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Protein

A-kinase anchor protein 9

Gene

AKAP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697).7 Publications
Isoform 4: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations.1 Publication

GO - Molecular functioni

  • DNA binding Source: InterPro
  • ion channel binding Source: BHF-UCL
  • potassium channel regulator activity Source: BHF-UCL
  • protein-containing complex scaffold activity Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • signaling receptor binding Source: ProtInc

GO - Biological processi

  • cellular response to cAMP Source: BHF-UCL
  • chemical synaptic transmission Source: ProtInc
  • ciliary basal body-plasma membrane docking Source: Reactome
  • G2/M transition of mitotic cell cycle Source: Reactome
  • maintenance of centrosome location Source: UniProtKB
  • MAPK cascade Source: Reactome
  • microtubule nucleation Source: UniProtKB
  • negative regulation of adenylate cyclase activity Source: Ensembl
  • positive regulation of microtubule polymerization Source: UniProtKB
  • positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
  • positive regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
  • regulation of cardiac muscle cell action potential involved in regulation of contraction Source: BHF-UCL
  • regulation of G2/M transition of mitotic cell cycle Source: Reactome
  • regulation of Golgi organization Source: UniProtKB
  • regulation of heart rate by cardiac conduction Source: BHF-UCL
  • regulation of membrane repolarization Source: BHF-UCL
  • regulation of ventricular cardiac muscle cell membrane repolarization Source: BHF-UCL
  • response to electrical stimulus Source: Ensembl
  • signal transduction Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition
R-HSA-380259 Loss of Nlp from mitotic centrosomes
R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes
R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome
R-HSA-380320 Recruitment of NuMA to mitotic centrosomes
R-HSA-438066 Unblocking of NMDA receptor, glutamate binding and activation
R-HSA-442729 CREB phosphorylation through the activation of CaMKII
R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor
R-HSA-5576890 Phase 3 - rapid repolarisation
R-HSA-5576893 Phase 2 - plateau phase
R-HSA-5620912 Anchoring of the basal body to the plasma membrane
R-HSA-5673001 RAF/MAP kinase cascade
R-HSA-6802952 Signaling by BRAF and RAF fusions
R-HSA-8854518 AURKA Activation by TPX2
SignaLinkiQ99996

Names & Taxonomyi

Protein namesi
Recommended name:
A-kinase anchor protein 9
Short name:
AKAP-9
Alternative name(s):
A-kinase anchor protein 350 kDa
Short name:
AKAP 350
Short name:
hgAKAP 350
A-kinase anchor protein 450 kDa
Short name:
AKAP 450
AKAP 120-like protein
Centrosome- and Golgi-localized PKN-associated protein1 Publication
Short name:
CG-NAP1 Publication
Protein hyperion1 Publication
Protein kinase A-anchoring protein 9
Short name:
PRKA9
Protein yotiao1 Publication
Gene namesi
Name:AKAP9
Synonyms:AKAP350, AKAP450, KIAA0803
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000127914.16
HGNCiHGNC:379 AKAP9
MIMi604001 gene
neXtProtiNX_Q99996

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Golgi apparatus

Pathology & Biotechi

Involvement in diseasei

Long QT syndrome 11 (LQT11)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA heart disorder characterized by a prolonged QT interval on the ECG and polymorphic ventricular arrhythmias. They cause syncope and sudden death in response to exercise or emotional stress, and can present with a sentinel event of sudden cardiac death in infancy.
See also OMIM:611820
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0434891570S → L in LQT11. 1 PublicationCorresponds to variant dbSNP:rs121908566EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Long QT syndrome

Organism-specific databases

DisGeNETi10142
GeneReviewsiAKAP9
MalaCardsiAKAP9
MIMi611820 phenotype
OpenTargetsiENSG00000127914
Orphaneti101016 Romano-Ward syndrome
PharmGKBiPA24673

Polymorphism and mutation databases

BioMutaiAKAP9
DMDMi14194461

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000645341 – 3907A-kinase anchor protein 9Add BLAST3907

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei153PhosphoserineCombined sources1
Modified residuei1327PhosphoserineCombined sources1
Modified residuei1765PhosphoserineCombined sources1
Modified residuei3690PhosphoserineCombined sources1
Modified residuei3842PhosphoserineCombined sources1
Modified residuei3865PhosphoserineCombined sources1
Modified residuei3897PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99996
MaxQBiQ99996
PaxDbiQ99996
PeptideAtlasiQ99996
PRIDEiQ99996
ProteomicsDBi78566
78567 [Q99996-2]
78568 [Q99996-3]
78569 [Q99996-4]
78570 [Q99996-5]
78571 [Q99996-6]

PTM databases

CarbonylDBiQ99996
iPTMnetiQ99996
PhosphoSitePlusiQ99996
SwissPalmiQ99996

Expressioni

Tissue specificityi

Widely expressed (PubMed:10202149). Isoform 4: Highly expressed in skeletal muscle and in pancreas (PubMed:9482789).2 Publications

Gene expression databases

BgeeiENSG00000127914
ExpressionAtlasiQ99996 baseline and differential
GenevisibleiQ99996 HS

Organism-specific databases

HPAiCAB012909
HPA008548
HPA026109

Interactioni

Subunit structurei

Interacts with the regulatory region of protein kinase N (PKN), protein phosphatase 2A (PP2A), protein phosphatase 1 (PP1) and the immature non-phosphorylated form of PKC epsilon. Interacts with CIP4 and FNBP1 (PubMed:15047863). Interacts with chloride intracellular channel proteins CLIC1, CLIC4 and CLIC5 (PubMed:12163479). CSNK1D binding promotes its centrosomal subcellular location (PubMed:12270714). Interacts with GM130/GOLGA2; leading to recruitment to the Golgi apparatus (PubMed:19242490). Interacts with KCNQ1; targets protein kinase A (PKA) catalytic and regulatory subunits and protein phosphatase 1 (PP1), to the heterodimer KCNQ1-KCNE1 (PubMed:11799244). Interacts with PDE4DIP isoform 13/MMG8/SMYLE; this interaction stabilizes both proteins (PubMed:25217626, PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13, recruits CAMSAP2 to the Golgi apparatus (PubMed:27666745, PubMed:28814570). Forms a pericentrosomal complex with CDK5RAP2, EB1/MAPRE1 and PDE4DIP isoform 13; within this complex, MAPRE1 binding to CDK5RAP2 may be mediated by PDE4DIP (PubMed:29162697). Interacts with MAPRE1 and MAPRE3 (PubMed:28814570). Interacts (via C-terminus) with CAMSAP2; this interaction is much stronger in the presence of PDE4DIP isoform 13/MMG8/SMYLE (PubMed:27666745). Interacts with CAMSAP3 (PubMed:28089391). Interacts (via C-terminus) with the gamma-tubulin ring complex (gamma-TuRC), composed of gamma-tubulin, TUBGCP2, TUBGCP3, TUBGCP4, TUBGCP5 and TUBGCP6 (PubMed:27666745).10 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • ion channel binding Source: BHF-UCL
  • protein-containing complex scaffold activity Source: UniProtKB
  • protein kinase A regulatory subunit binding Source: UniProtKB
  • Ras guanyl-nucleotide exchange factor activity Source: Reactome
  • signaling receptor binding Source: ProtInc

Protein-protein interaction databases

BioGridi115445, 79 interactors
CORUMiQ99996
DIPiDIP-29942N
IntActiQ99996, 58 interactors
MINTiQ99996
STRINGi9606.ENSP00000348573

Structurei

3D structure databases

ProteinModelPortaliQ99996
SMRiQ99996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2542 – 2555PKA-RII subunit binding domainAdd BLAST14

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili152 – 902Sequence analysisAdd BLAST751
Coiled coili932 – 1010Sequence analysisAdd BLAST79
Coiled coili1088 – 1173Sequence analysisAdd BLAST86
Coiled coili1241 – 1268Sequence analysisAdd BLAST28
Coiled coili1324 – 1380Sequence analysisAdd BLAST57
Coiled coili1422 – 1447Sequence analysisAdd BLAST26
Coiled coili1573 – 1647Sequence analysisAdd BLAST75
Coiled coili1845 – 2443Sequence analysisAdd BLAST599
Coiled coili2532 – 2549Sequence analysisAdd BLAST18
Coiled coili2591 – 2764Sequence analysisAdd BLAST174
Coiled coili3061 – 3088Sequence analysisAdd BLAST28
Coiled coili3120 – 3466Sequence analysisAdd BLAST347
Coiled coili3583 – 3685Sequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi191 – 280Gln-richAdd BLAST90
Compositional biasi309 – 998Glu-richAdd BLAST690
Compositional biasi1834 – 2760Glu-richAdd BLAST927
Compositional biasi3722 – 3726Poly-Leu5

Domaini

RII-binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.By similarity

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410II47 Eukaryota
ENOG41101YB LUCA
GeneTreeiENSGT00730000110871
HOVERGENiHBG050481
InParanoidiQ99996
KOiK16551
PhylomeDBiQ99996
TreeFamiTF105408

Family and domain databases

InterProiView protein in InterPro
IPR028745 AKAP9/Pericentrin
IPR005539 ELK_dom
IPR019528 PACT_domain
PANTHERiPTHR44981 PTHR44981, 1 hit
PfamiView protein in Pfam
PF10495 PACT_coil_coil, 1 hit
SMARTiView protein in SMART
SM01188 ELK, 4 hits

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q99996-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEDEERQKKL EAGKAKLAQF RQRKAQSDGQ SPSKKQKKKR KTSSSKHDVS
60 70 80 90 100
AHHDLNIDQS QCNEMYINSS QRVESTVIPE STIMRTLHSG EITSHEQGFS
110 120 130 140 150
VELESEISTT ADDCSSEVNG CSFVMRTGKP TNLLREEEFG VDDSYSEQGA
160 170 180 190 200
QDSPTHLEMM ESELAGKQHE IEELNRELEE MRVTYGTEGL QQLQEFEAAI
210 220 230 240 250
KQRDGIITQL TANLQQARRE KDETMREFLE LTEQSQKLQI QFQQLQASET
260 270 280 290 300
LRNSTHSSTA ADLLQAKQQI LTHQQQLEEQ DHLLEDYQKK KEDFTMQISF
310 320 330 340 350
LQEKIKVYEM EQDKKVENSN KEEIQEKETI IEELNTKIIE EEKKTLELKD
360 370 380 390 400
KLTTADKLLG ELQEQIVQKN QEIKNMKLEL TNSKQKERQS SEEIKQLMGT
410 420 430 440 450
VEELQKRNHK DSQFETDIVQ RMEQETQRKL EQLRAELDEM YGQQIVQMKQ
460 470 480 490 500
ELIRQHMAQM EEMKTRHKGE MENALRSYSN ITVNEDQIKL MNVAINELNI
510 520 530 540 550
KLQDTNSQKE KLKEELGLIL EEKCALQRQL EDLVEELSFS REQIQRARQT
560 570 580 590 600
IAEQESKLNE AHKSLSTVED LKAEIVSASE SRKELELKHE AEVTNYKIKL
610 620 630 640 650
EMLEKEKNAV LDRMAESQEA ELERLRTQLL FSHEEELSKL KEDLEIEHRI
660 670 680 690 700
NIEKLKDNLG IHYKQQIDGL QNEMSQKIET MQFEKDNLIT KQNQLILEIS
710 720 730 740 750
KLKDLQQSLV NSKSEEMTLQ INELQKEIEI LRQEEKEKGT LEQEVQELQL
760 770 780 790 800
KTELLEKQMK EKENDLQEKF AQLEAENSIL KDEKKTLEDM LKIHTPVSQE
810 820 830 840 850
ERLIFLDSIK SKSKDSVWEK EIEILIEENE DLKQQCIQLN EEIEKQRNTF
860 870 880 890 900
SFAEKNFEVN YQELQEEYAC LLKVKDDLED SKNKQELEYK SKLKALNEEL
910 920 930 940 950
HLQRINPTTV KMKSSVFDED KTFVAETLEM GEVVEKDTTE LMEKLEVTKR
960 970 980 990 1000
EKLELSQRLS DLSEQLKQKH GEISFLNEEV KSLKQEKEQV SLRCRELEII
1010 1020 1030 1040 1050
INHNRAENVQ SCDTQVSSLL DGVVTMTSRG AEGSVSKVNK SFGEESKIMV
1060 1070 1080 1090 1100
EDKVSFENMT VGEESKQEQL ILDHLPSVTK ESSLRATQPS ENDKLQKELN
1110 1120 1130 1140 1150
VLKSEQNDLR LQMEAQRICL SLVYSTHVDQ VREYMENEKD KALCSLKEEL
1160 1170 1180 1190 1200
IFAQEEKIKE LQKIHQLELQ TMKTQETGDE GKPLHLLIGK LQKAVSEECS
1210 1220 1230 1240 1250
YFLQTLCSVL GEYYTPALKC EVNAEDKENS GDYISENEDP ELQDYRYEVQ
1260 1270 1280 1290 1300
DFQENMHTLL NKVTEEYNKL LVLQTRLSKI WGQQTDGMKL EFGEENLPKE
1310 1320 1330 1340 1350
ETEFLSIHSQ MTNLEDIDVN HKSKLSSLQD LEKTKLEEQV QELESLISSL
1360 1370 1380 1390 1400
QQQLKETEQN YEAEIHCLQK RLQAVSESTV PPSLPVDSVV ITESDAQRTM
1410 1420 1430 1440 1450
YPGSCVKKNI DGTIEFSGEF GVKEETNIVK LLEKQYQEQL EEEVAKVIVS
1460 1470 1480 1490 1500
MSIAFAQQTE LSRISGGKEN TASSKQAHAV CQQEQHYFNE MKLSQDQIGF
1510 1520 1530 1540 1550
QTFETVDVKF KEEFKPLSKE LGEHGKEILL SNSDPHDIPE SKDCVLTISE
1560 1570 1580 1590 1600
EMFSKDKTFI VRQSIHDEIS VSSMDASRQL MLNEEQLEDM RQELVRQYQE
1610 1620 1630 1640 1650
HQQATELLRQ AHMRQMERQR EDQEQLQEEI KRLNRQLAQR SSIDNENLVS
1660 1670 1680 1690 1700
ERERVLLEEL EALKQLSLAG REKLCCELRN SSTQTQNGNE NQGEVEEQTF
1710 1720 1730 1740 1750
KEKELDRKPE DVPPEILSNE RYALQKANNR LLKILLEVVK TTAAVEETIG
1760 1770 1780 1790 1800
RHVLGILDRS SKSQSSASLI WRSEAEASVK SCVHEEHTRV TDESIPSYSG
1810 1820 1830 1840 1850
SDMPRNDINM WSKVTEEGTE LSQRLVRSGF AGTEIDPENE ELMLNISSRL
1860 1870 1880 1890 1900
QAAVEKLLEA ISETSSQLEH AKVTQTELMR ESFRQKQEAT ESLKCQEELR
1910 1920 1930 1940 1950
ERLHEESRAR EQLAVELSKA EGVIDGYADE KTLFERQIQE KTDIIDRLEQ
1960 1970 1980 1990 2000
ELLCASNRLQ ELEAEQQQIQ EERELLSRQK EAMKAEAGPV EQQLLQETEK
2010 2020 2030 2040 2050
LMKEKLEVQC QAEKVRDDLQ KQVKALEIDV EEQVSRFIEL EQEKNTELMD
2060 2070 2080 2090 2100
LRQQNQALEK QLEKMRKFLD EQAIDREHER DVFQQEIQKL EQQLKVVPRF
2110 2120 2130 2140 2150
QPISEHQTRE VEQLANHLKE KTDKCSELLL SKEQLQRDIQ ERNEEIEKLE
2160 2170 2180 2190 2200
FRVRELEQAL LVSADTFQKV EDRKHFGAVE AKPELSLEVQ LQAERDAIDR
2210 2220 2230 2240 2250
KEKEITNLEE QLEQFREELE NKNEEVQQLH MQLEIQKKES TTRLQELEQE
2260 2270 2280 2290 2300
NKLFKDDMEK LGLAIKESDA MSTQDQHVLF GKFAQIIQEK EVEIDQLNEQ
2310 2320 2330 2340 2350
VTKLQQQLKI TTDNKVIEEK NELIRDLETQ IECLMSDQEC VKRNREEEIE
2360 2370 2380 2390 2400
QLNEVIEKLQ QELANIGQKT SMNAHSLSEE ADSLKHQLDV VIAEKLALEQ
2410 2420 2430 2440 2450
QVETANEEMT FMKNVLKETN FKMNQLTQEL FSLKRERESV EKIQSIPENS
2460 2470 2480 2490 2500
VNVAIDHLSK DKPELEVVLT EDALKSLENQ TYFKSFEENG KGSIINLETR
2510 2520 2530 2540 2550
LLQLESTVSA KDLELTQCYK QIKDMQEQGQ FETEMLQKKI VNLQKIVEEK
2560 2570 2580 2590 2600
VAAALVSQIQ LEAVQEYAKF CQDNQTISSE PERTNIQNLN QLREDELGSD
2610 2620 2630 2640 2650
ISALTLRISE LESQVVEMHT SLILEKEQVE IAEKNVLEKE KKLLELQKLL
2660 2670 2680 2690 2700
EGNEKKQREK EKKRSPQDVE VLKTTTELFH SNEESGFFNE LEALRAESVA
2710 2720 2730 2740 2750
TKAELASYKE KAEKLQEELL VKETNMTSLQ KDLSQVRDHL AEAKEKLSIL
2760 2770 2780 2790 2800
EKEDETEVQE SKKACMFEPL PIKLSKSIAS QTDGTLKISS SNQTPQILVK
2810 2820 2830 2840 2850
NAGIQINLQS ECSSEEVTEI ISQFTEKIEK MQELHAAEIL DMESRHISET
2860 2870 2880 2890 2900
ETLKREHYVA VQLLKEECGT LKAVIQCLRS KEGSSIPELA HSDAYQTREI
2910 2920 2930 2940 2950
CSSDSGSDWG QGIYLTHSQG FDIASEGRGE ESESATDSFP KKIKGLLRAV
2960 2970 2980 2990 3000
HNEGMQVLSL TESPYSDGED HSIQQVSEPW LEERKAYINT ISSLKDLITK
3010 3020 3030 3040 3050
MQLQREAEVY DSSQSHESFS DWRGELLLAL QQVFLEERSV LLAAFRTELT
3060 3070 3080 3090 3100
ALGTTDAVGL LNCLEQRIQE QGVEYQAAME CLQKADRRSL LSEIQALHAQ
3110 3120 3130 3140 3150
MNGRKITLKR EQESEKPSQE LLEYNIQQKQ SQMLEMQVEL SSMKDRATEL
3160 3170 3180 3190 3200
QEQLSSEKMV VAELKSELAQ TKLELETTLK AQHKHLKELE AFRLEVKDKT
3210 3220 3230 3240 3250
DEVHLLNDTL ASEQKKSREL QWALEKEKAK LGRSEERDKE ELEDLKFSLE
3260 3270 3280 3290 3300
SQKQRNLQLN LLLEQQKQLL NESQQKIESQ RMLYDAQLSE EQGRNLELQV
3310 3320 3330 3340 3350
LLESEKVRIR EMSSTLDRER ELHAQLQSSD GTGQSRPPLP SEDLLKELQK
3360 3370 3380 3390 3400
QLEEKHSRIV ELLNETEKYK LDSLQTRQQM EKDRQVHRKT LQTEQEANTE
3410 3420 3430 3440 3450
GQKKMHELQS KVEDLQRQLE EKRQQVYKLD LEGQRLQGIM QEFQKQELER
3460 3470 3480 3490 3500
EEKRESRRIL YQNLNEPTTW SLTSDRTRNW VLQQKIEGET KESNYAKLIE
3510 3520 3530 3540 3550
MNGGGTGCNH ELEMIRQKLQ CVASKLQVLP QKASERLQFE TADDEDFIWV
3560 3570 3580 3590 3600
QENIDEIILQ LQKLTGQQGE EPSLVSPSTS CGSLTERLLR QNAELTGHIS
3610 3620 3630 3640 3650
QLTEEKNDLR NMVMKLEEQI RWYRQTGAGR DNSSRFSLNG GANIEAIIAS
3660 3670 3680 3690 3700
EKEVWNREKL TLQKSLKRAE AEVYKLKAEL RNDSLLQTLS PDSEHVTLKR
3710 3720 3730 3740 3750
IYGKYLRAES FRKALIYQKK YLLLLLGGFQ ECEDATLALL ARMGGQPAFT
3760 3770 3780 3790 3800
DLEVITNRPK GFTRFRSAVR VSIAISRMKF LVRRWHRVTG SVSININRDG
3810 3820 3830 3840 3850
FGLNQGAEKT DSFYHSSGGL ELYGEPRHTT YRSRSDLDYI RSPLPFQNRY
3860 3870 3880 3890 3900
PGTPADFNPG SLACSQLQNY DPDRALTDYI TRLEALQRRL GTIQSGSTTQ

FHAGMRR
Length:3,907
Mass (Da):452,987
Last modified:April 25, 2018 - v4
Checksum:i81761B4341430CDF
GO
Isoform 1 (identifier: Q99996-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: K → KIEELSLAFLVRQ
     2883-2903: GSSIPELAHSDAYQTREICSS → VFGFYNMCFSTLC

Note: No experimental confirmation available.
Show »
Length:3,911
Mass (Da):453,667
Checksum:i3FB1CB1C819B47AA
GO
Isoform 3 (identifier: Q99996-3) [UniParc]FASTAAdd to basket
Also known as: CG-NAP

The sequence of this isoform differs from the canonical sequence as follows:
     2163-2171: SADTFQKVE → E

Show »
Length:3,899
Mass (Da):452,110
Checksum:iF90C9F18B32FD314
GO
Isoform 4 (identifier: Q99996-4) [UniParc]FASTAAdd to basket
Also known as: Yotiao

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: K → KIEELSLAFLVRQ
     1625-3900: Missing.
     3901-3907: FHAGMRR → LAQVRVL

Show »
Length:1,643
Mass (Da):191,308
Checksum:iC41FBD5551FB644E
GO
Isoform 5 (identifier: Q99996-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: K → KIEELSLAFLVRQ
     2884-2945: Missing.

Show »
Length:3,857
Mass (Da):447,753
Checksum:i6DEB35CA282A0FDD
GO
Isoform 6 (identifier: Q99996-6) [UniParc]FASTAAdd to basket
Also known as: AKAP350

The sequence of this isoform differs from the canonical sequence as follows:
     16-16: K → KIEELSLAFLVRQ
     2163-2171: SADTFQKVE → E
     3897-3907: STTQFHAGMRR → ALSLTTSWQHHSARPTAPLFFEILSHSLG

Show »
Length:3,929
Mass (Da):455,424
Checksum:iA97D9B0A61DF57A3
GO

Sequence cautioni

The sequence AAB86384 differs from that shown. Reason: Frameshift at position 1625.Curated
The sequence AAC60380 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64E → Q in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti542E → G in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti626R → S in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti651N → S in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti901H → N in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti944K → N in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti968 – 970QKH → PKP in AAB86384 (PubMed:9482789).Curated3
Sequence conflicti968 – 970QKH → PKP in CAB40713 (PubMed:10202149).Curated3
Sequence conflicti985Q → P in AAB86384 (PubMed:9482789).Curated1
Sequence conflicti985Q → P in CAB40713 (PubMed:10202149).Curated1
Sequence conflicti989Q → P in AAB86384 (PubMed:9482789).Curated1
Sequence conflicti989Q → P in CAB40713 (PubMed:10202149).Curated1
Sequence conflicti1008N → D in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti1016V → E in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti1614R → P in AAB86384 (PubMed:9482789).Curated1
Sequence conflicti1614R → P in CAB40713 (PubMed:10202149).Curated1
Sequence conflicti1691N → T in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti1695V → G in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti1790 – 1791Missing in AAD22767 (PubMed:9915845).Curated2
Sequence conflicti1831A → P in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti1944I → V in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti2015V → D in AAD22767 (PubMed:9915845).Curated1
Sequence conflicti2145 – 2146EI → HE in AAD39719 (PubMed:9915845).Curated2
Sequence conflicti2157E → V in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti2171E → Q in AAD39719 (PubMed:9915845).Curated1
Sequence conflicti2502L → R in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti2839I → N in BAA34523 (PubMed:9872452).Curated1
Sequence conflicti2953E → D in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti3083Q → H in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti3214Q → H in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti3303 – 3305ESE → QSQ in BAA78718 (PubMed:10358086).Curated3
Sequence conflicti3747P → A in BAA78718 (PubMed:10358086).Curated1
Sequence conflicti3829T → S in BAA78718 (PubMed:10358086).Curated1
Isoform 6 (identifier: Q99996-6)
Sequence conflicti2175E → Q in AAD39719 (PubMed:9915845).1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024249463M → I1 PublicationCorresponds to variant dbSNP:rs6964587EnsemblClinVar.1
Natural variantiVAR_0109261335K → KQ1 Publication1
Natural variantiVAR_0434891570S → L in LQT11. 1 PublicationCorresponds to variant dbSNP:rs121908566EnsemblClinVar.1
Natural variantiVAR_0357852409M → I in a colorectal cancer sample; somatic mutation. 1 Publication1
Natural variantiVAR_0434902484K → R. Corresponds to variant dbSNP:rs35759833EnsemblClinVar.1
Natural variantiVAR_0301622792N → S. Corresponds to variant dbSNP:rs6960867EnsemblClinVar.1
Natural variantiVAR_0301632979P → S3 PublicationsCorresponds to variant dbSNP:rs1063242EnsemblClinVar.1
Natural variantiVAR_0357863297E → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs756245027Ensembl.1
Natural variantiVAR_0434913444Q → R. Corresponds to variant dbSNP:rs34956633EnsemblClinVar.1
Natural variantiVAR_0434923614M → V. Corresponds to variant dbSNP:rs34327395EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_05952216K → KIEELSLAFLVRQ in isoform 1, isoform 4, isoform 5 and isoform 6. 1
Alternative sequenceiVSP_0595231625 – 3900Missing in isoform 4. Add BLAST2276
Alternative sequenceiVSP_0595252163 – 2171SADTFQKVE → E in isoform 3 and isoform 6. 9
Alternative sequenceiVSP_0595262883 – 2903GSSIP…EICSS → VFGFYNMCFSTLC in isoform 1. Add BLAST21
Alternative sequenceiVSP_0595272884 – 2945Missing in isoform 5. Add BLAST62
Alternative sequenceiVSP_0595283897 – 3907STTQFHAGMRR → ALSLTTSWQHHSARPTAPLF FEILSHSLG in isoform 6. Add BLAST11
Alternative sequenceiVSP_0595243901 – 3907FHAGMRR → LAQVRVL in isoform 4. 7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ131693 mRNA Translation: CAB40713.1
AB019691 mRNA Translation: BAA78718.1
AJ010770 Genomic DNA Translation: CAA09361.1
AF026245 mRNA Translation: AAB86384.1 Frameshift.
AC004013 Genomic DNA Translation: AAB96867.2
AC000066 Genomic DNA Translation: AAC60380.1 Sequence problems.
AC000120 Genomic DNA Translation: AAS07419.1
CH236949 Genomic DNA Translation: EAL24155.1
CH236949 Genomic DNA Translation: EAL24156.1
CH236949 Genomic DNA Translation: EAL24157.1
AF083037 mRNA Translation: AAD22767.1
AF091711 mRNA Translation: AAD39719.1
AB018346 mRNA Translation: BAA34523.1
CCDSiCCDS5622.1 [Q99996-2]
PIRiT08880
RefSeqiNP_005742.4, NM_005751.4 [Q99996-2]
NP_671714.1, NM_147185.2 [Q99996-3]
UniGeneiHs.651221

Genome annotation databases

EnsembliENST00000356239; ENSP00000348573; ENSG00000127914 [Q99996-2]
GeneIDi10142
KEGGihsa:10142
UCSCiuc003ulg.4 human [Q99996-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiAKAP9_HUMAN
AccessioniPrimary (citable) accession number: Q99996
Secondary accession number(s): A4D1F0
, A4D1F2, A4D1F4, O14869, O43355, O94895, Q75N20, Q9UQH3, Q9UQQ4, Q9Y6B8, Q9Y6Y2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: April 25, 2018
Last modified: July 18, 2018
This is version 182 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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