Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 120 (16 Oct 2019)
Sequence version 1 (01 Jun 2001)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Attractin

Gene

Atrn

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in the initial immune cell clustering during inflammatory response and may regulate chemotactic activity of chemokines (By similarity). May play a role in melanocortin signaling pathways that regulate energy homeostasis and hair color. Low-affinity receptor for agouti (By similarity). Has a critical role in normal myelination in the central nervous system.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processInflammatory response
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Attractin
Alternative name(s):
Protein zitter
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AtrnImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Rat genome database

More...
RGDi
69063 Atrn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini87 – 1282ExtracellularSequence analysisAdd BLAST1196
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1283 – 1303HelicalSequence analysisAdd BLAST21
Topological domaini1304 – 1432CytoplasmicSequence analysisAdd BLAST129

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Defects in Atrn (isoform 1) are the cause of the autosomal recessive phenotype zitter (zi), which is characterized by progressive hypomyelination and vacuolation in the central nervous system resulting in early-onset tremor and progressive flaccid paresis of the hind limb. This is due to an 8-bp deletion at the splice donor site of intron 12, which results in aberrant and unstable transcripts.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000039477324 – 86By similarityAdd BLAST63
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000748587 – 1432AttractinAdd BLAST1346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi104 ↔ 114By similarity
Disulfide bondi108 ↔ 121By similarity
Disulfide bondi123 ↔ 132By similarity
Disulfide bondi135 ↔ 161By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi216N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi240N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi245N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 263By similarity
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi257 ↔ 274By similarity
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi276 ↔ 285By similarity
Glycosylationi303N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi328N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi365N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi419N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi578N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi626N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi734N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi819 ↔ 921By similarity
Glycosylationi866N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi917N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi926N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi989N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1046N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1057N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1066 ↔ 1074By similarity
Disulfide bondi1068 ↔ 1080By similarity
Glycosylationi1076N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1083 ↔ 1092By similarity
Disulfide bondi1095 ↔ 1109By similarity
Disulfide bondi1112 ↔ 1121By similarity
Disulfide bondi1114 ↔ 1128By similarity
Disulfide bondi1130 ↔ 1140By similarity
Disulfide bondi1143 ↔ 1158By similarity
Glycosylationi1201N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1209N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1262N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Heavily glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99J86

PRoteomics IDEntifications database

More...
PRIDEi
Q99J86

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99J86

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q99J86

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q99J86

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000021240 Expressed in 9 organ(s), highest expression level in liver

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99J86 RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homotrimer.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000028847

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99J86

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini100 – 133EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini135 – 251CUBPROSITE-ProRule annotationAdd BLAST117
Domaini249 – 286EGF-like 2PROSITE-ProRule annotationAdd BLAST38
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati355 – 405Kelch 1Sequence analysisAdd BLAST51
Repeati406 – 454Kelch 2Sequence analysisAdd BLAST49
Repeati464 – 511Kelch 3Sequence analysisAdd BLAST48
Repeati516 – 567Kelch 4Sequence analysisAdd BLAST52
Repeati569 – 627Kelch 5Sequence analysisAdd BLAST59
Repeati628 – 674Kelch 6Sequence analysisAdd BLAST47
Domaini706 – 751PSI 1Add BLAST46
Domaini758 – 797PSI 2Add BLAST40
Domaini798 – 922C-type lectinPROSITE-ProRule annotationAdd BLAST125
Domaini935 – 986PSI 3Add BLAST52
Domaini989 – 1064PSI 4Add BLAST76
Domaini1066 – 1111Laminin EGF-like 1PROSITE-ProRule annotationAdd BLAST46
Domaini1112 – 1160Laminin EGF-like 2PROSITE-ProRule annotationAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi932 – 1143Cys-richAdd BLAST212

Keywords - Domaini

EGF-like domain, Kelch repeat, Laminin EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1388 Eukaryota
ENOG410XRW4 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157346

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231727

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99J86

Identification of Orthologs from Complete Genome Data

More...
OMAi
SEWQGPG

Database of Orthologous Groups

More...
OrthoDBi
49565at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99J86

TreeFam database of animal gene trees

More...
TreeFami
TF321873

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00041 CUB, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00431 CUB, 1 hit
PF01344 Kelch_1, 2 hits
PF00059 Lectin_C, 1 hit
PF01437 PSI, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 1 hit
SM00042 CUB, 1 hit
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 2 hits
SM00423 PSI, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q99J86-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVAAAAAAEA TEARLRGYTT ATAAPAGWKE RQHRPCAATG AWRPWPRAGL
60 70 80 90 100
CLPRVLSRAL SPPPLLPLLP LLFSLLLLPL PREAEAAAVA AAVSGSAAAE
110 120 130 140 150
AKECDRPCVN GGRCNPGTGQ CVCPTGWVGE QCQHCGGRFR LTGSSGFVTD
160 170 180 190 200
GPGNYKYKTK CTWLIEGQPN KIMRLRFNHF ATECSWDHLY VYDGDSIYAP
210 220 230 240 250
LIAAFSGLIV PERDGNETAP EVTVTSGYAL LHFFSDAAYN LTGFNITYNF
260 270 280 290 300
DMCPNNCSGR GECKSSNSSS TVECECSENW KGESCDIPHC TDNCGFPHRG
310 320 330 340 350
ICNASDTRGC SCFPHWQGPG CSIPVPANQS FWTREEYSDL KLPRASHKAV
360 370 380 390 400
VNGNIMWVVG GYMFNHSDYS MVLAYDLASR EWLSLNHSVN SVVVRYGHSL
410 420 430 440 450
ALHKDKIYMY GGKIDSTGNV TNELRVFHIH NESWVLLTPK AKDQYAVVGH
460 470 480 490 500
SAHIVTLSSG RVVMLVIFGH CPLYGYISVV QEYDLEKNTW SILQTQGALV
510 520 530 540 550
QGGYGHSSVY DHRTKALYVH GGYKAFSANK YRLADDLYRY HVDTQMWTIL
560 570 580 590 600
KDSRFFRYLH TAVIVSGTML VFGGNTHNDT SMSHGAKCFS SDFMAYDIAC
610 620 630 640 650
DRWSVLPRPE LHHDVNRFGH SAVLHNSTMY VFGGFNSLLL SDVLVFTSEQ
660 670 680 690 700
CDAHRSEAAC VAAGPGIRCL WDTQSSRCTS WELATEEQAE KLKSECFSKR
710 720 730 740 750
TLDHDRCDQH TDCYSCTANT NDCHWCNDHC VPVNHSCTEG QISIAKYDNC
760 770 780 790 800
PKDNPMYYCN KKTSCRSCAL DQNCQWEPRN QECIALPENI CGIGWHLVGN
810 820 830 840 850
SCLKITTAKE NYDNAKLSCR NHNAFLASLT SQKKVEFVLK QLRLMQSSQS
860 870 880 890 900
TSKLTLTPWV GLRKINVSYW CWEDMSPFTN SLLQWMPSEP SDAGFCGILS
910 920 930 940 950
EPSTRGLKAA TCINPLNGSV CERPANHSAK QCRTPCALRT ACGECTSSSS
960 970 980 990 1000
ECMWCSNMKQ CVDSNAYVAS FPFGQCMEWY TMSSCPPENC SGYCTCSHCL
1010 1020 1030 1040 1050
EQPGCGWCTD PSNTGKGKCI EGSYKGPVKM PSHASTGNVY PQPLLNSSMC
1060 1070 1080 1090 1100
LEDSRYNWSF IHCPACQCNG HSKCINQSIC EKCEDLTTGK HCETCISGFY
1110 1120 1130 1140 1150
GDPTNGGKCQ PCKCNGHASL CNTNTGKCFC TTKGVKGEEC QLCEVENRYQ
1160 1170 1180 1190 1200
GNPLKGTCYY TLLIDYQFTF SLSQEDDRYY TAINFVATPD EQNRDLDMFI
1210 1220 1230 1240 1250
NASKNFNLNI TWATSFPAGT QTGEEVPVVS KTNIKEYKDS FSNEKFDFRN
1260 1270 1280 1290 1300
HPNITFFVYV SNFTWPIKIQ IAFSQHSNFM DLVQFFVTFF SCFLSLLLVA
1310 1320 1330 1340 1350
AVVWKIKQSC WASRRREQLL REMQQMASRP FASVNVALET DEEPPDLIGG
1360 1370 1380 1390 1400
SIKTVPKPIA LEPCFGNKAA VLSVFVRLPR GLGGIPPPGQ SGLAVASALV
1410 1420 1430
DISQQMPIVY KEKSGAVRNR KQQPPAQPGT CI
Length:1,432
Mass (Da):158,673
Last modified:June 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDE4177EE5D55E866
GO
Isoform 21 Publication (identifier: Q99J86-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1271-1275: IAFSQ → VRVTS
     1276-1432: Missing.

Show »
Length:1,275
Mass (Da):141,522
Checksum:iCED768A4E33B50C5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350V → E in BAB21018 (PubMed:11209055).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0516741271 – 1275IAFSQ → VRVTS in isoform 2. 1 Publication5
Alternative sequenceiVSP_0516751276 – 1432Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB038387 mRNA Translation: BAB21017.1
AB038388 mRNA Translation: BAB21018.1
AB049248 Genomic DNA Translation: BAB21058.1

NCBI Reference Sequences

More...
RefSeqi
NP_112641.1, NM_031351.1 [Q99J86-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000028847; ENSRNOP00000028847; ENSRNOG00000021240 [Q99J86-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
83526

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:83526

UCSC genome browser

More...
UCSCi
RGD:69063 rat [Q99J86-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB038387 mRNA Translation: BAB21017.1
AB038388 mRNA Translation: BAB21018.1
AB049248 Genomic DNA Translation: BAB21058.1
RefSeqiNP_112641.1, NM_031351.1 [Q99J86-1]

3D structure databases

SMRiQ99J86
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000028847

PTM databases

PhosphoSitePlusiQ99J86
SwissPalmiQ99J86
UniCarbKBiQ99J86

Proteomic databases

PaxDbiQ99J86
PRIDEiQ99J86

Genome annotation databases

EnsembliENSRNOT00000028847; ENSRNOP00000028847; ENSRNOG00000021240 [Q99J86-1]
GeneIDi83526
KEGGirno:83526
UCSCiRGD:69063 rat [Q99J86-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8455
RGDi69063 Atrn

Phylogenomic databases

eggNOGiKOG1388 Eukaryota
ENOG410XRW4 LUCA
GeneTreeiENSGT00940000157346
HOGENOMiHOG000231727
InParanoidiQ99J86
OMAiSEWQGPG
OrthoDBi49565at2759
PhylomeDBiQ99J86
TreeFamiTF321873

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q99J86

Gene expression databases

BgeeiENSRNOG00000021240 Expressed in 9 organ(s), highest expression level in liver
GenevisibleiQ99J86 RN

Family and domain databases

CDDicd00041 CUB, 1 hit
Gene3Di2.120.10.80, 2 hits
2.60.120.290, 1 hit
3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR000859 CUB_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
IPR002049 Laminin_EGF
IPR002165 Plexin_repeat
IPR016201 PSI
IPR035914 Sperma_CUB_dom_sf
PfamiView protein in Pfam
PF00431 CUB, 1 hit
PF01344 Kelch_1, 2 hits
PF00059 Lectin_C, 1 hit
PF01437 PSI, 2 hits
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SM00042 CUB, 1 hit
SM00181 EGF, 3 hits
SM00180 EGF_Lam, 2 hits
SM00423 PSI, 5 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF49854 SSF49854, 1 hit
SSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS50041 C_TYPE_LECTIN_2, 1 hit
PS01180 CUB, 1 hit
PS00022 EGF_1, 3 hits
PS01186 EGF_2, 1 hit
PS50026 EGF_3, 2 hits
PS01248 EGF_LAM_1, 1 hit
PS50027 EGF_LAM_2, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRN_RAT
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99J86
Secondary accession number(s): Q99PW0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: June 1, 2001
Last modified: October 16, 2019
This is version 120 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again