UniProtKB - Q99J47 (DRS7B_MOUSE)
Protein
Dehydrogenase/reductase SDR family member 7B
Gene
Dhrs7b
Organism
Mus musculus (Mouse)
Status
Functioni
Putative oxidoreductase.Curated
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 192 | SubstrateSequence analysis | 1 | |
Active sitei | 205 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 56 – 80 | NAD or NADPBy similarityAdd BLAST | 25 |
GO - Molecular functioni
- acylglycerone-phosphate reductase activity Source: MGI
- DNA-binding transcription factor binding Source: MGI
- transcription corepressor activity Source: MGI
GO - Biological processi
- adipose tissue development Source: MGI
- brown fat cell differentiation Source: MGI
- ether lipid biosynthetic process Source: MGI
- negative regulation of protein binding Source: MGI
- neutrophil differentiation Source: MGI
- phosphatidylcholine biosynthetic process Source: MGI
- regulation of cold-induced thermogenesis Source: MGI
- regulation of gene expression Source: MGI
- regulation of transcription, DNA-templated Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD, NADP |
Enzyme and pathway databases
Reactomei | R-MMU-75896, Plasmalogen biosynthesis |
Names & Taxonomyi
Protein namesi | Recommended name: Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)Alternative name(s): Short-chain dehydrogenase/reductase family 32C member 1By similarity |
Gene namesi | Name:Dhrs7b Synonyms:Sdr32c1By similarity |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2384931, Dhrs7b |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type II membrane protein By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: MGI
Peroxisome
- peroxisome Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
- transcription regulator complex Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 17 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 18 – 38 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 39 – 323 | LumenalSequence analysisAdd BLAST | 285 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000312106 | 1 – 323 | Dehydrogenase/reductase SDR family member 7BAdd BLAST | 323 |
Proteomic databases
jPOSTi | Q99J47 |
PaxDbi | Q99J47 |
PRIDEi | Q99J47 |
PTM databases
iPTMneti | Q99J47 |
PhosphoSitePlusi | Q99J47 |
SwissPalmi | Q99J47 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000042569, Expressed in brown adipose tissue and 282 other tissues |
ExpressionAtlasi | Q99J47, baseline and differential |
Genevisiblei | Q99J47, MM |
Interactioni
GO - Molecular functioni
- DNA-binding transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 229794, 5 interactors |
IntActi | Q99J47, 1 interactor |
STRINGi | 10090.ENSMUSP00000044924 |
Miscellaneous databases
RNActi | Q99J47, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1205, Eukaryota |
GeneTreei | ENSGT00940000158171 |
InParanoidi | Q99J47 |
PhylomeDBi | Q99J47 |
TreeFami | TF313474 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99J47-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MISPSFRKGM LKERVMDLAS QTTILPLLFG CLGIFSLFRL LQRIRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGRECAK VFHAAGAKLV LCGRNVKALE ELSRELAGSS
110 120 130 140 150
QGQTHQPFVV TFDLADPGTI AAAAAEILQC FGYVDVLINN AGISYRGTIS
160 170 180 190 200
DTIVDVDRKV MEINYFGPVA LTKALLPSMV ERKQGHIVAI SSIQGKISIP
210 220 230 240 250
FRSAYSASKH ATQAFFDCLR AEMEEANIKV TVISPGYIHT NLSVNAVTAD
260 270 280 290 300
GSRYGALDKN TAQGRSAAEV AQDVFDAVGK KKKDVLLTDF VPSMAVYIRT
310 320
LAPGLFFRIM ASRARKERKS KSS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketZ4YKT6 | Z4YKT6_MOUSE | Dehydrogenase/reductase SDR family ... | Dhrs7b | 308 | Annotation score: |
Sequence cautioni
The sequence CAI35261 differs from that shown. Reason: Erroneous initiation.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_029698 | 1 – 9 | Missing in isoform 2. 1 Publication | 9 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052209 mRNA Translation: BAC34887.1 AK139084 mRNA Translation: BAE23884.1 AK144057 mRNA Translation: BAE25674.1 AL596215 Genomic DNA Translation: CAI35261.1 Different initiation. BC003479 mRNA Translation: AAH03479.1 |
CCDSi | CCDS24800.1 [Q99J47-1] |
RefSeqi | NP_001165583.1, NM_001172112.1 [Q99J47-2] NP_663403.1, NM_145428.2 [Q99J47-1] |
Genome annotation databases
Ensembli | ENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569 [Q99J47-1] |
GeneIDi | 216820 |
KEGGi | mmu:216820 |
UCSCi | uc007jgq.2, mouse [Q99J47-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK052209 mRNA Translation: BAC34887.1 AK139084 mRNA Translation: BAE23884.1 AK144057 mRNA Translation: BAE25674.1 AL596215 Genomic DNA Translation: CAI35261.1 Different initiation. BC003479 mRNA Translation: AAH03479.1 |
CCDSi | CCDS24800.1 [Q99J47-1] |
RefSeqi | NP_001165583.1, NM_001172112.1 [Q99J47-2] NP_663403.1, NM_145428.2 [Q99J47-1] |
3D structure databases
SMRi | Q99J47 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 229794, 5 interactors |
IntActi | Q99J47, 1 interactor |
STRINGi | 10090.ENSMUSP00000044924 |
PTM databases
iPTMneti | Q99J47 |
PhosphoSitePlusi | Q99J47 |
SwissPalmi | Q99J47 |
Proteomic databases
jPOSTi | Q99J47 |
PaxDbi | Q99J47 |
PRIDEi | Q99J47 |
Protocols and materials databases
Antibodypediai | 2324, 129 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569 [Q99J47-1] |
GeneIDi | 216820 |
KEGGi | mmu:216820 |
UCSCi | uc007jgq.2, mouse [Q99J47-1] |
Organism-specific databases
CTDi | 25979 |
MGIi | MGI:2384931, Dhrs7b |
Phylogenomic databases
eggNOGi | KOG1205, Eukaryota |
GeneTreei | ENSGT00940000158171 |
InParanoidi | Q99J47 |
PhylomeDBi | Q99J47 |
TreeFami | TF313474 |
Enzyme and pathway databases
Reactomei | R-MMU-75896, Plasmalogen biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 216820, 4 hits in 17 CRISPR screens |
ChiTaRSi | Dhrs7b, mouse |
PROi | PR:Q99J47 |
RNActi | Q99J47, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042569, Expressed in brown adipose tissue and 282 other tissues |
ExpressionAtlasi | Q99J47, baseline and differential |
Genevisiblei | Q99J47, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DRS7B_MOUSE | |
Accessioni | Q99J47Primary (citable) accession number: Q99J47 Secondary accession number(s): Q3UNS3, Q5NCT5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 4, 2007 |
Last sequence update: | June 1, 2001 | |
Last modified: | February 10, 2021 | |
This is version 159 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families