UniProtKB - Q99952 (PTN18_HUMAN)
Protein
Tyrosine-protein phosphatase non-receptor type 18
Gene
PTPN18
Organism
Homo sapiens (Human)
Status
Functioni
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.
Catalytic activityi
- EC:3.1.3.48PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 197 | SubstrateBy similarity | 1 | |
Active sitei | 229 | Phosphocysteine intermediatePROSITE-ProRule annotation | 1 | |
Binding sitei | 276 | SubstrateBy similarity | 1 |
GO - Molecular functioni
- non-membrane spanning protein tyrosine phosphatase activity Source: GO_Central
- protein tyrosine phosphatase activity Source: Reactome
GO - Biological processi
- blastocyst formation Source: Ensembl
- cellular response to cytokine stimulus Source: Reactome
- ERBB2 signaling pathway Source: Reactome
- negative regulation of ERBB signaling pathway Source: Reactome
- peptidyl-tyrosine dephosphorylation Source: GO_Central
- protein dephosphorylation Source: ProtInc
Keywordsi
Molecular function | Hydrolase, Protein phosphatase |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q99952 |
Reactomei | R-HSA-8863795, Downregulation of ERBB2 signaling R-HSA-9008059, Interleukin-37 signaling |
SIGNORi | Q99952 |
Names & Taxonomyi
Protein namesi | Recommended name: Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)Alternative name(s): Brain-derived phosphatase |
Gene namesi | Name:PTPN18 Synonyms:BDP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:9649, PTPN18 |
MIMi | 606587, gene |
neXtProti | NX_Q99952 |
VEuPathDBi | HostDB:ENSG00000072135.12 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: Reactome
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 26469 |
OpenTargetsi | ENSG00000072135 |
PharmGKBi | PA33991 |
Miscellaneous databases
Pharosi | Q99952, Tbio |
Chemistry databases
ChEMBLi | CHEMBL3351197 |
Genetic variation databases
BioMutai | PTPN18 |
DMDMi | 215273871 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094773 | 1 – 460 | Tyrosine-protein phosphatase non-receptor type 18Add BLAST | 460 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 389 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 393 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 426 | PhosphotyrosineBy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q99952 |
jPOSTi | Q99952 |
MassIVEi | Q99952 |
MaxQBi | Q99952 |
PaxDbi | Q99952 |
PeptideAtlasi | Q99952 |
PRIDEi | Q99952 |
ProteomicsDBi | 78538 [Q99952-1] 78539 [Q99952-2] |
PTM databases
DEPODi | PTPN18 |
iPTMneti | Q99952 |
PhosphoSitePlusi | Q99952 |
Expressioni
Tissue specificityi
Expressed in brain, colon and several tumor-derived cell lines.1 Publication
Gene expression databases
Bgeei | ENSG00000072135, Expressed in monocyte and 238 other tissues |
ExpressionAtlasi | Q99952, baseline and differential |
Genevisiblei | Q99952, HS |
Organism-specific databases
HPAi | ENSG00000072135, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with PSTPIP1.
By similarityBinary interactionsi
Hide detailsQ99952
With | #Exp. | IntAct |
---|---|---|
BTRC [Q9Y297] | 2 | EBI-1384210,EBI-307461 |
ERBB2 [P04626] | 6 | EBI-1384210,EBI-641062 |
PSTPIP1 [O43586] | 4 | EBI-1384210,EBI-1050964 |
Isoform 1 [Q99952-1]
With | #Exp. | IntAct |
---|---|---|
BTRC [Q9Y297] | 2 | EBI-12739708,EBI-307461 |
ERBB2 [P04626] | 5 | EBI-12739708,EBI-641062 |
Protein-protein interaction databases
BioGRIDi | 117693, 43 interactors |
IntActi | Q99952, 8 interactors |
MINTi | Q99952 |
STRINGi | 9606.ENSP00000175756 |
Chemistry databases
BindingDBi | Q99952 |
Miscellaneous databases
RNActi | Q99952, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q99952 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99952 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 26 – 291 | Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST | 266 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 229 – 235 | Substrate bindingBy similarity | 7 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000162860 |
HOGENOMi | CLU_015557_0_0_1 |
InParanoidi | Q99952 |
OMAi | GIGFNCR |
OrthoDBi | 411281at2759 |
PhylomeDBi | Q99952 |
TreeFami | TF351977 |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
IDEALi | IID00581 |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q99952-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA
60 70 80 90 100
GSRPENVRKN RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CREIENGRKR CERYWAQEQE
160 170 180 190 200
PLQTGLFCIT LIKEKWLNED IMLRTLKVTF QKESRSVYQL QYMSWPDRGV
210 220 230 240 250
PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC TVDYVRQLLL
260 270 280 290 300
TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS
310 320 330 340 350
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM
360 370 380 390 400
ADTYAVVQKR GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG
410 420 430 440 450
AHAEDARGTL PGRVPADQSP AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP
460
RDPPAEWTRV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE7EMB8 | E7EMB8_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN18 | 269 | Annotation score: | ||
F8WBM9 | F8WBM9_HUMAN | Tyrosine-protein phosphatase non-re... | PTPN18 | 48 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 356 – 357 | VV → EE in CAA56105 (PubMed:8950995).Curated | 2 | |
Sequence conflicti | 378 – 379 | Missing in CAA56105 (PubMed:8950995).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_047651 | 193 | M → V. Corresponds to variant dbSNP:rs3739124Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043073 | 32 – 138 | Missing in isoform 2. 1 PublicationAdd BLAST | 107 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79568 mRNA Translation: CAA56105.1 AK303804 mRNA Translation: BAG64758.1 AC132479 Genomic DNA Translation: AAY24077.1 CH471263 Genomic DNA Translation: EAW55618.1 CH471263 Genomic DNA Translation: EAW55619.1 |
CCDSi | CCDS2161.1 [Q99952-1] CCDS46410.1 [Q99952-2] |
RefSeqi | NP_001135842.1, NM_001142370.1 [Q99952-2] NP_055184.2, NM_014369.3 [Q99952-1] |
Genome annotation databases
Ensembli | ENST00000175756; ENSP00000175756; ENSG00000072135 [Q99952-1] ENST00000347849; ENSP00000310092; ENSG00000072135 [Q99952-2] |
GeneIDi | 26469 |
KEGGi | hsa:26469 |
UCSCi | uc002trb.4, human [Q99952-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X79568 mRNA Translation: CAA56105.1 AK303804 mRNA Translation: BAG64758.1 AC132479 Genomic DNA Translation: AAY24077.1 CH471263 Genomic DNA Translation: EAW55618.1 CH471263 Genomic DNA Translation: EAW55619.1 |
CCDSi | CCDS2161.1 [Q99952-1] CCDS46410.1 [Q99952-2] |
RefSeqi | NP_001135842.1, NM_001142370.1 [Q99952-2] NP_055184.2, NM_014369.3 [Q99952-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2OC3 | X-ray | 1.50 | A | 6-299 | [»] | |
4GFU | X-ray | 2.00 | A | 6-300 | [»] | |
4GFV | X-ray | 2.10 | A/B | 6-300 | [»] | |
4NND | X-ray | 2.50 | A/B/D/G | 6-295 | [»] | |
SMRi | Q99952 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 117693, 43 interactors |
IntActi | Q99952, 8 interactors |
MINTi | Q99952 |
STRINGi | 9606.ENSP00000175756 |
Chemistry databases
BindingDBi | Q99952 |
ChEMBLi | CHEMBL3351197 |
PTM databases
DEPODi | PTPN18 |
iPTMneti | Q99952 |
PhosphoSitePlusi | Q99952 |
Genetic variation databases
BioMutai | PTPN18 |
DMDMi | 215273871 |
Proteomic databases
EPDi | Q99952 |
jPOSTi | Q99952 |
MassIVEi | Q99952 |
MaxQBi | Q99952 |
PaxDbi | Q99952 |
PeptideAtlasi | Q99952 |
PRIDEi | Q99952 |
ProteomicsDBi | 78538 [Q99952-1] 78539 [Q99952-2] |
Protocols and materials databases
Antibodypediai | 33499, 118 antibodies |
DNASUi | 26469 |
Genome annotation databases
Ensembli | ENST00000175756; ENSP00000175756; ENSG00000072135 [Q99952-1] ENST00000347849; ENSP00000310092; ENSG00000072135 [Q99952-2] |
GeneIDi | 26469 |
KEGGi | hsa:26469 |
UCSCi | uc002trb.4, human [Q99952-1] |
Organism-specific databases
CTDi | 26469 |
DisGeNETi | 26469 |
GeneCardsi | PTPN18 |
HGNCi | HGNC:9649, PTPN18 |
HPAi | ENSG00000072135, Low tissue specificity |
MIMi | 606587, gene |
neXtProti | NX_Q99952 |
OpenTargetsi | ENSG00000072135 |
PharmGKBi | PA33991 |
VEuPathDBi | HostDB:ENSG00000072135.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0789, Eukaryota |
GeneTreei | ENSGT00940000162860 |
HOGENOMi | CLU_015557_0_0_1 |
InParanoidi | Q99952 |
OMAi | GIGFNCR |
OrthoDBi | 411281at2759 |
PhylomeDBi | Q99952 |
TreeFami | TF351977 |
Enzyme and pathway databases
BRENDAi | 3.1.3.48, 2681 |
PathwayCommonsi | Q99952 |
Reactomei | R-HSA-8863795, Downregulation of ERBB2 signaling R-HSA-9008059, Interleukin-37 signaling |
SIGNORi | Q99952 |
Miscellaneous databases
BioGRID-ORCSi | 26469, 5 hits in 993 CRISPR screens |
ChiTaRSi | PTPN18, human |
EvolutionaryTracei | Q99952 |
GeneWikii | PTPN18 |
GenomeRNAii | 26469 |
Pharosi | Q99952, Tbio |
PROi | PR:Q99952 |
RNActi | Q99952, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000072135, Expressed in monocyte and 238 other tissues |
ExpressionAtlasi | Q99952, baseline and differential |
Genevisiblei | Q99952, HS |
Family and domain databases
Gene3Di | 3.90.190.10, 1 hit |
IDEALi | IID00581 |
InterProi | View protein in InterPro IPR029021, Prot-tyrosine_phosphatase-like IPR000242, PTPase_domain IPR016130, Tyr_Pase_AS IPR003595, Tyr_Pase_cat IPR000387, TYR_PHOSPHATASE_dom |
Pfami | View protein in Pfam PF00102, Y_phosphatase, 1 hit |
PRINTSi | PR00700, PRTYPHPHTASE |
SMARTi | View protein in SMART SM00194, PTPc, 1 hit SM00404, PTPc_motif, 1 hit |
SUPFAMi | SSF52799, SSF52799, 1 hit |
PROSITEi | View protein in PROSITE PS00383, TYR_PHOSPHATASE_1, 1 hit PS50056, TYR_PHOSPHATASE_2, 1 hit PS50055, TYR_PHOSPHATASE_PTP, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PTN18_HUMAN | |
Accessioni | Q99952Primary (citable) accession number: Q99952 Secondary accession number(s): B4E1E6, Q53P42 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 27, 2002 |
Last sequence update: | November 25, 2008 | |
Last modified: | April 7, 2021 | |
This is version 177 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families