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Protein

Semaphorin-3C

Gene

SEMA3C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance (By similarity).By similarity

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • neuropilin binding Source: GO_Central
  • semaphorin receptor binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

SIGNORiQ99985

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-3C
Alternative name(s):
Semaphorin-E
Short name:
Sema E
Gene namesi
Name:SEMA3C
Synonyms:SEMAE
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000075223.13
HGNCiHGNC:10725 SEMA3C
MIMi602645 gene
neXtProtiNX_Q99985

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi10512
MalaCardsiSEMA3C
OpenTargetsiENSG00000075223
Orphaneti388 Hirschsprung disease
PharmGKBiPA35647

Polymorphism and mutation databases

BioMutaiSEMA3C
DMDMi8134685

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003231121 – 751Semaphorin-3CAdd BLAST731

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi81N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi101 ↔ 112By similarity
Glycosylationi123N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi130 ↔ 139By similarity
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi266 ↔ 378By similarity
Glycosylationi268N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi290 ↔ 338By similarity
Glycosylationi465N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi514 ↔ 532By similarity
Glycosylationi585N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi643 ↔ 709By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ99985
MaxQBiQ99985
PaxDbiQ99985
PeptideAtlasiQ99985
PRIDEiQ99985
ProteomicsDBi78562

PTM databases

GlyConnecti1730
iPTMnetiQ99985
PhosphoSitePlusiQ99985

Expressioni

Tissue specificityi

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Gene expression databases

BgeeiENSG00000075223 Expressed in 225 organ(s), highest expression level in uterine cervix
CleanExiHS_SEMA3C
ExpressionAtlasiQ99985 baseline and differential
GenevisibleiQ99985 HS

Organism-specific databases

HPAiHPA042418

Interactioni

Subunit structurei

Interacts with PLXND1.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115768, 16 interactors
CORUMiQ99985
IntActiQ99985, 2 interactors
STRINGi9606.ENSP00000265361

Structurei

3D structure databases

ProteinModelPortaliQ99985
SMRiQ99985
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 511SemaPROSITE-ProRule annotationAdd BLAST484
Domaini571 – 655Ig-like C2-typeAdd BLAST85

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi724 – 745Arg/Lys-rich (basic)Add BLAST22

Sequence similaritiesi

Belongs to the semaphorin family.Curated

Keywords - Domaini

Immunoglobulin domain, Signal

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOVERGENiHBG055071
InParanoidiQ99985
KOiK06840
OMAiWPASAIK
OrthoDBiEOG091G01W0
PhylomeDBiQ99985
TreeFamiTF352628

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99985-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAFRTICVLV GVFICSICVK GSSQPQARVY LTFDELRETK TSEYFSLSHH
60 70 80 90 100
PLDYRILLMD EDQDRIYVGS KDHILSLNIN NISQEALSVF WPASTIKVEE
110 120 130 140 150
CKMAGKDPTH GCGNFVRVIQ TFNRTHLYVC GSGAFSPVCT YLNRGRRSED
160 170 180 190 200
QVFMIDSKCE SGKGRCSFNP NVNTVSVMIN EELFSGMYID FMGTDAAIFR
210 220 230 240 250
SLTKRNAVRT DQHNSKWLSE PMFVDAHVIP DGTDPNDAKV YFFFKEKLTD
260 270 280 290 300
NNRSTKQIHS MIARICPNDT GGLRSLVNKW TTFLKARLVC SVTDEDGPET
310 320 330 340 350
HFDELEDVFL LETDNPRTTL VYGIFTTSSS VFKGSAVCVY HLSDIQTVFN
360 370 380 390 400
GPFAHKEGPN HQLISYQGRI PYPRPGTCPG GAFTPNMRTT KEFPDDVVTF
410 420 430 440 450
IRNHPLMYNS IYPIHKRPLI VRIGTDYKYT KIAVDRVNAA DGRYHVLFLG
460 470 480 490 500
TDRGTVQKVV VLPTNNSVSG ELILEELEVF KNHAPITTMK ISSKKQQLYV
510 520 530 540 550
SSNEGVSQVS LHRCHIYGTA CADCCLARDP YCAWDGHSCS RFYPTGKRRS
560 570 580 590 600
RRQDVRHGNP LTQCRGFNLK AYRNAAEIVQ YGVKNNTTFL ECAPKSPQAS
610 620 630 640 650
IKWLLQKDKD RRKEVKLNER IIATSQGLLI RSVQGSDQGL YHCIATENSF
660 670 680 690 700
KQTIAKINFK VLDSEMVAVV TDKWSPWTWA SSVRALPFHP KDIMGAFSHS
710 720 730 740 750
EMQMINQYCK DTRQQHQQGD ESQKMRGDYG KLKALINSRK SRNRRNQLPE

S
Length:751
Mass (Da):85,207
Last modified:November 1, 1998 - v2
Checksum:iAA68A21FEF20C033
GO
Isoform 2 (identifier: Q99985-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     2-149: Missing.
     378-381: CPGG → NTCV
     382-751: Missing.

Note: No experimental confirmation available.
Show »
Length:233
Mass (Da):26,255
Checksum:i10D521391C76311A
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WEP9F8WEP9_HUMAN
Semaphorin-3C
SEMA3C
40Annotation score:
F2Z2Y0F2Z2Y0_HUMAN
Semaphorin-3C
SEMA3C
63Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051928302F → S. Corresponds to variant dbSNP:rs35070362Ensembl.1
Natural variantiVAR_020346337V → M. Corresponds to variant dbSNP:rs1527482Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0558862 – 149Missing in isoform 2. 1 PublicationAdd BLAST148
Alternative sequenceiVSP_055887378 – 381CPGG → NTCV in isoform 2. 1 Publication4
Alternative sequenceiVSP_055888382 – 751Missing in isoform 2. 1 PublicationAdd BLAST370

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000220 mRNA Translation: BAA32398.1
AK299322 mRNA Translation: BAG61330.1
AC004880 Genomic DNA No translation available.
AC004972 Genomic DNA No translation available.
AC073850 Genomic DNA No translation available.
AC093683 Genomic DNA No translation available.
BC030690 mRNA Translation: AAH30690.1
CCDSiCCDS5596.1 [Q99985-1]
RefSeqiNP_006370.1, NM_006379.3 [Q99985-1]
UniGeneiHs.269109

Genome annotation databases

EnsembliENST00000265361; ENSP00000265361; ENSG00000075223 [Q99985-1]
ENST00000419255; ENSP00000411193; ENSG00000075223 [Q99985-1]
GeneIDi10512
KEGGihsa:10512
UCSCiuc003uhj.3 human [Q99985-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000220 mRNA Translation: BAA32398.1
AK299322 mRNA Translation: BAG61330.1
AC004880 Genomic DNA No translation available.
AC004972 Genomic DNA No translation available.
AC073850 Genomic DNA No translation available.
AC093683 Genomic DNA No translation available.
BC030690 mRNA Translation: AAH30690.1
CCDSiCCDS5596.1 [Q99985-1]
RefSeqiNP_006370.1, NM_006379.3 [Q99985-1]
UniGeneiHs.269109

3D structure databases

ProteinModelPortaliQ99985
SMRiQ99985
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115768, 16 interactors
CORUMiQ99985
IntActiQ99985, 2 interactors
STRINGi9606.ENSP00000265361

PTM databases

GlyConnecti1730
iPTMnetiQ99985
PhosphoSitePlusiQ99985

Polymorphism and mutation databases

BioMutaiSEMA3C
DMDMi8134685

Proteomic databases

EPDiQ99985
MaxQBiQ99985
PaxDbiQ99985
PeptideAtlasiQ99985
PRIDEiQ99985
ProteomicsDBi78562

Protocols and materials databases

DNASUi10512
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265361; ENSP00000265361; ENSG00000075223 [Q99985-1]
ENST00000419255; ENSP00000411193; ENSG00000075223 [Q99985-1]
GeneIDi10512
KEGGihsa:10512
UCSCiuc003uhj.3 human [Q99985-1]

Organism-specific databases

CTDi10512
DisGeNETi10512
EuPathDBiHostDB:ENSG00000075223.13
GeneCardsiSEMA3C
HGNCiHGNC:10725 SEMA3C
HPAiHPA042418
MalaCardsiSEMA3C
MIMi602645 gene
neXtProtiNX_Q99985
OpenTargetsiENSG00000075223
Orphaneti388 Hirschsprung disease
PharmGKBiPA35647
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000118854
HOVERGENiHBG055071
InParanoidiQ99985
KOiK06840
OMAiWPASAIK
OrthoDBiEOG091G01W0
PhylomeDBiQ99985
TreeFamiTF352628

Enzyme and pathway databases

SIGNORiQ99985

Miscellaneous databases

ChiTaRSiSEMA3C human
GeneWikiiSEMA3C
GenomeRNAii10512
PROiPR:Q99985
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000075223 Expressed in 225 organ(s), highest expression level in uterine cervix
CleanExiHS_SEMA3C
ExpressionAtlasiQ99985 baseline and differential
GenevisibleiQ99985 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF01403 Sema, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSEM3C_HUMAN
AccessioniPrimary (citable) accession number: Q99985
Secondary accession number(s): B4DRL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1998
Last modified: November 7, 2018
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
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