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Protein

Dual specificity protein phosphatase 9

Gene

DUSP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inactivates MAP kinases. Has a specificity for the ERK family.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei290Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • MAP kinase tyrosine/serine/threonine phosphatase activity Source: GO_Central
  • phosphoprotein phosphatase activity Source: ProtInc
  • protein tyrosine/serine/threonine phosphatase activity Source: GO_Central
  • protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkiQ99956
SIGNORiQ99956

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 9 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 4
Short name:
MAP kinase phosphatase 4
Short name:
MKP-4
Gene namesi
Name:DUSP9
Synonyms:MKP4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000130829.17
HGNCiHGNC:3076 DUSP9
MIMi300134 gene
neXtProtiNX_Q99956

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi1852
OpenTargetsiENSG00000130829
PharmGKBiPA27533

Polymorphism and mutation databases

BioMutaiDUSP9
DMDMi3913541

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000948121 – 384Dual specificity protein phosphatase 9Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei16PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99956
MaxQBiQ99956
PaxDbiQ99956
PeptideAtlasiQ99956
PRIDEiQ99956
ProteomicsDBi78541

PTM databases

DEPODiQ99956
iPTMnetiQ99956
PhosphoSitePlusiQ99956

Expressioni

Gene expression databases

BgeeiENSG00000130829 Expressed in 81 organ(s), highest expression level in liver
CleanExiHS_DUSP9
GenevisibleiQ99956 HS

Organism-specific databases

HPAiHPA003336

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi108185, 68 interactors
IntActiQ99956, 14 interactors
MINTiQ99956
STRINGi9606.ENSP00000345853

Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99956
SMRiQ99956
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99956

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 139RhodanesePROSITE-ProRule annotationAdd BLAST122
Domaini203 – 384Tyrosine-protein phosphataseAdd BLAST182

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1717 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294079
HOVERGENiHBG007347
InParanoidiQ99956
KOiK18498
OMAiYLMQKRH
OrthoDBiEOG091G0249
PhylomeDBiQ99956
TreeFamiTF105122

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequencei

Sequence statusi: Complete.

Q99956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL
60 70 80 90 100
LRRLRRGSLS VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW
110 120 130 140 150
EAESVLGTLL QKLREEGYLA YYLQGGFSRF QAECPHLCET SLAGRAGSSM
160 170 180 190 200
APVPGPVPVV GLGSLCLGSD CSDAESEADR DSMSCGLDSE GATPPPVGLR
210 220 230 240 250
ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL PNFFEKNGDF
260 270 280 290 300
HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV
310 320 330 340 350
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH
360 370 380
SQEQGSGGQA SAASNPPSFF TTPTSDGAFE LAPT
Length:384
Mass (Da):41,868
Last modified:May 1, 1997 - v1
Checksum:iF8598CA95AB379B7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08302 mRNA Translation: CAA69610.1
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72847.1
CH471172 Genomic DNA Translation: EAW72848.1
CH471172 Genomic DNA Translation: EAW72849.1
CCDSiCCDS14724.1
RefSeqiNP_001305432.1, NM_001318503.1
NP_001386.1, NM_001395.3
XP_011529426.1, XM_011531124.1
UniGeneiHs.144879
Hs.744909

Genome annotation databases

EnsembliENST00000342782; ENSP00000345853; ENSG00000130829
ENST00000370167; ENSP00000359186; ENSG00000130829
GeneIDi1852
KEGGihsa:1852
UCSCiuc004fhx.5 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08302 mRNA Translation: CAA69610.1
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72847.1
CH471172 Genomic DNA Translation: EAW72848.1
CH471172 Genomic DNA Translation: EAW72849.1
CCDSiCCDS14724.1
RefSeqiNP_001305432.1, NM_001318503.1
NP_001386.1, NM_001395.3
XP_011529426.1, XM_011531124.1
UniGeneiHs.144879
Hs.744909

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HXPX-ray1.83A201-345[»]
3LJ8X-ray2.70A202-347[»]
ProteinModelPortaliQ99956
SMRiQ99956
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108185, 68 interactors
IntActiQ99956, 14 interactors
MINTiQ99956
STRINGi9606.ENSP00000345853

PTM databases

DEPODiQ99956
iPTMnetiQ99956
PhosphoSitePlusiQ99956

Polymorphism and mutation databases

BioMutaiDUSP9
DMDMi3913541

Proteomic databases

EPDiQ99956
MaxQBiQ99956
PaxDbiQ99956
PeptideAtlasiQ99956
PRIDEiQ99956
ProteomicsDBi78541

Protocols and materials databases

DNASUi1852
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342782; ENSP00000345853; ENSG00000130829
ENST00000370167; ENSP00000359186; ENSG00000130829
GeneIDi1852
KEGGihsa:1852
UCSCiuc004fhx.5 human

Organism-specific databases

CTDi1852
DisGeNETi1852
EuPathDBiHostDB:ENSG00000130829.17
GeneCardsiDUSP9
HGNCiHGNC:3076 DUSP9
HPAiHPA003336
MIMi300134 gene
neXtProtiNX_Q99956
OpenTargetsiENSG00000130829
PharmGKBiPA27533
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1717 Eukaryota
COG2453 LUCA
GeneTreeiENSGT00760000118902
HOGENOMiHOG000294079
HOVERGENiHBG007347
InParanoidiQ99956
KOiK18498
OMAiYLMQKRH
OrthoDBiEOG091G0249
PhylomeDBiQ99956
TreeFamiTF105122

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-112409 RAF-independent MAPK1/3 activation
R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkiQ99956
SIGNORiQ99956

Miscellaneous databases

ChiTaRSiDUSP9 human
EvolutionaryTraceiQ99956
GenomeRNAii1852
PROiPR:Q99956
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130829 Expressed in 81 organ(s), highest expression level in liver
CleanExiHS_DUSP9
GenevisibleiQ99956 HS

Family and domain databases

CDDicd00127 DSPc, 1 hit
Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340 Dual-sp_phosphatase_cat-dom
IPR024950 DUSP
IPR008343 MKP
IPR029021 Prot-tyrosine_phosphatase-like
IPR001763 Rhodanese-like_dom
IPR036873 Rhodanese-like_dom_sf
IPR000387 TYR_PHOSPHATASE_dom
IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERiPTHR10159 PTHR10159, 1 hit
PfamiView protein in Pfam
PF00782 DSPc, 1 hit
PF00581 Rhodanese, 1 hit
PIRSFiPIRSF000939 MAPK_Ptase, 1 hit
PRINTSiPR01764 MAPKPHPHTASE
SMARTiView protein in SMART
SM00195 DSPc, 1 hit
SM00450 RHOD, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
SSF52821 SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206 RHODANESE_3, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDUS9_HUMAN
AccessioniPrimary (citable) accession number: Q99956
Secondary accession number(s): D3DWU5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: November 7, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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