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UniProtKB - Q99JY3 (GIMA4_MOUSE)
Protein
GTPase IMAP family member 4
Gene
Gimap4
Organism
Mus musculus (Mouse)
Status
Functioni
During thymocyte development, may play a role in the regulation of apoptosis.
2 PublicationsSites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 58 | GTPBy similarity | 1 | |
Binding sitei | 191 | GTPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 37 – 45 | GTPBy similarity | 9 | |
Nucleotide bindingi | 155 – 157 | GTPBy similarity | 3 |
GO - Molecular functioni
- GTP binding Source: UniProtKB-KW
Keywordsi
Ligand | GTP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: GTPase IMAP family member 4Alternative name(s): Immunity-associated nucleotide 1 protein1 Publication Short name: IAN-11 Publication Immunity-associated protein 4 |
Gene namesi | Name:Gimap4 Synonyms:Ian11 Publication, Imap4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1349656, Gimap4 |
VEuPathDBi | HostDB:ENSMUSG00000054435 |
Subcellular locationi
Cytoplasm and Cytosol
- cytosol 2 Publications
Cytosol
- cytosol Source: UniProtKB
Other locations
- intracellular membrane-bounded organelle Source: Ensembl
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Disruption phenotypei
No visible phenotype. T-cell development, selection and activation in vivo appear to occur normally in knockout mice.1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 239 – 250 | RMQEL…EELER → QMQELYQEELEQ: Loss of interaction with CALM1. 1 PublicationAdd BLAST | 12 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000190988 | 1 – 328 | GTPase IMAP family member 4Add BLAST | 328 |
Post-translational modificationi
Phosphorylated at very low levels in resting splenocytes. Rapidly and transiently phosphorylated in response to splenocyte activation. Phosphorylation is increased in cells undergoing apoptosis.1 Publication
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99JY3 |
jPOSTi | Q99JY3 |
MaxQBi | Q99JY3 |
PaxDbi | Q99JY3 |
PeptideAtlasi | Q99JY3 |
PRIDEi | Q99JY3 |
ProteomicsDBi | 271222 [Q99JY3-1] 357534 |
PTM databases
iPTMneti | Q99JY3 |
PhosphoSitePlusi | Q99JY3 |
Expressioni
Tissue specificityi
Expressed in thymus (in thymocytes), spleen (in splenocytes), lymph node and lung (PubMed:16509771). Expressed in B-cells and T-cells (at protein level) (PubMed:16569770, PubMed:16509771).2 Publications
Developmental stagei
Up-regulated during T cell development, including upon the maturation of CD4/CD8 double-positive to CD4 single-positive thymocytes.2 Publications
Gene expression databases
Bgeei | ENSMUSG00000054435, Expressed in lymph node and 235 other tissues |
ExpressionAtlasi | Q99JY3, baseline and differential |
Genevisiblei | Q99JY3, MM |
Interactioni
Subunit structurei
Protein-protein interaction databases
IntActi | Q99JY3, 1 interactor |
STRINGi | 10090.ENSMUSP00000087524 |
Miscellaneous databases
RNActi | Q99JY3, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 230 | AIG1-type GPROSITE-ProRule annotationAdd BLAST | 203 | |
Domaini | 233 – 262 | IQPROSITE-ProRule annotationAdd BLAST | 30 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 25 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 37 – 44 | G1PROSITE-ProRule annotation | 8 | |
Regioni | 64 – 68 | G2PROSITE-ProRule annotation | 5 | |
Regioni | 85 – 88 | G3PROSITE-ProRule annotation | 4 | |
Regioni | 154 – 157 | G4PROSITE-ProRule annotation | 4 | |
Regioni | 190 – 192 | G5PROSITE-ProRule annotation | 3 |
Sequence similaritiesi
Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily.Curated
Phylogenomic databases
eggNOGi | ENOG502R7PE, Eukaryota |
GeneTreei | ENSGT00940000159317 |
HOGENOMi | CLU_010468_3_3_1 |
InParanoidi | Q99JY3 |
OMAi | CKEIARC |
OrthoDBi | 1092873at2759 |
TreeFami | TF330845 |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR045058, GIMA/IAN/Toc IPR000048, IQ_motif_EF-hand-BS IPR027417, P-loop_NTPase |
PANTHERi | PTHR10903, PTHR10903, 1 hit |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99JY3-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEVQCGGAGF IPESSRSSHE LGNQDQGIPQ LRIVLLGKTG AGKSSTGNSI
60 70 80 90 100
LGEKVFNSGI CAKSITKVCE KRVSTWDGKE LVVVDTPGIF DTEVPDADTQ
110 120 130 140 150
REITRYVALT SPGPHALLLV VPLGRYTVEE HKATQKILDM FGKQARRFMI
160 170 180 190 200
LLLTRKDDLE DTDIHEYLEK APKFFQEVMH EFQNRYCLFN NRASGAEKEE
210 220 230 240 250
QKMQLLTLVQ SMVRENGGRC FTNKMYESAE CVIQKETLRM QELYREELER
260 270 280 290 300
EKARIRREYE EQIKDLRDEL EREIRRARME REFKEREAIF TKNQQNARKE
310 320
VENTSMILEL IIKAWEIASF IFNQFMKD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketD3YWB5 | D3YWB5_MOUSE | GTPase IMAP family member 4 | Gimap4 | 200 | Annotation score: | ||
D3Z7Q4 | D3Z7Q4_MOUSE | GTPase IMAP family member 4 | Gimap4 | 89 | Annotation score: | ||
D6RGS2 | D6RGS2_MOUSE | GTPase IMAP family member 4 | Gimap4 | 69 | Annotation score: | ||
D3Z3F3 | D3Z3F3_MOUSE | GTPase IMAP family member 4 | Gimap4 | 58 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060167 | 213 – 219 | VRENGGR → FLSSRMK in isoform 2. | 7 | |
Alternative sequenceiVSP_060168 | 220 – 328 | Missing in isoform 2. Add BLAST | 109 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC153894 Genomic DNA No translation available. BC005577 mRNA Translation: AAH05577.1 |
CCDSi | CCDS20110.1 [Q99JY3-1] CCDS57423.1 [Q99JY3-2] |
RefSeqi | NP_001230128.1, NM_001243199.1 [Q99JY3-2] NP_778155.2, NM_174990.4 [Q99JY3-1] |
Genome annotation databases
Ensembli | ENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435 [Q99JY3-2] ENSMUST00000090070; ENSMUSP00000087524; ENSMUSG00000054435 [Q99JY3-1] |
GeneIDi | 107526 |
KEGGi | mmu:107526 |
UCSCi | uc009bvi.2, mouse [Q99JY3-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC153894 Genomic DNA No translation available. BC005577 mRNA Translation: AAH05577.1 |
CCDSi | CCDS20110.1 [Q99JY3-1] CCDS57423.1 [Q99JY3-2] |
RefSeqi | NP_001230128.1, NM_001243199.1 [Q99JY3-2] NP_778155.2, NM_174990.4 [Q99JY3-1] |
3D structure databases
AlphaFoldDBi | Q99JY3 |
SMRi | Q99JY3 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | Q99JY3, 1 interactor |
STRINGi | 10090.ENSMUSP00000087524 |
PTM databases
iPTMneti | Q99JY3 |
PhosphoSitePlusi | Q99JY3 |
Proteomic databases
EPDi | Q99JY3 |
jPOSTi | Q99JY3 |
MaxQBi | Q99JY3 |
PaxDbi | Q99JY3 |
PeptideAtlasi | Q99JY3 |
PRIDEi | Q99JY3 |
ProteomicsDBi | 271222 [Q99JY3-1] 357534 |
Protocols and materials databases
Antibodypediai | 18614, 292 antibodies from 28 providers |
DNASUi | 107526 |
Genome annotation databases
Ensembli | ENSMUST00000067506; ENSMUSP00000068398; ENSMUSG00000054435 [Q99JY3-2] ENSMUST00000090070; ENSMUSP00000087524; ENSMUSG00000054435 [Q99JY3-1] |
GeneIDi | 107526 |
KEGGi | mmu:107526 |
UCSCi | uc009bvi.2, mouse [Q99JY3-1] |
Organism-specific databases
CTDi | 55303 |
MGIi | MGI:1349656, Gimap4 |
VEuPathDBi | HostDB:ENSMUSG00000054435 |
Phylogenomic databases
eggNOGi | ENOG502R7PE, Eukaryota |
GeneTreei | ENSGT00940000159317 |
HOGENOMi | CLU_010468_3_3_1 |
InParanoidi | Q99JY3 |
OMAi | CKEIARC |
OrthoDBi | 1092873at2759 |
TreeFami | TF330845 |
Miscellaneous databases
BioGRID-ORCSi | 107526, 1 hit in 71 CRISPR screens |
ChiTaRSi | Gimap4, mouse |
PROi | PR:Q99JY3 |
RNActi | Q99JY3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000054435, Expressed in lymph node and 235 other tissues |
ExpressionAtlasi | Q99JY3, baseline and differential |
Genevisiblei | Q99JY3, MM |
Family and domain databases
Gene3Di | 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR006703, G_AIG1 IPR045058, GIMA/IAN/Toc IPR000048, IQ_motif_EF-hand-BS IPR027417, P-loop_NTPase |
PANTHERi | PTHR10903, PTHR10903, 1 hit |
Pfami | View protein in Pfam PF04548, AIG1, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS51720, G_AIG1, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GIMA4_MOUSE | |
Accessioni | Q99JY3Primary (citable) accession number: Q99JY3 Secondary accession number(s): D3YTN4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | May 8, 2019 | |
Last modified: | May 25, 2022 | |
This is version 129 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families