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Protein

Stomatin-like protein 2, mitochondrial

Gene

Stoml2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T-cell receptor signaling complex and its regulation.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandLipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-8949664 Processing of SMDT1

Names & Taxonomyi

Protein namesi
Recommended name:
Stomatin-like protein 2, mitochondrial
Short name:
SLP-2
Short name:
mslp2
Gene namesi
Name:Stoml2
Synonyms:Slp2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913842 Stoml2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Disruption phenotypei

Embryonic lethal at the preimplantation stage. T-cell-specific conditional knockout does not alter the normal development of those cells but decreases their responses to stimulation through the T-cell receptor.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28MitochondrionSequence analysisAdd BLAST28
ChainiPRO_000009403229 – 353Stomatin-like protein 2, mitochondrialAdd BLAST325

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei17Phosphoserine; by PKC/PRKCZBy similarity1
Modified residuei124PhosphotyrosineBy similarity1
Modified residuei145N6-acetyllysine; alternateCombined sources1
Modified residuei145N6-succinyllysine; alternateCombined sources1
Modified residuei233N6-acetyllysineCombined sources1
Modified residuei330PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Phosphoprotein

Proteomic databases

EPDiQ99JB2
MaxQBiQ99JB2
PaxDbiQ99JB2
PeptideAtlasiQ99JB2
PRIDEiQ99JB2

2D gel databases

REPRODUCTION-2DPAGEiQ99JB2

PTM databases

iPTMnetiQ99JB2
PhosphoSitePlusiQ99JB2
SwissPalmiQ99JB2

Expressioni

Gene expression databases

BgeeiENSMUSG00000028455 Expressed in 294 organ(s), highest expression level in ear
CleanExiMM_STOML2
ExpressionAtlasiQ99JB2 baseline and differential
GenevisibleiQ99JB2 MM

Interactioni

Subunit structurei

Forms homooligomers (By similarity). Interacts with MFN2; may form heterooligomers (By similarity). Interacts with PHB and PHB2; recruits them to cardiolipin-enriched mitochondrial membranes and stabilizes them (By similarity). Interacts with CACNA2D2.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi211578, 2 interactors
IntActiQ99JB2, 5 interactors
STRINGi10090.ENSMUSP00000030169

Structurei

3D structure databases

ProteinModelPortaliQ99JB2
SMRiQ99JB2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili215 – 252Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the band 7/mec-2 family.Curated

Keywords - Domaini

Coiled coil, Transit peptide

Phylogenomic databases

eggNOGiKOG2620 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074454
HOGENOMiHOG000217038
HOVERGENiHBG061488
InParanoidiQ99JB2
OMAiRDQINGQ
OrthoDBiEOG091G0MSB
PhylomeDBiQ99JB2
TreeFamiTF105750

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR032435 Band_7_C
IPR001972 Stomatin_fam
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF16200 Band_7_C, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q99JB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLARAARGTG ALLLRGSVQA SGRVPRRASS GLPRNTVILF VPQQEAWVVE
60 70 80 90 100
RMGRFHRILE PGLNVLIPVL DRIRYVQSLK EIVINVPEQS AVTLDNVTLQ
110 120 130 140 150
IDGVLYLRIM DPYKASYGVE DPEYAVTQLA QTTMRSELGK LSLDKVFRER
160 170 180 190 200
ESLNANIVDA INQAADCWGI RCLRYEIKDI HVPPRVKESM QMQVEAERRK
210 220 230 240 250
RATVLESEGT RESAINVAEG KKQAQILASE AEKAEQINQA AGEASAVLAK
260 270 280 290 300
AKAKAEAIRI LAGALTQHNG DAAASLTVAE QYVSAFSKLA KDSNTVLLPS
310 320 330 340 350
NPSDVTSMVA QAMGVYGALT KAPVPGAQNS SQSRRDVQAT DTSIEELGRV

KLS
Length:353
Mass (Da):38,385
Last modified:June 1, 2001 - v1
Checksum:i391D269576F6E6BB
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AG41A2AG41_MOUSE
Stomatin-like protein 2, mitochondr...
Stoml2
212Annotation score:
A2AG39A2AG39_MOUSE
Stomatin-like protein 2, mitochondr...
Stoml2
286Annotation score:
F6WI02F6WI02_MOUSE
Stomatin-like protein 2, mitochondr...
Stoml2
287Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5A → R in BAB22363 (PubMed:16141072).Curated1
Sequence conflicti152S → F in BAB22363 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323178 mRNA Translation: AAG53404.1
AK002793 mRNA Translation: BAB22363.1
BC003425 mRNA Translation: AAH03425.1
BC069941 mRNA Translation: AAH69941.1
CCDSiCCDS18089.1
RefSeqiNP_075720.1, NM_023231.2
UniGeneiMm.331565

Genome annotation databases

EnsembliENSMUST00000030169; ENSMUSP00000030169; ENSMUSG00000028455
GeneIDi66592
KEGGimmu:66592
UCSCiuc008soy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF323178 mRNA Translation: AAG53404.1
AK002793 mRNA Translation: BAB22363.1
BC003425 mRNA Translation: AAH03425.1
BC069941 mRNA Translation: AAH69941.1
CCDSiCCDS18089.1
RefSeqiNP_075720.1, NM_023231.2
UniGeneiMm.331565

3D structure databases

ProteinModelPortaliQ99JB2
SMRiQ99JB2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211578, 2 interactors
IntActiQ99JB2, 5 interactors
STRINGi10090.ENSMUSP00000030169

PTM databases

iPTMnetiQ99JB2
PhosphoSitePlusiQ99JB2
SwissPalmiQ99JB2

2D gel databases

REPRODUCTION-2DPAGEiQ99JB2

Proteomic databases

EPDiQ99JB2
MaxQBiQ99JB2
PaxDbiQ99JB2
PeptideAtlasiQ99JB2
PRIDEiQ99JB2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000030169; ENSMUSP00000030169; ENSMUSG00000028455
GeneIDi66592
KEGGimmu:66592
UCSCiuc008soy.1 mouse

Organism-specific databases

CTDi30968
MGIiMGI:1913842 Stoml2

Phylogenomic databases

eggNOGiKOG2620 Eukaryota
COG0330 LUCA
GeneTreeiENSGT00550000074454
HOGENOMiHOG000217038
HOVERGENiHBG061488
InParanoidiQ99JB2
OMAiRDQINGQ
OrthoDBiEOG091G0MSB
PhylomeDBiQ99JB2
TreeFamiTF105750

Enzyme and pathway databases

ReactomeiR-MMU-8949664 Processing of SMDT1

Miscellaneous databases

PROiPR:Q99JB2
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000028455 Expressed in 294 organ(s), highest expression level in ear
CleanExiMM_STOML2
ExpressionAtlasiQ99JB2 baseline and differential
GenevisibleiQ99JB2 MM

Family and domain databases

InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR032435 Band_7_C
IPR001972 Stomatin_fam
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PF16200 Band_7_C, 1 hit
PRINTSiPR00721 STOMATIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTML2_MOUSE
AccessioniPrimary (citable) accession number: Q99JB2
Secondary accession number(s): Q9DCG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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