Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

rRNA methyltransferase 1, mitochondrial

Gene

Mrm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methylguanosine at position 1145 (Gm1145) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA.By similarity

Catalytic activityi

S-adenosyl-L-methionine + guanosine(1145) in 16S rRNA = S-adenosyl-L-homocysteine + 2'-O-methylguanosine(1145) in 16S rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processrRNA processing
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA methyltransferase 1, mitochondrial1 Publication (EC:2.1.1.-By similarity)
Alternative name(s):
16S rRNA (guanosine(1145)-2'-O)-methyltransferaseBy similarity
16S rRNA [Gm1145] 2'-O-methyltransferaseBy similarity
Gene namesi
Name:Mrm1By similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2443470 Mrm1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 17MitochondrionSequence analysisAdd BLAST17
ChainiPRO_000027320318 – 320rRNA methyltransferase 1, mitochondrialAdd BLAST303

Proteomic databases

EPDiQ99J25
MaxQBiQ99J25
PaxDbiQ99J25
PeptideAtlasiQ99J25
PRIDEiQ99J25

PTM databases

PhosphoSitePlusiQ99J25

Expressioni

Gene expression databases

BgeeiENSMUSG00000018405
GenevisibleiQ99J25 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018549

Structurei

3D structure databases

ProteinModelPortaliQ99J25
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0838 Eukaryota
COG0566 LUCA
GeneTreeiENSGT00390000018761
HOGENOMiHOG000004826
HOVERGENiHBG081986
InParanoidiQ99J25
KOiK15507
OMAiWVEGVHQ
OrthoDBiEOG091G0IW1
PhylomeDBiQ99J25
TreeFamiTF315167

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
3.40.1280.10, 1 hit
InterProiView protein in InterPro
IPR029028 Alpha/beta_knot_MTases
IPR029064 L30e-like
IPR004441 rRNA_MeTrfase_TrmH
IPR001537 SpoU_MeTrfase
IPR013123 SpoU_subst-bd
IPR029026 tRNA_m1G_MTases_N
PANTHERiPTHR12029:SF58 PTHR12029:SF58, 1 hit
PfamiView protein in Pfam
PF00588 SpoU_methylase, 1 hit
PF08032 SpoU_sub_bind, 1 hit
SMARTiView protein in SMART
SM00967 SpoU_sub_bind, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
SSF75217 SSF75217, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99J25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRRLWTVGCF SRLIARHFSS VARRGERPGG EELSRLLLDD LAPAQRLERL
60 70 80 90 100
FGLSPCLLAL RAARRRVARL LLQAGKAGLQ GERAELLRVA EARGIPVLRP
110 120 130 140 150
RRQKLDALCG YQVHQGVCME VSPLRPRPCD EAADTSSGDD PQQLWLVLEG
160 170 180 190 200
LQDPRNLGAV MRSAHFLGVD RVITSQRNSC PLTPVVSKAS AGAMEVMDVF
210 220 230 240 250
ATPDLPGFLQ AKAQQGWLVV GTVGCPGPEI SQSSKVPITS CLEFVWDRPT
260 270 280 290 300
LLVLGSEGSG LSQEVFASCQ LLLTILPRRH LPPGLESLNV SVATGILLHS
310 320
ICSQKKGFPV QERGQLLQDS
Length:320
Mass (Da):34,843
Last modified:September 19, 2006 - v2
Checksum:i361D26D155A233D8
GO

Sequence cautioni

The sequence BAE33706 differs from that shown. Reason: Frameshift at positions 214 and 223.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK156416 mRNA Translation: BAE33706.1 Frameshift.
AK164059 mRNA Translation: BAE37607.1
AK163986 mRNA Translation: BAE37571.1
AL596083 Genomic DNA No translation available.
BC005625 mRNA Translation: AAH05625.2
CCDSiCCDS36260.1
RefSeqiNP_663408.2, NM_145433.1
UniGeneiMm.280825

Genome annotation databases

EnsembliENSMUST00000018549; ENSMUSP00000018549; ENSMUSG00000018405
GeneIDi217038
KEGGimmu:217038
UCSCiuc007kqr.1 mouse

Similar proteinsi

Entry informationi

Entry nameiMRM1_MOUSE
AccessioniPrimary (citable) accession number: Q99J25
Secondary accession number(s): Q3TPX8, Q3U0Z5, Q5ND22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: September 19, 2006
Last modified: May 23, 2018
This is version 116 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health