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Entry version 152 (05 Jun 2019)
Sequence version 2 (18 May 2010)
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Protein

Cbp/p300-interacting transactivator 1

Gene

CITED1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcriptional coactivator of the p300/CBP-mediated transcription complex. Enhances SMAD-mediated transcription by strengthening the functional link between the DNA-binding SMAD transcription factors and the p300/CBP transcription coactivator complex. Stimulates estrogen-dependent transactivation activity mediated by estrogen receptors signaling; stabilizes the interaction of estrogen receptor ESR1 and histone acetyltransferase EP300. Positively regulates TGF-beta signaling through its association with the SMAD/p300/CBP-mediated transcriptional coactivator complex. Induces transcription from estrogen-responsive promoters and protection against cell death. Potentiates EGR2-mediated transcriptional activation activity from the ERBB2 promoter. Acts as an inhibitor of osteoblastic mineralization through a cAMP-dependent parathyroid hormone receptor signaling. May play a role in pigmentation of melanocytes. Associates with chromatin to the estrogen-responsive TGF-alpha promoter region in a estrogen-dependent manner.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, Developmental protein
Biological processApoptosis, Differentiation, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

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SIGNORi
Q99966

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cbp/p300-interacting transactivator 1
Alternative name(s):
Melanocyte-specific protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CITED1
Synonyms:MSG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1986 CITED1

Online Mendelian Inheritance in Man (OMIM)

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MIMi
300149 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99966

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi16S → A: Reduces strongly phosphorylation but does not interfere with its NES-dependent nuclear export; when associated with A-63; A-67; A-71 and A-137. 1 Publication1
Mutagenesisi63S → A: Reduces strongly phosphorylation but does not interfere with its NES-dependent nuclear export; when associated with A-16; A-67; A-71 and A-137. 1 Publication1
Mutagenesisi67S → A: Reduces strongly phosphorylation but does not interfere with its NES-dependent nuclear export; when associated with A-16; A-63; A-71 and A-137. 1 Publication1
Mutagenesisi71S → A: Reduces strongly phosphorylation but does not interfere with its NES-dependent nuclear export; when associated with A-16; A-63; A-67 and A-137. 1 Publication1
Mutagenesisi91L → A: Does not change subcellular localization; when associated with A-95. 1
Mutagenesisi95M → A: Does not change subcellular localization; when associated with A-91. 1
Mutagenesisi137S → A: Reduces strongly phosphorylation; when associated with A-16; A-63; A-67 and A-71. 1 Publication1
Mutagenesisi155 – 156EE → AA: Does not inhibit interaction with ESR1 and ER-coactivation activity. 1 Publication2
Mutagenesisi157 – 158VL → AA: Inhibits interaction with ESR1 and ER-coactivation activity. 1 Publication2
Mutagenesisi159 – 160MS → AA: Does not inhibit interaction with ESR1 and ER-coactivation activity. 1 Publication2
Mutagenesisi161 – 162LV → AA: Does not inhibit interaction with ESR1 and ER-coactivation activity. 1 Publication2
Mutagenesisi163 – 164VE → AA: Does not inhibit interaction with ESR1 and ER-coactivation activity. 1 Publication2
Mutagenesisi165L → A: Does not inhibit interaction with ESR1 and ER-coactivation activity. Localizes mainly in the nucleus; when associated with A-167. 1 Publication1
Mutagenesisi166 – 167GL → AA: Does not inhibit interaction with ESR1 and ER-coactivation activity. Localizes mainly in the nucleus; when associated with A-165. 1 Publication2
Mutagenesisi176L → A: Does not change subcellular localization; when associated with A-178. 1
Mutagenesisi178L → A: Does not change subcellular localization; when associated with A-176. 1

Organism-specific databases

DisGeNET

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DisGeNETi
4435

Open Targets

More...
OpenTargetsi
ENSG00000125931

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA26523

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CITED1

Domain mapping of disease mutations (DMDM)

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DMDMi
296434447

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001447241 – 193Cbp/p300-interacting transactivator 1Add BLAST193

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated. Phosphorylation changes in a cell cycle-dependent manner and reduces its transcriptional coactivator activity.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99966

PeptideAtlas

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PeptideAtlasi
Q99966

PRoteomics IDEntifications database

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PRIDEi
Q99966

ProteomicsDB human proteome resource

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ProteomicsDBi
78553
78554 [Q99966-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99966

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99966

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed only in melanocytes and testis.

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by GPR39 in neuronal cells.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000125931 Expressed in 125 organ(s), highest expression level in right testis

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99966 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99966 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA049051

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts (via C-terminus) with CREBBP. Interacts with EGR2 (By similarity). Homodimer. Binds to RBM14. Interacts (via N-terminus) with HSPA8; the interaction suppresses the association of CITED1 with p300/CBP and SMAD-mediated transcription transactivation. Interacts (via C-terminus) with TOX3 (via HGM box); the interaction increases estrogen-response element (ERE)-dependent transcription and protection against cell death. Interacts with ESR1; the interaction occurs in a estrogen-dependent manner (By similarity). Interacts (unphosphorylated form preferentially and via C-terminus) with EP300.By similarity6 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
110572, 8 interactors

CORUM comprehensive resource of mammalian protein complexes

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CORUMi
Q99966

Protein interaction database and analysis system

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IntActi
Q99966, 7 interactors

Molecular INTeraction database

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MINTi
Q99966

STRING: functional protein association networks

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STRINGi
9606.ENSP00000401764

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99966

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi158 – 167Nuclear export signal10

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi149 – 188Asp/Glu-rich (acidic)Add BLAST40

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the CITED family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410J22W Eukaryota
ENOG4111X66 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00530000063624

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000072675

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99966

KEGG Orthology (KO)

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KOi
K22527

Identification of Orthologs from Complete Genome Data

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OMAi
TKPPPFN

Database of Orthologous Groups

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OrthoDBi
1378769at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99966

TreeFam database of animal gene trees

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TreeFami
TF331915

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR007576 CITED

The PANTHER Classification System

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PANTHERi
PTHR17045 PTHR17045, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF04487 CITED, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99966-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPTTSRPALD VKGGTSPAKE DANQEMSSVA YSNLAVKDRK AVAILHYPGV
60 70 80 90 100
ASNGTKASGA PTSSSGSPIG SPTTTPPTKP PSFNLHPAPH LLASMHLQKL
110 120 130 140 150
NSQYQGMAAA TPGQPGEAGP LQNWDFGAQA GGAESLSPSA GAQSPAIIDS
160 170 180 190
DPVDEEVLMS LVVELGLDRA NELPELWLGQ NEFDFTADFP SSC
Length:193
Mass (Da):19,896
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9B0CF50CA639ECCB
GO
Isoform 2 (identifier: Q99966-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEPSAQQLQLAASLPANLSNFCQGSEM

Note: No experimental confirmation available.
Show »
Length:219
Mass (Da):22,613
Checksum:iCB89284B2F0B952B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JRD8C9JRD8_HUMAN
Cbp/p300-interacting transactivator...
CITED1
140Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J7P8C9J7P8_HUMAN
Cbp/p300-interacting transactivator...
CITED1
109Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J300C9J300_HUMAN
Cbp/p300-interacting transactivator...
CITED1
138Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2S6H7C2S6_HUMAN
Cbp/p300-interacting transactivator...
CITED1
106Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J1P6C9J1P6_HUMAN
Cbp/p300-interacting transactivator...
CITED1
59Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence N30508 differs from that shown. Reason: Frameshift at position 67.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05303896H → Q4 PublicationsCorresponds to variant dbSNP:rs3012627Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0398971M → MEPSAQQLQLAASLPANLSN FCQGSEM in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U65092 mRNA Translation: AAC51113.1
AB451286 mRNA Translation: BAG70100.1
AB451418 mRNA Translation: BAG70232.1
AL135749 Genomic DNA No translation available.
CH471213 Genomic DNA Translation: EAW71819.1
BC004240 mRNA Translation: AAH04240.1
N30508 mRNA No translation available.

The Consensus CDS (CCDS) project

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CCDSi
CCDS14419.1 [Q99966-1]
CCDS48136.1 [Q99966-2]

Protein sequence database of the Protein Information Resource

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PIRi
JC6114

NCBI Reference Sequences

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RefSeqi
NP_001138357.1, NM_001144885.1 [Q99966-2]
NP_001138358.1, NM_001144886.1 [Q99966-1]
NP_001138359.1, NM_001144887.1 [Q99966-1]
NP_004134.2, NM_004143.3 [Q99966-1]
XP_011529260.1, XM_011530958.1 [Q99966-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000246139; ENSP00000246139; ENSG00000125931 [Q99966-1]
ENST00000373619; ENSP00000362721; ENSG00000125931 [Q99966-1]
ENST00000431381; ENSP00000388548; ENSG00000125931 [Q99966-2]
ENST00000445983; ENSP00000403274; ENSG00000125931 [Q99966-1]
ENST00000453707; ENSP00000401764; ENSG00000125931 [Q99966-2]
ENST00000651998; ENSP00000499148; ENSG00000125931 [Q99966-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
4435

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:4435

UCSC genome browser

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UCSCi
uc004eas.4 human [Q99966-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U65092 mRNA Translation: AAC51113.1
AB451286 mRNA Translation: BAG70100.1
AB451418 mRNA Translation: BAG70232.1
AL135749 Genomic DNA No translation available.
CH471213 Genomic DNA Translation: EAW71819.1
BC004240 mRNA Translation: AAH04240.1
N30508 mRNA No translation available.
CCDSiCCDS14419.1 [Q99966-1]
CCDS48136.1 [Q99966-2]
PIRiJC6114
RefSeqiNP_001138357.1, NM_001144885.1 [Q99966-2]
NP_001138358.1, NM_001144886.1 [Q99966-1]
NP_001138359.1, NM_001144887.1 [Q99966-1]
NP_004134.2, NM_004143.3 [Q99966-1]
XP_011529260.1, XM_011530958.1 [Q99966-2]

3D structure databases

SMRiQ99966
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110572, 8 interactors
CORUMiQ99966
IntActiQ99966, 7 interactors
MINTiQ99966
STRINGi9606.ENSP00000401764

PTM databases

iPTMnetiQ99966
PhosphoSitePlusiQ99966

Polymorphism and mutation databases

BioMutaiCITED1
DMDMi296434447

Proteomic databases

PaxDbiQ99966
PeptideAtlasiQ99966
PRIDEiQ99966
ProteomicsDBi78553
78554 [Q99966-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
4435
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000246139; ENSP00000246139; ENSG00000125931 [Q99966-1]
ENST00000373619; ENSP00000362721; ENSG00000125931 [Q99966-1]
ENST00000431381; ENSP00000388548; ENSG00000125931 [Q99966-2]
ENST00000445983; ENSP00000403274; ENSG00000125931 [Q99966-1]
ENST00000453707; ENSP00000401764; ENSG00000125931 [Q99966-2]
ENST00000651998; ENSP00000499148; ENSG00000125931 [Q99966-1]
GeneIDi4435
KEGGihsa:4435
UCSCiuc004eas.4 human [Q99966-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
4435
DisGeNETi4435

GeneCards: human genes, protein and diseases

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GeneCardsi
CITED1

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0016869
HGNCiHGNC:1986 CITED1
HPAiHPA049051
MIMi300149 gene
neXtProtiNX_Q99966
OpenTargetsiENSG00000125931
PharmGKBiPA26523

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410J22W Eukaryota
ENOG4111X66 LUCA
GeneTreeiENSGT00530000063624
HOGENOMiHOG000072675
InParanoidiQ99966
KOiK22527
OMAiTKPPPFN
OrthoDBi1378769at2759
PhylomeDBiQ99966
TreeFamiTF331915

Enzyme and pathway databases

ReactomeiR-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-9018519 Estrogen-dependent gene expression
SIGNORiQ99966

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CITED1 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CITED1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
4435

Protein Ontology

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PROi
PR:Q99966

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000125931 Expressed in 125 organ(s), highest expression level in right testis
ExpressionAtlasiQ99966 baseline and differential
GenevisibleiQ99966 HS

Family and domain databases

InterProiView protein in InterPro
IPR007576 CITED
PANTHERiPTHR17045 PTHR17045, 1 hit
PfamiView protein in Pfam
PF04487 CITED, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCITE1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99966
Secondary accession number(s): B5BU50, B5BUI2
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 18, 2010
Last modified: June 5, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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