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UniProtKB - Q99956 (DUS9_HUMAN)
Protein
Dual specificity protein phosphatase 9
Gene
DUSP9
Organism
Homo sapiens (Human)
Status
Functioni
Inactivates MAP kinases. Has a specificity for the ERK family.
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 290 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- MAP kinase tyrosine/serine/threonine phosphatase activity Source: GO_Central
- phosphoprotein phosphatase activity Source: GO_Central
- protein serine phosphatase activity Source: UniProtKB-EC
- protein threonine phosphatase activity Source: UniProtKB-EC
- protein tyrosine/serine/threonine phosphatase activity Source: Reactome
- protein tyrosine/threonine phosphatase activity Source: GO_Central
- protein tyrosine phosphatase activity Source: UniProtKB-EC
GO - Biological processi
- JNK cascade Source: ProtInc
- MAPK cascade Source: Reactome
- negative regulation of ERK1 and ERK2 cascade Source: GO_Central
- negative regulation of MAPK cascade Source: GO_Central
- positive regulation of apoptotic process Source: GO_Central
- protein dephosphorylation Source: ProtInc
- regulation of heart growth Source: GO_Central
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q99956 |
Reactomei | R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-9652817, Signaling by MAPK mutants |
SignaLinki | Q99956 |
SIGNORi | Q99956 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:DUSP9 Synonyms:MKP4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3076, DUSP9 |
MIMi | 300134, gene |
neXtProti | NX_Q99956 |
VEuPathDBi | HostDB:ENSG00000130829 |
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 1852 |
OpenTargetsi | ENSG00000130829 |
PharmGKBi | PA27533 |
Miscellaneous databases
Pharosi | Q99956, Tbio |
Genetic variation databases
BioMutai | DUSP9 |
DMDMi | 3913541 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094812 | 1 – 384 | Dual specificity protein phosphatase 9Add BLAST | 384 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 16 | PhosphoserineCombined sources | 1 | |
Modified residuei | 262 | PhosphoserineCombined sources | 1 | |
Modified residuei | 351 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99956 |
jPOSTi | Q99956 |
MassIVEi | Q99956 |
MaxQBi | Q99956 |
PaxDbi | Q99956 |
PeptideAtlasi | Q99956 |
PRIDEi | Q99956 |
ProteomicsDBi | 78541 |
PTM databases
DEPODi | DUSP9 |
iPTMneti | Q99956 |
PhosphoSitePlusi | Q99956 |
Expressioni
Gene expression databases
Bgeei | ENSG00000130829, Expressed in liver and 91 other tissues |
Genevisiblei | Q99956, HS |
Organism-specific databases
HPAi | ENSG00000130829, Group enriched (kidney, placenta) |
Interactioni
Binary interactionsi
Q99956
With | #Exp. | IntAct |
---|---|---|
MAPK1 [P28482] | 3 | EBI-3906678,EBI-959949 |
MAPK14 [Q16539] | 2 | EBI-3906678,EBI-73946 |
Mapk14 [P47811] from Mus musculus. | 2 | EBI-3906678,EBI-298727 |
Protein-protein interaction databases
BioGRIDi | 108185, 92 interactors |
IntActi | Q99956, 17 interactors |
MINTi | Q99956 |
STRINGi | 9606.ENSP00000345853 |
Miscellaneous databases
RNActi | Q99956, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q99956 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99956 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 18 – 139 | RhodanesePROSITE-ProRule annotationAdd BLAST | 122 | |
Domaini | 203 – 346 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 144 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 348 – 384 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 353 – 378 | Polar residuesSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.Curated
Phylogenomic databases
eggNOGi | KOG1717, Eukaryota |
GeneTreei | ENSGT00940000161880 |
HOGENOMi | CLU_027074_0_0_1 |
InParanoidi | Q99956 |
OMAi | CARDSAN |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q99956 |
TreeFami | TF105122 |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR008343, MKP IPR029021, Prot-tyrosine_phosphatase-like IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR000387, Tyr_Pase_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit PF00581, Rhodanese, 1 hit |
PIRSFi | PIRSF000939, MAPK_Ptase, 1 hit |
PRINTSi | PR01764, MAPKPHPHTASE |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit SM00450, RHOD, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
i Sequence
Sequence statusi: Complete.
Q99956-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGLGRSCLW LRRELSPPRP RLLLLDCRSR ELYESARIGG ALSVALPALL
60 70 80 90 100
LRRLRRGSLS VRALLPGPPL QPPPPAPVLL YDQGGGRRRR GEAEAEAEEW
110 120 130 140 150
EAESVLGTLL QKLREEGYLA YYLQGGFSRF QAECPHLCET SLAGRAGSSM
160 170 180 190 200
APVPGPVPVV GLGSLCLGSD CSDAESEADR DSMSCGLDSE GATPPPVGLR
210 220 230 240 250
ASFPVQILPN LYLGSARDSA NLESLAKLGI RYILNVTPNL PNFFEKNGDF
260 270 280 290 300
HYKQIPISDH WSQNLSRFFP EAIEFIDEAL SQNCGVLVHC LAGVSRSVTV
310 320 330 340 350
TVAYLMQKLH LSLNDAYDLV KRKKSNISPN FNFMGQLLDF ERSLRLEERH
360 370 380
SQEQGSGGQA SAASNPPSFF TTPTSDGAFE LAPT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08302 mRNA Translation: CAA69610.1 U52111 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72847.1 CH471172 Genomic DNA Translation: EAW72848.1 CH471172 Genomic DNA Translation: EAW72849.1 |
CCDSi | CCDS14724.1 |
RefSeqi | NP_001305432.1, NM_001318503.1 NP_001386.1, NM_001395.3 XP_011529426.1, XM_011531124.1 |
Genome annotation databases
Ensembli | ENST00000342782; ENSP00000345853; ENSG00000130829 ENST00000370167; ENSP00000359186; ENSG00000130829 |
GeneIDi | 1852 |
KEGGi | hsa:1852 |
MANE-Selecti | ENST00000342782.4; ENSP00000345853.3; NM_001318503.2; NP_001305432.1 |
UCSCi | uc004fhx.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y08302 mRNA Translation: CAA69610.1 U52111 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72847.1 CH471172 Genomic DNA Translation: EAW72848.1 CH471172 Genomic DNA Translation: EAW72849.1 |
CCDSi | CCDS14724.1 |
RefSeqi | NP_001305432.1, NM_001318503.1 NP_001386.1, NM_001395.3 XP_011529426.1, XM_011531124.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2HXP | X-ray | 1.83 | A | 201-345 | [»] | |
3LJ8 | X-ray | 2.70 | A | 202-347 | [»] | |
SMRi | Q99956 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108185, 92 interactors |
IntActi | Q99956, 17 interactors |
MINTi | Q99956 |
STRINGi | 9606.ENSP00000345853 |
PTM databases
DEPODi | DUSP9 |
iPTMneti | Q99956 |
PhosphoSitePlusi | Q99956 |
Genetic variation databases
BioMutai | DUSP9 |
DMDMi | 3913541 |
Proteomic databases
EPDi | Q99956 |
jPOSTi | Q99956 |
MassIVEi | Q99956 |
MaxQBi | Q99956 |
PaxDbi | Q99956 |
PeptideAtlasi | Q99956 |
PRIDEi | Q99956 |
ProteomicsDBi | 78541 |
Protocols and materials databases
Antibodypediai | 519, 291 antibodies from 32 providers |
DNASUi | 1852 |
Genome annotation databases
Ensembli | ENST00000342782; ENSP00000345853; ENSG00000130829 ENST00000370167; ENSP00000359186; ENSG00000130829 |
GeneIDi | 1852 |
KEGGi | hsa:1852 |
MANE-Selecti | ENST00000342782.4; ENSP00000345853.3; NM_001318503.2; NP_001305432.1 |
UCSCi | uc004fhx.5, human |
Organism-specific databases
CTDi | 1852 |
DisGeNETi | 1852 |
GeneCardsi | DUSP9 |
HGNCi | HGNC:3076, DUSP9 |
HPAi | ENSG00000130829, Group enriched (kidney, placenta) |
MIMi | 300134, gene |
neXtProti | NX_Q99956 |
OpenTargetsi | ENSG00000130829 |
PharmGKBi | PA27533 |
VEuPathDBi | HostDB:ENSG00000130829 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1717, Eukaryota |
GeneTreei | ENSGT00940000161880 |
HOGENOMi | CLU_027074_0_0_1 |
InParanoidi | Q99956 |
OMAi | CARDSAN |
OrthoDBi | 1576308at2759 |
PhylomeDBi | Q99956 |
TreeFami | TF105122 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q99956 |
Reactomei | R-HSA-112409, RAF-independent MAPK1/3 activation R-HSA-5675221, Negative regulation of MAPK pathway R-HSA-9652817, Signaling by MAPK mutants |
SignaLinki | Q99956 |
SIGNORi | Q99956 |
Miscellaneous databases
BioGRID-ORCSi | 1852, 14 hits in 674 CRISPR screens |
ChiTaRSi | DUSP9, human |
EvolutionaryTracei | Q99956 |
GenomeRNAii | 1852 |
Pharosi | Q99956, Tbio |
PROi | PR:Q99956 |
RNActi | Q99956, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000130829, Expressed in liver and 91 other tissues |
Genevisiblei | Q99956, HS |
Family and domain databases
Gene3Di | 3.40.250.10, 1 hit 3.90.190.10, 1 hit |
InterProi | View protein in InterPro IPR000340, Dual-sp_phosphatase_cat-dom IPR008343, MKP IPR029021, Prot-tyrosine_phosphatase-like IPR001763, Rhodanese-like_dom IPR036873, Rhodanese-like_dom_sf IPR000387, Tyr_Pase_dom IPR020422, TYR_PHOSPHATASE_DUAL_dom |
Pfami | View protein in Pfam PF00782, DSPc, 1 hit PF00581, Rhodanese, 1 hit |
PIRSFi | PIRSF000939, MAPK_Ptase, 1 hit |
PRINTSi | PR01764, MAPKPHPHTASE |
SMARTi | View protein in SMART SM00195, DSPc, 1 hit SM00450, RHOD, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit SSF52821, SSF52821, 1 hit |
PROSITEi | View protein in PROSITE PS50206, RHODANESE_3, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50054, TYR_PHOSPHATASE_DUAL, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | DUS9_HUMAN | |
Accessioni | Q99956Primary (citable) accession number: Q99956 Secondary accession number(s): D3DWU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | May 1, 1997 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families