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Protein

Diphosphomevalonate decarboxylase

Gene

Mvd

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Performs the first committed step in the biosynthesis of isoprenes.

Catalytic activityi

ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2.

Pathwayi: cholesterol biosynthesis

This protein is involved in the pathway cholesterol biosynthesis, which is part of Steroid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway cholesterol biosynthesis and in Steroid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processCholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-191273 Cholesterol biosynthesis
R-MMU-446199 Synthesis of Dolichyl-phosphate
UniPathwayi
UPA00063

Names & Taxonomyi

Protein namesi
Recommended name:
Diphosphomevalonate decarboxylase (EC:4.1.1.33)
Alternative name(s):
Mevalonate (diphospho)decarboxylase
Short name:
MDDase
Mevalonate pyrophosphate decarboxylase
Gene namesi
Name:Mvd
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2179327 Mvd

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000870132 – 401Diphosphomevalonate decarboxylaseAdd BLAST400

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ99JF5
MaxQBiQ99JF5
PaxDbiQ99JF5
PRIDEiQ99JF5

PTM databases

iPTMnetiQ99JF5
PhosphoSitePlusiQ99JF5

Expressioni

Gene expression databases

BgeeiENSMUSG00000006517 Expressed in 224 organ(s), highest expression level in liver
CleanExiMM_MVD
ExpressionAtlasiQ99JF5 baseline and differential
GenevisibleiQ99JF5 MM

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006692

Structurei

Secondary structure

1401
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99JF5
SMRiQ99JF5
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99JF5

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi51 – 54Poly-Thr4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2833 Eukaryota
COG3407 LUCA
GeneTreeiENSGT00390000015359
HOVERGENiHBG051503
InParanoidiQ99JF5
KOiK01597
OMAiLTLHAMM
OrthoDBiEOG091G0EUU
PhylomeDBiQ99JF5
TreeFamiTF105952

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR005935 Mev_decarb
IPR029765 Mev_diP_decarb
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF015950 Mev_P_decrbx, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR01240 mevDPdecarb, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99JF5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASEKPQDLM VTCTAPVNIA VIKYWGKRDE ALILPINSSL SVTLHQDQLK
60 70 80 90 100
TTTTVAISKD FTEDRIWLNG REEDVGQPRL QACLREIRRL ARKRRSTEDG
110 120 130 140 150
DTLPLSLSYK VHVASVNNFP TAAGLASSAA GYACLAYTLA QVYGVEGDLS
160 170 180 190 200
EVARRGSGSA CRSLYGGFVE WQMGEQADGK DSIARQIAPE WHWPQLRILI
210 220 230 240 250
LVVSADKKQT GSTVGMQTSV ETSTLLKFRA ESVVPERMKE MTRCIQEQDF
260 270 280 290 300
QGFAQLTMKD SNQFHATCLD TFPPISYLND TSRRIIQLVH RFNTHQGQTK
310 320 330 340 350
VAYTFDAGPN AVIFTLEDTV AEFVAAVRHS FPPAANGDKF LKGLQVAPVL
360 370 380 390 400
LSDELKAALA VEPSPGGVQY IIATQVGPGP QVLDDTHDHL LGQDGLPQRD

L
Length:401
Mass (Da):44,072
Last modified:November 13, 2007 - v2
Checksum:iBDF58921709C55AE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5RLX3A0A1D5RLX3_MOUSE
Diphosphomevalonate decarboxylase
Mvd
78Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229R → Q in BAE32901 (PubMed:16141072).Curated1
Sequence conflicti229R → Q in BAC40852 (PubMed:16141072).Curated1
Sequence conflicti233V → G in CAC35731 (Ref. 1) Curated1
Sequence conflicti254A → G in CAC35731 (Ref. 1) Curated1
Sequence conflicti266A → V in BAE32901 (PubMed:16141072).Curated1
Sequence conflicti266A → V in BAC40852 (PubMed:16141072).Curated1
Sequence conflicti296Q → H in BAE42019 (PubMed:16141072).Curated1
Sequence conflicti296Q → H in AAH08526 (PubMed:15489334).Curated1
Sequence conflicti360A → V in AAH08526 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ309922 mRNA Translation: CAC35731.1
AK089354 mRNA Translation: BAC40852.1
AK154883 mRNA Translation: BAE32901.1
AK170773 mRNA Translation: BAE42019.1
BC008526 mRNA Translation: AAH08526.1
CCDSiCCDS22738.1
RefSeqiNP_619597.2, NM_138656.2
UniGeneiMm.28146

Genome annotation databases

EnsembliENSMUST00000006692; ENSMUSP00000006692; ENSMUSG00000006517
GeneIDi192156
KEGGimmu:192156
UCSCiuc009nss.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ309922 mRNA Translation: CAC35731.1
AK089354 mRNA Translation: BAC40852.1
AK154883 mRNA Translation: BAE32901.1
AK170773 mRNA Translation: BAE42019.1
BC008526 mRNA Translation: AAH08526.1
CCDSiCCDS22738.1
RefSeqiNP_619597.2, NM_138656.2
UniGeneiMm.28146

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3F0NX-ray1.90A/B6-401[»]
ProteinModelPortaliQ99JF5
SMRiQ99JF5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006692

PTM databases

iPTMnetiQ99JF5
PhosphoSitePlusiQ99JF5

Proteomic databases

EPDiQ99JF5
MaxQBiQ99JF5
PaxDbiQ99JF5
PRIDEiQ99JF5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000006692; ENSMUSP00000006692; ENSMUSG00000006517
GeneIDi192156
KEGGimmu:192156
UCSCiuc009nss.2 mouse

Organism-specific databases

CTDi4597
MGIiMGI:2179327 Mvd

Phylogenomic databases

eggNOGiKOG2833 Eukaryota
COG3407 LUCA
GeneTreeiENSGT00390000015359
HOVERGENiHBG051503
InParanoidiQ99JF5
KOiK01597
OMAiLTLHAMM
OrthoDBiEOG091G0EUU
PhylomeDBiQ99JF5
TreeFamiTF105952

Enzyme and pathway databases

UniPathwayi
UPA00063

ReactomeiR-MMU-191273 Cholesterol biosynthesis
R-MMU-446199 Synthesis of Dolichyl-phosphate

Miscellaneous databases

EvolutionaryTraceiQ99JF5
PROiPR:Q99JF5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000006517 Expressed in 224 organ(s), highest expression level in liver
CleanExiMM_MVD
ExpressionAtlasiQ99JF5 baseline and differential
GenevisibleiQ99JF5 MM

Family and domain databases

Gene3Di3.30.230.10, 1 hit
3.30.70.890, 1 hit
InterProiView protein in InterPro
IPR036554 GHMP_kinase_C_sf
IPR006204 GHMP_kinase_N_dom
IPR005935 Mev_decarb
IPR029765 Mev_diP_decarb
IPR020568 Ribosomal_S5_D2-typ_fold
IPR014721 Ribosomal_S5_D2-typ_fold_subgr
PfamiView protein in Pfam
PF00288 GHMP_kinases_N, 1 hit
PIRSFiPIRSF015950 Mev_P_decrbx, 1 hit
SUPFAMiSSF54211 SSF54211, 1 hit
SSF55060 SSF55060, 1 hit
TIGRFAMsiTIGR01240 mevDPdecarb, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMVD1_MOUSE
AccessioniPrimary (citable) accession number: Q99JF5
Secondary accession number(s): Q3TCD8, Q8BTM4, Q922D7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: November 13, 2007
Last modified: September 12, 2018
This is version 121 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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