UniProtKB - Q99J47 (DRS7B_MOUSE)

BLAST

>sp|Q99J47|DRS7B_MOUSE Dehydrogenase/reductase SDR family member 7B OS=Mus musculus OX=10090 GN=Dhrs7b PE=1 SV=1
MISPSFRKGMLKERVMDLASQTTILPLLFGCLGIFSLFRLLQRIRSKAYLRNAVVVVTGA
TSGLGRECAKVFHAAGAKLVLCGRNVKALEELSRELAGSSQGQTHQPFVVTFDLADPGTI
AAAAAEILQCFGYVDVLINNAGISYRGTISDTIVDVDRKVMEINYFGPVALTKALLPSMV
ERKQGHIVAISSIQGKISIPFRSAYSASKHATQAFFDCLRAEMEEANIKVTVISPGYIHT
NLSVNAVTADGSRYGALDKNTAQGRSAAEVAQDVFDAVGKKKKDVLLTDFVPSMAVYIRT
LAPGLFFRIMASRARKERKSKSS

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History
Entry version 142 (12 Sep 2018)
Sequence version 1 (01 Jun 2001)
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Protein

Dehydrogenase/reductase SDR family member 7B

Gene

Dhrs7b

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Putative oxidoreductase.Curated

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	192	SubstrateSequence analysis		1
Active siteⁱ	205	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	56 – 80	NAD or NADPBy similarityAdd BLAST		25

GO - Molecular functionⁱ

acylglycerone-phosphate reductase activity
Source: MGI
Traceable author statementⁱ
- 25565205

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

ether lipid biosynthetic process
Source: MGI
Inferred from mutant phenotypeⁱ
- 25565205
neutrophil differentiation
Source: MGI
Inferred from mutant phenotypeⁱ
- 25565205

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase
Ligand	NAD, NADP

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dehydrogenase/reductase SDR family member 7B (EC:1.1.-.-) Alternative name(s): Short-chain dehydrogenase/reductase family 32C member 1By similarity
Gene namesⁱ	Name:Dhrs7b Synonyms:Sdr32c1By similarity
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:2384931 Dhrs7b

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 17	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	18 – 38	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	21
Topological domainⁱ	39 – 323	LumenalSequence analysisAdd BLAST	285

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000312106	1 – 323	Dehydrogenase/reductase SDR family member 7BAdd BLAST		323

Proteomic databases

PaxDbⁱ	Q99J47
PRIDEⁱ	Q99J47

PTM databases

iPTMnetⁱ	Q99J47
PhosphoSitePlusⁱ	Q99J47
SwissPalmⁱ	Q99J47

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000042569 Expressed in 265 organ(s), highest expression level in brown adipose tissue
CleanExⁱ	MM_DHRS7B
ExpressionAtlasⁱ	Q99J47 baseline and differential
Genevisibleⁱ	Q99J47 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	229794, 2 interactors
IntActⁱ	Q99J47, 1 interactor
STRINGⁱ	10090.ENSMUSP00000044924

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q99J47
SMRⁱ	Q99J47
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG1205 Eukaryota COG1028 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148940
HOVERGENⁱ	HBG107825
InParanoidⁱ	Q99J47
KEGG Orthology (KO) More...KOⁱ	K11166
OMAⁱ	SMIKRRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BO9
PhylomeDBⁱ	Q99J47
TreeFamⁱ	TF313474

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q99J47-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MISPSFRKGM LKERVMDLAS QTTILPLLFG CLGIFSLFRL LQRIRSKAYL 
        60         70         80         90        100
RNAVVVVTGA TSGLGRECAK VFHAAGAKLV LCGRNVKALE ELSRELAGSS 
       110        120        130        140        150
QGQTHQPFVV TFDLADPGTI AAAAAEILQC FGYVDVLINN AGISYRGTIS 
       160        170        180        190        200
DTIVDVDRKV MEINYFGPVA LTKALLPSMV ERKQGHIVAI SSIQGKISIP 
       210        220        230        240        250
FRSAYSASKH ATQAFFDCLR AEMEEANIKV TVISPGYIHT NLSVNAVTAD 
       260        270        280        290        300
GSRYGALDKN TAQGRSAAEV AQDVFDAVGK KKKDVLLTDF VPSMAVYIRT 
       310        320 
LAPGLFFRIM ASRARKERKS KSS

Length:323

Mass (Da):34,987

Last modified:June 1, 2001 - v1

Checksum:ⁱ6C75A07F9BC9B398

Isoform 2 (identifier: Q99J47-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-9: Missing.

« Hide

        10         20         30         40         50
MLKERVMDLA SQTTILPLLF GCLGIFSLFR LLQRIRSKAY LRNAVVVVTG 
        60         70         80         90        100
ATSGLGRECA KVFHAAGAKL VLCGRNVKAL EELSRELAGS SQGQTHQPFV 
       110        120        130        140        150
VTFDLADPGT IAAAAAEILQ CFGYVDVLIN NAGISYRGTI SDTIVDVDRK 
       160        170        180        190        200
VMEINYFGPV ALTKALLPSM VERKQGHIVA ISSIQGKISI PFRSAYSASK 
       210        220        230        240        250
HATQAFFDCL RAEMEEANIK VTVISPGYIH TNLSVNAVTA DGSRYGALDK 
       260        270        280        290        300
NTAQGRSAAE VAQDVFDAVG KKKKDVLLTD FVPSMAVYIR TLAPGLFFRI 
       310 
MASRARKERK SKSS

Show »

Length:314

Mass (Da):33,982

Checksum:ⁱ1E04957327E4F1C6

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	Z4YKT6	Z4YKT6_MOUSE		Dehydrogenase/reductase SDR family ... Dehydrogenase/reductase SDR family member 7B	Dhrs7b	308	Annotation score:

Sequence cautionⁱ

The sequence CAI35261 differs from that shown. Reason: Erroneous initiation.Curated

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_029698	1 – 9	Missing in isoform 2. 1 Publication		9

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK052209 mRNA Translation: BAC34887.1 AK139084 mRNA Translation: BAE23884.1 AK144057 mRNA Translation: BAE25674.1 AL596215 Genomic DNA Translation: CAI35261.1 Different initiation. BC003479 mRNA Translation: AAH03479.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24800.1 [Q99J47-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001165583.1, NM_001172112.1 [Q99J47-2] NP_663403.1, NM_145428.2 [Q99J47-1]
UniGeneⁱ	Mm.21475

Genome annotation databases

Ensemblⁱ	ENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569 [Q99J47-1]
GeneIDⁱ	216820
KEGGⁱ	mmu:216820
UCSC genome browser More...UCSCⁱ	uc007jgq.2 mouse [Q99J47-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99J47	PexRAP		MOUSE		323	UniRef100_Q99J47
Dehydrogenase/reductase SDR family member 7B		MOUSE		308
Isoform 2 of Dehydrogenase/reductase SDR family member 7B		MOUSE		314

Protein	Similar proteins		Species	Score	Length	Source
Q99J47	Dehydrogenase/reductase SDR family member 7B		RAT		325	UniRef90_Q99J47
PexRAP		MOUSE		323
UPI000A3179B5		MUSCR		323
UPI000A30F73A		MUSPA		315
Dehydrogenase/reductase SDR family member 7B		MOUSE		308
+4

Protein	Similar proteins		Species	Score	Length	Source
Q99J47	Dehydrogenase/reductase SDR family member 7B		RAT		325	UniRef50_Q99J47
Dehydrogenase/reductase SDR family member 7B		XENLA		323
Dehydrogenase/reductase SDR family member 7B		XENTR		309
PexRAP		MOUSE		323
Dehydrogenase/reductase SDR family member 7B (Fragment)		ESCRO		293
+112

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK052209 mRNA Translation: BAC34887.1 AK139084 mRNA Translation: BAE23884.1 AK144057 mRNA Translation: BAE25674.1 AL596215 Genomic DNA Translation: CAI35261.1 Different initiation. BC003479 mRNA Translation: AAH03479.1
CCDSⁱ	CCDS24800.1 [Q99J47-1]
RefSeqⁱ	NP_001165583.1, NM_001172112.1 [Q99J47-2] NP_663403.1, NM_145428.2 [Q99J47-1]
UniGeneⁱ	Mm.21475

3D structure databases

ProteinModelPortalⁱ	Q99J47
SMRⁱ	Q99J47
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	229794, 2 interactors
IntActⁱ	Q99J47, 1 interactor
STRINGⁱ	10090.ENSMUSP00000044924

PTM databases

iPTMnetⁱ	Q99J47
PhosphoSitePlusⁱ	Q99J47
SwissPalmⁱ	Q99J47

Proteomic databases

PaxDbⁱ	Q99J47
PRIDEⁱ	Q99J47

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000042281; ENSMUSP00000044924; ENSMUSG00000042569 [Q99J47-1]
GeneIDⁱ	216820
KEGGⁱ	mmu:216820
UCSCⁱ	uc007jgq.2 mouse [Q99J47-1]

Organism-specific databases

CTDⁱ	25979
MGIⁱ	MGI:2384931 Dhrs7b

Phylogenomic databases

eggNOGⁱ	KOG1205 Eukaryota COG1028 LUCA
GeneTreeⁱ	ENSGT00920000148940
HOVERGENⁱ	HBG107825
InParanoidⁱ	Q99J47
KOⁱ	K11166
OMAⁱ	SMIKRRQ
OrthoDBⁱ	EOG091G0BO9
PhylomeDBⁱ	Q99J47
TreeFamⁱ	TF313474

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q99J47
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000042569 Expressed in 265 organ(s), highest expression level in brown adipose tissue
CleanExⁱ	MM_DHRS7B
ExpressionAtlasⁱ	Q99J47 baseline and differential
Genevisibleⁱ	Q99J47 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR036291 NAD(P)-bd_dom_sf IPR020904 Sc_DH/Rdtase_CS IPR002347 SDR_fam
Pfamⁱ	View protein in Pfam PF00106 adh_short, 1 hit
PRINTSⁱ	PR00081 GDHRDH PR00080 SDRFAMILY
SUPFAMⁱ	SSF51735 SSF51735, 1 hit
PROSITEⁱ	View protein in PROSITE PS00061 ADH_SHORT, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DRS7B_MOUSE
Accessionⁱ	Q99J47Primary (citable) accession number: Q99J47 Secondary accession number(s): Q3UNS3, Q5NCT5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 4, 2007
	Last sequence update:	June 1, 2001
	Last modified:	September 12, 2018
	This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99J47 (DRS7B_MOUSE)

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Dehydrogenase/reductase SDR family member 7B

Dhrs7b

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ