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Protein

Tyrosine-protein phosphatase non-receptor type 18

Gene

PTPN18

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei197SubstrateBy similarity1
Active sitei229Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei276SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-8863795 Downregulation of ERBB2 signaling
R-HSA-9008059 Interleukin-37 signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Tyrosine-protein phosphatase non-receptor type 18 (EC:3.1.3.48)
Alternative name(s):
Brain-derived phosphatase
Gene namesi
Name:PTPN18
Synonyms:BDP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000072135.12
HGNCiHGNC:9649 PTPN18
MIMi606587 gene
neXtProtiNX_Q99952

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi26469
OpenTargetsiENSG00000072135
PharmGKBiPA33991

Chemistry databases

ChEMBLiCHEMBL3351197

Polymorphism and mutation databases

BioMutaiPTPN18
DMDMi215273871

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000947731 – 460Tyrosine-protein phosphatase non-receptor type 18Add BLAST460

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei389PhosphotyrosineBy similarity1
Modified residuei393PhosphothreonineCombined sources1
Modified residuei426PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ99952
MaxQBiQ99952
PaxDbiQ99952
PeptideAtlasiQ99952
PRIDEiQ99952
ProteomicsDBi78538
78539 [Q99952-2]

PTM databases

DEPODiQ99952
iPTMnetiQ99952
PhosphoSitePlusiQ99952

Expressioni

Tissue specificityi

Expressed in brain, colon and several tumor-derived cell lines.1 Publication

Gene expression databases

BgeeiENSG00000072135
CleanExiHS_BDP1
HS_PTPN18
ExpressionAtlasiQ99952 baseline and differential
GenevisibleiQ99952 HS

Organism-specific databases

HPAiCAB012174
HPA053367

Interactioni

Subunit structurei

Interacts with PSTPIP1.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi117693, 39 interactors
IntActiQ99952, 7 interactors
MINTiQ99952
STRINGi9606.ENSP00000175756

Chemistry databases

BindingDBiQ99952

Structurei

Secondary structure

1460
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi11 – 14Combined sources4
Helixi20 – 22Combined sources3
Helixi25 – 43Combined sources19
Helixi49 – 52Combined sources4
Turni54 – 56Combined sources3
Helixi57 – 59Combined sources3
Helixi69 – 71Combined sources3
Beta strandi72 – 74Combined sources3
Helixi79 – 81Combined sources3
Beta strandi85 – 93Combined sources9
Beta strandi97 – 104Combined sources8
Helixi109 – 111Combined sources3
Helixi112 – 121Combined sources10
Beta strandi126 – 129Combined sources4
Beta strandi133 – 135Combined sources3
Beta strandi152 – 154Combined sources3
Beta strandi157 – 168Combined sources12
Beta strandi171 – 180Combined sources10
Beta strandi183 – 192Combined sources10
Beta strandi197 – 199Combined sources3
Helixi205 – 218Combined sources14
Beta strandi220 – 222Combined sources3
Beta strandi225 – 228Combined sources4
Beta strandi230 – 233Combined sources4
Helixi234 – 250Combined sources17
Helixi260 – 268Combined sources9
Helixi278 – 292Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2OC3X-ray1.50A6-299[»]
4GFUX-ray2.00A6-300[»]
4GFVX-ray2.10A/B6-300[»]
4NNDX-ray2.50A/B/D/G6-295[»]
ProteinModelPortaliQ99952
SMRiQ99952
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99952

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 291Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST266

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni229 – 235Substrate bindingBy similarity7

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0789 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00900000140785
HOGENOMiHOG000115776
HOVERGENiHBG053419
InParanoidiQ99952
KOiK18024
OMAiNCAPLYD
OrthoDBiEOG091G0B5O
PhylomeDBiQ99952
TreeFamiTF351977

Family and domain databases

Gene3Di3.90.190.10, 1 hit
InterProiView protein in InterPro
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00102 Y_phosphatase, 1 hit
PRINTSiPR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00194 PTPc, 1 hit
SM00404 PTPc_motif, 1 hit
SUPFAMiSSF52799 SSF52799, 1 hit
PROSITEiView protein in PROSITE
PS00383 TYR_PHOSPHATASE_1, 1 hit
PS50056 TYR_PHOSPHATASE_2, 1 hit
PS50055 TYR_PHOSPHATASE_PTP, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99952-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA
60 70 80 90 100
GSRPENVRKN RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA
110 120 130 140 150
YIATQGPLPH TLLDFWRLVW EFGVKVILMA CREIENGRKR CERYWAQEQE
160 170 180 190 200
PLQTGLFCIT LIKEKWLNED IMLRTLKVTF QKESRSVYQL QYMSWPDRGV
210 220 230 240 250
PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC TVDYVRQLLL
260 270 280 290 300
TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS
310 320 330 340 350
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM
360 370 380 390 400
ADTYAVVQKR GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG
410 420 430 440 450
AHAEDARGTL PGRVPADQSP AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP
460
RDPPAEWTRV
Length:460
Mass (Da):50,482
Last modified:November 25, 2008 - v2
Checksum:i67ED24A0504D1883
GO
Isoform 2 (identifier: Q99952-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     32-138: Missing.

Note: No experimental confirmation available.
Show »
Length:353
Mass (Da):38,476
Checksum:i12B3D38CA2A8A7DE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti356 – 357VV → EE in CAA56105 (PubMed:8950995).Curated2
Sequence conflicti378 – 379Missing in CAA56105 (PubMed:8950995).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047651193M → V. Corresponds to variant dbSNP:rs3739124Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04307332 – 138Missing in isoform 2. 1 PublicationAdd BLAST107

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79568 mRNA Translation: CAA56105.1
AK303804 mRNA Translation: BAG64758.1
AC132479 Genomic DNA Translation: AAY24077.1
CH471263 Genomic DNA Translation: EAW55618.1
CH471263 Genomic DNA Translation: EAW55619.1
CCDSiCCDS2161.1 [Q99952-1]
CCDS46410.1 [Q99952-2]
RefSeqiNP_001135842.1, NM_001142370.1 [Q99952-2]
NP_055184.2, NM_014369.3 [Q99952-1]
UniGeneiHs.516390
Hs.744861

Genome annotation databases

EnsembliENST00000175756; ENSP00000175756; ENSG00000072135 [Q99952-1]
ENST00000347849; ENSP00000310092; ENSG00000072135 [Q99952-2]
GeneIDi26469
KEGGihsa:26469
UCSCiuc002trb.4 human [Q99952-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPTN18_HUMAN
AccessioniPrimary (citable) accession number: Q99952
Secondary accession number(s): B4E1E6, Q53P42
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 25, 2008
Last modified: June 20, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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