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Entry version 135 (08 May 2019)
Sequence version 3 (20 Dec 2017)
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Protein

DNA dC->dU-editing enzyme APOBEC-3

Gene

Apobec3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons.4 Publications

Miscellaneous

Probable human APOBEC3G ortholog.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi82ZincBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei84Proton donorBy similarity1
Metal bindingi116ZincBy similarity1
Metal bindingi119ZincBy similarity1
Metal bindingi299ZincBy similarity1
Metal bindingi327ZincBy similarity1
Metal bindingi330ZincBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAntiviral defense, Immunity, Innate immunity
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.5.4.1 3474

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-72200 mRNA Editing: C to U Conversion
R-MMU-75094 Formation of the Editosome

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
DNA dC->dU-editing enzyme APOBEC-3 (EC:3.5.4.38)
Alternative name(s):
Apolipoprotein B mRNA-editing complex 3
Short name:
Arp3
CEM-15
Short name:
CEM15
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Apobec3
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1933111 Apobec3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi84E → A: Decrease in cytidine deaminase and antiviral activity. 1 Publication1
Mutagenesisi84E → A: Decrease in cytidine deaminase and antiviral activity; when associated with A-301. 1 Publication1
Mutagenesisi301E → A: Decrease in cytidine deaminase and antiviral activity; when associated with A-84. 1 Publication1
Mutagenesisi301E → A: No effect on cytidine deaminase and antiviral activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001717721 – 440DNA dC->dU-editing enzyme APOBEC-3Add BLAST440

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q99J72

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99J72

PRoteomics IDEntifications database

More...
PRIDEi
Q99J72

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99J72

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99J72

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in spleen, node and lung.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000009585 Expressed in 195 organ(s), highest expression level in bone marrow

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99J72 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99J72 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with mouse mammary tumor virus (MMTV) nucleocapsid protein p14.

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000135027

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99J72

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini49 – 165CMP/dCMP-type deaminase 1PROSITE-ProRule annotationAdd BLAST117
Domaini249 – 368CMP/dCMP-type deaminase 2PROSITE-ProRule annotationAdd BLAST120

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CMP/dCMP deaminase domain 1 confers deoxycytidine deaminase activity, whereas the CMP/dCMP deaminase domain 2 mediates RNA-dependent oligomerization and virion incorporation.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410JBA1 Eukaryota
ENOG41119MS LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162772

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000033755

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99J72

Database of Orthologous Groups

More...
OrthoDBi
586309at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q99J72

TreeFam database of animal gene trees

More...
TreeFami
TF331356

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53927 SSF53927, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 2 hits
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99J72-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPQRLGPRA GMGPFCLGCS HRKCYSPIRN LISQETFKFH FKNLGYAKGR
60 70 80 90 100
KDTFLCYEVT RKDCDSPVSL HHGVFKNKDN IHAEICFLYW FHDKVLKVLS
110 120 130 140 150
PREEFKITWY MSWSPCFECA EQIVRFLATH HNLSLDIFSS RLYNVQDPET
160 170 180 190 200
QQNLCRLVQE GAQVAAMDLY EFKKCWKKFV DNGGRRFRPW KRLLTNFRYQ
210 220 230 240 250
DSKLQEILRP CYISVPSSSS STLSNICLTK GLPETRFWVE GRRMDPLSEE
260 270 280 290 300
EFYSQFYNQR VKHLCYYHRM KPYLCYQLEQ FNGQAPLKGC LLSEKGKQHA
310 320 330 340 350
EILFLDKIRS MELSQVTITC YLTWSPCPNC AWQLAAFKRD RPDLILHIYT
360 370 380 390 400
SRLYFHWKRP FQKGLCSLWQ SGILVDVMDL PQFTDCWTNF VNPKRPFWPW
410 420 430 440
KGLEIISRRT QRRLRRIKES WGLQDLVNDF GNLQLGPPMS
Length:440
Mass (Da):52,213
Last modified:December 20, 2017 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAA0DA7AC616252E9
GO
Isoform 2 (identifier: Q99J72-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-440: SWGLQDLVNDFGNLQLGPPMS → VRTTLLQGPAS

Show »
Length:430
Mass (Da):51,067
Checksum:i236E70AA28F7E16C
GO
Isoform 3 (identifier: Q99J72-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-241: Missing.
     420-440: SWGLQDLVNDFGNLQLGPPMS → SRSHAS

Show »
Length:392
Mass (Da):46,970
Checksum:i457EC3A5D3B011E8
GO
Isoform 4 (identifier: Q99J72-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-241: Missing.

Note: Lacks exon V. Found in cell line MDTF.
Show »
Length:407
Mass (Da):48,615
Checksum:iAE01BC74D716229A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q3U5C5Q3U5C5_MOUSE
Apolipoprotein B mRNA editing enzym...
Apobec3 APOBEC3
396Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9QMH1E9QMH1_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3TI69Q3TI69_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VKS7A0A2R8VKS7_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
97Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKS1H3BKS1_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJD1H3BJD1_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BJJ6H3BJJ6_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BL97H3BL97_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BKS5H3BKS5_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8VHT8A0A2R8VHT8_MOUSE
DNA dC->dU-editing enzyme APOBEC-3
Apobec3
62Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH03314 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC31901 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC34023 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti6L → M in BAC31901 (PubMed:16141072).Curated1
Sequence conflicti6L → M in AAH03314 (PubMed:15489334).Curated1
Sequence conflicti214S → P in BAC31901 (PubMed:16141072).Curated1
Sequence conflicti214S → P in AAH03314 (PubMed:15489334).Curated1
Sequence conflicti238W → C in BAC31901 (PubMed:16141072).Curated1
Sequence conflicti238W → C in AAH03314 (PubMed:15489334).Curated1
Sequence conflicti241G → R no nucleotide entry (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti31L → V in cell line MDTF. 1
Natural varianti42K → E in cell line MDTF. 1
Natural varianti45 – 46GY → PF in cell line MDTF. 2
Natural varianti45G → R in cell lines L1.2 and 3T3. 2 Publications1
Natural varianti48 – 49KG → ID in cell lines L1.2 and 3T3. 2 Publications2
Natural varianti49G → K in cell line MDTF; requires 2 nucleotide substitutions. 1
Natural varianti122Q → R in cell line L1.2. 1
Natural varianti123 – 124IV → VL in cell lines L1.2 and 3T3. 2 Publications2
Natural varianti123I → V in cell line MDTF. 1
Natural varianti139S → F in cell line MDTF. 1
Natural varianti145 – 150VQDPET → IRNPEN in cell line MDTF. 6
Natural varianti145 – 146VQ → IR in cell lines L1.2 and 3T3. 2 Publications2
Natural varianti150 – 151TQ → NQL in cell line 3T3. 2
Natural varianti150T → N in cell line L1.2. 2 Publications1
Natural varianti159Q → L in cell line MDTF. 1
Natural varianti173 – 174KK → EE in cell line MDTF. 2
Natural varianti192R → K in cell lines L1.2 and 3T3. 2 Publications1
Natural varianti241 – 246GRRMDP → RRRVHL in cell line 3T3. 6
Natural varianti244 – 246MDP → VHL2 Publications3
Natural varianti245 – 246DP → SL in cell line MDTF. 2
Natural varianti259Q → L in cell line MDTF. 1
Natural varianti269 – 270RM → GV in cell line 3T3. 2
Natural varianti269R → G in cell line L1.2. 2 Publications1
Natural varianti275C → F in cell line MDTF. 1
Natural varianti280Q → W in cell line MDTF; requires 2 nucleotide substitutions. 1
Natural varianti285A → E in cell line MDTF. 1
Natural varianti295 – 307Missing in cell line MDTF. Add BLAST13
Natural varianti317T → I in cell lines L1.2 and 3T3. 2 Publications1
Natural varianti325S → G in cell line EL4. 1
Natural varianti339R → K in cell line MDTF. 1
Natural varianti392N → S in cell line MDTF. 1
Natural varianti398W → R in splenocytes. 1
Natural varianti405 – 406II → KT in cell line MDTF. 2
Natural varianti410T → A in cell line L1.2. 1
Natural varianti415R → C in cell lines MDTF and 3T3. 1
Natural varianti415R → H in cell line L1.2. 2 Publications1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_009831209 – 241Missing in isoform 3 and isoform 4. 1 PublicationAdd BLAST33
Alternative sequenceiVSP_009832420 – 440SWGLQ…GPPMS → VRTTLLQGPAS in isoform 2. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_009833420 – 440SWGLQ…GPPMS → SRSHAS in isoform 3. 1 PublicationAdd BLAST21

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK044394 mRNA Translation: BAC31901.1 Different initiation.
AK049998 mRNA Translation: BAC34023.1 Different initiation.
AC113595 Genomic DNA No translation available.
BC003314 mRNA Translation: AAH03314.1 Different initiation.

NCBI Reference Sequences

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RefSeqi
XP_017172295.1, XM_017316806.1 [Q99J72-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000175714; ENSMUSP00000135027; ENSMUSG00000009585 [Q99J72-1]
ENSMUST00000175752; ENSMUSP00000135358; ENSMUSG00000009585 [Q99J72-4]
ENSMUST00000176325; ENSMUSP00000134838; ENSMUSG00000009585 [Q99J72-2]
ENSMUST00000177098; ENSMUSP00000135079; ENSMUSG00000009585 [Q99J72-3]

Database of genes from NCBI RefSeq genomes

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GeneIDi
80287

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK044394 mRNA Translation: BAC31901.1 Different initiation.
AK049998 mRNA Translation: BAC34023.1 Different initiation.
AC113595 Genomic DNA No translation available.
BC003314 mRNA Translation: AAH03314.1 Different initiation.
RefSeqiXP_017172295.1, XM_017316806.1 [Q99J72-3]

3D structure databases

SMRiQ99J72
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000135027

PTM databases

iPTMnetiQ99J72
PhosphoSitePlusiQ99J72

Proteomic databases

MaxQBiQ99J72
PaxDbiQ99J72
PRIDEiQ99J72

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000175714; ENSMUSP00000135027; ENSMUSG00000009585 [Q99J72-1]
ENSMUST00000175752; ENSMUSP00000135358; ENSMUSG00000009585 [Q99J72-4]
ENSMUST00000176325; ENSMUSP00000134838; ENSMUSG00000009585 [Q99J72-2]
ENSMUST00000177098; ENSMUSP00000135079; ENSMUSG00000009585 [Q99J72-3]
GeneIDi80287

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80287
MGIiMGI:1933111 Apobec3

Phylogenomic databases

eggNOGiENOG410JBA1 Eukaryota
ENOG41119MS LUCA
GeneTreeiENSGT00940000162772
HOGENOMiHOG000033755
InParanoidiQ99J72
OrthoDBi586309at2759
PhylomeDBiQ99J72
TreeFamiTF331356

Enzyme and pathway databases

BRENDAi3.5.4.1 3474
ReactomeiR-MMU-72200 mRNA Editing: C to U Conversion
R-MMU-75094 Formation of the Editosome

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q99J72

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000009585 Expressed in 195 organ(s), highest expression level in bone marrow
ExpressionAtlasiQ99J72 baseline and differential
GenevisibleiQ99J72 MM

Family and domain databases

InterProiView protein in InterPro
IPR016192 APOBEC/CMP_deaminase_Zn-bd
IPR002125 CMP_dCMP_dom
IPR016193 Cytidine_deaminase-like
SUPFAMiSSF53927 SSF53927, 2 hits
PROSITEiView protein in PROSITE
PS00903 CYT_DCMP_DEAMINASES_1, 2 hits
PS51747 CYT_DCMP_DEAMINASES_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABEC3_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99J72
Secondary accession number(s): H3BJL0, Q8C7L0, Q8C8V7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: December 20, 2017
Last modified: May 8, 2019
This is version 135 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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