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Protein

Nuclear receptor-binding protein

Gene

Nrbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases.By similarity

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: UniProtKB
  • protein serine/threonine kinase activity Source: MGI

GO - Biological processi

  • ER to Golgi vesicle-mediated transport Source: UniProtKB
  • intracellular signal transduction Source: GO_Central

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor-binding protein
Alternative name(s):
HLS7-interacting protein kinase
MLF1 adapter molecule
Gene namesi
Name:Nrbp1
Synonyms:Madm, Nrbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2183436 Nrbp1

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000864512 – 535Nuclear receptor-binding proteinAdd BLAST534

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei2PhosphoserineBy similarity1
Modified residuei431PhosphothreonineCombined sources1
Modified residuei433PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ99J45
MaxQBiQ99J45
PaxDbiQ99J45
PRIDEiQ99J45

PTM databases

iPTMnetiQ99J45
PhosphoSitePlusiQ99J45

Expressioni

Gene expression databases

BgeeiENSMUSG00000029148 Expressed in 288 organ(s), highest expression level in female gonad
CleanExiMM_NRBP1
ExpressionAtlasiQ99J45 baseline and differential
GenevisibleiQ99J45 MM

Interactioni

Subunit structurei

Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm.1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi228688, 5 interactors
IntActiQ99J45, 4 interactors
MINTiQ99J45
STRINGi10090.ENSMUSP00000031034

Structurei

3D structure databases

ProteinModelPortaliQ99J45
SMRiQ99J45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini68 – 327Protein kinasePROSITE-ProRule annotationAdd BLAST260

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1266 Eukaryota
ENOG410XSIC LUCA
GeneTreeiENSGT00800000124049
HOGENOMiHOG000267147
HOVERGENiHBG057400
InParanoidiQ99J45
KOiK08875
OrthoDBiEOG091G031V
PhylomeDBiQ99J45
TreeFamiTF315519

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q99J45-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEGESQTVV SSGSDPKVES SSLAPGLTSV SPPVTSTTSA ASPEEEEESE
60 70 80 90 100
DESEILEESP CGRWQKRREE VNQRNVPGID SAYLAMDTEE GVEVVWNEVQ
110 120 130 140 150
FSERKNYKLQ EEKVRAVFDN LIQLEHLNIV KFHKYWADVK ENKARVIFIT
160 170 180 190 200
EYMSSGSLKQ FLKKTKKNHK TMNEKAWKRW CTQILSALSY LHSCDPPIIH
210 220 230 240 250
GNLTCDTIFI QHNGLIKIGS VAPDTINNHV KTCREEQKNL HFFAPEYGEV
260 270 280 290 300
TNVTTAVDIY SFGMCALEMA VLEIQGNGES SYVPQEAISS AIQLLEDSLQ
310 320 330 340 350
REFIQKCLQS EPARRPTARE LLFHPALFEV PSLKLLAAHC IVGHQHMIPE
360 370 380 390 400
NALEEITKNM DTSAVLAEIP AGPGREPVQT LYSQSPALEL DKFLEDVRNG
410 420 430 440 450
IYPLTAFGLP RPQQPQQEEV TSPVVPPSVK TPTPEPAEVE TRKVVLMQCN
460 470 480 490 500
IESVEEGVKH HLTLLLKLED KLNRHLSCDL MPNESIPDLA AELVQLGFIS
510 520 530
EADQSRLTSL LEETLNKFNF TRNSTLNTAT VTVSS
Length:535
Mass (Da):59,866
Last modified:June 1, 2001 - v1
Checksum:i85DD5F6FC25C5AB7
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YUV1D3YUV1_MOUSE
Nuclear receptor-binding protein
Nrbp1
543Annotation score:
A0A0J9YUQ4A0A0J9YUQ4_MOUSE
Nuclear receptor-binding protein
Nrbp1
188Annotation score:
A0A0J9YTX8A0A0J9YTX8_MOUSE
Nuclear receptor-binding protein
Nrbp1
88Annotation score:
A0A0J9YUZ6A0A0J9YUZ6_MOUSE
Nuclear receptor-binding protein
Nrbp1
62Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti220S → SVFHRIFAN in BAC32612 (PubMed:16141072).Curated1
Sequence conflicti494V → G in BAC32612 (PubMed:16141072).Curated1
Sequence conflicti508 – 510TSL → SSV in BAC32612 (PubMed:16141072).Curated3
Sequence conflicti521T → S in BAC32612 (PubMed:16141072).Curated1
Sequence conflicti535S → VVELT in BAC32612 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302138 mRNA Translation: AAK97260.1
AF302139 Genomic DNA Translation: AAK97261.1
AK046142 mRNA Translation: BAC32612.1
BC004756 mRNA Translation: AAH04756.1
BC018463 mRNA Translation: AAH18463.1
CCDSiCCDS19180.1
RefSeqiNP_671734.1, NM_147201.2
UniGeneiMm.292040

Genome annotation databases

EnsembliENSMUST00000031034; ENSMUSP00000031034; ENSMUSG00000029148
GeneIDi192292
KEGGimmu:192292
UCSCiuc008wxt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302138 mRNA Translation: AAK97260.1
AF302139 Genomic DNA Translation: AAK97261.1
AK046142 mRNA Translation: BAC32612.1
BC004756 mRNA Translation: AAH04756.1
BC018463 mRNA Translation: AAH18463.1
CCDSiCCDS19180.1
RefSeqiNP_671734.1, NM_147201.2
UniGeneiMm.292040

3D structure databases

ProteinModelPortaliQ99J45
SMRiQ99J45
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi228688, 5 interactors
IntActiQ99J45, 4 interactors
MINTiQ99J45
STRINGi10090.ENSMUSP00000031034

PTM databases

iPTMnetiQ99J45
PhosphoSitePlusiQ99J45

Proteomic databases

EPDiQ99J45
MaxQBiQ99J45
PaxDbiQ99J45
PRIDEiQ99J45

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031034; ENSMUSP00000031034; ENSMUSG00000029148
GeneIDi192292
KEGGimmu:192292
UCSCiuc008wxt.1 mouse

Organism-specific databases

CTDi29959
MGIiMGI:2183436 Nrbp1

Phylogenomic databases

eggNOGiKOG1266 Eukaryota
ENOG410XSIC LUCA
GeneTreeiENSGT00800000124049
HOGENOMiHOG000267147
HOVERGENiHBG057400
InParanoidiQ99J45
KOiK08875
OrthoDBiEOG091G031V
PhylomeDBiQ99J45
TreeFamiTF315519

Enzyme and pathway databases

ReactomeiR-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSiNrbp1 mouse
PROiPR:Q99J45
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029148 Expressed in 288 organ(s), highest expression level in female gonad
CleanExiMM_NRBP1
ExpressionAtlasiQ99J45 baseline and differential
GenevisibleiQ99J45 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNRBP_MOUSE
AccessioniPrimary (citable) accession number: Q99J45
Secondary accession number(s): Q8BL77
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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