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Protein

TNFAIP3-interacting protein 2

Gene

Tnip2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibits NF-kappa-B activation by blocking the interaction of RIPK1 with its downstream effector NEMO/IKBKG. Forms a ternary complex with NFKB1 and MAP3K8 but appears to function upstream of MAP3K8 in the TLR4 signaling pathway that regulates MAP3K8 activation. Involved in activation of the MEK/ERK signaling pathway during innate immune response; this function seems to be stimulus- and cell type specific. Required for stability of MAP3K8. Involved in regulation of apoptosis in endothelial cells; promotes TEK agonist-stimulated endothelial survival. May act as transcriptional coactivator when translocated to the nucleus. Enhances CHUK-mediated NF-kappa-B activation involving NF-kappa-B p50-p65 and p50-c-Rel complexes.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri398 – 430CCHC NOA-typePROSITE-ProRule annotationAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Inflammatory response, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-MMU-5689896 Ovarian tumor domain proteases

Names & Taxonomyi

Protein namesi
Recommended name:
TNFAIP3-interacting protein 2
Alternative name(s):
A20-binding inhibitor of NF-kappa-B activation 2
Short name:
ABIN-2
Gene namesi
Name:Tnip2Imported
Synonyms:Abin2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2386643 Tnip2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003225841 – 430TNFAIP3-interacting protein 2Add BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei8PhosphoserineBy similarity1

Post-translational modificationi

In vitro phosphorylated by CHUK.By similarity
Ubiquitinated; undergoes 'Lys-48'-linked polyubiquitination probably leading to constitutive proteasomal degradation which can be impaired by IKK-A/CHUK or IKBKB probably involving deubiquitination.By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99JG7
MaxQBiQ99JG7
PaxDbiQ99JG7
PRIDEiQ99JG7

PTM databases

iPTMnetiQ99JG7
PhosphoSitePlusiQ99JG7

Expressioni

Tissue specificityi

Ubiquitously expressed in all tissues examined.1 Publication

Gene expression databases

BgeeiENSMUSG00000059866 Expressed in 176 organ(s), highest expression level in female gonad
CleanExiMM_TNIP2
ExpressionAtlasiQ99JG7 baseline and differential
GenevisibleiQ99JG7 MM

Interactioni

Subunit structurei

Interacts with STK11/LKB1, TNFAIP3, IKBKG, NFKB1, MAP3K8, TEK, RIPK1, CHUK, IKBKB and SMARCD1. Interacts with polyubiquitin (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ99JG7, 2 interactors
STRINGi10090.ENSMUSP00000085030

Structurei

3D structure databases

ProteinModelPortaliQ99JG7
SMRiQ99JG7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni290 – 348Ubiquitin-binding domain (UBD)Add BLAST59

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili30 – 139Sequence analysisAdd BLAST110
Coiled coili198 – 227Sequence analysisAdd BLAST30
Coiled coili256 – 344Sequence analysisAdd BLAST89

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri398 – 430CCHC NOA-typePROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IEB1 Eukaryota
ENOG410XRZP LUCA
GeneTreeiENSGT00390000009019
HOGENOMiHOG000049046
HOVERGENiHBG055553
InParanoidiQ99JG7
OMAiDCAEVKQ
PhylomeDBiQ99JG7
TreeFamiTF332167

Family and domain databases

InterProiView protein in InterPro
IPR032419 CC2-LZ_dom
IPR022008 EABR
IPR034735 NEMO_ZF
PfamiView protein in Pfam
PF16516 CC2-LZ, 1 hit
PF12180 EABR, 1 hit
PROSITEiView protein in PROSITE
PS51801 ZF_CCHC_NOA, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99JG7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSGDPRSGR QDGAPRAAAA LCGLYHEAGQ QLQRLKDQLA ARDALIASLR
60 70 80 90 100
TRLAALEGHT APSLVDALLD QVERFREQLR RQEEGASETQ LRQEVERLTE
110 120 130 140 150
RLEEKEREMQ QLMSQPQHEQ EKEVVLLRRS VAEKEKARAA SDVLCRSLAD
160 170 180 190 200
ETHQLRRTLA ATAHMCQHLA KCLDERQCAQ GDAGEKSPAE LEQTSSDASG
210 220 230 240 250
QSVIKKLQEE NRLLKQKVTH VEDLNAKWQR YDASRDEYVK GLHAQLKRRQ
260 270 280 290 300
VPLEPELMKK EISRLNRQLE EKISDCAEAN QELTAMRMSR DTALERVQML
310 320 330 340 350
EQQILAYKDD FKSERADRER AHSRIQELEE KIMSLMYQVS QRQDSREPGP
360 370 380 390 400
CRIHTGNKTA KYLEMDALEH VTPGGWRPES RSQQMEPSAE GGHVCTAQRG
410 420 430
QGDLQCPHCL RCFSDEQGEA FLRHLSECCQ
Length:430
Mass (Da):49,094
Last modified:June 1, 2001 - v1
Checksum:i35F533967072512D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80VZ7Q80VZ7_MOUSE
TNFAIP3-interacting protein 2
Tnip2
451Annotation score:
D3Z039D3Z039_MOUSE
TNFAIP3-interacting protein 2
Tnip2
347Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti164H → N in BAE35666 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304865 mRNA Translation: CAC34841.1
AK160165 mRNA Translation: BAE35666.1
CCDSiCCDS19214.1
RefSeqiNP_620703.1, NM_139064.2
UniGeneiMm.28615

Genome annotation databases

EnsembliENSMUST00000087737; ENSMUSP00000085030; ENSMUSG00000059866
GeneIDi231130
KEGGimmu:231130
UCSCiuc008xcj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ304865 mRNA Translation: CAC34841.1
AK160165 mRNA Translation: BAE35666.1
CCDSiCCDS19214.1
RefSeqiNP_620703.1, NM_139064.2
UniGeneiMm.28615

3D structure databases

ProteinModelPortaliQ99JG7
SMRiQ99JG7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99JG7, 2 interactors
STRINGi10090.ENSMUSP00000085030

PTM databases

iPTMnetiQ99JG7
PhosphoSitePlusiQ99JG7

Proteomic databases

EPDiQ99JG7
MaxQBiQ99JG7
PaxDbiQ99JG7
PRIDEiQ99JG7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000087737; ENSMUSP00000085030; ENSMUSG00000059866
GeneIDi231130
KEGGimmu:231130
UCSCiuc008xcj.1 mouse

Organism-specific databases

CTDi79155
MGIiMGI:2386643 Tnip2

Phylogenomic databases

eggNOGiENOG410IEB1 Eukaryota
ENOG410XRZP LUCA
GeneTreeiENSGT00390000009019
HOGENOMiHOG000049046
HOVERGENiHBG055553
InParanoidiQ99JG7
OMAiDCAEVKQ
PhylomeDBiQ99JG7
TreeFamiTF332167

Enzyme and pathway databases

ReactomeiR-MMU-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation
R-MMU-5689896 Ovarian tumor domain proteases

Miscellaneous databases

ChiTaRSiTnip2 mouse
PROiPR:Q99JG7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000059866 Expressed in 176 organ(s), highest expression level in female gonad
CleanExiMM_TNIP2
ExpressionAtlasiQ99JG7 baseline and differential
GenevisibleiQ99JG7 MM

Family and domain databases

InterProiView protein in InterPro
IPR032419 CC2-LZ_dom
IPR022008 EABR
IPR034735 NEMO_ZF
PfamiView protein in Pfam
PF16516 CC2-LZ, 1 hit
PF12180 EABR, 1 hit
PROSITEiView protein in PROSITE
PS51801 ZF_CCHC_NOA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTNIP2_MOUSE
AccessioniPrimary (citable) accession number: Q99JG7
Secondary accession number(s): Q3TVF3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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