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Protein

Acetyl-coenzyme A transporter 1

Gene

Slc33a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable acetyl-CoA transporter necessary for O-acetylation of gangliosides (PubMed:10570973). Negatively regulates BMP signaling (By similarity).By similarity1 Publication

GO - Molecular functioni

  • acetyl-CoA transmembrane transporter activity Source: InterPro
  • solute:proton symporter activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTransport

Enzyme and pathway databases

ReactomeiR-MMU-425397 Transport of vitamins, nucleosides, and related molecules

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A transporter 1
Short name:
AT-1
Short name:
Acetyl-CoA transporter 1
Alternative name(s):
Solute carrier family 33 member 1
Gene namesi
Name:Slc33a1
Synonyms:Acatn
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1332247 Slc33a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 74CytoplasmicSequence analysisAdd BLAST74
Transmembranei75 – 95HelicalSequence analysisAdd BLAST21
Topological domaini96 – 113ExtracellularSequence analysisAdd BLAST18
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Topological domaini135 – 141CytoplasmicSequence analysis7
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 175ExtracellularSequence analysisAdd BLAST13
Transmembranei176 – 196HelicalSequence analysisAdd BLAST21
Topological domaini197 – 217CytoplasmicSequence analysisAdd BLAST21
Transmembranei218 – 238HelicalSequence analysisAdd BLAST21
Topological domaini239 – 256ExtracellularSequence analysisAdd BLAST18
Transmembranei257 – 277HelicalSequence analysisAdd BLAST21
Topological domaini278 – 300CytoplasmicSequence analysisAdd BLAST23
Transmembranei301 – 321HelicalSequence analysisAdd BLAST21
Topological domaini322 – 344ExtracellularSequence analysisAdd BLAST23
Transmembranei345 – 365HelicalSequence analysisAdd BLAST21
Topological domaini366 – 375CytoplasmicSequence analysis10
Transmembranei376 – 396HelicalSequence analysisAdd BLAST21
Topological domaini397 – 405ExtracellularSequence analysis9
Transmembranei406 – 426HelicalSequence analysisAdd BLAST21
Topological domaini427 – 509CytoplasmicSequence analysisAdd BLAST83
Transmembranei510 – 530HelicalSequence analysisAdd BLAST21
Topological domaini531 – 550ExtracellularSequence analysisAdd BLAST20

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000761661 – 550Acetyl-coenzyme A transporter 1Add BLAST550

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei42PhosphoserineCombined sources1
Glycosylationi103N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ99J27
MaxQBiQ99J27
PaxDbiQ99J27
PeptideAtlasiQ99J27
PRIDEiQ99J27

PTM databases

iPTMnetiQ99J27
PhosphoSitePlusiQ99J27
SwissPalmiQ99J27

Expressioni

Tissue specificityi

Expressed in all adult tissues examined including brain, heart, kidney, liver and spleen, with maximum expression in liver and kidney.1 Publication

Developmental stagei

Highly expressed at day 7 of embryonic development. Detected at lower levels throughout the later stages of embryonic development.1 Publication

Gene expression databases

BgeeiENSMUSG00000027822 Expressed in 282 organ(s), highest expression level in islet of Langerhans
GenevisibleiQ99J27 MM

Interactioni

Protein-protein interaction databases

BioGridi197916, 1 interactor
STRINGi10090.ENSMUSP00000029402

Structurei

3D structure databases

ProteinModelPortaliQ99J27
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SLC33A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3574 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00730000111115
HOGENOMiHOG000194770
HOVERGENiHBG052723
InParanoidiQ99J27
KOiK03372
OMAiLWFWGIT
OrthoDBiEOG091G06Y7
PhylomeDBiQ99J27
TreeFamiTF300008

Family and domain databases

InterProiView protein in InterPro
IPR024371 AcetylCoA_trans_1-like
IPR004752 AmpG_permease/AT-1
IPR036259 MFS_trans_sf
PANTHERiPTHR12778 PTHR12778, 1 hit
PfamiView protein in Pfam
PF13000 Acatn, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit

Sequencei

Sequence statusi: Complete.

Q99J27-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPTISHKDS SRQRRSGMFS HALDMKSGPL PPGGWDDSRR DSVGGEGDRE
60 70 80 90 100
VLLGDAGPGD LPKAPRSYRS ELSSILLLLF LYVLQGIPLG LAGSIPLILQ
110 120 130 140 150
SKNVSYTDQA FFSFVFWPFS LKLLWAPLVD AVYFKNFGRR KSWLVPTQYT
160 170 180 190 200
LGIFMIYLST QVDRLLGNID GRTPDVVALT VTFFLFEFLA ATQDIAVDGW
210 220 230 240 250
ALTMLSRENV GYASTCNSVG QTAGYFLGNV LFLALESADF CNKYLRFQPQ
260 270 280 290 300
PRGIVTLSDF LFFWGTVFLI TTTLVALLKK ENREASIVKE ETQGITDTYK
310 320 330 340 350
LLFSIIKMPA VLAFCLLILT SKIGFSAADA VTGLKLVEEG VPKEHLALLA
360 370 380 390 400
VPMVPLQIIL PLLISKYTAG PQPLNIFYKA MPYRLLLGLE YALLVWWTPK
410 420 430 440 450
VEHQGGFPLY YYIIVLLSYA LHQVTLYSMY VSIMAFNAKV SDPLIGGTYM
460 470 480 490 500
TLLNTVSNLG GNWPSTVALW LVDPLTVKEC VGASNQNCRT PDAIELCKKL
510 520 530 540 550
GGSCVTALDG YYVESIICVL IGFGWWFFLG PKFKKLQDEG PSSWKCKRNN
Length:550
Mass (Da):61,075
Last modified:June 1, 2001 - v1
Checksum:i5A55A7F40A2A9661
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti255 – 257VTL → GNP (PubMed:10570973).Curated3
Sequence conflicti255 – 257VTL → GNP (PubMed:10812068).Curated3
Sequence conflicti274 – 275LV → SL (PubMed:10570973).Curated2
Sequence conflicti274 – 275LV → SL (PubMed:10812068).Curated2
Sequence conflicti293Q → P (PubMed:10570973).Curated1
Sequence conflicti293Q → P (PubMed:10812068).Curated1
Sequence conflicti337V → E (PubMed:10570973).Curated1
Sequence conflicti337V → E (PubMed:10812068).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016795 mRNA Translation: BAA76933.1
AB037368 Genomic DNA Translation: BAA93087.1
BC005616 mRNA Translation: AAH05616.1
BC054395 mRNA Translation: AAH54395.1
BC063104 mRNA Translation: AAH63104.1
CCDSiCCDS17382.1
RefSeqiNP_001258964.1, NM_001272035.1
NP_056543.2, NM_015728.5
UniGeneiMm.135619

Genome annotation databases

EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822
GeneIDi11416
KEGGimmu:11416
UCSCiuc008pkd.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB016795 mRNA Translation: BAA76933.1
AB037368 Genomic DNA Translation: BAA93087.1
BC005616 mRNA Translation: AAH05616.1
BC054395 mRNA Translation: AAH54395.1
BC063104 mRNA Translation: AAH63104.1
CCDSiCCDS17382.1
RefSeqiNP_001258964.1, NM_001272035.1
NP_056543.2, NM_015728.5
UniGeneiMm.135619

3D structure databases

ProteinModelPortaliQ99J27
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi197916, 1 interactor
STRINGi10090.ENSMUSP00000029402

PTM databases

iPTMnetiQ99J27
PhosphoSitePlusiQ99J27
SwissPalmiQ99J27

Proteomic databases

EPDiQ99J27
MaxQBiQ99J27
PaxDbiQ99J27
PeptideAtlasiQ99J27
PRIDEiQ99J27

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029402; ENSMUSP00000029402; ENSMUSG00000027822
ENSMUST00000160883; ENSMUSP00000125713; ENSMUSG00000027822
ENSMUST00000161659; ENSMUSP00000123986; ENSMUSG00000027822
GeneIDi11416
KEGGimmu:11416
UCSCiuc008pkd.2 mouse

Organism-specific databases

CTDi9197
MGIiMGI:1332247 Slc33a1

Phylogenomic databases

eggNOGiKOG3574 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00730000111115
HOGENOMiHOG000194770
HOVERGENiHBG052723
InParanoidiQ99J27
KOiK03372
OMAiLWFWGIT
OrthoDBiEOG091G06Y7
PhylomeDBiQ99J27
TreeFamiTF300008

Enzyme and pathway databases

ReactomeiR-MMU-425397 Transport of vitamins, nucleosides, and related molecules

Miscellaneous databases

ChiTaRSiSlc33a1 mouse
PROiPR:Q99J27
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027822 Expressed in 282 organ(s), highest expression level in islet of Langerhans
GenevisibleiQ99J27 MM

Family and domain databases

InterProiView protein in InterPro
IPR024371 AcetylCoA_trans_1-like
IPR004752 AmpG_permease/AT-1
IPR036259 MFS_trans_sf
PANTHERiPTHR12778 PTHR12778, 1 hit
PfamiView protein in Pfam
PF13000 Acatn, 2 hits
SUPFAMiSSF103473 SSF103473, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiACATN_MOUSE
AccessioniPrimary (citable) accession number: Q99J27
Secondary accession number(s): Q9WTN1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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