UniProtKB - Q99JU7 (BNIPL_MOUSE)
Protein
Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein
Gene
Bnipl
Organism
Mus musculus (Mouse)
Status
Functioni
May be a bridge molecule between BCL2 and ARHGAP1/CDC42 in promoting cell death.
GO - Molecular functioni
- exopolyphosphatase activity Source: GO_Central
- identical protein binding Source: MGI
GO - Biological processi
- apoptotic process Source: MGI
- negative regulation of cell population proliferation Source: MGI
- polyphosphate catabolic process Source: GO_Central
- regulation of growth rate Source: MGI
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein |
Gene namesi | Name:Bnipl |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384749, Bnipl |
Subcellular locationi
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000210771 | 1 – 328 | Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like proteinAdd BLAST | 328 |
Proteomic databases
PaxDbi | Q99JU7 |
PRIDEi | Q99JU7 |
PTM databases
iPTMneti | Q99JU7 |
PhosphoSitePlusi | Q99JU7 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000028115, Expressed in lip and 52 other tissues |
Genevisiblei | Q99JU7, MM |
Interactioni
Subunit structurei
Homodimer.
Interacts with BCL2, ARHGAP1, MIF and GFER (By similarity).
By similarityGO - Molecular functioni
- identical protein binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102813 |
Miscellaneous databases
RNActi | Q99JU7, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 162 – 323 | CRAL-TRIOPROSITE-ProRule annotationAdd BLAST | 162 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 81 – 86 | Poly-Ser | 6 |
Phylogenomic databases
eggNOGi | ENOG502QUPS, Eukaryota |
GeneTreei | ENSGT00940000161723 |
HOGENOMi | CLU_039135_1_0_1 |
InParanoidi | Q99JU7 |
PhylomeDBi | Q99JU7 |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR022181, Bcl2-/adenovirus-E1B IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf |
Pfami | View protein in Pfam PF12496, BNIP2, 1 hit PF13716, CRAL_TRIO_2, 1 hit |
SMARTi | View protein in SMART SM00516, SEC14, 1 hit |
SUPFAMi | SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q99JU7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLGELELRE EWQDEEFPRL LPEEPGSPGD PEDPQRGSQA GTPSSLALCG
60 70 80 90 100
QRPMRKRLSA PEWQLSLTEG TGENGASPTR SASSSSAGSL DLEVDELETP
110 120 130 140 150
SDSEQLDSGH EFEWEDDLPR AEGLGASEAA ERLGRGCVCD VAGEDGHRWR
160 170 180 190 200
VFRTGQREQR VDMTIIEPYK KVLSHGGYHG DGLNAVILFA SCYLPRSSIP
210 220 230 240 250
NYTYIMEHLF RYMVGTLELL VAENYLLVHL SGGTSRAQVP PLSWIRQCYR
260 270 280 290 300
TLDRRLRKNL RALVVVHATW YVKAFLALVR PFISSKFTRK IRFLDSLGEL
310 320
AQLISLEQVH IPEVVRQLDR DLHGSKGT
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9QME1 | E9QME1_MOUSE | Bcl-2/adenovirus E1B 19 kDa-interac... | Bnipl | 356 | Annotation score: | ||
E9Q8I3 | E9Q8I3_MOUSE | Bcl-2/adenovirus E1B 19 kDa-interac... | Bnipl | 280 | Annotation score: | ||
D3YY90 | D3YY90_MOUSE | Bcl-2/adenovirus E1B 19 kDa-interac... | Bnipl | 259 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC005659 mRNA Translation: AAH05659.1 BC006585 mRNA Translation: AAH06585.1 |
Genome annotation databases
Ensembli | ENSMUST00000137250; ENSMUSP00000115197; ENSMUSG00000028115 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC005659 mRNA Translation: AAH05659.1 BC006585 mRNA Translation: AAH06585.1 |
3D structure databases
SMRi | Q99JU7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000102813 |
PTM databases
iPTMneti | Q99JU7 |
PhosphoSitePlusi | Q99JU7 |
Proteomic databases
PaxDbi | Q99JU7 |
PRIDEi | Q99JU7 |
Protocols and materials databases
Antibodypediai | 20308, 86 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000137250; ENSMUSP00000115197; ENSMUSG00000028115 |
Organism-specific databases
MGIi | MGI:2384749, Bnipl |
Phylogenomic databases
eggNOGi | ENOG502QUPS, Eukaryota |
GeneTreei | ENSGT00940000161723 |
HOGENOMi | CLU_039135_1_0_1 |
InParanoidi | Q99JU7 |
PhylomeDBi | Q99JU7 |
Miscellaneous databases
PROi | PR:Q99JU7 |
RNActi | Q99JU7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000028115, Expressed in lip and 52 other tissues |
Genevisiblei | Q99JU7, MM |
Family and domain databases
CDDi | cd00170, SEC14, 1 hit |
Gene3Di | 3.40.525.10, 1 hit |
InterProi | View protein in InterPro IPR022181, Bcl2-/adenovirus-E1B IPR001251, CRAL-TRIO_dom IPR036865, CRAL-TRIO_dom_sf |
Pfami | View protein in Pfam PF12496, BNIP2, 1 hit PF13716, CRAL_TRIO_2, 1 hit |
SMARTi | View protein in SMART SM00516, SEC14, 1 hit |
SUPFAMi | SSF52087, SSF52087, 1 hit |
PROSITEi | View protein in PROSITE PS50191, CRAL_TRIO, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BNIPL_MOUSE | |
Accessioni | Q99JU7Primary (citable) accession number: Q99JU7 Secondary accession number(s): Q923E3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 4, 2005 |
Last sequence update: | June 1, 2001 | |
Last modified: | August 12, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot