UniProtKB - Q99956 (DUS9_HUMAN)

BLAST

>sp|Q99956|DUS9_HUMAN Dual specificity protein phosphatase 9 OS=Homo sapiens OX=9606 GN=DUSP9 PE=1 SV=1
MEGLGRSCLWLRRELSPPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLS
VRALLPGPPLQPPPPAPVLLYDQGGGRRRRGEAEAEAEEWEAESVLGTLLQKLREEGYLA
YYLQGGFSRFQAECPHLCETSLAGRAGSSMAPVPGPVPVVGLGSLCLGSDCSDAESEADR
DSMSCGLDSEGATPPPVGLRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNL
PNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERHSQEQGSGGQA
SAASNPPSFFTTPTSDGAFELAPT

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History
Entry version 161 (07 Nov 2018)
Sequence version 1 (01 May 1997)
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Protein

Dual specificity protein phosphatase 9

Gene

DUSP9

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Inactivates MAP kinases. Has a specificity for the ERK family.

Catalytic activityⁱ

Protein tyrosine phosphate + H₂O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H₂O = [a protein]-serine/threonine + phosphate.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Active siteⁱ	290	Phosphocysteine intermediateBy similarity		1

GO - Molecular functionⁱ

MAP kinase tyrosine/serine/threonine phosphatase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
phosphoprotein phosphatase activity
Source: ProtInc
Traceable author statementⁱ
- 9030581
protein tyrosine/serine/threonine phosphatase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein tyrosine phosphatase activity Source: UniProtKB-EC

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of MAPK activity Source: Reactome
inactivation of MAPK activity
Source: ProtInc
Traceable author statementⁱ
- 9030581
JNK cascade
Source: ProtInc
Traceable author statementⁱ
- 9030581
MAPK cascade Source: Reactome
protein dephosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Hydrolase, Protein phosphatase

Molecular function

Hydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkⁱ	Q99956
SIGNORⁱ	Q99956

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Dual specificity protein phosphatase 9 (EC:3.1.3.16, EC:3.1.3.48) Alternative name(s): Mitogen-activated protein kinase phosphatase 4 Short name: MAP kinase phosphatase 4 Short name: MKP-4
Gene namesⁱ	Name:DUSP9 Synonyms:MKP4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000130829.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:3076 DUSP9
MIMⁱ	300134 gene
neXtProtⁱ	NX_Q99956

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1852
Open Targets More...OpenTargetsⁱ	ENSG00000130829
PharmGKBⁱ	PA27533

Polymorphism and mutation databases

BioMutaⁱ	DUSP9
DMDMⁱ	3913541

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000094812	1 – 384	Dual specificity protein phosphatase 9Add BLAST		384

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	16	PhosphoserineCombined sources	1
Modified residueⁱ	262	PhosphoserineCombined sources	1
Modified residueⁱ	351	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q99956
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99956
PaxDbⁱ	Q99956
PeptideAtlas More...PeptideAtlasⁱ	Q99956
PRIDEⁱ	Q99956
ProteomicsDBⁱ	78541

PTM databases

DEPODⁱ	Q99956
iPTMnetⁱ	Q99956
PhosphoSitePlusⁱ	Q99956

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000130829 Expressed in 81 organ(s), highest expression level in liver
CleanExⁱ	HS_DUSP9
Genevisibleⁱ	Q99956 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA003336

HPAⁱ

HPA003336

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
MAPK14	Q16539	2	EBI-3906678,EBI-73946
Mapk14	P47811	2	EBI-3906678,EBI-298727	From Mus musculus.

Protein-protein interaction databases

BioGridⁱ	108185, 68 interactors
IntActⁱ	Q99956, 14 interactors
Molecular INTeraction database More...MINTⁱ	Q99956
STRINGⁱ	9606.ENSP00000345853

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	205 – 208	Combined sources	4
Beta strandⁱ	211 – 214	Combined sources	4
Helixⁱ	218 – 220	Combined sources	3
Helixⁱ	222 – 227	Combined sources	6
Beta strandⁱ	230 – 235	Combined sources	6
Beta strandⁱ	237 – 239	Combined sources	3
Turnⁱ	243 – 246	Combined sources	4
Beta strandⁱ	251 – 254	Combined sources	4
Helixⁱ	259 – 264	Combined sources	6
Helixⁱ	265 – 281	Combined sources	17
Beta strandⁱ	285 – 289	Combined sources	5
Beta strandⁱ	291 – 295	Combined sources	5
Helixⁱ	296 – 309	Combined sources	14
Helixⁱ	313 – 323	Combined sources	11
Helixⁱ	331 – 344	Combined sources	14

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99956
SMRⁱ	Q99956
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99956

EvolutionaryTraceⁱ

Q99956

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	18 – 139	RhodanesePROSITE-ProRule annotationAdd BLAST		122
Domainⁱ	203 – 384	Tyrosine-protein phosphataseAdd BLAST		182

Sequence similaritiesⁱ

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1717 Eukaryota COG2453 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118902
HOGENOMⁱ	HOG000294079
HOVERGENⁱ	HBG007347
InParanoidⁱ	Q99956
KEGG Orthology (KO) More...KOⁱ	K18498
OMAⁱ	YLMQKRH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0249
PhylomeDBⁱ	Q99956
TreeFamⁱ	TF105122

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00127 DSPc, 1 hit
Gene3Dⁱ	3.40.250.10, 1 hit 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR000340 Dual-sp_phosphatase_cat-dom IPR024950 DUSP IPR008343 MKP IPR029021 Prot-tyrosine_phosphatase-like IPR001763 Rhodanese-like_dom IPR036873 Rhodanese-like_dom_sf IPR000387 TYR_PHOSPHATASE_dom IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERⁱ	PTHR10159 PTHR10159, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00782 DSPc, 1 hit PF00581 Rhodanese, 1 hit
PIRSFⁱ	PIRSF000939 MAPK_Ptase, 1 hit
PRINTSⁱ	PR01764 MAPKPHPHTASE
SMARTⁱ	View protein in SMART SM00195 DSPc, 1 hit SM00450 RHOD, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit SSF52821 SSF52821, 1 hit
PROSITEⁱ	View protein in PROSITE PS50206 RHODANESE_3, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50054 TYR_PHOSPHATASE_DUAL, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q99956-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL 
        60         70         80         90        100
LRRLRRGSLS VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW 
       110        120        130        140        150
EAESVLGTLL QKLREEGYLA YYLQGGFSRF QAECPHLCET SLAGRAGSSM 
       160        170        180        190        200
APVPGPVPVV GLGSLCLGSD CSDAESEADR DSMSCGLDSE GATPPPVGLR 
       210        220        230        240        250
ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL PNFFEKNGDF 
       260        270        280        290        300
HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV 
       310        320        330        340        350
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH 
       360        370        380 
SQEQGSGGQA SAASNPPSFF TTPTSDGAFE LAPT

Length:384

Mass (Da):41,868

Last modified:May 1, 1997 - v1

Checksum:ⁱF8598CA95AB379B7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08302 mRNA Translation: CAA69610.1 U52111 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72847.1 CH471172 Genomic DNA Translation: EAW72848.1 CH471172 Genomic DNA Translation: EAW72849.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14724.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001305432.1, NM_001318503.1 NP_001386.1, NM_001395.3 XP_011529426.1, XM_011531124.1
UniGeneⁱ	Hs.144879 Hs.744909

Genome annotation databases

Ensemblⁱ	ENST00000342782; ENSP00000345853; ENSG00000130829 ENST00000370167; ENSP00000359186; ENSG00000130829
GeneIDⁱ	1852
KEGGⁱ	hsa:1852
UCSC genome browser More...UCSCⁱ	uc004fhx.5 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99956	Dual specificity protein phosphatase		COLAP		385	UniRef90_Q99956
Dual specificity protein phosphatase		PANPA		384
Dual specificity protein phosphatase		GORGO		384
Dual specificity protein phosphatase homolog hMKP-R (Fragment)		HUMAN		68
Dual specificity protein phosphatase		RABIT		384
+58

Protein	Similar proteins		Species	Score	Length	Source
Q99956	Dual specificity protein phosphatase		COLAP		385	UniRef50_Q99956
Dual specificity protein phosphatase		SAIBB		384
Dual specificity protein phosphatase		DIPOR		384
Dual specificity protein phosphatase		HUMAN		384
Dual specificity protein phosphatase		PANPA		384
+71

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Y08302 mRNA Translation: CAA69610.1 U52111 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72847.1 CH471172 Genomic DNA Translation: EAW72848.1 CH471172 Genomic DNA Translation: EAW72849.1
CCDSⁱ	CCDS14724.1
RefSeqⁱ	NP_001305432.1, NM_001318503.1 NP_001386.1, NM_001395.3 XP_011529426.1, XM_011531124.1
UniGeneⁱ	Hs.144879 Hs.744909

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2HXP	X-ray	1.83	A	201-345	[»]
	3LJ8	X-ray	2.70	A	202-347	[»]
ProteinModelPortalⁱ	Q99956
SMRⁱ	Q99956
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108185, 68 interactors
IntActⁱ	Q99956, 14 interactors
MINTⁱ	Q99956
STRINGⁱ	9606.ENSP00000345853

PTM databases

DEPODⁱ	Q99956
iPTMnetⁱ	Q99956
PhosphoSitePlusⁱ	Q99956

Polymorphism and mutation databases

BioMutaⁱ	DUSP9
DMDMⁱ	3913541

Proteomic databases

EPDⁱ	Q99956
MaxQBⁱ	Q99956
PaxDbⁱ	Q99956
PeptideAtlasⁱ	Q99956
PRIDEⁱ	Q99956
ProteomicsDBⁱ	78541

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1852
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000342782; ENSP00000345853; ENSG00000130829 ENST00000370167; ENSP00000359186; ENSG00000130829
GeneIDⁱ	1852
KEGGⁱ	hsa:1852
UCSCⁱ	uc004fhx.5 human

Organism-specific databases

CTDⁱ	1852
DisGeNETⁱ	1852
EuPathDBⁱ	HostDB:ENSG00000130829.17
GeneCardsⁱ	DUSP9
HGNCⁱ	HGNC:3076 DUSP9
HPAⁱ	HPA003336
MIMⁱ	300134 gene
neXtProtⁱ	NX_Q99956
OpenTargetsⁱ	ENSG00000130829
PharmGKBⁱ	PA27533
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1717 Eukaryota COG2453 LUCA
GeneTreeⁱ	ENSGT00760000118902
HOGENOMⁱ	HOG000294079
HOVERGENⁱ	HBG007347
InParanoidⁱ	Q99956
KOⁱ	K18498
OMAⁱ	YLMQKRH
OrthoDBⁱ	EOG091G0249
PhylomeDBⁱ	Q99956
TreeFamⁱ	TF105122

Enzyme and pathway databases

BRENDAⁱ	3.1.3.48 2681
Reactomeⁱ	R-HSA-112409 RAF-independent MAPK1/3 activation R-HSA-5675221 Negative regulation of MAPK pathway
SignaLinkⁱ	Q99956
SIGNORⁱ	Q99956

Miscellaneous databases

ChiTaRSⁱ	DUSP9 human
EvolutionaryTraceⁱ	Q99956
GenomeRNAiⁱ	1852
Protein Ontology More...PROⁱ	PR:Q99956
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000130829 Expressed in 81 organ(s), highest expression level in liver
CleanExⁱ	HS_DUSP9
Genevisibleⁱ	Q99956 HS

Family and domain databases

CDDⁱ	cd00127 DSPc, 1 hit
Gene3Dⁱ	3.40.250.10, 1 hit 3.90.190.10, 1 hit
InterProⁱ	View protein in InterPro IPR000340 Dual-sp_phosphatase_cat-dom IPR024950 DUSP IPR008343 MKP IPR029021 Prot-tyrosine_phosphatase-like IPR001763 Rhodanese-like_dom IPR036873 Rhodanese-like_dom_sf IPR000387 TYR_PHOSPHATASE_dom IPR020422 TYR_PHOSPHATASE_DUAL_dom
PANTHERⁱ	PTHR10159 PTHR10159, 1 hit
Pfamⁱ	View protein in Pfam PF00782 DSPc, 1 hit PF00581 Rhodanese, 1 hit
PIRSFⁱ	PIRSF000939 MAPK_Ptase, 1 hit
PRINTSⁱ	PR01764 MAPKPHPHTASE
SMARTⁱ	View protein in SMART SM00195 DSPc, 1 hit SM00450 RHOD, 1 hit
SUPFAMⁱ	SSF52799 SSF52799, 1 hit SSF52821 SSF52821, 1 hit
PROSITEⁱ	View protein in PROSITE PS50206 RHODANESE_3, 1 hit PS50056 TYR_PHOSPHATASE_2, 1 hit PS50054 TYR_PHOSPHATASE_DUAL, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	DUS9_HUMAN
Accessionⁱ	Q99956Primary (citable) accession number: Q99956 Secondary accession number(s): D3DWU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
	Last sequence update:	May 1, 1997
	Last modified:	November 7, 2018
	This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q99956 (DUS9_HUMAN)

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Dual specificity protein phosphatase 9

DUSP9

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ