Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ERBB receptor feedback inhibitor 1

Gene

Errfi1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.5 Publications

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ERBB receptor feedback inhibitor 1
Alternative name(s):
Mitogen-inducible gene 6 protein homolog
Short name:
MIG-6
Gene namesi
Name:Errfi1
Synonyms:Mig6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1921405 Errfi1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Embryos are present at the expected Mendelian ratio, but half of the mice die before adolescence, due to defects in prenatal and perinatal lung development. In the E15.5 embryo, lungs are smaller, have a less complex structure than normal, and present fewer blood vessels. Lungs in newborns present abnormal patterns of cell proliferation and apoptosis. Adults develop chronic obstructive pulmonary disease (COPD). Mice present epidermal hyperplasia with thickening and flaking skin and ulcerations on tail and footpads. Papillomas develop at sites of wounding. Mice are highly susceptible to chemical carcinogens and develop melanomas and/or papillomas after application of a carcinogen. They have a high incidence of spontaneous hyperplastic and neoplastic lesions, such as adenocarcinomas or squamous cell carcinomas. They present bone and cartilage hyperplasia, leading to fixed joints. Mice have altered response to progesterone in the uterus, resulting in endometrial epithelial hyperplasia and complete loss of fertility. Mice have a shortened life span and die prematurely at an age of five to seven months.4 Publications

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000964882 – 461ERBB receptor feedback inhibitor 1Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei126PhosphothreonineCombined sources1
Modified residuei130PhosphothreonineCombined sources1
Modified residuei251PhosphoserineCombined sources1
Modified residuei272PhosphoserineCombined sources1
Modified residuei301PhosphoserineCombined sources1
Modified residuei460PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99JZ7
PaxDbiQ99JZ7
PRIDEiQ99JZ7

PTM databases

iPTMnetiQ99JZ7
PhosphoSitePlusiQ99JZ7

Expressioni

Tissue specificityi

Detected in lung, in airway epithelial cells and alveolar type 2 cells (at protein level). Detected in uterus stroma, luminal epithelium and glandular epithelium.2 Publications

Developmental stagei

Detected at low levels during embryogenesis. Strongly up-regulated during the first days after birth. Levels are increased on the first day after birth, and culminate three days after birth. Detected at low levels four days after birth, and throughout the remaining life span.1 Publication

Inductioni

Up-regulated by lysophosphatidic acid (LPA) and sphingosine 1-phosphate. Up-regulated by globular actin monomers, via MKL1 signaling. Up-regulated in uterus in response to progesterone. Up-regulated in uterus in response to estrogen. Up-regulated in pregnant uterus.3 Publications

Gene expression databases

BgeeiENSMUSG00000028967 Expressed in 292 organ(s), highest expression level in liver
CleanExiMM_ERRFI1
ExpressionAtlasiQ99JZ7 baseline and differential
GenevisibleiQ99JZ7 MM

Interactioni

Subunit structurei

Interacts with EGFR (By similarity). Interacts with ERBB2.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Grb2Q606313EBI-643375,EBI-1688

GO - Molecular functioni

Protein-protein interaction databases

BioGridi216532, 1 interactor
IntActiQ99JZ7, 2 interactors
STRINGi10090.ENSMUSP00000030811

Structurei

3D structure databases

ProteinModelPortaliQ99JZ7
SMRiQ99JZ7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni333 – 362Interaction with EGFR and ERBB2 and regulation of EGFR activationBy similarityAdd BLAST30

Domaini

The EGFR-binding region prevents binding of a cyclin-like activator to the EGFR kinase domain, and thereby keeps EGFR in an inactive conformation. Also maintains EGFR in an inactive conformation by preventing formation of an asymmetric homodimer (By similarity).By similarity

Sequence similaritiesi

Belongs to the MIG6 family.Curated

Phylogenomic databases

eggNOGiENOG410IEVS Eukaryota
ENOG4111HB5 LUCA
GeneTreeiENSGT00440000033870
HOGENOMiHOG000234207
HOVERGENiHBG031710
InParanoidiQ99JZ7
OMAiYTHRASP
OrthoDBiEOG091G0BER
PhylomeDBiQ99JZ7
TreeFamiTF335720

Family and domain databases

InterProiView protein in InterPro
IPR015116 Cdc42_binding_dom-like
IPR021619 Mig-6
PfamiView protein in Pfam
PF09027 GTPase_binding, 1 hit
PF11555 Inhibitor_Mig-6, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99JZ7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSTAGVAAQD IRVPLKTGFL HNGQALGNMK SCWGSHSEFE NNFLNIDPIT
60 70 80 90 100
MAYNLNSPAQ EHLTTVGCAA RSAPGSGHFF AECGPSPRSS LPPLVISPSE
110 120 130 140 150
SSGQREEDQV MCGFKKLSVN GVCTSTPPLT PIKSCPSPFP CAALCDRGSR
160 170 180 190 200
PLPPLPISED LCVDEADSEV ELLTTSSDTD LLLEDSAPSD FKYDAPGRRS
210 220 230 240 250
FRGCGQINYA YFDSPTVSVA DLSCASDQNR VVPDPNPPPP QSHRRLRRSH
260 270 280 290 300
SGPAGSFNKP AIRISSCTHR ASPSSDEDKP EVPPRVPIPP RPAKPDYRRW
310 320 330 340 350
SAEVTSNTYS DEDRPPKVPP REPLSRSNSR TPSPKSLPSY LNGVMPPTQS
360 370 380 390 400
FAPDPKYVSS KALQRQSSEG SANKVPCILP IIENGKKVSS THYYLLPERP
410 420 430 440 450
PYLDKYEKYF KEAEETNPST QIQPLPAACG MASATEKLAS RMKIDMGSHG
460
KRKHLSYVVS P
Length:461
Mass (Da):50,075
Last modified:June 1, 2001 - v1
Checksum:i0CA414516FAE27A6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005546 mRNA Translation: AAH05546.1
BC057646 mRNA Translation: AAH57646.1
CCDSiCCDS18974.1
RefSeqiNP_598514.1, NM_133753.1
XP_006539273.1, XM_006539210.1
UniGeneiMm.318841

Genome annotation databases

EnsembliENSMUST00000030811; ENSMUSP00000030811; ENSMUSG00000028967
ENSMUST00000073600; ENSMUSP00000073285; ENSMUSG00000028967
GeneIDi74155
KEGGimmu:74155
UCSCiuc008vxw.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005546 mRNA Translation: AAH05546.1
BC057646 mRNA Translation: AAH57646.1
CCDSiCCDS18974.1
RefSeqiNP_598514.1, NM_133753.1
XP_006539273.1, XM_006539210.1
UniGeneiMm.318841

3D structure databases

ProteinModelPortaliQ99JZ7
SMRiQ99JZ7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi216532, 1 interactor
IntActiQ99JZ7, 2 interactors
STRINGi10090.ENSMUSP00000030811

PTM databases

iPTMnetiQ99JZ7
PhosphoSitePlusiQ99JZ7

Proteomic databases

MaxQBiQ99JZ7
PaxDbiQ99JZ7
PRIDEiQ99JZ7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030811; ENSMUSP00000030811; ENSMUSG00000028967
ENSMUST00000073600; ENSMUSP00000073285; ENSMUSG00000028967
GeneIDi74155
KEGGimmu:74155
UCSCiuc008vxw.1 mouse

Organism-specific databases

CTDi54206
MGIiMGI:1921405 Errfi1

Phylogenomic databases

eggNOGiENOG410IEVS Eukaryota
ENOG4111HB5 LUCA
GeneTreeiENSGT00440000033870
HOGENOMiHOG000234207
HOVERGENiHBG031710
InParanoidiQ99JZ7
OMAiYTHRASP
OrthoDBiEOG091G0BER
PhylomeDBiQ99JZ7
TreeFamiTF335720

Miscellaneous databases

ChiTaRSiErrfi1 mouse
PROiPR:Q99JZ7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028967 Expressed in 292 organ(s), highest expression level in liver
CleanExiMM_ERRFI1
ExpressionAtlasiQ99JZ7 baseline and differential
GenevisibleiQ99JZ7 MM

Family and domain databases

InterProiView protein in InterPro
IPR015116 Cdc42_binding_dom-like
IPR021619 Mig-6
PfamiView protein in Pfam
PF09027 GTPase_binding, 1 hit
PF11555 Inhibitor_Mig-6, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiERRFI_MOUSE
AccessioniPrimary (citable) accession number: Q99JZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 27, 2003
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again