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Protein

Ufm1-specific protease 2

Gene

Ufsp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins (PubMed:17182609, PubMed:21228277). Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity).By similarity2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2941 Publication1
Active sitei4181 Publication1
Active sitei4201 Publication1

GO - Molecular functioni

  • thiolester hydrolase activity Source: UniProtKB
  • UFM1 hydrolase activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Protein family/group databases

MEROPSiC78.002

Names & Taxonomyi

Protein namesi
Recommended name:
Ufm1-specific protease 2 (EC:3.4.22.-1 Publication)
Short name:
UfSP2
Gene namesi
Name:Ufsp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1913679 Ufsp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi282Y → H: Loss of enzyme activity. 1 Publication1
Mutagenesisi294C → S: Loss of enzyme activity. 2 Publications1
Mutagenesisi398H → A: No effect on enzyme activity. 1 Publication1
Mutagenesisi418D → A: Reduced enzyme activity. 1 Publication1
Mutagenesisi420H → A: Loss of enzyme activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002803631 – 461Ufm1-specific protease 2Add BLAST461

Proteomic databases

EPDiQ99K23
MaxQBiQ99K23
PaxDbiQ99K23
PeptideAtlasiQ99K23
PRIDEiQ99K23

PTM databases

iPTMnetiQ99K23
PhosphoSitePlusiQ99K23

Expressioni

Tissue specificityi

Expressed at high level in brain, kidney, stomach, skeletal muscle and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000031634 Expressed in 272 organ(s), highest expression level in seminal vesicle
CleanExiMM_UFSP2
ExpressionAtlasiQ99K23 baseline and differential
GenevisibleiQ99K23 MM

Interactioni

Subunit structurei

Interacts with DDRGK1 (PubMed:21228277). Interacts with TRIP4; deufmylates TRIP4 (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ99K23, 1 interactor
MINTiQ99K23
STRINGi10090.ENSMUSP00000034051

Structurei

Secondary structure

1461
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99K23
SMRiQ99K23
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99K23

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C78 family.Curated

Phylogenomic databases

eggNOGiKOG2433 Eukaryota
ENOG410XTJE LUCA
GeneTreeiENSGT00520000055644
HOGENOMiHOG000007858
HOVERGENiHBG094132
InParanoidiQ99K23
KOiK01376
OMAiGSEMASQ
OrthoDBiEOG091G04IB
PhylomeDBiQ99K23
TreeFamiTF325896

Family and domain databases

InterProiView protein in InterPro
IPR012462 Peptidase_C78_UfSP1/2
PfamiView protein in Pfam
PF07910 Peptidase_C78, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

Q99K23-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDILFRIRGG FDLAFQLAPP KEMFIKNALR QVLSDLTTKL SSDALVLRVC
60 70 80 90 100
NSSVYLWPNS DANTGELTDS SACKNVVRFI QFDQEEDTKR KFIKKKDKKL
110 120 130 140 150
TDTQQIVNID LMLEISTPLG AVTPILEREN EEHHYINMSL PIDAVVSVAP
160 170 180 190 200
EESWGKVRKL LVDAILRQLV DVEKCILRYM KGTSIVVPEP LHFQLPGKKN
210 220 230 240 250
LVTVLYPSGI PDDQLQAYRK ELHDLFNLPH DRPYFKRINA YHFPDELYKD
260 270 280 290 300
GYIRNPHTYL SPPNIEGSMI CVVQGTYAYH HYMQDRIDDN GWGCAYRSLQ
310 320 330 340 350
TICSWFRHQG YTERSIPTHR EIQQALVDAG DKPATFVGSR QWIGSIEVQM
360 370 380 390 400
VLNQLIGVTS KILFVNQGSE MASQGRELAN HFQNVGTPVM VGGGVLAHTI
410 420 430 440 450
LGVAWNETTG QIKFLILDPH YTGAEDLQVM LEKGWCGWKS PDFWNKDAYY
460
NLCLPQRPNA L
Length:461
Mass (Da):52,515
Last modified:June 1, 2001 - v1
Checksum:iA04A842782C2A0CE
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GSM1A0A1B0GSM1_MOUSE
Ufm1-specific protease 2
Ufsp2
211Annotation score:
A0A1B0GSY4A0A1B0GSY4_MOUSE
Ufm1-specific protease 2
Ufsp2
81Annotation score:
A0A1B0GSK1A0A1B0GSK1_MOUSE
Ufm1-specific protease 2
Ufsp2
117Annotation score:
A0A1B0GRT2A0A1B0GRT2_MOUSE
Ufm1-specific protease 2
Ufsp2
91Annotation score:
A0A1B0GQY6A0A1B0GQY6_MOUSE
Ufm1-specific protease 2
Ufsp2
44Annotation score:

Sequence cautioni

The sequence BAC37214 differs from that shown. Reason: Erroneous termination at position 438. Translated as Trp.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK075795 mRNA Translation: BAC35964.1
AK078309 mRNA Translation: BAC37214.1 Sequence problems.
BC005503 mRNA Translation: AAH05503.1
CCDSiCCDS22284.1
RefSeqiNP_619609.1, NM_138668.2
XP_017168107.1, XM_017312618.1
UniGeneiMm.210882
Mm.445934

Genome annotation databases

EnsembliENSMUST00000034051; ENSMUSP00000034051; ENSMUSG00000031634
GeneIDi192169
KEGGimmu:192169
UCSCiuc009lpp.2 mouse

Similar proteinsi

Entry informationi

Entry nameiUFSP2_MOUSE
AccessioniPrimary (citable) accession number: Q99K23
Secondary accession number(s): Q8C5I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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