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Protein

SEC14-like protein 2

Gene

Sec14l2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol. Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
SEC14-like protein 2
Alternative name(s):
Alpha-tocopherol-associated protein
Short name:
TAP
Gene namesi
Name:Sec14l2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1915065 Sec14l2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002107561 – 403SEC14-like protein 2Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei11N6-succinyllysineCombined sources1
Modified residuei51N6-succinyllysineCombined sources1
Modified residuei253N6-succinyllysineCombined sources1
Modified residuei257N6-succinyllysineCombined sources1
Modified residuei393N6-succinyllysineCombined sources1

Proteomic databases

MaxQBiQ99J08
PaxDbiQ99J08
PeptideAtlasiQ99J08
PRIDEiQ99J08

PTM databases

iPTMnetiQ99J08
PhosphoSitePlusiQ99J08
SwissPalmiQ99J08

Expressioni

Gene expression databases

BgeeiENSMUSG00000003585 Expressed in 225 organ(s), highest expression level in frontal cortex
CleanExiMM_SEC14L2
GenevisibleiQ99J08 MM

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ99J08, 2 interactors
MINTiQ99J08
STRINGi10090.ENSMUSP00000003681

Structurei

3D structure databases

ProteinModelPortaliQ99J08
SMRiQ99J08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 249CRAL-TRIOPROSITE-ProRule annotationAdd BLAST174
Domaini275 – 383GOLDPROSITE-ProRule annotationAdd BLAST109

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000232201
HOVERGENiHBG055336
InParanoidiQ99J08
OMAiGLCHCEG
OrthoDBiEOG091G0MI9
PhylomeDBiQ99J08
TreeFamiTF313988

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit

Sequencei

Sequence statusi: Complete.

Q99J08-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGRVGDLSP KQEEALAKFR ENVQDVLPTL PNPDDYFLLR WLRARSFDLQ
60 70 80 90 100
KSEAMLRKHV EFRKQKDIDK IISWQPPEVI QQYLSGGRCG YDLDGCPVWY
110 120 130 140 150
DIIGPLDAKG LLFSASKQDL LRTKMRDCEL LLQECIQQTT KLGKKIETIT
160 170 180 190 200
MIYDCEGLGL KHLWKPAVEA YGEFLTMFEE NYPETLKRLF VVKAPKLFPV
210 220 230 240 250
AYNLIKPFLS EDTRRKIMVL GANWKEVLLK HISPDQLPVE YGGTMTDPDG
260 270 280 290 300
NPKCKSKINY GGDIPKQYYV RDQVKQQYEH TVQVSRGSSH QVEYEILFPG
310 320 330 340 350
CVLRWQFMSE GSDVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHMVPED
360 370 380 390 400
GTLTCSEPGI YVLRFDNTYS FIHAKKVSFT VEVLLPDKAA EEKMNQQGAD

TPK
Length:403
Mass (Da):46,300
Last modified:June 1, 2001 - v1
Checksum:i42E0BBAFE3004841
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005759 mRNA Translation: AAH05759.1
CCDSiCCDS24377.1
RefSeqiNP_653103.1, NM_144520.2
UniGeneiMm.253922

Genome annotation databases

EnsembliENSMUST00000003681; ENSMUSP00000003681; ENSMUSG00000003585
GeneIDi67815
KEGGimmu:67815
UCSCiuc007huh.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC005759 mRNA Translation: AAH05759.1
CCDSiCCDS24377.1
RefSeqiNP_653103.1, NM_144520.2
UniGeneiMm.253922

3D structure databases

ProteinModelPortaliQ99J08
SMRiQ99J08
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ99J08, 2 interactors
MINTiQ99J08
STRINGi10090.ENSMUSP00000003681

PTM databases

iPTMnetiQ99J08
PhosphoSitePlusiQ99J08
SwissPalmiQ99J08

Proteomic databases

MaxQBiQ99J08
PaxDbiQ99J08
PeptideAtlasiQ99J08
PRIDEiQ99J08

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000003681; ENSMUSP00000003681; ENSMUSG00000003585
GeneIDi67815
KEGGimmu:67815
UCSCiuc007huh.1 mouse

Organism-specific databases

CTDi23541
MGIiMGI:1915065 Sec14l2

Phylogenomic databases

eggNOGiKOG1471 Eukaryota
ENOG410XRSQ LUCA
GeneTreeiENSGT00550000074580
HOGENOMiHOG000232201
HOVERGENiHBG055336
InParanoidiQ99J08
OMAiGLCHCEG
OrthoDBiEOG091G0MI9
PhylomeDBiQ99J08
TreeFamiTF313988

Miscellaneous databases

ChiTaRSiSec14l2 mouse
PROiPR:Q99J08
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003585 Expressed in 225 organ(s), highest expression level in frontal cortex
CleanExiMM_SEC14L2
GenevisibleiQ99J08 MM

Family and domain databases

CDDicd00170 SEC14, 1 hit
Gene3Di3.40.525.10, 1 hit
InterProiView protein in InterPro
IPR001251 CRAL-TRIO_dom
IPR036865 CRAL-TRIO_dom_sf
IPR011074 CRAL/TRIO_N_dom
IPR036273 CRAL/TRIO_N_dom_sf
IPR009038 GOLD_dom
IPR036598 GOLD_dom_sf
PfamiView protein in Pfam
PF00650 CRAL_TRIO, 1 hit
SMARTiView protein in SMART
SM01100 CRAL_TRIO_N, 1 hit
SM00516 SEC14, 1 hit
SUPFAMiSSF101576 SSF101576, 1 hit
SSF46938 SSF46938, 1 hit
SSF52087 SSF52087, 1 hit
PROSITEiView protein in PROSITE
PS50191 CRAL_TRIO, 1 hit
PS50866 GOLD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiS14L2_MOUSE
AccessioniPrimary (citable) accession number: Q99J08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 20, 2002
Last sequence update: June 1, 2001
Last modified: November 7, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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