Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
We will be switching to the new UniProt website soon. Please explore and share your feedback. Take me to the new website.

UniProtKB - Q99956 (DUS9_HUMAN)

Entry version 180 (23 Feb 2022)
Sequence version 1 (01 May 1997)
Previous versions | rss
Add a publicationFeedback
Protein

Dual specificity protein phosphatase 9

Gene

DUSP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inactivates MAP kinases. Has a specificity for the ERK family.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei290Phosphocysteine intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		3.1.3.48, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99956

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-112409, RAF-independent MAPK1/3 activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-9652817, Signaling by MAPK mutants

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99956

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99956

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Dual specificity protein phosphatase 9 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Mitogen-activated protein kinase phosphatase 4
Short name:
MAP kinase phosphatase 4
Short name:
MKP-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DUSP9
Synonyms:MKP4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3076, DUSP9

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300134, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99956

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000130829

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1852

Open Targets

More...OpenTargetsi		ENSG00000130829

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27533

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99956, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		DUSP9

Domain mapping of disease mutations (DMDM)

More...DMDMi		3913541

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000948121 – 384Dual specificity protein phosphatase 9Add BLAST384

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei16PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei351PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99956

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99956

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99956

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99956

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99956

PeptideAtlas

More...PeptideAtlasi		Q99956

PRoteomics IDEntifications database

More...PRIDEi		Q99956

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78541

PTM databases

DEPOD human dephosphorylation database

More...DEPODi		DUSP9

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99956

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99956

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000130829, Expressed in liver and 91 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99956, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000130829, Group enriched (kidney, placenta)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108185, 92 interactors

Protein interaction database and analysis system

More...IntActi		Q99956, 17 interactors

Molecular INTeraction database

More...MINTi		Q99956

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000345853

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99956, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1384
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99956

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99956

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini18 – 139RhodanesePROSITE-ProRule annotationAdd BLAST122
Domaini203 – 346Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni348 – 384DisorderedSequence analysisAdd BLAST37

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi353 – 378Polar residuesSequence analysisAdd BLAST26

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1717, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000161880

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027074_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99956

Identification of Orthologs from Complete Genome Data

More...OMAi		CARDSAN

Database of Orthologous Groups

More...OrthoDBi		1576308at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99956

TreeFam database of animal gene trees

More...TreeFami		TF105122

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.250.10, 1 hit
3.90.190.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000340, Dual-sp_phosphatase_cat-dom
IPR008343, MKP
IPR029021, Prot-tyrosine_phosphatase-like
IPR001763, Rhodanese-like_dom
IPR036873, Rhodanese-like_dom_sf
IPR000387, Tyr_Pase_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00782, DSPc, 1 hit
PF00581, Rhodanese, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000939, MAPK_Ptase, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01764, MAPKPHPHTASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00195, DSPc, 1 hit
SM00450, RHOD, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52799, SSF52799, 1 hit
SSF52821, SSF52821, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50206, RHODANESE_3, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q99956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL 
        60         70         80         90        100
LRRLRRGSLS VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW 
       110        120        130        140        150
EAESVLGTLL QKLREEGYLA YYLQGGFSRF QAECPHLCET SLAGRAGSSM 
       160        170        180        190        200
APVPGPVPVV GLGSLCLGSD CSDAESEADR DSMSCGLDSE GATPPPVGLR 
       210        220        230        240        250
ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL PNFFEKNGDF 
       260        270        280        290        300
HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV 
       310        320        330        340        350
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH 
       360        370        380 
SQEQGSGGQA SAASNPPSFF TTPTSDGAFE LAPT
Length:384
Mass (Da):41,868
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF8598CA95AB379B7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y08302 mRNA Translation: CAA69610.1
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72847.1
CH471172 Genomic DNA Translation: EAW72848.1
CH471172 Genomic DNA Translation: EAW72849.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14724.1

NCBI Reference Sequences

More...RefSeqi		NP_001305432.1, NM_001318503.1
NP_001386.1, NM_001395.3
XP_011529426.1, XM_011531124.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000342782; ENSP00000345853; ENSG00000130829
ENST00000370167; ENSP00000359186; ENSG00000130829

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1852

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1852

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000342782.4; ENSP00000345853.3; NM_001318503.2; NP_001305432.1

UCSC genome browser

More...UCSCi		uc004fhx.5, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08302 mRNA Translation: CAA69610.1
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72847.1
CH471172 Genomic DNA Translation: EAW72848.1
CH471172 Genomic DNA Translation: EAW72849.1
CCDSiCCDS14724.1
RefSeqiNP_001305432.1, NM_001318503.1
NP_001386.1, NM_001395.3
XP_011529426.1, XM_011531124.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2HXPX-ray1.83A201-345[»]
3LJ8X-ray2.70A202-347[»]
SMRiQ99956
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108185, 92 interactors
IntActiQ99956, 17 interactors
MINTiQ99956
STRINGi9606.ENSP00000345853

PTM databases

DEPODiDUSP9
iPTMnetiQ99956
PhosphoSitePlusiQ99956

Genetic variation databases

BioMutaiDUSP9
DMDMi3913541

Proteomic databases

EPDiQ99956
jPOSTiQ99956
MassIVEiQ99956
MaxQBiQ99956
PaxDbiQ99956
PeptideAtlasiQ99956
PRIDEiQ99956
ProteomicsDBi78541

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		519, 291 antibodies from 32 providers

The DNASU plasmid repository

More...DNASUi		1852

Genome annotation databases

EnsembliENST00000342782; ENSP00000345853; ENSG00000130829
ENST00000370167; ENSP00000359186; ENSG00000130829
GeneIDi1852
KEGGihsa:1852
MANE-SelectiENST00000342782.4; ENSP00000345853.3; NM_001318503.2; NP_001305432.1
UCSCiuc004fhx.5, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1852
DisGeNETi1852

GeneCards: human genes, protein and diseases

More...GeneCardsi		DUSP9
HGNCiHGNC:3076, DUSP9
HPAiENSG00000130829, Group enriched (kidney, placenta)
MIMi300134, gene
neXtProtiNX_Q99956
OpenTargetsiENSG00000130829
PharmGKBiPA27533
VEuPathDBiHostDB:ENSG00000130829

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1717, Eukaryota
GeneTreeiENSGT00940000161880
HOGENOMiCLU_027074_0_0_1
InParanoidiQ99956
OMAiCARDSAN
OrthoDBi1576308at2759
PhylomeDBiQ99956
TreeFamiTF105122

Enzyme and pathway databases

BRENDAi3.1.3.48, 2681
PathwayCommonsiQ99956
ReactomeiR-HSA-112409, RAF-independent MAPK1/3 activation
R-HSA-5675221, Negative regulation of MAPK pathway
R-HSA-9652817, Signaling by MAPK mutants
SignaLinkiQ99956
SIGNORiQ99956

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1852, 14 hits in 674 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		DUSP9, human
EvolutionaryTraceiQ99956

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1852
PharosiQ99956, Tbio

Protein Ontology

More...PROi		PR:Q99956
RNActiQ99956, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000130829, Expressed in liver and 91 other tissues
GenevisibleiQ99956, HS

Family and domain databases

Gene3Di3.40.250.10, 1 hit
3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR000340, Dual-sp_phosphatase_cat-dom
IPR008343, MKP
IPR029021, Prot-tyrosine_phosphatase-like
IPR001763, Rhodanese-like_dom
IPR036873, Rhodanese-like_dom_sf
IPR000387, Tyr_Pase_dom
IPR020422, TYR_PHOSPHATASE_DUAL_dom
PfamiView protein in Pfam
PF00782, DSPc, 1 hit
PF00581, Rhodanese, 1 hit
PIRSFiPIRSF000939, MAPK_Ptase, 1 hit
PRINTSiPR01764, MAPKPHPHTASE
SMARTiView protein in SMART
SM00195, DSPc, 1 hit
SM00450, RHOD, 1 hit
SUPFAMiSSF52799, SSF52799, 1 hit
SSF52821, SSF52821, 1 hit
PROSITEiView protein in PROSITE
PS50206, RHODANESE_3, 1 hit
PS50056, TYR_PHOSPHATASE_2, 1 hit
PS50054, TYR_PHOSPHATASE_DUAL, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDUS9_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99956
Secondary accession number(s): D3DWU5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: May 1, 1997
Last modified: February 23, 2022
This is version 180 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again