VRK1

Functionⁱ

Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.6 Publications

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.1 Publication

Activity regulationⁱ

Active in presence of Mn²⁺, Mg²⁺ and Zn²⁺, but is not functional with Ca²⁺ or Cu²⁺. Has a higher affinity for Mn²⁺ than for Mg²⁺. RAN inhibits its autophosphorylation and its ability to phosphorylate histone H3.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	71	ATPPROSITE-ProRule annotation		1
Active siteⁱ	177	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	43 – 51	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
histone kinase activity (H3-S10 specific)
Source: UniProtKB
Inferred from direct assayⁱ
- 22194607
histone kinase activity (H3-T3 specific)
Source: UniProtKB
Inferred from direct assayⁱ
- 22194607
nucleosomal histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22194607
protein kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 22194607
protein kinase binding
Source: MGI
Inferred from direct assayⁱ
- 22572157
protein serine/threonine kinase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 21543316

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell division Source: UniProtKB-KW
Golgi disassembly
Source: UniProtKB
Inferred from direct assayⁱ
- 19103756
histone H3-S10 phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 22194607
histone H3-T3 phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 22194607
mitotic nuclear envelope disassembly Source: Reactome
mitotic nuclear envelope reassembly Source: Reactome
protein autophosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 21543316
- 22194607
protein phosphorylation
Source: UniProtKB
Inferred from direct assayⁱ
- 22194607
regulation of cell shape Source: GO_Central

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cell cycle, Cell division, Mitosis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin R-HSA-2995383 Initiation of Nuclear Envelope Reformation
SignaLinkⁱ	Q99986
SIGNORⁱ	Q99986

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Serine/threonine-protein kinase VRK1 (EC:2.7.11.1) Alternative name(s): Vaccinia-related kinase 1
Gene namesⁱ	Name:VRK1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 14

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000100749.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12718 VRK1
MIMⁱ	602168 gene
neXtProtⁱ	NX_Q99986

Keywords - Cellular componentⁱ

Cytoplasm, Cytoskeleton, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Pontocerebellar hypoplasia 1A (PCH1A)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder characterized by an abnormally small cerebellum and brainstem, central and peripheral motor dysfunction from birth, gliosis and spinal cord anterior horn cells degeneration resembling infantile spinal muscular atrophy. Additional features include muscle hypotonia, congenital contractures and respiratory insufficiency that is evident at birth.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	14	S → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	102	T → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	125	S → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	150	S → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	158	S → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	179	K → A: Does not affect phosphorylation at S-342. 1 Publication	1
Mutagenesisⁱ	239	S → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	305	T → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	312	T → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	342	S → A: Abolishes phosphorylation by PLK3 and induction of Golgi fragmentation during mitosis. Strongly reduced autophosphorylation. 2 Publications	1
Mutagenesisⁱ	353	T → A: Strongly reduced autophosphorylation. 1 Publication	1
Mutagenesisⁱ	355	T → A: Does not abolish autophosphorylation. 1 Publication	1
Mutagenesisⁱ	390	T → A: Does not abolish autophosphorylation. 1 Publication	1

Keywords - Diseaseⁱ

Neurodegeneration

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7443
MalaCards human disease database More...MalaCardsⁱ	VRK1
MIMⁱ	607596 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000100749
Orphanetⁱ	2254 Pontocerebellar hypoplasia type 1
PharmGKBⁱ	PA37330

Chemistry databases

ChEMBLⁱ	CHEMBL1293199

ChEMBLⁱ

CHEMBL1293199

Polymorphism and mutation databases

BioMutaⁱ	VRK1
DMDMⁱ	45593726

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000086803	1 – 396	Serine/threonine-protein kinase VRK1Add BLAST		396

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Cross-linkⁱ	71	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residueⁱ	342	Phosphoserine; by PLK3Combined sources1 Publication	1
Modified residueⁱ	355	Phosphothreonine; by autocatalysis1 Publication	1
Modified residueⁱ	376	PhosphoserineCombined sources	1
Modified residueⁱ	378	PhosphothreonineCombined sources	1

Post-translational modificationⁱ

Autophosphorylated at various serine and threonine residues. Autophosphorylation does not impair its ability to phosphorylate p53/TP53. Phosphorylation by PLK3 leads to induction of Golgi fragmentation during mitosis.3 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q99986
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99986
PaxDbⁱ	Q99986
PeptideAtlas More...PeptideAtlasⁱ	Q99986
PRIDEⁱ	Q99986
ProteomicsDBⁱ	78563

PTM databases

iPTMnetⁱ	Q99986
PhosphoSitePlusⁱ	Q99986

Expressionⁱ

Tissue specificityⁱ

Widely expressed. Highly expressed in fetal liver, testis and thymus.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000100749 Expressed in 222 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_VRK1
ExpressionAtlasⁱ	Q99986 baseline and differential
Genevisibleⁱ	Q99986 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000660 HPA017929

HPAⁱ

HPA000660
HPA017929

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ATF2	P15336	5	EBI-1769146,EBI-1170906
AURKB	Q96GD4	14	EBI-1769146,EBI-624291
COIL	P38432	9	EBI-1769146,EBI-945751
H2AFX	P16104	3	EBI-1769146,EBI-494830
JUN	P05412	5	EBI-1769146,EBI-852823
NBN	O60934	13	EBI-1769146,EBI-494844
PLK3	Q9H4B4	12	EBI-1769146,EBI-751877
RAN	P62826	12	EBI-1769146,EBI-286642
RNF8	O76064	2	EBI-1769146,EBI-373337
SOX2	P48431	14	EBI-1769146,EBI-6124081
TP53	P04637	11	EBI-1769146,EBI-366083
TP53BP1	Q12888	8	EBI-1769146,EBI-396540

GO - Molecular functionⁱ

nucleosomal histone binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 22194607
protein kinase binding
Source: MGI
Inferred from direct assayⁱ
- 22572157

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	113282, 36 interactors
IntActⁱ	Q99986, 20 interactors
Molecular INTeraction database More...MINTⁱ	Q99986
STRINGⁱ	9606.ENSP00000216639

Chemistry databases

BindingDBⁱ

Q99986

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	2 – 4	Combined sources	3
Beta strandⁱ	11 – 13	Combined sources	3
Beta strandⁱ	22 – 24	Combined sources	3
Beta strandⁱ	28 – 30	Combined sources	3
Beta strandⁱ	36 – 42	Combined sources	7
Beta strandⁱ	45 – 47	Combined sources	3
Beta strandⁱ	51 – 56	Combined sources	6
Beta strandⁱ	58 – 60	Combined sources	3
Beta strandⁱ	67 – 74	Combined sources	8
Helixⁱ	78 – 90	Combined sources	13
Helixⁱ	93 – 102	Combined sources	10
Beta strandⁱ	113 – 121	Combined sources	9
Beta strandⁱ	124 – 132	Combined sources	9
Beta strandⁱ	134 – 137	Combined sources	4
Helixⁱ	138 – 144	Combined sources	7
Turnⁱ	145 – 147	Combined sources	3
Helixⁱ	151 – 170	Combined sources	20
Helixⁱ	180 – 182	Combined sources	3
Beta strandⁱ	183 – 188	Combined sources	6
Beta strandⁱ	193 – 195	Combined sources	3
Helixⁱ	198 – 200	Combined sources	3
Beta strandⁱ	202 – 205	Combined sources	4
Helixⁱ	206 – 208	Combined sources	3
Turnⁱ	225 – 227	Combined sources	3
Helixⁱ	230 – 233	Combined sources	4
Helixⁱ	240 – 256	Combined sources	17
Turnⁱ	260 – 263	Combined sources	4
Helixⁱ	268 – 280	Combined sources	13
Helixⁱ	282 – 289	Combined sources	8
Helixⁱ	291 – 293	Combined sources	3
Helixⁱ	297 – 307	Combined sources	11
Beta strandⁱ	311 – 313	Combined sources	3
Helixⁱ	317 – 330	Combined sources	14
Beta strandⁱ	355 – 357	Combined sources	3

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99986
SMRⁱ	Q99986
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99986

EvolutionaryTraceⁱ

Q99986

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	37 – 317	Protein kinasePROSITE-ProRule annotationAdd BLAST		281

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. VRK subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1164 Eukaryota ENOG410XPGP LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00920000148988
HOGENOMⁱ	HOG000069991
HOVERGENⁱ	HBG007532
InParanoidⁱ	Q99986
KEGG Orthology (KO) More...KOⁱ	K08816
OMAⁱ	YMRAAKP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G05V5
PhylomeDBⁱ	Q99986
TreeFamⁱ	TF106473

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show all Align All

Q99986-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPRVKAAQAG RQSSAKRHLA EQFAVGEIIT DMAKKEWKVG LPIGQGGFGC 
        60         70         80         90        100
IYLADMNSSE SVGSDAPCVV KVEPSDNGPL FTELKFYQRA AKPEQIQKWI 
       110        120        130        140        150
RTRKLKYLGV PKYWGSGLHD KNGKSYRFMI MDRFGSDLQK IYEANAKRFS 
       160        170        180        190        200
RKTVLQLSLR ILDILEYIHE HEYVHGDIKA SNLLLNYKNP DQVYLVDYGL 
       210        220        230        240        250
AYRYCPEGVH KEYKEDPKRC HDGTIEFTSI DAHNGVAPSR RGDLEILGYC 
       260        270        280        290        300
MIQWLTGHLP WEDNLKDPKY VRDSKIRYRE NIASLMDKCF PEKNKPGEIA 
       310        320        330        340        350
KYMETVKLLD YTEKPLYENL RDILLQGLKA IGSKDDGKLD LSVVENGGLK 
       360        370        380        390 
AKTITKKRKK EIEESKEPGV EDTEWSNTQT EEAIQTRSRT RKRVQK

Length:396

Mass (Da):45,476

Last modified:May 1, 1997 - v1

Checksum:ⁱ5640C624BF059949

GO

Computationally mapped potential isoform sequencesⁱ

There are 3 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H0YJJ9	H0YJJ9_HUMAN	Serine/threonine-protein kinase VRK... Serine/threonine-protein kinase VRK1	VRK1	176	Annotation score:
H0YJ50	H0YJ50_HUMAN	Serine/threonine-protein kinase VRK... Serine/threonine-protein kinase VRK1	VRK1	232	Annotation score:
H0YJF7	H0YJF7_HUMAN	Serine/threonine-protein kinase VRK... Serine/threonine-protein kinase VRK1	VRK1	65	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000449 mRNA Translation: BAA19108.1 BC103761 mRNA Translation: AAI03762.1 BC112075 mRNA Translation: AAI12076.1 BC113510 mRNA Translation: AAI13511.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS9947.1
NCBI Reference Sequences More...RefSeqⁱ	NP_003375.1, NM_003384.2
UniGeneⁱ	Hs.422662

Genome annotation databases

Ensemblⁱ	ENST00000216639; ENSP00000216639; ENSG00000100749
GeneIDⁱ	7443
KEGGⁱ	hsa:7443
UCSC genome browser More...UCSCⁱ	uc001yft.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99986	Uncharacterized protein		PANPA		422	UniRef90_Q99986
Vaccinia related kinase 1		PANTR		420
Uncharacterized protein		MACMU		420
Testis cDNA clone: QtsA-12587, similar to human vaccinia related kinase 1 (VRK1)		MACFA		170
Uncharacterized protein		PAPAN		170
+49

Protein	Similar proteins		Species	Score	Length	Source
Q99986	Uncharacterized protein		PANPA		422	UniRef50_Q99986
Vaccinia related kinase 1		PANTR		420
Uncharacterized protein		MACMU		420
Testis cDNA clone: QtsA-12587, similar to human vaccinia related kinase 1 (VRK1)		MACFA		170
Uncharacterized protein		PAPAN		170
+118

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AB000449 mRNA Translation: BAA19108.1 BC103761 mRNA Translation: AAI03762.1 BC112075 mRNA Translation: AAI12076.1 BC113510 mRNA Translation: AAI13511.1
CCDSⁱ	CCDS9947.1
RefSeqⁱ	NP_003375.1, NM_003384.2
UniGeneⁱ	Hs.422662

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2KTY	NMR	-	A	1-360	[»]
	2KUL	NMR	-	A	1-360	[»]
	2LAV	NMR	-	A	1-361	[»]
	2RSV	NMR	-	A	1-396	[»]
	3OP5	X-ray	2.40	A/B/C/D	3-364	[»]
	5UKF	X-ray	2.40	A/B/C/D	3-364	[»]
	5UVF	X-ray	2.00	A/B/C/D	3-364	[»]
	6BP0	X-ray	1.90	A/B/C/D	3-364	[»]
	6BRU	X-ray	1.80	A/B/C/D	3-364	[»]
	6BTW	X-ray	1.90	A/B/C/D	3-364	[»]
	6BU6	X-ray	1.80	A/B/C/D	3-364	[»]
	6CFM	X-ray	2.45	A/B/C/D	3-364	[»]
	6CMM	X-ray	2.10	A/B/C/D	3-364	[»]
	6CNX	X-ray	2.00	A/B/C/D	3-364	[»]
	6CQH	X-ray	2.15	A/B/C/D	3-364	[»]
	6CSW	X-ray	2.25	A/B/C/D	3-364	[»]
	6DD4	X-ray	2.10	A/B/C/D	3-364	[»]
ProteinModelPortalⁱ	Q99986
SMRⁱ	Q99986
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113282, 36 interactors
IntActⁱ	Q99986, 20 interactors
MINTⁱ	Q99986
STRINGⁱ	9606.ENSP00000216639

Chemistry databases

BindingDBⁱ	Q99986
ChEMBLⁱ	CHEMBL1293199

PTM databases

iPTMnetⁱ	Q99986
PhosphoSitePlusⁱ	Q99986

Polymorphism and mutation databases

BioMutaⁱ	VRK1
DMDMⁱ	45593726

Proteomic databases

EPDⁱ	Q99986
MaxQBⁱ	Q99986
PaxDbⁱ	Q99986
PeptideAtlasⁱ	Q99986
PRIDEⁱ	Q99986
ProteomicsDBⁱ	78563

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7443
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000216639; ENSP00000216639; ENSG00000100749
GeneIDⁱ	7443
KEGGⁱ	hsa:7443
UCSCⁱ	uc001yft.4 human

Organism-specific databases

CTDⁱ	7443
DisGeNETⁱ	7443
EuPathDBⁱ	HostDB:ENSG00000100749.7
GeneCardsⁱ	VRK1
HGNCⁱ	HGNC:12718 VRK1
HPAⁱ	HPA000660 HPA017929
MalaCardsⁱ	VRK1
MIMⁱ	602168 gene 607596 phenotype
neXtProtⁱ	NX_Q99986
OpenTargetsⁱ	ENSG00000100749
Orphanetⁱ	2254 Pontocerebellar hypoplasia type 1
PharmGKBⁱ	PA37330
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1164 Eukaryota ENOG410XPGP LUCA
GeneTreeⁱ	ENSGT00920000148988
HOGENOMⁱ	HOG000069991
HOVERGENⁱ	HBG007532
InParanoidⁱ	Q99986
KOⁱ	K08816
OMAⁱ	YMRAAKP
OrthoDBⁱ	EOG091G05V5
PhylomeDBⁱ	Q99986
TreeFamⁱ	TF106473

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2993913 Clearance of Nuclear Envelope Membranes from Chromatin R-HSA-2995383 Initiation of Nuclear Envelope Reformation
SignaLinkⁱ	Q99986
SIGNORⁱ	Q99986

Miscellaneous databases

ChiTaRSⁱ	VRK1 human
EvolutionaryTraceⁱ	Q99986
GeneWikiⁱ	VRK1
GenomeRNAiⁱ	7443
Protein Ontology More...PROⁱ	PR:Q99986
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000100749 Expressed in 222 organ(s), highest expression level in bone marrow
CleanExⁱ	HS_VRK1
ExpressionAtlasⁱ	Q99986 baseline and differential
Genevisibleⁱ	Q99986 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	VRK1_HUMAN
Accessionⁱ	Q99986Primary (citable) accession number: Q99986 Secondary accession number(s): Q3SYL2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 10, 2003
	Last sequence update:	May 1, 1997
	Last modified:	September 12, 2018
	This is version 181 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human and mouse protein kinases
Human and mouse protein kinases: classification and index
SIMILARITY comments
Index of protein domains and families
Human chromosome 14
Human chromosome 14: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99986 (VRK1_HUMAN)

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Serine/threonine-protein kinase VRK1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Cytoskeleton

Other locations

Cytoskeleton

Cytosol

Golgi apparatus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ