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Protein

Syntenin-2

Gene

Sdcbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Syntenin-2
Alternative name(s):
Syndecan-binding protein 2
Gene namesi
Name:Sdcbp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385156 Sdcbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840051 – 292Syntenin-2Add BLAST292

Proteomic databases

MaxQBiQ99JZ0
PaxDbiQ99JZ0
PRIDEiQ99JZ0

PTM databases

PhosphoSitePlusiQ99JZ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000027456 Expressed in 133 organ(s), highest expression level in colon
CleanExiMM_SDCBP2
GenevisibleiQ99JZ0 MM

Interactioni

Subunit structurei

Monomer and homodimer. Interacts with SDCBP. Interacts with TM4SF1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

MINTiQ99JZ0
STRINGi10090.ENSMUSP00000028950

Structurei

3D structure databases

ProteinModelPortaliQ99JZ0
SMRiQ99JZ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 187PDZ 1PROSITE-ProRule annotationAdd BLAST80
Domaini192 – 267PDZ 2PROSITE-ProRule annotationAdd BLAST76

Domaini

The two PDZ domains mediate the interaction with phosphatidylinositol 4,5-bisphosphate (PIP2) and target SDCBP2 to the plasma membranes and nucleoli, PIP2-rich regions.By similarity

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410IK98 Eukaryota
ENOG410YNPQ LUCA
GeneTreeiENSGT00390000014465
HOGENOMiHOG000231604
HOVERGENiHBG053211
InParanoidiQ99JZ0
OMAiTLLHHTM
OrthoDBiEOG091G0HJI
PhylomeDBiQ99JZ0
TreeFamiTF327131

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits

Sequencei

Sequence statusi: Complete.

Q99JZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVLYPSLED LKVGQVIQAQ GRASPTMPTL PAPMASAPPL SELYPNLAEL
60 70 80 90 100
ESYMGLSLSS QEVQKNLTQI PDSDNMVVTS PGPGQVVAPV SGNNLGILRA
110 120 130 140 150
EIKPGVREIH LCKDERGKTG LRLQAVDKGL FVQLVQANTP ASLVGLRFGD
160 170 180 190 200
QILQIDGCDC AGWNTHKAHK VLKKASAEKI VMVIRDRPFQ RTVTMHKDSS
210 220 230 240 250
GQVGFSIKKG KIVSVVKGSS AARNGLLTNH YVCEVNGQNV IGLKDKKVTE
260 270 280 290
ILTTAGDVIT LTIIPTVIYE HMIKRLSPLL LHHTMDHSIP DT
Length:292
Mass (Da):31,565
Last modified:June 1, 2001 - v1
Checksum:iC694316BC0A0931D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136572 mRNA Translation: BAE23054.1
AK144452 mRNA Translation: BAE25896.1
AK160483 mRNA Translation: BAE35814.1
BC005556 mRNA Translation: AAH05556.1
CCDSiCCDS16870.1
RefSeqiNP_663510.1, NM_145535.2
XP_006499367.1, XM_006499304.2
XP_006499368.1, XM_006499305.1
UniGeneiMm.32068

Genome annotation databases

EnsembliENSMUST00000028950; ENSMUSP00000028950; ENSMUSG00000027456
GeneIDi228765
KEGGimmu:228765
UCSCiuc008nec.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136572 mRNA Translation: BAE23054.1
AK144452 mRNA Translation: BAE25896.1
AK160483 mRNA Translation: BAE35814.1
BC005556 mRNA Translation: AAH05556.1
CCDSiCCDS16870.1
RefSeqiNP_663510.1, NM_145535.2
XP_006499367.1, XM_006499304.2
XP_006499368.1, XM_006499305.1
UniGeneiMm.32068

3D structure databases

ProteinModelPortaliQ99JZ0
SMRiQ99JZ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiQ99JZ0
STRINGi10090.ENSMUSP00000028950

PTM databases

PhosphoSitePlusiQ99JZ0

Proteomic databases

MaxQBiQ99JZ0
PaxDbiQ99JZ0
PRIDEiQ99JZ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028950; ENSMUSP00000028950; ENSMUSG00000027456
GeneIDi228765
KEGGimmu:228765
UCSCiuc008nec.2 mouse

Organism-specific databases

CTDi27111
MGIiMGI:2385156 Sdcbp2

Phylogenomic databases

eggNOGiENOG410IK98 Eukaryota
ENOG410YNPQ LUCA
GeneTreeiENSGT00390000014465
HOGENOMiHOG000231604
HOVERGENiHBG053211
InParanoidiQ99JZ0
OMAiTLLHHTM
OrthoDBiEOG091G0HJI
PhylomeDBiQ99JZ0
TreeFamiTF327131

Miscellaneous databases

ChiTaRSiTrappc4 mouse
PROiPR:Q99JZ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027456 Expressed in 133 organ(s), highest expression level in colon
CleanExiMM_SDCBP2
GenevisibleiQ99JZ0 MM

Family and domain databases

InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
PfamiView protein in Pfam
PF00595 PDZ, 2 hits
SMARTiView protein in SMART
SM00228 PDZ, 2 hits
SUPFAMiSSF50156 SSF50156, 2 hits
PROSITEiView protein in PROSITE
PS50106 PDZ, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSDCB2_MOUSE
AccessioniPrimary (citable) accession number: Q99JZ0
Secondary accession number(s): Q3UN51
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 120 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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