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Protein

Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein

Gene

Bnipl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.

GO - Molecular functioni

  • exopolyphosphatase activity Source: GO_Central
  • identical protein binding Source: MGI

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Gene namesi
Name:Bnipl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2384749 Bnipl

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107711 – 328Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like proteinAdd BLAST328

Proteomic databases

PaxDbiQ99JU7
PRIDEiQ99JU7

PTM databases

iPTMnetiQ99JU7
PhosphoSitePlusiQ99JU7

Expressioni

Gene expression databases

BgeeiENSMUSG00000028115 Expressed in 20 organ(s), highest expression level in zone of skin
CleanExiMM_BNIPL
ExpressionAtlasiQ99JU7 baseline and differential
GenevisibleiQ99JU7 MM

Interactioni

Subunit structurei

Homodimer. Interacts with BCL2, ARHGAP1, MIF and GFER (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102813

Structurei

3D structure databases

ProteinModelPortaliQ99JU7
SMRiQ99JU7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini162 – 323CRAL-TRIOPROSITE-ProRule annotationAdd BLAST162

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi81 – 86Poly-Ser6

Phylogenomic databases

eggNOGiENOG410IE6U Eukaryota
ENOG4111F6D LUCA
GeneTreeiENSGT00420000029688
HOGENOMiHOG000230952
HOVERGENiHBG054692
InParanoidiQ99JU7
PhylomeDBiQ99JU7

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR022181 Bcl2-/adenovirus-E1B
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
PfamiView protein in Pfam
PF12496 BNIP2, 1 hit
PF13716 CRAL_TRIO_2, 1 hit
SMARTiView protein in SMART
SM00516 SEC14, 1 hit
SUPFAMiSSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99JU7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLGELELRE EWQDEEFPRL LPEEPGSPGD PEDPQRGSQA GTPSSLALCG
60 70 80 90 100
QRPMRKRLSA PEWQLSLTEG TGENGASPTR SASSSSAGSL DLEVDELETP
110 120 130 140 150
SDSEQLDSGH EFEWEDDLPR AEGLGASEAA ERLGRGCVCD VAGEDGHRWR
160 170 180 190 200
VFRTGQREQR VDMTIIEPYK KVLSHGGYHG DGLNAVILFA SCYLPRSSIP
210 220 230 240 250
NYTYIMEHLF RYMVGTLELL VAENYLLVHL SGGTSRAQVP PLSWIRQCYR
260 270 280 290 300
TLDRRLRKNL RALVVVHATW YVKAFLALVR PFISSKFTRK IRFLDSLGEL
310 320
AQLISLEQVH IPEVVRQLDR DLHGSKGT
Length:328
Mass (Da):36,785
Last modified:June 1, 2001 - v1
Checksum:iBE1F7790F5F885F0
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9QME1E9QME1_MOUSE
Bcl-2/adenovirus E1B 19 kDa-interac...
Bnipl
356Annotation score:
E9Q8I3E9Q8I3_MOUSE
Bcl-2/adenovirus E1B 19 kDa-interac...
Bnipl
280Annotation score:
D3YY90D3YY90_MOUSE
Bcl-2/adenovirus E1B 19 kDa-interac...
Bnipl
259Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005659 mRNA Translation: AAH05659.1
BC006585 mRNA Translation: AAH06585.1
UniGeneiMm.331209

Genome annotation databases

EnsembliENSMUST00000137250; ENSMUSP00000115197; ENSMUSG00000028115

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005659 mRNA Translation: AAH05659.1
BC006585 mRNA Translation: AAH06585.1
UniGeneiMm.331209

3D structure databases

ProteinModelPortaliQ99JU7
SMRiQ99JU7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000102813

PTM databases

iPTMnetiQ99JU7
PhosphoSitePlusiQ99JU7

Proteomic databases

PaxDbiQ99JU7
PRIDEiQ99JU7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000137250; ENSMUSP00000115197; ENSMUSG00000028115

Organism-specific databases

MGIiMGI:2384749 Bnipl

Phylogenomic databases

eggNOGiENOG410IE6U Eukaryota
ENOG4111F6D LUCA
GeneTreeiENSGT00420000029688
HOGENOMiHOG000230952
HOVERGENiHBG054692
InParanoidiQ99JU7
PhylomeDBiQ99JU7

Miscellaneous databases

PROiPR:Q99JU7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028115 Expressed in 20 organ(s), highest expression level in zone of skin
CleanExiMM_BNIPL
ExpressionAtlasiQ99JU7 baseline and differential
GenevisibleiQ99JU7 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR022181 Bcl2-/adenovirus-E1B
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
PfamiView protein in Pfam
PF12496 BNIP2, 1 hit
PF13716 CRAL_TRIO_2, 1 hit
SMARTiView protein in SMART
SM00516 SEC14, 1 hit
SUPFAMiSSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiBNIPL_MOUSE
AccessioniPrimary (citable) accession number: Q99JU7
Secondary accession number(s): Q923E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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