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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Putative oxidoreductase.Curated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei192SubstrateSequence analysis1
Active sitei205Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi56 – 80NAD or NADPBy similarityAdd BLAST25

GO - Molecular functioni

  • acylglycerone-phosphate reductase activity Source: MGI

GO - Biological processi

  • ether lipid biosynthetic process Source: MGI
  • neutrophil differentiation Source: MGI

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-)
Alternative name(s):
Short-chain dehydrogenase/reductase family 32C member 1By similarity
Gene namesi
Name:Dhrs7b
Synonyms:Sdr32c1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2384931 Dhrs7b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 17CytoplasmicSequence analysisAdd BLAST17
Transmembranei18 – 38Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini39 – 323LumenalSequence analysisAdd BLAST285

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003121061 – 323Dehydrogenase/reductase SDR family member 7BAdd BLAST323

Proteomic databases

PaxDbiQ99J47
PRIDEiQ99J47

PTM databases

iPTMnetiQ99J47
PhosphoSitePlusiQ99J47
SwissPalmiQ99J47

Expressioni

Gene expression databases

BgeeiENSMUSG00000042569 Expressed in 265 organ(s), highest expression level in brown adipose tissue
CleanExiMM_DHRS7B
ExpressionAtlasiQ99J47 baseline and differential
GenevisibleiQ99J47 MM

Interactioni

Protein-protein interaction databases

BioGridi229794, 2 interactors
IntActiQ99J47, 1 interactor
STRINGi10090.ENSMUSP00000044924

Structurei

3D structure databases

ProteinModelPortaliQ99J47
SMRiQ99J47
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG107825
InParanoidiQ99J47
KOiK11166
OMAiSMIKRRQ
OrthoDBiEOG091G0BO9
PhylomeDBiQ99J47
TreeFamiTF313474

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99J47-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MISPSFRKGM LKERVMDLAS QTTILPLLFG CLGIFSLFRL LQRIRSKAYL
60 70 80 90 100
RNAVVVVTGA TSGLGRECAK VFHAAGAKLV LCGRNVKALE ELSRELAGSS
110 120 130 140 150
QGQTHQPFVV TFDLADPGTI AAAAAEILQC FGYVDVLINN AGISYRGTIS
160 170 180 190 200
DTIVDVDRKV MEINYFGPVA LTKALLPSMV ERKQGHIVAI SSIQGKISIP
210 220 230 240 250
FRSAYSASKH ATQAFFDCLR AEMEEANIKV TVISPGYIHT NLSVNAVTAD
260 270 280 290 300
GSRYGALDKN TAQGRSAAEV AQDVFDAVGK KKKDVLLTDF VPSMAVYIRT
310 320
LAPGLFFRIM ASRARKERKS KSS
Length:323
Mass (Da):34,987
Last modified:June 1, 2001 - v1
Checksum:i6C75A07F9BC9B398
GO
Isoform 2 (identifier: Q99J47-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: Missing.

Show »
Length:314
Mass (Da):33,982
Checksum:i1E04957327E4F1C6
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Z4YKT6Z4YKT6_MOUSE
Dehydrogenase/reductase SDR family ...
Dhrs7b
308Annotation score:

Sequence cautioni

The sequence CAI35261 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0296981 – 9Missing in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052209 mRNA Translation: BAC34887.1
AK139084 mRNA Translation: BAE23884.1
AK144057 mRNA Translation: BAE25674.1
AL596215 Genomic DNA Translation: CAI35261.1 Different initiation.
BC003479 mRNA Translation: AAH03479.1
CCDSiCCDS24800.1 [Q99J47-1]
RefSeqiNP_001165583.1, NM_001172112.1 [Q99J47-2]
NP_663403.1, NM_145428.2 [Q99J47-1]
UniGeneiMm.21475

Genome annotation databases

EnsembliENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569 [Q99J47-1]
GeneIDi216820
KEGGimmu:216820
UCSCiuc007jgq.2 mouse [Q99J47-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052209 mRNA Translation: BAC34887.1
AK139084 mRNA Translation: BAE23884.1
AK144057 mRNA Translation: BAE25674.1
AL596215 Genomic DNA Translation: CAI35261.1 Different initiation.
BC003479 mRNA Translation: AAH03479.1
CCDSiCCDS24800.1 [Q99J47-1]
RefSeqiNP_001165583.1, NM_001172112.1 [Q99J47-2]
NP_663403.1, NM_145428.2 [Q99J47-1]
UniGeneiMm.21475

3D structure databases

ProteinModelPortaliQ99J47
SMRiQ99J47
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229794, 2 interactors
IntActiQ99J47, 1 interactor
STRINGi10090.ENSMUSP00000044924

PTM databases

iPTMnetiQ99J47
PhosphoSitePlusiQ99J47
SwissPalmiQ99J47

Proteomic databases

PaxDbiQ99J47
PRIDEiQ99J47

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569 [Q99J47-1]
GeneIDi216820
KEGGimmu:216820
UCSCiuc007jgq.2 mouse [Q99J47-1]

Organism-specific databases

CTDi25979
MGIiMGI:2384931 Dhrs7b

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG107825
InParanoidiQ99J47
KOiK11166
OMAiSMIKRRQ
OrthoDBiEOG091G0BO9
PhylomeDBiQ99J47
TreeFamiTF313474

Miscellaneous databases

PROiPR:Q99J47
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000042569 Expressed in 265 organ(s), highest expression level in brown adipose tissue
CleanExiMM_DHRS7B
ExpressionAtlasiQ99J47 baseline and differential
GenevisibleiQ99J47 MM

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDRS7B_MOUSE
AccessioniPrimary (citable) accession number: Q99J47
Secondary accession number(s): Q3UNS3, Q5NCT5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: June 1, 2001
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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