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UniProtKB - Q99JD3 (ODC_RAT)
Protein
Mitochondrial 2-oxodicarboxylate carrier
Gene
Slc25a21
Organism
Rattus norvegicus (Rat)
Status
Functioni
Transports C5-C7 oxodicarboxylates across the inner membranes of mitochondria. Can transport 2-oxoadipate, 2-oxoglutarate, adipate, glutarate, and to a lesser extent, pimelate, 2-oxopimelate, 2-aminoadipate, oxaloacetate, and citrate.
By similarityGO - Molecular functioni
GO - Biological processi
Keywordsi
Biological process | Transport |
Enzyme and pathway databases
Reactomei | R-RNO-71064, Lysine catabolism |
Names & Taxonomyi
Protein namesi | Recommended name: Mitochondrial 2-oxodicarboxylate carrierAlternative name(s): Solute carrier family 25 member 21 |
Gene namesi | Name:Slc25a21 Synonyms:Odc |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621444, Slc25a21 |
Subcellular locationi
Mitochondrion
- Mitochondrion inner membrane By similarity; Multi-pass membrane protein By similarity
Mitochondrion
- mitochondrial inner membrane Source: UniProtKB-SubCell
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 16 – 36 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Transmembranei | 69 – 88 | Helical; Name=2Sequence analysisAdd BLAST | 20 | |
Transmembranei | 112 – 132 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Transmembranei | 166 – 186 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Transmembranei | 204 – 224 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Transmembranei | 276 – 296 | Helical; Name=6Sequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Membrane, Mitochondrion, Mitochondrion inner membranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000090647 | 1 – 298 | Mitochondrial 2-oxodicarboxylate carrierAdd BLAST | 298 |
Proteomic databases
PaxDbi | Q99JD3 |
PTM databases
iPTMneti | Q99JD3 |
PhosphoSitePlusi | Q99JD3 |
Expressioni
Tissue specificityi
Widely expressed.1 Publication
Gene expression databases
Genevisiblei | Q99JD3, RN |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 10 – 99 | Solcar 1Add BLAST | 90 | |
Repeati | 106 – 195 | Solcar 2Add BLAST | 90 | |
Repeati | 204 – 293 | Solcar 3Add BLAST | 90 |
Sequence similaritiesi
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0754, Eukaryota |
HOGENOMi | CLU_015166_5_2_1 |
InParanoidi | Q99JD3 |
OrthoDBi | 1236425at2759 |
PhylomeDBi | Q99JD3 |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99JD3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSASNVSLLH ETCRQVAAGG CAGLVEICLM HPLDVVKTRF QVQRSVTDPQ
60 70 80 90 100
SYKSLRDSFQ VIFRTEGLFG FYKGIIPPIL AETPKRAVKF STFELYKKFL
110 120 130 140 150
GYMSLSPGLT FPIAGLGSGL TEAVVVNPFE VVKVGLQVNR NMFTEQPSTF
160 170 180 190 200
AYARQIIKKE GWGFQGLNKG FTATLGRHGI FNMTYFGFYY NVKDNIPSSK
210 220 230 240 250
DPTLEFLRKF GIGFVSGTVG SVFNIPFDVA KSRIQGPQPV PGEIKYRGCF
260 270 280 290
KTMETVYREE GILALYKGLL PKVMRLGPGG GVMLLVYEYT YAWLQENW
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A140TAF1 | A0A140TAF1_RAT | Mitochondrial 2-oxodicarboxylate ca... | Slc25a21 | 277 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ289714 mRNA Translation: CAC27796.1 BC089099 mRNA Translation: AAH89099.1 |
RefSeqi | NP_598298.1, NM_133614.2 XP_006240176.1, XM_006240114.3 |
Genome annotation databases
GeneIDi | 171151 |
KEGGi | rno:171151 |
UCSCi | RGD:621444, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ289714 mRNA Translation: CAC27796.1 BC089099 mRNA Translation: AAH89099.1 |
RefSeqi | NP_598298.1, NM_133614.2 XP_006240176.1, XM_006240114.3 |
3D structure databases
SMRi | Q99JD3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000037607 |
PTM databases
iPTMneti | Q99JD3 |
PhosphoSitePlusi | Q99JD3 |
Proteomic databases
PaxDbi | Q99JD3 |
Genome annotation databases
GeneIDi | 171151 |
KEGGi | rno:171151 |
UCSCi | RGD:621444, rat |
Organism-specific databases
CTDi | 89874 |
RGDi | 621444, Slc25a21 |
Phylogenomic databases
eggNOGi | KOG0754, Eukaryota |
HOGENOMi | CLU_015166_5_2_1 |
InParanoidi | Q99JD3 |
OrthoDBi | 1236425at2759 |
PhylomeDBi | Q99JD3 |
Enzyme and pathway databases
Reactomei | R-RNO-71064, Lysine catabolism |
Miscellaneous databases
PROi | PR:Q99JD3 |
Gene expression databases
Genevisiblei | Q99JD3, RN |
Family and domain databases
Gene3Di | 1.50.40.10, 2 hits |
InterProi | View protein in InterPro IPR018108, Mitochondrial_sb/sol_carrier IPR023395, Mt_carrier_dom_sf |
Pfami | View protein in Pfam PF00153, Mito_carr, 3 hits |
SUPFAMi | SSF103506, SSF103506, 1 hit |
PROSITEi | View protein in PROSITE PS50920, SOLCAR, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ODC_RAT | |
Accessioni | Q99JD3Primary (citable) accession number: Q99JD3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 11, 2002 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 119 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families