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Protein

Sialic acid synthase

Gene

Nans

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Produces N-acetylneuraminate-9-phosphate (Neu5Ac-9-P) from N-acetylmannosamine 6-phosphate. Has no detectable activity towards N-acetylmannosamine or mannose 6-phosphate.1 Publication

Catalytic activityi

Phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O = N-acylneuraminate 9-phosphate + phosphate.1 Publication

GO - Molecular functioni

  • N-acylneuraminate-9-phosphate synthase activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-14514
BRENDAi2.5.1.57 3474
ReactomeiR-MMU-4085001 Sialic acid metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid synthase1 Publication
Alternative name(s):
N-acetylneuraminate-9-phosphate synthase1 Publication (EC:2.5.1.571 Publication)
N-acetylneuraminic acid phosphate synthase1 Publication
Gene namesi
Name:NansImported
Synonyms:SasImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2149820 Nans

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004386811 – 359Sialic acid synthaseBy similarityAdd BLAST359

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei61N6-acetyllysineCombined sources1
Modified residuei74N6-acetyllysineCombined sources1
Modified residuei79N6-acetyllysineCombined sources1
Modified residuei275PhosphoserineCombined sources1
Modified residuei290N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ99J77
PaxDbiQ99J77
PeptideAtlasiQ99J77
PRIDEiQ99J77

PTM databases

iPTMnetiQ99J77
PhosphoSitePlusiQ99J77
SwissPalmiQ99J77

Expressioni

Tissue specificityi

Ubiquitious.1 Publication

Gene expression databases

BgeeiENSMUSG00000028334

Interactioni

Protein-protein interaction databases

IntActiQ99J77, 2 interactors
MINTiQ99J77
STRINGi10090.ENSMUSP00000030018

Structurei

3D structure databases

ProteinModelPortaliQ99J77
SMRiQ99J77
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini294 – 353AFP-likePROSITE-ProRule annotationAdd BLAST60

Phylogenomic databases

eggNOGiENOG410IHMI Eukaryota
COG2089 LUCA
GeneTreeiENSGT00390000011081
HOGENOMiHOG000284783
HOVERGENiHBG000665
KOiK05304
OMAiTFGVKFG
OrthoDBiEOG091G0D9G
PhylomeDBiQ99J77
TreeFamiTF324826

Family and domain databases

Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR006190 AFP_Neu5c_C
IPR036732 AFP_Neu5c_C_sf
IPR013785 Aldolase_TIM
IPR006013 Antifreeze_III
IPR013132 Neu5Ac_N
IPR013974 SAF
PfamiView protein in Pfam
PF03102 NeuB, 1 hit
PF08666 SAF, 1 hit
PRINTSiPR00357 ANTIFREEZIII
SMARTiView protein in SMART
SM00858 SAF, 1 hit
SUPFAMiSSF51269 SSF51269, 1 hit
PROSITEiView protein in PROSITE
PS50844 AFP_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Q99J77-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLELELCPG RWVGGKHPCF IIAEIGQNHQ GDIDVAKRMI RTAKECGADC
60 70 80 90 100
AKFQKSELEF KFNRKALERP YTSKHSWGKT YGEHKRHLEF SHDQYKELQS
110 120 130 140 150
YAQEIGIFFT ASGMDEMAVE FLHELNVPFF KVGSGDTNNF PYLEKTAKKG
160 170 180 190 200
RPMVISSGMQ SMDTMKQVYQ IVKPLNPNFC FLQCTSAYPL QPEDANLRVI
210 220 230 240 250
SEYQKLFPDI PIGYSGHETG IAISVAAVAL GAKVLERHIT LDKTWKGSDH
260 270 280 290 300
SASLEPGELA ELVRSVRLVE RALGSPTKQL LPCEMACNEK LGKSVVAKVK
310 320 330 340 350
IPAGTTLTLD MLTVKVGEPK GYPPEDIFNL AGKKVLVTIE EDDTVMEESV

ESHSKKIKA
Length:359
Mass (Da):40,024
Last modified:June 1, 2001 - v1
Checksum:i4C66CB883558A373
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti311M → T in BAA98131 (PubMed:10873658).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB041263 mRNA Translation: BAA98131.1
AK076290 mRNA Translation: BAC36290.1
AK156254 mRNA Translation: BAE33642.1
AL683884 Genomic DNA No translation available.
CH466565 Genomic DNA Translation: EDL02367.1
BC003307 mRNA Translation: AAH03307.1
BC057977 mRNA Translation: AAH57977.1
CCDSiCCDS18152.1
PIRiJC7321
RefSeqiNP_444409.1, NM_053179.3
UniGeneiMm.249349

Genome annotation databases

EnsembliENSMUST00000030018; ENSMUSP00000030018; ENSMUSG00000028334
GeneIDi94181
KEGGimmu:94181
UCSCiuc008stv.1 mouse

Similar proteinsi

Entry informationi

Entry nameiSIAS_MOUSE
AccessioniPrimary (citable) accession number: Q99J77
Secondary accession number(s): Q9JJH0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 18, 2017
Last sequence update: June 1, 2001
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

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