CITED2

Functionⁱ

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Acts as a bridge, linking TFAP2 transcription factors and the p300/CBP transcriptional coactivator complex in order to stimulate TFAP2-mediated transcriptional activation. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Stimulates the peroxisome proliferator-activated receptors PPARA transcriptional activity. Enhances estrogen-dependent transactivation mediated by estrogen receptors. Acts also as a transcriptional corepressor; interferes with the binding of the transcription factors HIF1A or STAT2 and the p300/CBP transcriptional coactivator complex. Participates in sex determination and early gonad development by stimulating transcription activation of SRY. Plays a role in controlling left-right patterning during embryogenesis; potentiates transcriptional activation of NODAL-mediated gene transcription in the left lateral plate mesoderm (LPM). Plays an essential role in differentiation of the adrenal cortex from the adrenogonadal primordium (AGP); stimulates WT1-mediated transcription activation thereby up-regulating the nuclear hormone receptor NR5A1 promoter activity. Associates with chromatin to the PITX2 P1 promoter region.3 Publications

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
DNA-binding transcription factor activity Source: UniProtKB
histone acetyltransferase binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 22735262
LBD domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15051727
protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 14594809
transcription coactivator activity
Source: UniProtKB
Inferred from direct assayⁱ
transcription corepressor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 9887100

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adrenal cortex formation Source: UniProtKB
cell differentiation Source: UniProtKB-KW
cell proliferation
Source: UniProtKB
Inferred from direct assayⁱ
- 15051727
determination of left/right symmetry Source: UniProtKB
embryonic heart tube left/right pattern formation Source: BHF-UCL
heart development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 16287139
left/right axis specification Source: BHF-UCL
liver development Source: BHF-UCL
negative regulation of apoptotic process Source: BHF-UCL
negative regulation of cell migration
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18054336
negative regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 15051727
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15051727
negative regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 17906695
negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
Source: BHF-UCL
Inferred from direct assayⁱ
- 22735262
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry Source: BHF-UCL
outflow tract morphogenesis Source: BHF-UCL
positive regulation of cell-cell adhesion Source: BHF-UCL
positive regulation of cell cycle Source: UniProtKB
positive regulation of gene expression
Source: UniProtKB
Inferred from direct assayⁱ
- 15051727
positive regulation of male gonad development Source: UniProtKB
positive regulation of peroxisome proliferator activated receptor signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 15051727
positive regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 15051727
- 9434189
positive regulation of transcription by RNA polymerase II
Source: BHF-UCL
Inferred from direct assayⁱ
- 22735262
positive regulation of transforming growth factor beta receptor signaling pathway Source: UniProtKB
regulation of animal organ formation Source: UniProtKB
regulation of transcription by RNA polymerase II
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
response to estrogen
Source: UniProtKB
Inferred from direct assayⁱ
- 11581164
response to fluid shear stress
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 12960175
response to hypoxia
Source: UniProtKB
Inferred from direct assayⁱ
- 9887100
sex determination Source: UniProtKB
spleen development Source: BHF-UCL
ventricular septum morphogenesis Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, Developmental protein, Repressor
Biological process	Differentiation, Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
SIGNORⁱ	Q99967

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cbp/p300-interacting transactivator 2 Alternative name(s): MSG-related protein 1 Short name: MRG-1 P35srj
Gene namesⁱ	Name:CITED2 Synonyms:MRG1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000164442.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1987 CITED2
MIMⁱ	602937 gene
neXtProtⁱ	NX_Q99967

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Ventricular septal defect 2 (VSD2)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA common form of congenital cardiovascular anomaly that may occur alone or in combination with other cardiac malformations. It can affect any portion of the ventricular septum, resulting in abnormal communications between the two lower chambers of the heart. Classification is based on location of the communication, such as perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular defect. Large defects that go unrepaired may give rise to cardiac enlargement, congestive heart failure, pulmonary hypertension, Eisenmenger's syndrome, delayed fetal brain development, arrhythmias, and even sudden cardiac death.

Atrial septal defect 8 (ASD8)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA congenital heart malformation characterized by incomplete closure of the wall between the atria resulting in blood flow from the left to the right atria.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_067584	179	S → GGSSTPGGS in ASD8; demonstrates only about 75% of the repressive activity of wild-type.		1
Natural variantⁱVAR_067585	198 – 199	Missing in ASD8; demonstrates only about 75% of the repressive activity of wild-type. 1 Publication		2

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	243 – 246	Missing : Inhibits transactivation activity. 1 Publication	4
Mutagenesisⁱ	243	L → E: Inhibits transactivation activity; when associated with E-246. 1 Publication	1
Mutagenesisⁱ	246	L → E: Inhibits transactivation activity; when associated with E-243. 1 Publication	1

Keywords - Diseaseⁱ

Atrial septal defect, Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10370
MalaCards human disease database More...MalaCardsⁱ	CITED2
MIMⁱ	614431 phenotype 614433 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000164442
Orphanetⁱ	99103 Atrial septal defect, ostium secundum type 99105 Atrial septal defect, sinus venosus type 1480 NON RARE IN EUROPE: Ventricular septal defect 101063 Situs inversus totalis 3303 Tetralogy of Fallot
PharmGKBⁱ	PA26524

Polymorphism and mutation databases

BioMutaⁱ	CITED2
DMDMⁱ	21542403

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000144726	1 – 270	Cbp/p300-interacting transactivator 2Add BLAST		270

Proteomic databases

EPDⁱ	Q99967
PaxDbⁱ	Q99967
PeptideAtlas More...PeptideAtlasⁱ	Q99967
PRIDEⁱ	Q99967
ProteomicsDBⁱ	78555 78556 [Q99967-2]

PTM databases

iPTMnetⁱ	Q99967
PhosphoSitePlusⁱ	Q99967

Expressionⁱ

Inductionⁱ

By hypoxia and deferoxamine.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000164442 Expressed in 228 organ(s), highest expression level in female gonad
CleanExⁱ	HS_CITED2
ExpressionAtlasⁱ	Q99967 baseline and differential
Genevisibleⁱ	Q99967 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB016157 CAB069879

HPAⁱ

CAB016157
CAB069879

Interactionⁱ

Subunit structureⁱ

Interacts (via C-terminus) with SMAD2. Interacts (via C-terminus) with SMAD3 (via MH2 domain). Interacts with LHX2 (via LIM domains). Interacts with WT1 (By similarity). Interacts (via C-terminus) with EP300 (via CH1 domain); the interaction is stimulated in response to hypoxia. Interacts with PPARA. Interacts (via C-terminus) with TFAP2A, TFAP2B and TFAP2C.By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
EP300	Q09472	3	EBI-937732,EBI-447295
HNF4A	P41235	3	EBI-937732,EBI-1049011
TFAP2C	Q92754	2	EBI-937732,EBI-937309

GO - Molecular functionⁱ

histone acetyltransferase binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 22735262
LBD domain binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 15051727
protein domain specific binding
Source: CAFA
Inferred from physical interactionⁱ
- 14594809

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	115649, 13 interactors
IntActⁱ	Q99967, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q99967
STRINGⁱ	9606.ENSP00000356623

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	221 – 223	Combined sources	3
Helixⁱ	227 – 235	Combined sources	9
Beta strandⁱ	237 – 239	Combined sources	3
Helixⁱ	251 – 253	Combined sources	3
Helixⁱ	254 – 256	Combined sources	3
Helixⁱ	266 – 268	Combined sources	3

Show more details

3D structure databases

Database of protein disorder More...DisProtⁱ	DP00356
ProteinModelPortalⁱ	Q99967
SMRⁱ	Q99967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99967

EvolutionaryTraceⁱ

Q99967

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	21 – 57	His-richAdd BLAST	37
Compositional biasⁱ	162 – 199	Gly-richAdd BLAST	38
Compositional biasⁱ	219 – 258	Asp/Glu-rich (acidic)Add BLAST	40

Sequence similaritiesⁱ

Belongs to the CITED family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IH9P Eukaryota ENOG410Y09Y LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063624
HOGENOMⁱ	HOG000231079
HOVERGENⁱ	HBG075182
InParanoidⁱ	Q99967
KEGG Orthology (KO) More...KOⁱ	K21361
PhylomeDBⁱ	Q99967
TreeFamⁱ	TF331915

Family and domain databases

InterProⁱ	View protein in InterPro IPR007576 CITED
PANTHERⁱ	PTHR17045 PTHR17045, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF04487 CITED, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q99967-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA 
        60         70         80         90        100
LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG 
       110        120        130        140        150
PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN 
       160        170        180        190        200
QHFRDCNPKH SGGSSTPGGS GGSSTPGGSG SSSGGGAGSS NSGGGSGSGN 
       210        220        230        240        250
MPASVAHVPA AMLPPNVIDT DFIDEEVLMS LVIEMGLDRI KELPELWLGQ 
       260        270
NEFDFMTDFV CKQQPSRVSC

Length:270

Mass (Da):28,497

Last modified:June 20, 2002 - v2

Checksum:ⁱ45DDE3A9E2B4C472

GO

Isoform 2 (identifier: Q99967-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
159-215: Missing.

« Hide

        10         20         30         40         50
MADHMMAMNH GRFPDGTNGL HHHPAHRMGM GQFPSPHHHQ QQQPQHAFNA 
        60         70         80         90        100
LMGEHIHYGA GNMNATSGIR HAMGPGTVNG GHPPSALAPA ARFNNSQFMG 
       110        120        130        140        150
PPVASQGGSL PASMQLQKLN NQYFNHHPYP HNHYMPDLHP AAGHQMNGTN 
       160        170        180        190        200
QHFRDCNPNV IDTDFIDEEV LMSLVIEMGL DRIKELPELW LGQNEFDFMT 
       210 
DFVCKQQPSR VSC

Show »

Length:213

Mass (Da):23,732

Checksum:ⁱC91FAABA3D2A9AD1

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A0A0MTM3	A0A0A0MTM3_HUMAN		Cbp/p300-interacting transactivator... Cbp/p300-interacting transactivator 2	CITED2	275	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_067583	170 – 178	Missing in VSD2; reduces coactivation of the TFAP2C gene to 50% of that obtained with wild-type and represses HIF1A with about 60% efficiency compared to wild-type. 1 Publication	9
Natural variantⁱVAR_067584	179	S → GGSSTPGGS in ASD8; demonstrates only about 75% of the repressive activity of wild-type.	1
Natural variantⁱVAR_067585	198 – 199	Missing in ASD8; demonstrates only about 75% of the repressive activity of wild-type. 1 Publication	2

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_001089	159 – 215	Missing in isoform 2. 1 PublicationAdd BLAST		57

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65093 mRNA Translation: AAC51114.1 AF129290 Genomic DNA Translation: AAF01263.1 AF129290 Genomic DNA Translation: AAF01264.1 AF109161 mRNA Translation: AAD10055.1 AL592429 Genomic DNA No translation available. BC004377 mRNA Translation: AAH04377.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5195.1 [Q99967-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001161860.1, NM_001168388.2 [Q99967-1] NP_001161861.2, NM_001168389.2 NP_006070.2, NM_006079.4 [Q99967-1]
UniGeneⁱ	Hs.82071

Genome annotation databases

Ensemblⁱ	ENST00000367651; ENSP00000356623; ENSG00000164442 [Q99967-1] ENST00000536159; ENSP00000442831; ENSG00000164442 [Q99967-1] ENST00000618718; ENSP00000479918; ENSG00000164442 [Q99967-2]
GeneIDⁱ	10370
KEGGⁱ	hsa:10370
UCSC genome browser More...UCSCⁱ	uc003qip.3 human [Q99967-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99967	Cbp/p300-interacting transactivator 2		HUMAN		275	UniRef100_Q99967
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2		HUMAN		270
Q99967-2	CITED2 isoform 4		PONAB		213	UniRef100_A0A2J8X9X3
CITED2 isoform 2		PANTR		213

Protein	Similar proteins		Species	Score	Length	Source
Q99967	Cbp/p300-interacting transactivator 2		MOUSE		269	UniRef90_O35740
Cbp/p300-interacting transactivator 2		BOVIN		273
Cbp/p300-interacting transactivator 2		SAGLB		273
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2		CALJA		278
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2		GORGO		278
+82
Q99967-2	Isoform 3 of Cbp/p300-interacting transactivator 2		MOUSE		214	UniRef90_O35740-3
Uncharacterized protein		MACMU		213
cbp/p300-interacting transactivator 2		TARSY		213
CITED2 isoform 4		PONAB		213
CITED2 isoform 2		PANTR		213
+8

Protein	Similar proteins		Species	Score	Length	Source
Q99967	Cbp/p300-interacting transactivator 2		MOUSE		269	UniRef50_O35740
Cbp/p300-interacting transactivator 2		SAGLB		273
Cbp/p300-interacting transactivator 2		BOVIN		273
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2		CALJA		278
Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2		FELCA		278
+97
Q99967-2	Isoform 3 of Cbp/p300-interacting transactivator 2		MOUSE		214	UniRef50_O35740-3
cbp/p300-interacting transactivator 2		TARSY		213
Uncharacterized protein		MACMU		213
CITED2 isoform 4		PONAB		213
CITED2 isoform 2		PANTR		213
+14

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U65093 mRNA Translation: AAC51114.1 AF129290 Genomic DNA Translation: AAF01263.1 AF129290 Genomic DNA Translation: AAF01264.1 AF109161 mRNA Translation: AAD10055.1 AL592429 Genomic DNA No translation available. BC004377 mRNA Translation: AAH04377.1
CCDSⁱ	CCDS5195.1 [Q99967-1]
RefSeqⁱ	NP_001161860.1, NM_001168388.2 [Q99967-1] NP_001161861.2, NM_001168389.2 NP_006070.2, NM_006079.4 [Q99967-1]
UniGeneⁱ	Hs.82071

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1P4Q	NMR	-	A	216-259	[»]
	1R8U	NMR	-	A	220-269	[»]
DisProtⁱ	DP00356
ProteinModelPortalⁱ	Q99967
SMRⁱ	Q99967
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	115649, 13 interactors
IntActⁱ	Q99967, 7 interactors
MINTⁱ	Q99967
STRINGⁱ	9606.ENSP00000356623

PTM databases

iPTMnetⁱ	Q99967
PhosphoSitePlusⁱ	Q99967

Polymorphism and mutation databases

BioMutaⁱ	CITED2
DMDMⁱ	21542403

Proteomic databases

EPDⁱ	Q99967
PaxDbⁱ	Q99967
PeptideAtlasⁱ	Q99967
PRIDEⁱ	Q99967
ProteomicsDBⁱ	78555 78556 [Q99967-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	10370
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000367651; ENSP00000356623; ENSG00000164442 [Q99967-1] ENST00000536159; ENSP00000442831; ENSG00000164442 [Q99967-1] ENST00000618718; ENSP00000479918; ENSG00000164442 [Q99967-2]
GeneIDⁱ	10370
KEGGⁱ	hsa:10370
UCSCⁱ	uc003qip.3 human [Q99967-1]

Organism-specific databases

CTDⁱ	10370
DisGeNETⁱ	10370
EuPathDBⁱ	HostDB:ENSG00000164442.9
GeneCardsⁱ	CITED2
H-InvDBⁱ	HIX0006261
HGNCⁱ	HGNC:1987 CITED2
HPAⁱ	CAB016157 CAB069879
MalaCardsⁱ	CITED2
MIMⁱ	602937 gene 614431 phenotype 614433 phenotype
neXtProtⁱ	NX_Q99967
OpenTargetsⁱ	ENSG00000164442
Orphanetⁱ	99103 Atrial septal defect, ostium secundum type 99105 Atrial septal defect, sinus venosus type 1480 NON RARE IN EUROPE: Ventricular septal defect 101063 Situs inversus totalis 3303 Tetralogy of Fallot
PharmGKBⁱ	PA26524
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IH9P Eukaryota ENOG410Y09Y LUCA
GeneTreeⁱ	ENSGT00530000063624
HOGENOMⁱ	HOG000231079
HOVERGENⁱ	HBG075182
InParanoidⁱ	Q99967
KOⁱ	K21361
PhylomeDBⁱ	Q99967
TreeFamⁱ	TF331915

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
SIGNORⁱ	Q99967

Miscellaneous databases

ChiTaRSⁱ	CITED2 human
EvolutionaryTraceⁱ	Q99967
GeneWikiⁱ	CITED2
GenomeRNAiⁱ	10370
Protein Ontology More...PROⁱ	PR:Q99967
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000164442 Expressed in 228 organ(s), highest expression level in female gonad
CleanExⁱ	HS_CITED2
ExpressionAtlasⁱ	Q99967 baseline and differential
Genevisibleⁱ	Q99967 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007576 CITED
PANTHERⁱ	PTHR17045 PTHR17045, 1 hit
Pfamⁱ	View protein in Pfam PF04487 CITED, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CITE2_HUMAN
Accessionⁱ	Q99967Primary (citable) accession number: Q99967 Secondary accession number(s): O95426, Q5VTF4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	June 20, 2002
	Last modified:	November 7, 2018
	This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q99967 (CITE2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cbp/p300-interacting transactivator 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ