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Protein

Derlin-1

Gene

Derl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport, Unfolded protein response

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle

Names & Taxonomyi

Protein namesi
Recommended name:
Derlin-11 Publication
Alternative name(s):
Degradation in endoplasmic reticulum protein 1
Der1-like protein 11 Publication
Gene namesi
Name:Derl1Imported
Synonyms:Der1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:1915069 Derl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 22CytoplasmicSequence analysisAdd BLAST21
Transmembranei23 – 43Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini44 – 59LumenalSequence analysisAdd BLAST16
Transmembranei60 – 80Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini81 – 105CytoplasmicSequence analysisAdd BLAST25
Transmembranei106 – 126Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini127 – 154LumenalSequence analysisAdd BLAST28
Transmembranei155 – 175Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini176 – 251CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002190432 – 251Derlin-1Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei201PhosphoserineCombined sources1
Modified residuei202PhosphothreonineBy similarity1
Modified residuei226PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99J56
MaxQBiQ99J56
PaxDbiQ99J56
PRIDEiQ99J56

PTM databases

iPTMnetiQ99J56
PhosphoSitePlusiQ99J56
SwissPalmiQ99J56

Expressioni

Tissue specificityi

Widely expressed, with lowest levels in brain and heart.1 Publication

Inductioni

Up-regulated in response to endoplasmic reticulum stress via the ERN1-XBP1 pathway of the unfolded protein response (UPR).2 Publications

Gene expression databases

BgeeiENSMUSG00000022365 Expressed in 288 organ(s), highest expression level in carotid body
CleanExiMM_DERL1
GenevisibleiQ99J56 MM

Interactioni

Subunit structurei

Forms homo- and heterooligomers with DERL2 and DERL3; binding to DERL3 is poorer than that between DERL2 and DERL3. Interacts with AMFR, SELENOS, SEL1L, SELENOK, SYVN1 and VCP, as well as with SEL1L-SYVN1 and VCP-SELENOS protein complexes; this interaction is weaker than that observed between DERL2 and these complexes. Interacts with NGLY1 and YOD1. Does not bind to EDEM1 (By similarity). Interacts with DNAJB9 (PubMed:22267725). Interacts with RNF103. Interacts with HM13. Interacts with XBP1 isoform 1 (via luminal/ectodomain domain); the interaction obviates the need for ectodomain shedding prior HM13/SPP-mediated XBP1 isoform 1 cleavage. Interacts with the signal recognition particle/SRP and the SRP receptor; in the process of endoplasmic reticulum stress-induced pre-emptive quality control. May interact with UBXN6 (By similarity). Interacts with ZFAND2B; probably through VCP (PubMed:24160817).By similarity2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212459, 3 interactors
STRINGi10090.ENSMUSP00000022993

Structurei

3D structure databases

ProteinModelPortaliQ99J56
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the derlin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0858 Eukaryota
COG5291 LUCA
GeneTreeiENSGT00530000063156
HOGENOMiHOG000200949
HOVERGENiHBG105143
InParanoidiQ99J56
KOiK11519
OMAiTYIWCQL
OrthoDBiEOG091G0EP1
PhylomeDBiQ99J56
TreeFamiTF354297

Family and domain databases

InterProiView protein in InterPro
IPR007599 DER1
PANTHERiPTHR11009 PTHR11009, 1 hit
PfamiView protein in Pfam
PF04511 DER1, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99J56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSDIGDWFRS IPAITRYWFA ATVAVPLIGK LGIISPAYFF LWPEAFLYRF
60 70 80 90 100
QIWRPFTATF YFPVGPGTGF LYLVNLYFLY QYSTRLEAGA FDGRPADYLF
110 120 130 140 150
MLLFNWICIV ITGLAMDMQL LMIPLIMSVL YVWAQLNRDL IVSFWFGTRF
160 170 180 190 200
KACYLPWVIL GFNYIIGGSV INELIGNLVG HLYFFLMFRY PMDLGGRNFL
210 220 230 240 250
STPQFLYRWL PSRRGGVSGF GVPPASMRRA ADQNGGGGRH NWGQGFRLGD

Q
Length:251
Mass (Da):28,835
Last modified:June 1, 2001 - v1
Checksum:i2E1B79DEAFD3FDC8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti13A → V in BAB25036 (PubMed:16141072).Curated1
Sequence conflicti17Y → N in BAB25036 (PubMed:16141072).Curated1
Sequence conflicti20A → V in BAB25036 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007435 mRNA Translation: BAB25036.1
AK043420 mRNA Translation: BAC31545.1
AK075631 mRNA Translation: BAC35868.1
AK152197 mRNA Translation: BAE31026.1
AK152901 mRNA Translation: BAE31582.1
BC003454 mRNA Translation: AAH03454.1
BC085490 mRNA Translation: AAH85490.1
CCDSiCCDS27484.1
RefSeqiNP_077169.1, NM_024207.4
UniGeneiMm.289387
Mm.444431

Genome annotation databases

EnsembliENSMUST00000022993; ENSMUSP00000022993; ENSMUSG00000022365
GeneIDi67819
KEGGimmu:67819
UCSCiuc007vsq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK007435 mRNA Translation: BAB25036.1
AK043420 mRNA Translation: BAC31545.1
AK075631 mRNA Translation: BAC35868.1
AK152197 mRNA Translation: BAE31026.1
AK152901 mRNA Translation: BAE31582.1
BC003454 mRNA Translation: AAH03454.1
BC085490 mRNA Translation: AAH85490.1
CCDSiCCDS27484.1
RefSeqiNP_077169.1, NM_024207.4
UniGeneiMm.289387
Mm.444431

3D structure databases

ProteinModelPortaliQ99J56
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212459, 3 interactors
STRINGi10090.ENSMUSP00000022993

PTM databases

iPTMnetiQ99J56
PhosphoSitePlusiQ99J56
SwissPalmiQ99J56

Proteomic databases

EPDiQ99J56
MaxQBiQ99J56
PaxDbiQ99J56
PRIDEiQ99J56

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022993; ENSMUSP00000022993; ENSMUSG00000022365
GeneIDi67819
KEGGimmu:67819
UCSCiuc007vsq.1 mouse

Organism-specific databases

CTDi79139
MGIiMGI:1915069 Derl1

Phylogenomic databases

eggNOGiKOG0858 Eukaryota
COG5291 LUCA
GeneTreeiENSGT00530000063156
HOGENOMiHOG000200949
HOVERGENiHBG105143
InParanoidiQ99J56
KOiK11519
OMAiTYIWCQL
OrthoDBiEOG091G0EP1
PhylomeDBiQ99J56
TreeFamiTF354297

Enzyme and pathway databases

ReactomeiR-MMU-382556 ABC-family proteins mediated transport
R-MMU-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle

Miscellaneous databases

ChiTaRSiDerl1 mouse
PROiPR:Q99J56
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022365 Expressed in 288 organ(s), highest expression level in carotid body
CleanExiMM_DERL1
GenevisibleiQ99J56 MM

Family and domain databases

InterProiView protein in InterPro
IPR007599 DER1
PANTHERiPTHR11009 PTHR11009, 1 hit
PfamiView protein in Pfam
PF04511 DER1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDERL1_MOUSE
AccessioniPrimary (citable) accession number: Q99J56
Secondary accession number(s): Q3U6Z2, Q9D918
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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