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Protein

Krueppel-like factor 7

Gene

Klf7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional activator. Binds specifically to an Ikaros core binding element that is crucial for in vivo NTRK1/TrkA enhancer function.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 242C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri248 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 7
Gene namesi
Name:Klf7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1935151 Klf7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000471751 – 301Krueppel-like factor 7Add BLAST301

Proteomic databases

MaxQBiQ99JB0
PaxDbiQ99JB0
PRIDEiQ99JB0

PTM databases

iPTMnetiQ99JB0
PhosphoSitePlusiQ99JB0

Expressioni

Tissue specificityi

Expressed primarily in the nervous system.

Gene expression databases

BgeeiENSMUSG00000025959 Expressed in 288 organ(s), highest expression level in rostral migratory stream
CleanExiMM_KLF7
ExpressionAtlasiQ99JB0 baseline and differential
GenevisibleiQ99JB0 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054674

Structurei

3D structure databases

ProteinModelPortaliQ99JB0
SMRiQ99JB0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi214 – 219Nuclear localization signalSequence analysis6

Domaini

The acidic N-terminal part may favor interaction with the basic domain of transcription factors.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri218 – 242C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri248 – 272C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri278 – 300C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000231192
HOVERGENiHBG000836
InParanoidiQ99JB0
KOiK09207
OMAiDLDCFLR
OrthoDBiEOG091G1BN0
PhylomeDBiQ99JB0
TreeFamiTF350556

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99JB0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVLASYSIF QELQLVHDTG YFSALPSLEE TWQQTCLELE RYLQTEPRRI
60 70 80 90 100
SETFGEDLDC FLHASPPPCI EESFRRLDPL LLPVEATICE KSSAVDILLS
110 120 130 140 150
RDKLLSETCL SLQPTSSSLD SYTAVNQAQL NAVTSLTPPS SPELSRHLVK
160 170 180 190 200
TSQTLSAVDG TVTLKLVAKK ASLSSVKVGG VAAAAAVTPA GAVKSGQSDS
210 220 230 240 250
EQGGGGADTC PENKKRVHRC QFNGCRKVYT KSSHLKAHQR THTGEKPYKC
260 270 280 290 300
SWEGCEWRFA RSDELTRHYR KHTGAKPFKC NHCDRCFSRS DHLALHMKRH

I
Length:301
Mass (Da):33,337
Last modified:June 1, 2001 - v1
Checksum:i3AEB7135A9F6E6E7
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3UES6Q3UES6_MOUSE
Krueppel-like factor 7
Klf7
285Annotation score:
A2AAB6A2AAB6_MOUSE
Krueppel-like factor 7
Klf7
111Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti175S → P in AAK08964 (PubMed:11336497).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338369 mRNA Translation: AAK31139.1
AF327568 mRNA Translation: AAK08964.1
BC004700 mRNA Translation: AAH04700.1
BC019604 mRNA Translation: AAH19604.1
BC040794 mRNA Translation: AAH40794.1
CCDSiCCDS15003.1
RefSeqiNP_291041.2, NM_033563.2
XP_006496417.1, XM_006496354.3
UniGeneiMm.29466
Mm.458200

Genome annotation databases

EnsembliENSMUST00000114086; ENSMUSP00000109720; ENSMUSG00000025959
GeneIDi93691
KEGGimmu:93691
UCSCiuc007bgo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338369 mRNA Translation: AAK31139.1
AF327568 mRNA Translation: AAK08964.1
BC004700 mRNA Translation: AAH04700.1
BC019604 mRNA Translation: AAH19604.1
BC040794 mRNA Translation: AAH40794.1
CCDSiCCDS15003.1
RefSeqiNP_291041.2, NM_033563.2
XP_006496417.1, XM_006496354.3
UniGeneiMm.29466
Mm.458200

3D structure databases

ProteinModelPortaliQ99JB0
SMRiQ99JB0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054674

PTM databases

iPTMnetiQ99JB0
PhosphoSitePlusiQ99JB0

Proteomic databases

MaxQBiQ99JB0
PaxDbiQ99JB0
PRIDEiQ99JB0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000114086; ENSMUSP00000109720; ENSMUSG00000025959
GeneIDi93691
KEGGimmu:93691
UCSCiuc007bgo.2 mouse

Organism-specific databases

CTDi8609
MGIiMGI:1935151 Klf7

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118998
HOGENOMiHOG000231192
HOVERGENiHBG000836
InParanoidiQ99JB0
KOiK09207
OMAiDLDCFLR
OrthoDBiEOG091G1BN0
PhylomeDBiQ99JB0
TreeFamiTF350556

Miscellaneous databases

ChiTaRSiKlf7 mouse
PROiPR:Q99JB0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000025959 Expressed in 288 organ(s), highest expression level in rostral migratory stream
CleanExiMM_KLF7
ExpressionAtlasiQ99JB0 baseline and differential
GenevisibleiQ99JB0 MM

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 3 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits
ProtoNetiSearch...

Entry informationi

Entry nameiKLF7_MOUSE
AccessioniPrimary (citable) accession number: Q99JB0
Secondary accession number(s): Q99P62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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