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Protein

Non-structural protein 1

Gene
N/A
Organism
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in the inhibition of host innate immunity by inducing the degradation of key host factors required to activate interferon production such as IRF3, IRF5 or IRF7. Associates with components of cullin RING ligases (CRLs) including CUL1 or CUL3, which are essential multisubunit ubiquitination complexes, to modulate their activities.UniRule annotation4 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding
Biological processHost-virus interaction, Inhibition of host innate immune response by virus, Inhibition of host IRF3 by virus, Inhibition of host IRF7 by virus, Inhibition of host RLR pathway by virus, Interferon antiviral system evasion, Viral immunoevasion
LigandMetal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Non-structural protein 1UniRule annotation
Short name:
NSP1UniRule annotation
Alternative name(s):
NCVP2UniRule annotation
Non-structural RNA-binding protein 53UniRule annotation
Short name:
NS53UniRule annotation
OrganismiRotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
Taxonomic identifieri36436 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSedoreovirinaeRotavirusRotavirus A
Virus hostiMacaca mulatta (Rhesus macaque) [TaxID: 9544]

Subcellular locationi

  • host cytoskeleton UniRule annotation1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Host cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003678201 – 496Non-structural protein 1Add BLAST496

Interactioni

Subunit structurei

Interacts (via C-terminus) with host IRF3; this interaction leads to IRF3 degradation. Interacts with host IRF7; this interaction leads to IRF7 degradation. Interacts with host CUL1 and CUL3.UniRule annotation2 Publications

Structurei

3D structure databases

SMRiQ99FX5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 81RNA-bindingUniRule annotationAdd BLAST81
Regioni42 – 79Zinc-binding domainUniRule annotationAdd BLAST38
Regioni82 – 177Important for cytoskeleton localizationUniRule annotationAdd BLAST96
Regioni321 – 496Interaction with host IRF3UniRule annotationAdd BLAST176

Domaini

The integrity of the zinc-binding domain in NSP1 is important for degradation of host IRF3.UniRule annotation

Sequence similaritiesi

Belongs to the rotavirus NSP1 family.UniRule annotation

Family and domain databases

HAMAPiMF_04088 ROTA_NSP1, 1 hit
InterProiView protein in InterPro
IPR002148 Rotavirus_NSP1
PfamiView protein in Pfam
PF00981 Rota_NS53, 1 hit

Sequencei

Sequence statusi: Complete.

Q99FX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATFKDACFH YRRLTALNRR LCNIGANSIC MPVPDAKIKG WCLECCQIAD
60 70 80 90 100
LTHCYGCSLP HVCKWCVQNR RCFLDNEPHL LKLRTVKHPI TKDKLQCIID
110 120 130 140 150
LYNIIFPIND KVIRKFERMI KQRKCRNQYK IEWYNHLLLP ITLNAAAFKF
160 170 180 190 200
DENNLYYVFG LYEKSVSDIY APYRIVNFIN EFDKLLLDDI NFTRMSNLPI
210 220 230 240 250
ELRNHYAKKY FQLSRLPSSK LKQIYFSDFT KETVIFNTYT KTPGRSIYRN
260 270 280 290 300
VTEFNWRDEL ELYSDLKNDK NKLIAAMMTS KYTRFYAHDN NFGRLKMTIF
310 320 330 340 350
ELGHHCQPNY VASNHPGNAS DIQYCKWCNI KYFLSKIDWR IRDMYNLLME
360 370 380 390 400
FIKDCYKSNV NVGHCSSVEN IYPLIKRLIW SLFTNHMDQT IEEVFNHMSP
410 420 430 440 450
VSVEGTNVIM LILGLNISLY NEIKRTLNVD SIPMVLNLNE FSSIVKSISS
460 470 480 490
KWYNVDELDK LPMSIKSTEE LIEMKNSGTL TEEFELLISN SEDDNE
Length:496
Mass (Da):58,565
Last modified:June 1, 2001 - v1
Checksum:i5877EA0A0C078CAD
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti479T → I in strain: Isolate 5S. 1
Natural varianti480 – 496Missing in strain: Isolate 5S. Add BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF290883 Genomic RNA Translation: AAK14071.1
AF290884 Genomic RNA Translation: AAK14072.1

Similar proteinsi

Entry informationi

Entry nameiNSP1_ROTS4
AccessioniPrimary (citable) accession number: Q99FX5
Secondary accession number(s): Q99FX4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: June 1, 2001
Last modified: April 25, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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