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Entry version 188 (02 Jun 2021)
Sequence version 3 (27 Jul 2011)
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Protein

Nuclear RNA export factor 1

Gene

Nxf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the nuclear export of mRNA species bearing retroviral constitutive transport elements (CTE) and in the export of mRNA from the nucleus to the cytoplasm (TAP/NFX1 pathway). The NXF1-NXT1 heterodimer is involved in the export of HSP70 mRNA in conjunction with ALYREF/THOC4 and THOC5 components of the TREX complex. ALYREF/THOC4-bound mRNA is thought to be transferred to the NXF1-NXT1 heterodimer for export. Also involved in nuclear export of m6A-containing mRNAs: interaction between SRSF3 and YTHDC1 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processmRNA transport, Protein transport, Translocation, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-159227, Transport of the SLBP independent Mature mRNA
R-MMU-159230, Transport of the SLBP Dependant Mature mRNA
R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nuclear RNA export factor 1
Alternative name(s):
Tip-associated protein
Tip-associating protein
mRNA export factor TAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Nxf1
Synonyms:Tap
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1858330, Nxf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nuclear pore complex, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205302 – 618Nuclear RNA export factor 1Add BLAST617

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei41Asymmetric dimethylarginine; alternateCombined sources1
Modified residuei41Omega-N-methylarginine; alternateCombined sources1
Modified residuei1253'-nitrotyrosineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Nitration

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q99JX7

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99JX7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99JX7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99JX7

PeptideAtlas

More...
PeptideAtlasi
Q99JX7

PRoteomics IDEntifications database

More...
PRIDEi
Q99JX7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291930

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99JX7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99JX7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed ubiquitously.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000010097, Expressed in undifferentiated genital tubercle and 317 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99JX7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99JX7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer (via NTF2 domain) with NXT1 (By similarity). The formation of NXF1-NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export (By similarity).

Forms a complex with RANBP2/NUP358, NXT1 and RANGAP1 (By similarity). Associates with the exon junction complex (EJC) (PubMed:12093754). Associates with the transcription/export (TREX) complex (By similarity).

Found in a mRNA complex with UPF3A and UPF3B (By similarity).

Found in a post-splicing complex with RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1 (By similarity).

Interacts (via N-terminus) with DHX9 (via N-terminus); this interaction is direct and negatively regulates NXF1-mediated nuclear export of constitutive transport element (CTE)-containing cellular mRNAs (By similarity).

Interacts with FYTTD1/UIF (By similarity).

Interacts with EIF4A3 (By similarity).

Interacts with NUP42 (By similarity).

Interacts with ALYREF/THOC4 (PubMed:10786854).

Interacts with CHTOP (By similarity).

Interacts with FRG1 (via N-terminus) (By similarity).

Interacts with LUZP4 (By similarity).

Interacts with FMR1; the interaction occurs in a mRNA-dependent and polyribosomes-independent manner in the nucleus (By similarity).

Interacts with CPSF6 (via N-terminus); this interaction is direct (By similarity).

Interacts with RBM15 (By similarity).

Interacts with RBM15B (By similarity).

Interacts with MCM3AP; this interaction is not mediated by RNA (By similarity).

Interacts with DDX3X (via C-terminus); this interaction may be partly involved in DDX3X nuclear export and in NXF1 localization to stress granules.

Interacts with PABPC1/PABP1 (By similarity).

By similarity2 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
207282, 19 interactors

Protein interaction database and analysis system

More...
IntActi
Q99JX7, 1 interactor

Molecular INTeraction database

More...
MINTi
Q99JX7

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000010241

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99JX7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q99JX7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99JX7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini118 – 197RRMAdd BLAST80
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati265 – 290LRR 1Add BLAST26
Repeati291 – 314LRR 2Add BLAST24
Repeati315 – 342LRR 3Add BLAST28
Repeati343 – 370LRR 4Add BLAST28
Domaini385 – 535NTF2PROSITE-ProRule annotationAdd BLAST151
Domaini564 – 618TAP-CPROSITE-ProRule annotationAdd BLAST55

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 113DisorderedSequence analysisAdd BLAST113
Regioni2 – 197Interaction with ALYREF/THOC4 and LUZP4By similarityAdd BLAST196
Regioni2 – 117RNA-binding (RBD)By similarityAdd BLAST116
Regioni2 – 59Minor non-specific RNA-bindingBy similarityAdd BLAST58
Regioni60 – 117Major non-specific RNA-bindingBy similarityAdd BLAST58
Regioni60 – 117RNA bindingBy similarityAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi66 – 99Nuclear localization signalBy similarityAdd BLAST34
Motifi82 – 109Nuclear export signalBy similarityAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 20Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi80 – 103Basic and acidic residuesSequence analysisAdd BLAST24

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The minimal CTE binding domain consists of an RNP-type RNA binding domain (RBD) and leucine-rich repeats.By similarity
The nucleoporin binding domain consists of a NTF2 domain (also called NTF2-like domain) and a TAP-C domain (also called UBA-like domain). It has 2 nucleoporin-FG-repeats binding sites (one in the NTF2 and the other in the TAP-C domain) which contribute to nucleoporin association and act synergistically to export cellular mRNAs.By similarity
The NTF2 domain is functional only in the presence of NXT1 and is essential for the export of mRNA from the nucleus. It inhibits RNA binding activity through an intramolecular interaction with the N-terminal RNA binding domain (RBD); the inhibition is removed by an association with the TREX complex, specifically involving ALYREF/THOC4 and THOC5.By similarity
The TAP-C domain mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The conserved loop 594-NWD-596 of the TAP-C domain has a critical role in the interaction with nucleoporins.By similarity
The leucine-rich repeats are essential for the export of mRNA from the nucleus.By similarity
The RNA-binding domain is a non-canonical RNP-type domain.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NXF family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3763, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011280_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99JX7

Identification of Orthologs from Complete Genome Data

More...
OMAi
IMDCHPL

Database of Orthologous Groups

More...
OrthoDBi
1051093at2759

TreeFam database of animal gene trees

More...
TreeFami
TF314566

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00780, NTF2, 1 hit
cd14342, UBA_TAP-C, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.70.330, 1 hit
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR002075, NTF2
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR005637, TAP_C_dom
IPR015245, Tap_RNA-bd
IPR009060, UBA-like_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10662, PTHR10662, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02136, NTF2, 1 hit
PF09162, Tap-RNA_bind, 1 hit
PF03943, TAP_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00804, TAP_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46934, SSF46934, 1 hit
SSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 3 hits
PS50177, NTF2_DOMAIN, 1 hit
PS51281, TAP_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99JX7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADEGKSYNE HDDRVSFPQR RKKGRGPFRW KCGEGNRRSG RGGSGVQSSR
60 70 80 90 100
FEEDDGDVAM NDPQDGPRVR YNPYTNRPNR RGDGWHDRDR IHITVRRDRA
110 120 130 140 150
PAERGGAGTS QDGTTKNWFK ITIPYGRKYD KTWLLSMIQS KCSVPFNPIE
160 170 180 190 200
FHYENTRAHF FVEDATTASA LKGVNHKIQD RENRRISIII NASAPPYTVQ
210 220 230 240 250
NELKPEQIEQ LKLIMSKRYD GNQQALDLKG LRSDPDLVAQ NIDVVLNRRS
260 270 280 290 300
CMAATLRIIE ENIPELLSLN LSSNRLYKLD DMSSIVQKAP NLKTLNLSGN
310 320 330 340 350
ELKTERELDK IKGLKLEELW LDRNPMCDNF GDQSSYISAI RERFPKLLRL
360 370 380 390 400
DGHELPPPIS FDVEAPTMLP PCKGSYFGTE NLKSLVLRFL QQYYVIYDSG
410 420 430 440 450
DRQGLLYAYH DGACCSLSIP YNPQNPVRKN LAEYVKDSRN VKKLKEPTQR
460 470 480 490 500
FRLLKHTRLN VVAFLNELPK TQHDVNAFVV DISAQTSTLL CFSVNGVFKE
510 520 530 540 550
VDGKSRDSLR AFTRTFIAVP ASNSGLCIVN DELFVRNASP EEIQRAFAMS
560 570 580 590 600
APTPSSSPVP TLSPEQQEML QAFSTQSGMN LEWSQKCLQD NNWDYTRSAQ
610
AFTLLKAKGE IPEVAFMK
Length:618
Mass (Da):70,300
Last modified:July 27, 2011 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0556EF8553B4055F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXF3V9GXF3_MOUSE
Nuclear RNA export factor 1
Nxf1
418Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXW3V9GXW3_MOUSE
Nuclear RNA export factor 1
Nxf1
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GX96V9GX96_MOUSE
Nuclear RNA export factor 1
Nxf1
75Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
V9GXM5V9GXM5_MOUSE
Nuclear RNA export factor 1
Nxf1
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti79N → D in AAC63368 (Ref. 1) Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF093140 mRNA Translation: AAC63368.1
AK133883 mRNA Translation: BAE21911.1
AK167518 mRNA Translation: BAE39590.1
CH466612 Genomic DNA Translation: EDL33363.1
BC005594 mRNA Translation: AAH05594.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS29543.1

NCBI Reference Sequences

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RefSeqi
NP_058093.2, NM_016813.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000010241; ENSMUSP00000010241; ENSMUSG00000010097

Database of genes from NCBI RefSeq genomes

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GeneIDi
53319

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:53319

UCSC genome browser

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UCSCi
uc008gmr.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF093140 mRNA Translation: AAC63368.1
AK133883 mRNA Translation: BAE21911.1
AK167518 mRNA Translation: BAE39590.1
CH466612 Genomic DNA Translation: EDL33363.1
BC005594 mRNA Translation: AAH05594.1
CCDSiCCDS29543.1
RefSeqiNP_058093.2, NM_016813.2

3D structure databases

BMRBiQ99JX7
SMRiQ99JX7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi207282, 19 interactors
IntActiQ99JX7, 1 interactor
MINTiQ99JX7
STRINGi10090.ENSMUSP00000010241

PTM databases

iPTMnetiQ99JX7
PhosphoSitePlusiQ99JX7

Proteomic databases

EPDiQ99JX7
jPOSTiQ99JX7
MaxQBiQ99JX7
PaxDbiQ99JX7
PeptideAtlasiQ99JX7
PRIDEiQ99JX7
ProteomicsDBi291930

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
4277, 289 antibodies

The DNASU plasmid repository

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DNASUi
53319

Genome annotation databases

EnsembliENSMUST00000010241; ENSMUSP00000010241; ENSMUSG00000010097
GeneIDi53319
KEGGimmu:53319
UCSCiuc008gmr.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
10482
MGIiMGI:1858330, Nxf1

Phylogenomic databases

eggNOGiKOG3763, Eukaryota
GeneTreeiENSGT00390000007539
HOGENOMiCLU_011280_2_0_1
InParanoidiQ99JX7
OMAiIMDCHPL
OrthoDBi1051093at2759
TreeFamiTF314566

Enzyme and pathway databases

ReactomeiR-MMU-159227, Transport of the SLBP independent Mature mRNA
R-MMU-159230, Transport of the SLBP Dependant Mature mRNA
R-MMU-159231, Transport of Mature mRNA Derived from an Intronless Transcript
R-MMU-159236, Transport of Mature mRNA derived from an Intron-Containing Transcript

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
53319, 23 hits in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Nxf1, mouse

Protein Ontology

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PROi
PR:Q99JX7
RNActiQ99JX7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000010097, Expressed in undifferentiated genital tubercle and 317 other tissues
ExpressionAtlasiQ99JX7, baseline and differential
GenevisibleiQ99JX7, MM

Family and domain databases

CDDicd00780, NTF2, 1 hit
cd14342, UBA_TAP-C, 1 hit
Gene3Di3.30.70.330, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR001611, Leu-rich_rpt
IPR032675, LRR_dom_sf
IPR002075, NTF2
IPR032710, NTF2-like_dom_sf
IPR018222, Nuclear_transport_factor_2_euk
IPR012677, Nucleotide-bd_a/b_plait_sf
IPR030217, NXF_fam
IPR035979, RBD_domain_sf
IPR005637, TAP_C_dom
IPR015245, Tap_RNA-bd
IPR009060, UBA-like_sf
PANTHERiPTHR10662, PTHR10662, 1 hit
PfamiView protein in Pfam
PF02136, NTF2, 1 hit
PF09162, Tap-RNA_bind, 1 hit
PF03943, TAP_C, 1 hit
SMARTiView protein in SMART
SM00804, TAP_C, 1 hit
SUPFAMiSSF46934, SSF46934, 1 hit
SSF54427, SSF54427, 1 hit
SSF54928, SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS51450, LRR, 3 hits
PS50177, NTF2_DOMAIN, 1 hit
PS51281, TAP_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNXF1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99JX7
Secondary accession number(s): O88985, Q3TJA5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: July 27, 2011
Last modified: June 2, 2021
This is version 188 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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