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Entry version 164 (07 Apr 2021)
Sequence version 1 (01 May 1997)
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Protein

Epidermal growth factor-like protein 8

Gene

EGFL8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandCalcium

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q99944

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Epidermal growth factor-like protein 8
Short name:
EGF-like protein 8
Alternative name(s):
Vascular endothelial statin-2
Short name:
VE-statin-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:EGFL8
Synonyms:C6orf8, NG3
ORF Names:UNQ8752/PRO29920
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:13944, EGFL8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
609897, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99944

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000241404.6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80864

Open Targets

More...
OpenTargetsi
ENSG00000241404

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA38372

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q99944, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
EGFL8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
55584040

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 251 PublicationAdd BLAST25
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000753126 – 293Epidermal growth factor-like protein 8Add BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 97By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi65 ↔ 71By similarity
Disulfide bondi96 ↔ 110By similarity
Disulfide bondi114 ↔ 124By similarity
Disulfide bondi118 ↔ 130By similarity
Disulfide bondi132 ↔ 141By similarity
Disulfide bondi148 ↔ 159By similarity
Disulfide bondi155 ↔ 168By similarity
Disulfide bondi170 ↔ 183By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q99944

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q99944

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q99944

PeptideAtlas

More...
PeptideAtlasi
Q99944

PRoteomics IDEntifications database

More...
PRIDEi
Q99944

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
34007
78535

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q99944, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q99944

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q99944

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000241404, Expressed in tibial nerve and 112 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q99944, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q99944, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000241404, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
123336, 10 interactors

Protein interaction database and analysis system

More...
IntActi
Q99944, 19 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000378888

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q99944, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q99944

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini34 – 112EMIPROSITE-ProRule annotationAdd BLAST79
Domaini111 – 142EGF-like 1PROSITE-ProRule annotationAdd BLAST32
Domaini144 – 184EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili195 – 232Sequence analysisAdd BLAST38

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162975

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_083642_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q99944

Identification of Orthologs from Complete Genome Data

More...
OMAi
TCSCEDN

Database of Orthologous Groups

More...
OrthoDBi
749722at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331360

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR011489, EMI_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00008, EGF, 1 hit
PF07645, EGF_CA, 1 hit
PF07546, EMI, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 2 hits
SM00179, EGF_CA, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS51041, EMI, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99944-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSRAELCTL LGGFSFLLLL IPGEGAKGGS LRESQGVCSK QTLVVPLHYN
60 70 80 90 100
ESYSQPVYKP YLTLCAGRRI CSTYRTMYRV MWREVRREVQ QTHAVCCQGW
110 120 130 140 150
KKRHPGALTC EAICAKPCLN GGVCVRPDQC ECAPGWGGKH CHVDVDECRT
160 170 180 190 200
SITLCSHHCF NTAGSFTCGC PHDLVLGVDG RTCMEGSPEP PTSASILSVA
210 220 230 240 250
VREAEKDERA LKQEIHELRG RLERLEQWAG QAGAWVRAVL PVPPEELQPE
260 270 280 290
QVAELWGRGD RIESLSDQVL LLEERLGACS CEDNSLGLGV NHR
Length:293
Mass (Da):32,262
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6519CA254FB23FD0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q5JP22Q5JP22_HUMAN
Epidermal growth factor-like protei...
EGFL8
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A140T9I6A0A140T9I6_HUMAN
Epidermal growth factor-like protei...
EGFL8
258Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti273E → Q in AAH35574 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_01979286R → K1 PublicationCorresponds to variant dbSNP:rs3096697Ensembl.1
Natural variantiVAR_019793204A → E. Corresponds to variant dbSNP:rs2071289Ensembl.1
Natural variantiVAR_048983277G → C. Corresponds to variant dbSNP:rs35587174Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AB190520 mRNA Translation: BAD51398.1
AY358139 mRNA Translation: AAQ88506.1
U89336 Genomic DNA Translation: AAB47494.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03598.1
BC035574 mRNA Translation: AAH35574.1
BC052591 mRNA Translation: AAH52591.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS4743.1

NCBI Reference Sequences

More...
RefSeqi
NP_085155.1, NM_030652.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000333845; ENSP00000333380; ENSG00000241404
ENST00000395512; ENSP00000378888; ENSG00000241404
ENST00000399648; ENSP00000382556; ENSG00000242038
ENST00000413733; ENSP00000390866; ENSG00000239974
ENST00000414111; ENSP00000415577; ENSG00000240389
ENST00000418252; ENSP00000414996; ENSG00000244444
ENST00000433364; ENSP00000388000; ENSG00000240389
ENST00000436155; ENSP00000405502; ENSG00000243897
ENST00000443511; ENSP00000394193; ENSG00000244444
ENST00000447331; ENSP00000407236; ENSG00000242038
ENST00000450526; ENSP00000398893; ENSG00000243897
ENST00000452189; ENSP00000397426; ENSG00000239974
ENST00000452290; ENSP00000416366; ENSG00000240592
ENST00000455889; ENSP00000411023; ENSG00000240592

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80864

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:80864

UCSC genome browser

More...
UCSCi
uc003oab.2, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB190520 mRNA Translation: BAD51398.1
AY358139 mRNA Translation: AAQ88506.1
U89336 Genomic DNA Translation: AAB47494.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03598.1
BC035574 mRNA Translation: AAH35574.1
BC052591 mRNA Translation: AAH52591.1
CCDSiCCDS4743.1
RefSeqiNP_085155.1, NM_030652.3

3D structure databases

SMRiQ99944
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi123336, 10 interactors
IntActiQ99944, 19 interactors
STRINGi9606.ENSP00000378888

PTM databases

GlyGeniQ99944, 1 site
iPTMnetiQ99944
PhosphoSitePlusiQ99944

Genetic variation databases

BioMutaiEGFL8
DMDMi55584040

Proteomic databases

jPOSTiQ99944
MassIVEiQ99944
PaxDbiQ99944
PeptideAtlasiQ99944
PRIDEiQ99944
ProteomicsDBi34007
78535

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
34956, 67 antibodies

Genome annotation databases

EnsembliENST00000333845; ENSP00000333380; ENSG00000241404
ENST00000395512; ENSP00000378888; ENSG00000241404
ENST00000399648; ENSP00000382556; ENSG00000242038
ENST00000413733; ENSP00000390866; ENSG00000239974
ENST00000414111; ENSP00000415577; ENSG00000240389
ENST00000418252; ENSP00000414996; ENSG00000244444
ENST00000433364; ENSP00000388000; ENSG00000240389
ENST00000436155; ENSP00000405502; ENSG00000243897
ENST00000443511; ENSP00000394193; ENSG00000244444
ENST00000447331; ENSP00000407236; ENSG00000242038
ENST00000450526; ENSP00000398893; ENSG00000243897
ENST00000452189; ENSP00000397426; ENSG00000239974
ENST00000452290; ENSP00000416366; ENSG00000240592
ENST00000455889; ENSP00000411023; ENSG00000240592
GeneIDi80864
KEGGihsa:80864
UCSCiuc003oab.2, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80864
DisGeNETi80864

GeneCards: human genes, protein and diseases

More...
GeneCardsi
EGFL8
HGNCiHGNC:13944, EGFL8
HPAiENSG00000241404, Tissue enhanced (brain)
MIMi609897, gene
neXtProtiNX_Q99944
OpenTargetsiENSG00000241404
PharmGKBiPA38372
VEuPathDBiHostDB:ENSG00000241404.6

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
GeneTreeiENSGT00940000162975
HOGENOMiCLU_083642_0_0_1
InParanoidiQ99944
OMAiTCSCEDN
OrthoDBi749722at2759
TreeFamiTF331360

Enzyme and pathway databases

PathwayCommonsiQ99944

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
80864, 9 hits in 986 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80864
PharosiQ99944, Tdark

Protein Ontology

More...
PROi
PR:Q99944
RNActiQ99944, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000241404, Expressed in tibial nerve and 112 other tissues
ExpressionAtlasiQ99944, baseline and differential
GenevisibleiQ99944, HS

Family and domain databases

InterProiView protein in InterPro
IPR001881, EGF-like_Ca-bd_dom
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR011489, EMI_domain
PfamiView protein in Pfam
PF00008, EGF, 1 hit
PF07645, EGF_CA, 1 hit
PF07546, EMI, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 2 hits
SM00179, EGF_CA, 1 hit
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 1 hit
PS00022, EGF_1, 1 hit
PS01186, EGF_2, 1 hit
PS50026, EGF_3, 2 hits
PS01187, EGF_CA, 1 hit
PS51041, EMI, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEGFL8_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99944
Secondary accession number(s): B0S884
, G5E9Q0, Q5JP23, Q5SSX3, Q8IV30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: May 1, 1997
Last modified: April 7, 2021
This is version 164 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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