UniProtKB - Q99JA8 (NGB_RAT)
Protein
Neuroglobin
Gene
Ngb
Organism
Rattus norvegicus (Rat)
Status
Functioni
Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 64 | Iron (heme distal ligand)PROSITE-ProRule annotation | 1 | |
Metal bindingi | 96 | Iron (heme proximal ligand)PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- heme binding Source: InterPro
- metal ion binding Source: UniProtKB-KW
- oxygen binding Source: InterPro
- oxygen carrier activity Source: RGD
GO - Biological processi
- aging Source: RGD
- negative regulation of hydrogen peroxide-induced cell death Source: RGD
- neuron projection development Source: RGD
- oxygen transport Source: RGD
- positive regulation of catalytic activity Source: RGD
- response to hypoxia Source: RGD
- response to iron ion Source: RGD
- visual perception Source: RGD
Keywordsi
Biological process | Oxygen transport, Transport |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
Reactomei | R-RNO-8981607, Intracellular oxygen transport |
Names & Taxonomyi
Protein namesi | Recommended name: Neuroglobin |
Gene namesi | Name:Ngb |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 621461, Ngb |
Subcellular locationi
Other locations
- Perikaryon By similarity
Mitochondrion
- mitochondrion Source: RGD
Other locations
- cytoplasm Source: RGD
- neuron projection Source: RGD
- perikaryon Source: RGD
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000053396 | 1 – 151 | NeuroglobinAdd BLAST | 151 |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | Q99JA8 |
Expressioni
Tissue specificityi
Widely distributed throughout the adult brain, including cerebral cortex, hippocampus, thalamus, hypothalamus, olfactory bulb, and cerebellum.1 Publication
Interactioni
Subunit structurei
Monomer. Homodimer and homotetramer; disulfide-linked.
By similarityProtein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016057 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 149 | GlobinAdd BLAST | 149 |
Sequence similaritiesi
Belongs to the globin family.PROSITE-ProRule annotation
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
InParanoidi | Q99JA8 |
OrthoDBi | 1529889at2759 |
PhylomeDBi | Q99JA8 |
Family and domain databases
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q99JA8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERPESELIR QSWRAVSRSP LEHGTVLFSR LFALEPSLLP LFQYNGRQFS
60 70 80 90 100
SPEDCLSSPE FLDHIRKVML VIDAAVTNVE DLSSLEEYLA TLGRKHRAVG
110 120 130 140 150
VRLSSFSTVG ESLLYMLEKC LGPDFTPATR TAWSQLYGAV VQAMSRGWDG
E
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2JSL1 | A0A0G2JSL1_RAT | Globin h | Ngb Glnh, rCG_20665 | 176 | Annotation score: | ||
A0A0G2K4D1 | A0A0G2K4D1_RAT | Neuroglobin | Ngb | 36 | Annotation score: | ||
A0A0G2K4N3 | A0A0G2K4N3_RAT | Neuroglobin | Ngb | 36 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 | P → L in AAL47568 (Ref. 4) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF333245 mRNA Translation: AAK15763.1 AF334379 mRNA Translation: AAG59898.1 AY066001 mRNA Translation: AAL47568.1 AB056655 mRNA Translation: BAB39149.1 |
RefSeqi | NP_203523.2, NM_033359.3 |
Genome annotation databases
GeneIDi | 85382 |
KEGGi | rno:85382 |
UCSCi | RGD:621461, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF333245 mRNA Translation: AAK15763.1 AF334379 mRNA Translation: AAG59898.1 AY066001 mRNA Translation: AAL47568.1 AB056655 mRNA Translation: BAB39149.1 |
RefSeqi | NP_203523.2, NM_033359.3 |
3D structure databases
SMRi | Q99JA8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000016057 |
Proteomic databases
PaxDbi | Q99JA8 |
Genome annotation databases
GeneIDi | 85382 |
KEGGi | rno:85382 |
UCSCi | RGD:621461, rat |
Organism-specific databases
CTDi | 58157 |
RGDi | 621461, Ngb |
Phylogenomic databases
eggNOGi | KOG3378, Eukaryota |
InParanoidi | Q99JA8 |
OrthoDBi | 1529889at2759 |
PhylomeDBi | Q99JA8 |
Enzyme and pathway databases
Reactomei | R-RNO-8981607, Intracellular oxygen transport |
Miscellaneous databases
PROi | PR:Q99JA8 |
Family and domain databases
Gene3Di | 1.10.490.10, 1 hit |
InterProi | View protein in InterPro IPR000971, Globin IPR009050, Globin-like_sf IPR012292, Globin/Proto |
Pfami | View protein in Pfam PF00042, Globin, 1 hit |
SUPFAMi | SSF46458, SSF46458, 1 hit |
PROSITEi | View protein in PROSITE PS01033, GLOBIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NGB_RAT | |
Accessioni | Q99JA8Primary (citable) accession number: Q99JA8 Secondary accession number(s): Q8VH38, Q99N62 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 20, 2003 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 108 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families