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Protein

Calcitonin gene-related peptide 1

Gene

Calca

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP (By similarity).By similarity

GO - Molecular functioni

  • calcitonin receptor binding Source: MGI
  • hormone activity Source: UniProtKB-KW
  • signaling receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-418555 G alpha (s) signalling events
R-MMU-419812 Calcitonin-like ligand receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin gene-related peptide 1
Alternative name(s):
Alpha-type CGRP
Calcitonin gene-related peptide I
Short name:
CGRP-I
Gene namesi
Name:Calca
Synonyms:Calc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2151253 Calca

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
PropeptideiPRO_000000405926 – 80By similarityAdd BLAST55
PeptideiPRO_000000406083 – 119Calcitonin gene-related peptide 1Add BLAST37
PropeptideiPRO_0000004061125 – 128By similarity4

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi84 ↔ 89By similarity
Modified residuei119Phenylalanine amideBy similarity1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PRIDEiQ99JA0

Expressioni

Tissue specificityi

Detected in nerve cells of cerebrum, hippocampus and pons/midbrain in newborns, and only in nerve cells of pons/midbrain in adult.1 Publication

Gene expression databases

BgeeiENSMUSG00000030669 Expressed in 114 organ(s), highest expression level in facial nucleus
CleanExiMM_CALCA
ExpressionAtlasiQ99JA0 baseline and differential
GenevisibleiQ99JA0 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60043N
IntActiQ99JA0, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ99JA0
SMRiQ99JA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calcitonin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00390000010511
HOGENOMiHOG000038203
HOVERGENiHBG031362
OMAiESMSERV

Family and domain databases

InterProiView protein in InterPro
IPR021117 Calcitonin-like
IPR021116 Calcitonin/adrenomedullin
IPR018360 Calcitonin_CS
IPR015476 Calcitonin_gene-rel_peptide
IPR001693 Calcitonin_peptide-like
PANTHERiPTHR10505 PTHR10505, 1 hit
PfamiView protein in Pfam
PF00214 Calc_CGRP_IAPP, 1 hit
PRINTSiPR00817 CALCITONINB
SMARTiView protein in SMART
SM00113 CALCITONIN, 1 hit
PROSITEiView protein in PROSITE
PS00258 CALCITONIN, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform Calcitonin-gene related peptide I (identifier: Q99JA0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGFLKFSPFL VVSILLLYQA CSLQAVPLRS ILESSPGMAT LSEEEVRLLA
60 70 80 90 100
ALVQDYMQMK ARELEQEEEQ EAEGSSVTAQ KRSCNTATCV THRLAGLLSR
110 120
SGGVVKDNFV PTNVGSEAFG RRRRDLQA
Length:128
Mass (Da):14,065
Last modified:June 1, 2001 - v1
Checksum:i83BB0E36C8B4239E
GO
Isoform Calcitonin (identifier: P70160-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P70160.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:136
Mass (Da):15,141
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF330212 mRNA Translation: AAK06841.1
AF325522, AF325521 Genomic DNA Translation: AAK18181.1
BC028771 mRNA Translation: AAH28771.1
CCDSiCCDS21762.1 [Q99JA0-1]
RefSeqiNP_001029126.1, NM_001033954.3 [Q99JA0-1]
NP_001276373.1, NM_001289444.1 [Q99JA0-1]
XP_011239962.1, XM_011241660.2 [Q99JA0-1]
UniGeneiMm.4361

Genome annotation databases

EnsembliENSMUST00000032906; ENSMUSP00000032906; ENSMUSG00000030669 [Q99JA0-1]
GeneIDi12310
KEGGimmu:12310
UCSCiuc009jif.2 mouse [Q99JA0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCALCA_MOUSE
AccessioniPrimary (citable) accession number: Q99JA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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