K48-2] uc009txs.2 mouse [Q99K48-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99K48	Putative Non-POU domain-containing octamer-binding protein (Fragment)		Daphnia magna		290	UniRef100_Q99K48
Uncharacterized protein (Fragment)		MOUSE		528
UPI000A30D1F9		MUSPA		382
Non-POU domain-containing octamer-binding protein (Fragment)		MOUSE		98
Nono protein		MOUSE		473
+1

Protein	Similar proteins		Species	Score	Length	Source
Q99K48	Non-POU domain-containing octamer-binding protein	)	HUMAN		471	UniRef90_Q15233
Non-POU domain-containing octamer-binding protein		PONAB		471
Non-POU domain-containing octamer-binding protein		RAT		476
Non-POU domain containing octamer binding		CALJA		471
Non-POU domain containing octamer binding		PANTR		471
+149

Protein	Similar proteins		Species	Score	Length	Source
Q99K48	Non-POU domain-containing octamer-binding protein	)	HUMAN		471	UniRef50_Q15233
Non-POU domain-containing octamer-binding protein		PONAB		471
Non-POU domain-containing octamer-binding protein		RAT		476
Non-POU domain containing octamer binding		CALJA		471
Non-POU domain containing octamer binding		PANTR		471
+309

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	S64860 mRNA Translation: AAB27887.1 AK004830 mRNA Translation: BAB23598.1 Sequence problems. AK013444 mRNA Translation: BAB28857.1 Sequence problems. AK028338 mRNA Translation: BAC25890.1 BC005465 mRNA Translation: AAH05465.1 BC083074 mRNA Translation: AAH83074.1
CCDSⁱ	CCDS30316.1 [Q99K48-1]
RefSeqⁱ	NP_001239447.1, NM_001252518.1 [Q99K48-1] NP_075633.2, NM_023144.2 [Q99K48-1]
UniGeneⁱ	Mm.280069 Mm.475350

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2CPJ	NMR	-	A	68-153	[»]
	2RS8	NMR	-	A	68-153	[»]
ProteinModelPortalⁱ	Q99K48
SMRⁱ	Q99K48
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	207330, 19 interactors
DIPⁱ	DIP-34308N
ELMⁱ	Q99K48
IntActⁱ	Q99K48, 6 interactors
MINTⁱ	Q99K48
STRINGⁱ	10090.ENSMUSP00000033673

PTM databases

iPTMnetⁱ	Q99K48
PhosphoSitePlusⁱ	Q99K48
SwissPalmⁱ	Q99K48

Proteomic databases

EPDⁱ	Q99K48
PaxDbⁱ	Q99K48
PeptideAtlasⁱ	Q99K48
PRIDEⁱ	Q99K48
TopDownProteomicsⁱ	Q99K48-1 [Q99K48-1]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000033673; ENSMUSP00000033673; ENSMUSG00000031311 [Q99K48-1]
GeneIDⁱ	53610
KEGGⁱ	mmu:53610
UCSCⁱ	uc009txr.2 mouse [Q99K48-2] uc009txs.2 mouse [Q99K48-1]

Organism-specific databases

CTDⁱ	4841
MGIⁱ	MGI:1855692 Nono

Phylogenomic databases

eggNOGⁱ	KOG0115 Eukaryota ENOG410XQA0 LUCA
GeneTreeⁱ	ENSGT00390000005004
HOVERGENⁱ	HBG009801
InParanoidⁱ	Q99K48
KOⁱ	K13214
OMAⁱ	NQQYHKE
OrthoDBⁱ	EOG091G09T7
TreeFamⁱ	TF315795

Miscellaneous databases

ChiTaRSⁱ	Nono mouse
EvolutionaryTraceⁱ	Q99K48
Protein Ontology More...PROⁱ	PR:Q99K48
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000031311 Expressed in 227 organ(s), highest expression level in thymus
ExpressionAtlasⁱ	Q99K48 baseline and differential
Genevisibleⁱ	Q99K48 MM

Family and domain databases

CDDⁱ	cd12588 RRM1_p54nrb, 1 hit
Gene3Dⁱ	3.30.70.330, 2 hits
InterProⁱ	View protein in InterPro IPR012975 NOPS IPR012677 Nucleotide-bd_a/b_plait_sf IPR034552 p54nrb_RRM1 IPR035979 RBD_domain_sf IPR000504 RRM_dom
Pfamⁱ	View protein in Pfam PF08075 NOPS, 1 hit PF00076 RRM_1, 2 hits
SMARTⁱ	View protein in SMART SM00360 RRM, 2 hits
SUPFAMⁱ	SSF54928 SSF54928, 1 hit
PROSITEⁱ	View protein in PROSITE PS50102 RRM, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NONO_MOUSE
Accessionⁱ	Q99K48Primary (citable) accession number: Q99K48 Secondary accession number(s): Q63887, Q9CYQ4, Q9DBP2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
	Last sequence update:	July 5, 2005
	Last modified:	September 12, 2018
	This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99K48 (NONO_MOUSE)

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Non-POU domain-containing octamer-binding protein

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Coiled coil

Compositional bias

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ