Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Osteomodulin

Gene

OMD

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be implicated in biomineralization processes. Has a function in binding of osteoblasts via the alpha(V)beta3-integrin (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2022857 Keratan sulfate degradation
R-HSA-3656225 Defective CHST6 causes MCDC1
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
SIGNORiQ99983

Names & Taxonomyi

Protein namesi
Recommended name:
Osteomodulin
Alternative name(s):
Keratan sulfate proteoglycan osteomodulin
Short name:
KSPG osteomodulin
Osteoadherin
Short name:
OSAD
Gene namesi
Name:OMD
Synonyms:SLRR2C
ORF Names:UNQ190/PRO216
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000127083.7
HGNCiHGNC:8134 OMD
neXtProtiNX_Q99983

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4958
OpenTargetsiENSG00000127083
PharmGKBiPA31921

Polymorphism and mutation databases

BioMutaiOMD
DMDMi20138850

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000003275421 – 421OsteomodulinAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei22Sulfotyrosine1 Publication1
Modified residuei25Sulfotyrosine1 Publication1
Modified residuei31Sulfotyrosine1 Publication1
Modified residuei39Sulfotyrosine1 Publication1
Modified residuei51Sulfotyrosine1 Publication1
Modified residuei58Sulfotyrosine1 Publication1
Modified residuei77Sulfotyrosine1 Publication1
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi242N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi321 ↔ 353By similarity
Modified residuei416Sulfotyrosine1 Publication1
Modified residuei417Sulfotyrosine1 Publication1

Post-translational modificationi

Binds keratan sulfate chains.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Proteoglycan, Sulfation

Proteomic databases

PaxDbiQ99983
PeptideAtlasiQ99983
PRIDEiQ99983
ProteomicsDBi78561

PTM databases

GlyConnecti1588
iPTMnetiQ99983
PhosphoSitePlusiQ99983

Expressioni

Tissue specificityi

Bone specific.

Gene expression databases

BgeeiENSG00000127083 Expressed in 161 organ(s), highest expression level in periodontal ligament
CleanExiHS_OMD
GenevisibleiQ99983 HS

Organism-specific databases

HPAiHPA005731
HPA069948

Interactioni

Subunit structurei

Binds the alpha(V)beta3-integrin.By similarity

Protein-protein interaction databases

BioGridi111011, 4 interactors
STRINGi9606.ENSP00000364700

Structurei

Secondary structure

1421
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99983
SMRiQ99983
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 91LRRNTAdd BLAST39
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 129LRR 2Add BLAST14
Repeati142 – 164LRR 3Add BLAST23
Repeati165 – 184LRR 4Add BLAST20
Repeati187 – 210LRR 5Add BLAST24
Repeati213 – 233LRR 6Add BLAST21
Repeati234 – 255LRR 7Add BLAST22
Repeati258 – 280LRR 8Add BLAST23
Repeati281 – 294LRR 9Add BLAST14
Repeati301 – 321LRR 10Add BLAST21
Repeati331 – 353LRR 11Add BLAST23

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi62 – 78Cys-richAdd BLAST17
Compositional biasi385 – 409Asp/Glu-rich (acidic)Add BLAST25

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiQ99983
KOiK08124
OMAiAFYIPRN
OrthoDBiEOG091G044B
PhylomeDBiQ99983
TreeFamiTF334562

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR030705 Osteomodulin
PANTHERiPTHR24373:SF155 PTHR24373:SF155, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q99983-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGFLSPIYVI FFFFGVKVHC QYETYQWDED YDQEPDDDYQ TGFPFRQNVD
60 70 80 90 100
YGVPFHQYTL GCVSECFCPT NFPSSMYCDN RKLKTIPNIP MHIQQLYLQF
110 120 130 140 150
NEIEAVTANS FINATHLKEI NLSHNKIKSQ KIDYGVFAKL PNLLQLHLEH
160 170 180 190 200
NNLEEFPFPL PKSLERLLLG YNEISKLQTN AMDGLVNLTM LDLCYNYLHD
210 220 230 240 250
SLLKDKIFAK MEKLMQLNLC SNRLESMPPG LPSSLMYLSL ENNSISSIPE
260 270 280 290 300
KYFDKLPKLH TLRMSHNKLQ DIPYNIFNLP NIVELSVGHN KLKQAFYIPR
310 320 330 340 350
NLEHLYLQNN EIEKMNLTVM CPSIDPLHYH HLTYIRVDQN KLKEPISSYI
360 370 380 390 400
FFCFPHIHTI YYGEQRSTNG QTIQLKTQVF RRFPDDDDES EDHDDPDNAH
410 420
ESPEQEGAEG HFDLHYYENQ E
Length:421
Mass (Da):49,492
Last modified:May 1, 1997 - v1
Checksum:iCED47B2BC33BB872
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052014200D → G. Corresponds to variant dbSNP:rs34069871Ensembl.1
Natural variantiVAR_052015212E → G. Corresponds to variant dbSNP:rs34413259Ensembl.1
Natural variantiVAR_052016221S → N. Corresponds to variant dbSNP:rs34860658Ensembl.1
Natural variantiVAR_052017282I → T. Corresponds to variant dbSNP:rs35779901Ensembl.1
Natural variantiVAR_052018353C → W. Corresponds to variant dbSNP:rs34059114Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000114 mRNA Translation: BAA19055.1
AB009589 Genomic DNA Translation: BAA23982.1
AY358872 mRNA Translation: AAQ89231.1
AL137848 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62821.1
BC046356 mRNA Translation: AAH46356.1
CCDSiCCDS6696.1
RefSeqiNP_005005.1, NM_005014.2
UniGeneiHs.94070

Genome annotation databases

EnsembliENST00000375550; ENSP00000364700; ENSG00000127083
GeneIDi4958
KEGGihsa:4958
UCSCiuc004asd.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB000114 mRNA Translation: BAA19055.1
AB009589 Genomic DNA Translation: BAA23982.1
AY358872 mRNA Translation: AAQ89231.1
AL137848 Genomic DNA No translation available.
CH471089 Genomic DNA Translation: EAW62821.1
BC046356 mRNA Translation: AAH46356.1
CCDSiCCDS6696.1
RefSeqiNP_005005.1, NM_005014.2
UniGeneiHs.94070

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5YQ5X-ray2.17A/B/C/D21-421[»]
ProteinModelPortaliQ99983
SMRiQ99983
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111011, 4 interactors
STRINGi9606.ENSP00000364700

PTM databases

GlyConnecti1588
iPTMnetiQ99983
PhosphoSitePlusiQ99983

Polymorphism and mutation databases

BioMutaiOMD
DMDMi20138850

Proteomic databases

PaxDbiQ99983
PeptideAtlasiQ99983
PRIDEiQ99983
ProteomicsDBi78561

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375550; ENSP00000364700; ENSG00000127083
GeneIDi4958
KEGGihsa:4958
UCSCiuc004asd.5 human

Organism-specific databases

CTDi4958
DisGeNETi4958
EuPathDBiHostDB:ENSG00000127083.7
GeneCardsiOMD
HGNCiHGNC:8134 OMD
HPAiHPA005731
HPA069948
neXtProtiNX_Q99983
OpenTargetsiENSG00000127083
PharmGKBiPA31921
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118969
HOGENOMiHOG000234447
HOVERGENiHBG108061
InParanoidiQ99983
KOiK08124
OMAiAFYIPRN
OrthoDBiEOG091G044B
PhylomeDBiQ99983
TreeFamiTF334562

Enzyme and pathway databases

ReactomeiR-HSA-2022854 Keratan sulfate biosynthesis
R-HSA-2022857 Keratan sulfate degradation
R-HSA-3656225 Defective CHST6 causes MCDC1
R-HSA-3656243 Defective ST3GAL3 causes MCT12 and EIEE15
R-HSA-3656244 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
SIGNORiQ99983

Miscellaneous databases

GeneWikiiOMD_(gene)
GenomeRNAii4958
PROiPR:Q99983

Gene expression databases

BgeeiENSG00000127083 Expressed in 161 organ(s), highest expression level in periodontal ligament
CleanExiHS_OMD
GenevisibleiQ99983 HS

Family and domain databases

Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
IPR030705 Osteomodulin
PANTHERiPTHR24373:SF155 PTHR24373:SF155, 1 hit
PfamiView protein in Pfam
PF13855 LRR_8, 3 hits
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00013 LRRNT, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiOMD_HUMAN
AccessioniPrimary (citable) accession number: Q99983
Secondary accession number(s): Q5TBF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 11, 2002
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again