UniProtKB - Q99J36 (THUM1_MOUSE)
Protein
THUMP domain-containing protein 1
Gene
Thumpd1
Organism
Mus musculus (Mouse)
Status
Functioni
Functions as a tRNA-binding adapter to mediate NAT10-dependent tRNA acetylation.By similarity
GO - Molecular functioni
- RNA binding Source: GO_Central
GO - Biological processi
- tRNA modification Source: GO_Central
Names & Taxonomyi
Protein namesi | Recommended name: THUMP domain-containing protein 1 |
Gene namesi | Name:Thumpd1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2444479, Thumpd1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000072531 | 2 – 350 | THUMP domain-containing protein 1Add BLAST | 349 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Modified residuei | 8 | PhosphoserineCombined sources | 1 | |
Modified residuei | 86 | PhosphoserineCombined sources | 1 | |
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Modified residuei | 119 | PhosphoserineBy similarity | 1 | |
Modified residuei | 270 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q99J36 |
jPOSTi | Q99J36 |
MaxQBi | Q99J36 |
PaxDbi | Q99J36 |
PeptideAtlasi | Q99J36 |
PRIDEi | Q99J36 |
PTM databases
iPTMneti | Q99J36 |
PhosphoSitePlusi | Q99J36 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000030942, Expressed in secondary oocyte and 300 other tissues |
Genevisiblei | Q99J36, MM |
Interactioni
Subunit structurei
Interacts with NAT10.
By similarityProtein-protein interaction databases
BioGRIDi | 231447, 3 interactors |
IntActi | Q99J36, 1 interactor |
MINTi | Q99J36 |
STRINGi | 10090.ENSMUSP00000033236 |
Miscellaneous databases
RNActi | Q99J36, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 147 – 254 | THUMPPROSITE-ProRule annotationAdd BLAST | 108 |
Sequence similaritiesi
Belongs to the THUMPD1 family.Curated
Phylogenomic databases
eggNOGi | KOG3943, Eukaryota |
GeneTreei | ENSGT00390000002365 |
HOGENOMi | CLU_039352_0_0_1 |
InParanoidi | Q99J36 |
OMAi | CFKNNIG |
OrthoDBi | 1478461at2759 |
PhylomeDBi | Q99J36 |
TreeFami | TF313884 |
Family and domain databases
CDDi | cd11717, THUMP_THUMPD1_like, 1 hit |
InterProi | View protein in InterPro IPR004114, THUMP_dom IPR040183, THUMPD1-like |
PANTHERi | PTHR13452, PTHR13452, 1 hit |
Pfami | View protein in Pfam PF02926, THUMP, 1 hit |
SMARTi | View protein in SMART SM00981, THUMP, 1 hit |
PROSITEi | View protein in PROSITE PS51165, THUMP, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q99J36-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATTAQQSPQ PVAGKRKGKS QFLPAKRARR GDAGGPRQLE PGLQGILITC
60 70 80 90 100
NMNERKCVEE AYSLLNEYGD DMYGPEKFID KDQQPSGSEG EDDDAEAALK
110 120 130 140 150
KEVGDIKAST EKRLRRFQSV ESGANNVVFI RTLGIEPEKL VHHILQDMYK
160 170 180 190 200
TKKKKTRVIL RMLPISGTCK AFLEDMKKYA ETFLEPWFKA PNKGTFQIVY
210 220 230 240 250
KSRNNSHMNR EEVIKELAGI VGSLNSENKV DLTNPEYTVV VEIIKAVCCL
260 270 280 290 300
SVVKDYVLFR KYNLQEVVKS AKDSQPHPKL GNGKEAKLEP DSKLSQSDPP
310 320 330 340 350
EGNQVAPESI EELGQTEPGS ETQAGSEGDA KPEPESQVSE VPKTNENELS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032078 mRNA Translation: BAC27685.1 AK152912 mRNA Translation: BAE31591.1 BC004776 mRNA Translation: AAH04776.1 |
CCDSi | CCDS21785.1 |
RefSeqi | NP_663560.1, NM_145585.2 XP_017177688.1, XM_017322199.1 |
Genome annotation databases
Ensembli | ENSMUST00000033236; ENSMUSP00000033236; ENSMUSG00000030942 |
GeneIDi | 233802 |
KEGGi | mmu:233802 |
UCSCi | uc009jlo.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK032078 mRNA Translation: BAC27685.1 AK152912 mRNA Translation: BAE31591.1 BC004776 mRNA Translation: AAH04776.1 |
CCDSi | CCDS21785.1 |
RefSeqi | NP_663560.1, NM_145585.2 XP_017177688.1, XM_017322199.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 231447, 3 interactors |
IntActi | Q99J36, 1 interactor |
MINTi | Q99J36 |
STRINGi | 10090.ENSMUSP00000033236 |
PTM databases
iPTMneti | Q99J36 |
PhosphoSitePlusi | Q99J36 |
Proteomic databases
EPDi | Q99J36 |
jPOSTi | Q99J36 |
MaxQBi | Q99J36 |
PaxDbi | Q99J36 |
PeptideAtlasi | Q99J36 |
PRIDEi | Q99J36 |
Protocols and materials databases
Antibodypediai | 25603, 126 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000033236; ENSMUSP00000033236; ENSMUSG00000030942 |
GeneIDi | 233802 |
KEGGi | mmu:233802 |
UCSCi | uc009jlo.2, mouse |
Organism-specific databases
CTDi | 55623 |
MGIi | MGI:2444479, Thumpd1 |
Phylogenomic databases
eggNOGi | KOG3943, Eukaryota |
GeneTreei | ENSGT00390000002365 |
HOGENOMi | CLU_039352_0_0_1 |
InParanoidi | Q99J36 |
OMAi | CFKNNIG |
OrthoDBi | 1478461at2759 |
PhylomeDBi | Q99J36 |
TreeFami | TF313884 |
Miscellaneous databases
BioGRID-ORCSi | 233802, 0 hits in 17 CRISPR screens |
ChiTaRSi | Thumpd1, mouse |
PROi | PR:Q99J36 |
RNActi | Q99J36, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030942, Expressed in secondary oocyte and 300 other tissues |
Genevisiblei | Q99J36, MM |
Family and domain databases
CDDi | cd11717, THUMP_THUMPD1_like, 1 hit |
InterProi | View protein in InterPro IPR004114, THUMP_dom IPR040183, THUMPD1-like |
PANTHERi | PTHR13452, PTHR13452, 1 hit |
Pfami | View protein in Pfam PF02926, THUMP, 1 hit |
SMARTi | View protein in SMART SM00981, THUMP, 1 hit |
PROSITEi | View protein in PROSITE PS51165, THUMP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | THUM1_MOUSE | |
Accessioni | Q99J36Primary (citable) accession number: Q99J36 Secondary accession number(s): Q3U6Y3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 5, 2004 |
Last sequence update: | June 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families