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Protein

Transcription cofactor vestigial-like protein 1

Gene

VGLL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a specific coactivator for the mammalian TEFs.1 Publication

GO - Molecular functioni

  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription cofactor vestigial-like protein 1
Short name:
Vgl-1
Alternative name(s):
Protein TONDU
Gene namesi
Name:VGLL1
Synonyms:TDU
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102243.12
HGNCiHGNC:20985 VGLL1
MIMi300583 gene
neXtProtiNX_Q99990

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51442
OpenTargetsiENSG00000102243
PharmGKBiPA134923162

Polymorphism and mutation databases

BioMutaiVGLL1
DMDMi50401655

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001913471 – 258Transcription cofactor vestigial-like protein 1Add BLAST258

Proteomic databases

EPDiQ99990
MaxQBiQ99990
PaxDbiQ99990
PeptideAtlasiQ99990
PRIDEiQ99990
ProteomicsDBi78565

PTM databases

iPTMnetiQ99990
PhosphoSitePlusiQ99990

Expressioni

Gene expression databases

BgeeiENSG00000102243 Expressed in 65 organ(s), highest expression level in placenta
CleanExiHS_VGLL1
ExpressionAtlasiQ99990 baseline and differential
GenevisibleiQ99990 HS

Organism-specific databases

HPAiHPA042403
HPA064616

Interactioni

Subunit structurei

Interacts with TEFs.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TEAD2Q15562-24EBI-11983165,EBI-9370956

Protein-protein interaction databases

BioGridi119544, 4 interactors
IntActiQ99990, 14 interactors
STRINGi9606.ENSP00000359668

Structurei

3D structure databases

ProteinModelPortaliQ99990
SMRiQ99990
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the vestigial family.Curated

Phylogenomic databases

eggNOGiENOG410IZ27 Eukaryota
ENOG410YSUV LUCA
GeneTreeiENSGT00730000111322
HOGENOMiHOG000231385
HOVERGENiHBG055872
InParanoidiQ99990
OMAiLRNDSDM
OrthoDBiEOG091G0GKN
PhylomeDBiQ99990
TreeFamiTF326340

Family and domain databases

InterProiView protein in InterPro
IPR006627 TDU_repeat
IPR011520 Vg_fam
PANTHERiPTHR15950 PTHR15950, 1 hit
PfamiView protein in Pfam
PF07545 Vg_Tdu, 1 hit
SMARTiView protein in SMART
SM00711 TDU, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99990-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEEMKKTAIR LPKGKQKPIK TEWNSRCVLF TYFQGDISSV VDEHFSRALS
60 70 80 90 100
NIKSPQELTP SSQSEGVMLK NDDSMSPNQW RYSSPWTKPQ PEVPVTNRAA
110 120 130 140 150
NCNLHVPGPM AVNQFSPSLA RRASVRPGEL WHFSSLAGTS SLEPGYSHPF
160 170 180 190 200
PARHLVPEPQ PDGKREPLLS LLQQDRCLAR PQESAARENG NPGQIAGSTG
210 220 230 240 250
LLFNLPPGSV HYKKLYVSRG SASTSLPNET LSELETPGKY SLTPPNHWGH

PHRYLQHL
Length:258
Mass (Da):28,707
Last modified:May 1, 1997 - v1
Checksum:iEA688B03E04AAD7F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y5G3H0Y5G3_HUMAN
Transcription cofactor vestigial-li...
VGLL1
162Annotation score:
Q5H916Q5H916_HUMAN
Transcription cofactor vestigial-li...
VGLL1
60Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05373559T → I. Corresponds to variant dbSNP:rs3027860Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137387 mRNA Translation: AAF13149.1
AC000115 Genomic DNA Translation: AAB46354.1
Z97632 Genomic DNA No translation available.
CH471150 Genomic DNA Translation: EAW88467.1
BC000045 mRNA Translation: AAH00045.1
BC003362 mRNA Translation: AAH03362.1
CCDSiCCDS14658.1
RefSeqiNP_057351.1, NM_016267.3
UniGeneiHs.496843

Genome annotation databases

EnsembliENST00000370634; ENSP00000359668; ENSG00000102243
GeneIDi51442
KEGGihsa:51442
UCSCiuc004ezy.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137387 mRNA Translation: AAF13149.1
AC000115 Genomic DNA Translation: AAB46354.1
Z97632 Genomic DNA No translation available.
CH471150 Genomic DNA Translation: EAW88467.1
BC000045 mRNA Translation: AAH00045.1
BC003362 mRNA Translation: AAH03362.1
CCDSiCCDS14658.1
RefSeqiNP_057351.1, NM_016267.3
UniGeneiHs.496843

3D structure databases

ProteinModelPortaliQ99990
SMRiQ99990
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119544, 4 interactors
IntActiQ99990, 14 interactors
STRINGi9606.ENSP00000359668

PTM databases

iPTMnetiQ99990
PhosphoSitePlusiQ99990

Polymorphism and mutation databases

BioMutaiVGLL1
DMDMi50401655

Proteomic databases

EPDiQ99990
MaxQBiQ99990
PaxDbiQ99990
PeptideAtlasiQ99990
PRIDEiQ99990
ProteomicsDBi78565

Protocols and materials databases

DNASUi51442
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000370634; ENSP00000359668; ENSG00000102243
GeneIDi51442
KEGGihsa:51442
UCSCiuc004ezy.3 human

Organism-specific databases

CTDi51442
DisGeNETi51442
EuPathDBiHostDB:ENSG00000102243.12
GeneCardsiVGLL1
HGNCiHGNC:20985 VGLL1
HPAiHPA042403
HPA064616
MIMi300583 gene
neXtProtiNX_Q99990
OpenTargetsiENSG00000102243
PharmGKBiPA134923162
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ27 Eukaryota
ENOG410YSUV LUCA
GeneTreeiENSGT00730000111322
HOGENOMiHOG000231385
HOVERGENiHBG055872
InParanoidiQ99990
OMAiLRNDSDM
OrthoDBiEOG091G0GKN
PhylomeDBiQ99990
TreeFamiTF326340

Miscellaneous databases

ChiTaRSiVGLL1 human
GenomeRNAii51442
PROiPR:Q99990
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102243 Expressed in 65 organ(s), highest expression level in placenta
CleanExiHS_VGLL1
ExpressionAtlasiQ99990 baseline and differential
GenevisibleiQ99990 HS

Family and domain databases

InterProiView protein in InterPro
IPR006627 TDU_repeat
IPR011520 Vg_fam
PANTHERiPTHR15950 PTHR15950, 1 hit
PfamiView protein in Pfam
PF07545 Vg_Tdu, 1 hit
SMARTiView protein in SMART
SM00711 TDU, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVGLL1_HUMAN
AccessioniPrimary (citable) accession number: Q99990
Secondary accession number(s): Q5H915
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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