Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q99943 (PLCA_HUMAN)

Entry version 178 (17 Jun 2020)
Sequence version 2 (01 Jan 1998)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

Gene

AGPAT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=137.97 µM for C14:0-CoA1 Publication
  2. KM=3.04 µM for C15:0-CoA1 Publication
  3. KM=116.73 µM for C18:0-CoA1 Publication
  4. KM=39.37 µM for C18:1-CoA1 Publication
  5. KM=6.0 µM for LPA sn-1 C18:11 Publication
  1. Vmax=96.21 nmol/min/mg enzyme for C14:0-CoA1 Publication
  2. Vmax=86.09 nmol/min/mg enzyme for C15:0-CoA1 Publication
  3. Vmax=91.94 nmol/min/mg enzyme for C18:0-CoA1 Publication
  4. Vmax=77.57 nmol/min/mg enzyme for C18:1-CoA1 Publication
  5. Vmax=92.0 nmol/min/mg enzyme for LPA sn-1 C18:11 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: CDP-diacylglycerol biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glycerol-3-phosphate acyltransferase 2, mitochondrial (GPAT2), Glycerol-3-phosphate acyltransferase 1, mitochondrial, Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 1, mitochondrial (DKFZp451B1115), Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM), Glycerol-3-phosphate acyltransferase 4 (GPAT4), Glycerol-3-phosphate acyltransferase 3 (GPAT3)
  2. 1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon (AGPAT5), 1-acyl-sn-glycerol-3-phosphate acyltransferase gamma (AGPAT3), 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (AGPAT1), 1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2), 1-acyl-sn-glycerol-3-phosphate acyltransferase delta (AGPAT4), Lysocardiolipin acyltransferase 1 (LCLAT1)
  3. Phosphatidate cytidylyltransferase 1 (CDS1), Phosphatidate cytidylyltransferase 2 (CDS2), Phosphatidate cytidylyltransferase, mitochondrial (TAMM41), Phosphatidate cytidylyltransferase (CDS1), Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase, Phosphatidate cytidylyltransferase
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processLipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS09762-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.3.1.51 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1483166 Synthesis of PA
R-HSA-163765 ChREBP activates metabolic gene expression

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00557;UER00613

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000095

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha (EC:2.3.1.512 Publications)
Alternative name(s):
1-acylglycerol-3-phosphate O-acyltransferase 1
Short name:
1-AGP acyltransferase 1
Short name:
1-AGPAT 1
Lysophosphatidic acid acyltransferase alpha1 Publication
Short name:
LPAAT-alpha
Protein G15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:AGPAT1
Synonyms:G15
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000204310.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:324 AGPAT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603099 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99943

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini27 – 37Lumenal1 PublicationAdd BLAST11
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 127Cytoplasmic1 PublicationAdd BLAST69
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 283Lumenal1 PublicationAdd BLAST135

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		10554

Open Targets

More...OpenTargetsi		ENSG00000204310

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA24621

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99943 Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3583

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		AGPAT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		3914372

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000020819027 – 2831-acyl-sn-glycerol-3-phosphate acyltransferase alphaAdd BLAST257

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99943

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99943

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99943

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99943

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99943

PeptideAtlas

More...PeptideAtlasi		Q99943

PRoteomics IDEntifications database

More...PRIDEi		Q99943

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78534

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99943

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99943

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q99943

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed in adipose tissue and at high levels in testis and pancreas. Expressed at lower levels in tissues such as heart, brain, placenta, kidney, lung, spleen, thymus, prostate, ovary, intestine, colon, leukocyte and liver.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000204310 Expressed in right frontal lobe and 219 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99943 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99943 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000204310 Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115805, 23 interactors

Protein interaction database and analysis system

More...IntActi		Q99943, 10 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000378877

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99943 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi104 – 109HXXXXD motifBy similarity6
Motifi178 – 181EGTR motif1 Publication4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2848 Eukaryota
COG0204 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00390000008726

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_027938_10_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99943

KEGG Orthology (KO)

More...KOi		K13509

Identification of Orthologs from Complete Genome Data

More...OMAi		FHMAIDQ

Database of Orthologous Groups

More...OrthoDBi		1623097at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99943

TreeFam database of animal gene trees

More...TreeFami		TF314867

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004552 AGP_acyltrans
IPR002123 Plipid/glycerol_acylTrfase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01553 Acyltransferase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00563 PlsC, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00530 AGP_acyltrn, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q99943-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDLWPGAWML LLLLFLLLLF LLPTLWFCSP SAKYFFKMAF YNGWILFLAV 
        60         70         80         90        100
LAIPVCAVRG RNVENMKILR LMLLHIKYLY GIRVEVRGAH HFPPSQPYVV 
       110        120        130        140        150
VSNHQSSLDL LGMMEVLPGR CVPIAKRELL WAGSAGLACW LAGVIFIDRK 
       160        170        180        190        200
RTGDAISVMS EVAQTLLTQD VRVWVFPEGT RNHNGSMLPF KRGAFHLAVQ 
       210        220        230        240        250
AQVPIVPIVM SSYQDFYCKK ERRFTSGQCQ VRVLPPVPTE GLTPDDVPAL 
       260        270        280 
ADRVRHSMLT VFREISTDGR GGGDYLKKPG GGG
Length:283
Mass (Da):31,717
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71F3207259747C68
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB47493 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_05059330P → S. Corresponds to variant dbSNP:rs11964847Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U56417 mRNA Translation: AAB58775.1
U75971 mRNA Translation: AAB96378.1
Y09565 mRNA Translation: CAA70758.1
U89336 Genomic DNA Translation: AAB47493.1 Different initiation.
AL662884 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03600.1
BC002402 mRNA Translation: AAH02402.1
BC003007 mRNA Translation: AAH03007.1
BC004310 mRNA Translation: AAH04310.1
BC090849 mRNA Translation: AAH90849.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4744.1

NCBI Reference Sequences

More...RefSeqi		NP_006402.1, NM_006411.3
NP_116130.2, NM_032741.4
XP_005248863.1, XM_005248806.2
XP_011512536.1, XM_011514234.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000336984; ENSP00000337463; ENSG00000204310
ENST00000375104; ENSP00000364245; ENSG00000204310
ENST00000375107; ENSP00000364248; ENSG00000204310
ENST00000383294; ENSP00000372782; ENSG00000206324
ENST00000395496; ENSP00000378874; ENSG00000204310
ENST00000395497; ENSP00000378875; ENSG00000204310
ENST00000395499; ENSP00000378877; ENSG00000204310
ENST00000399825; ENSP00000382721; ENSG00000206324
ENST00000399827; ENSP00000382723; ENSG00000206324
ENST00000399829; ENSP00000382725; ENSG00000206324
ENST00000399830; ENSP00000382726; ENSG00000206324
ENST00000399833; ENSP00000382728; ENSG00000206324
ENST00000414520; ENSP00000406615; ENSG00000227642
ENST00000414933; ENSP00000388870; ENSG00000227642
ENST00000415173; ENSP00000412805; ENSG00000228892
ENST00000416363; ENSP00000407189; ENSG00000236873
ENST00000417388; ENSP00000415015; ENSG00000228892
ENST00000424030; ENSP00000397765; ENSG00000236873
ENST00000425204; ENSP00000388253; ENSG00000226467
ENST00000425572; ENSP00000394919; ENSG00000235758
ENST00000427763; ENSP00000401410; ENSG00000226467
ENST00000430226; ENSP00000412304; ENSG00000235758
ENST00000430777; ENSP00000392820; ENSG00000236873
ENST00000433376; ENSP00000387810; ENSG00000228892
ENST00000433896; ENSP00000408842; ENSG00000236873
ENST00000434614; ENSP00000401287; ENSG00000235758
ENST00000436149; ENSP00000388090; ENSG00000235758
ENST00000439774; ENSP00000398016; ENSG00000236873
ENST00000440840; ENSP00000395863; ENSG00000236873
ENST00000444369; ENSP00000408032; ENSG00000227642
ENST00000446323; ENSP00000392083; ENSG00000226467
ENST00000446463; ENSP00000405864; ENSG00000226467
ENST00000448196; ENSP00000404106; ENSG00000235758
ENST00000449776; ENSP00000410831; ENSG00000226467
ENST00000451833; ENSP00000406582; ENSG00000228892
ENST00000452393; ENSP00000406614; ENSG00000228892
ENST00000452427; ENSP00000387738; ENSG00000235758
ENST00000454929; ENSP00000390988; ENSG00000227642
ENST00000455898; ENSP00000395613; ENSG00000228892
ENST00000456421; ENSP00000389516; ENSG00000227642
ENST00000456679; ENSP00000388815; ENSG00000227642
ENST00000457923; ENSP00000405565; ENSG00000226467

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10554

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10554

UCSC genome browser

More...UCSCi		uc003oae.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56417 mRNA Translation: AAB58775.1
U75971 mRNA Translation: AAB96378.1
Y09565 mRNA Translation: CAA70758.1
U89336 Genomic DNA Translation: AAB47493.1 Different initiation.
AL662884 Genomic DNA No translation available.
AL662828 Genomic DNA No translation available.
AL845464 Genomic DNA No translation available.
BX284686 Genomic DNA No translation available.
BX927239 Genomic DNA No translation available.
CR933878 Genomic DNA No translation available.
CR812478 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03600.1
BC002402 mRNA Translation: AAH02402.1
BC003007 mRNA Translation: AAH03007.1
BC004310 mRNA Translation: AAH04310.1
BC090849 mRNA Translation: AAH90849.1
CCDSiCCDS4744.1
RefSeqiNP_006402.1, NM_006411.3
NP_116130.2, NM_032741.4
XP_005248863.1, XM_005248806.2
XP_011512536.1, XM_011514234.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi115805, 23 interactors
IntActiQ99943, 10 interactors
STRINGi9606.ENSP00000378877

Chemistry databases

ChEMBLiCHEMBL3583
SwissLipidsiSLP:000000095

PTM databases

iPTMnetiQ99943
PhosphoSitePlusiQ99943
SwissPalmiQ99943

Polymorphism and mutation databases

BioMutaiAGPAT1
DMDMi3914372

Proteomic databases

EPDiQ99943
jPOSTiQ99943
MassIVEiQ99943
MaxQBiQ99943
PaxDbiQ99943
PeptideAtlasiQ99943
PRIDEiQ99943
ProteomicsDBi78534

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28453 130 antibodies

Genome annotation databases

EnsembliENST00000336984; ENSP00000337463; ENSG00000204310
ENST00000375104; ENSP00000364245; ENSG00000204310
ENST00000375107; ENSP00000364248; ENSG00000204310
ENST00000383294; ENSP00000372782; ENSG00000206324
ENST00000395496; ENSP00000378874; ENSG00000204310
ENST00000395497; ENSP00000378875; ENSG00000204310
ENST00000395499; ENSP00000378877; ENSG00000204310
ENST00000399825; ENSP00000382721; ENSG00000206324
ENST00000399827; ENSP00000382723; ENSG00000206324
ENST00000399829; ENSP00000382725; ENSG00000206324
ENST00000399830; ENSP00000382726; ENSG00000206324
ENST00000399833; ENSP00000382728; ENSG00000206324
ENST00000414520; ENSP00000406615; ENSG00000227642
ENST00000414933; ENSP00000388870; ENSG00000227642
ENST00000415173; ENSP00000412805; ENSG00000228892
ENST00000416363; ENSP00000407189; ENSG00000236873
ENST00000417388; ENSP00000415015; ENSG00000228892
ENST00000424030; ENSP00000397765; ENSG00000236873
ENST00000425204; ENSP00000388253; ENSG00000226467
ENST00000425572; ENSP00000394919; ENSG00000235758
ENST00000427763; ENSP00000401410; ENSG00000226467
ENST00000430226; ENSP00000412304; ENSG00000235758
ENST00000430777; ENSP00000392820; ENSG00000236873
ENST00000433376; ENSP00000387810; ENSG00000228892
ENST00000433896; ENSP00000408842; ENSG00000236873
ENST00000434614; ENSP00000401287; ENSG00000235758
ENST00000436149; ENSP00000388090; ENSG00000235758
ENST00000439774; ENSP00000398016; ENSG00000236873
ENST00000440840; ENSP00000395863; ENSG00000236873
ENST00000444369; ENSP00000408032; ENSG00000227642
ENST00000446323; ENSP00000392083; ENSG00000226467
ENST00000446463; ENSP00000405864; ENSG00000226467
ENST00000448196; ENSP00000404106; ENSG00000235758
ENST00000449776; ENSP00000410831; ENSG00000226467
ENST00000451833; ENSP00000406582; ENSG00000228892
ENST00000452393; ENSP00000406614; ENSG00000228892
ENST00000452427; ENSP00000387738; ENSG00000235758
ENST00000454929; ENSP00000390988; ENSG00000227642
ENST00000455898; ENSP00000395613; ENSG00000228892
ENST00000456421; ENSP00000389516; ENSG00000227642
ENST00000456679; ENSP00000388815; ENSG00000227642
ENST00000457923; ENSP00000405565; ENSG00000226467
GeneIDi10554
KEGGihsa:10554
UCSCiuc003oae.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10554
DisGeNETi10554
EuPathDBiHostDB:ENSG00000204310.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		AGPAT1
HGNCiHGNC:324 AGPAT1
HPAiENSG00000204310 Low tissue specificity
MIMi603099 gene
neXtProtiNX_Q99943
OpenTargetsiENSG00000204310
PharmGKBiPA24621

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2848 Eukaryota
COG0204 LUCA
GeneTreeiENSGT00390000008726
HOGENOMiCLU_027938_10_1_1
InParanoidiQ99943
KOiK13509
OMAiFHMAIDQ
OrthoDBi1623097at2759
PhylomeDBiQ99943
TreeFamiTF314867

Enzyme and pathway databases

UniPathwayiUPA00557;UER00613
BioCyciMetaCyc:HS09762-MONOMER
BRENDAi2.3.1.51 2681
ReactomeiR-HSA-1483166 Synthesis of PA
R-HSA-163765 ChREBP activates metabolic gene expression

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10554 23 hits in 786 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		AGPAT1 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		AGPAT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10554
PharosiQ99943 Tbio

Protein Ontology

More...PROi		PR:Q99943
RNActiQ99943 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000204310 Expressed in right frontal lobe and 219 other tissues
ExpressionAtlasiQ99943 baseline and differential
GenevisibleiQ99943 HS

Family and domain databases

InterProiView protein in InterPro
IPR004552 AGP_acyltrans
IPR002123 Plipid/glycerol_acylTrfase
PfamiView protein in Pfam
PF01553 Acyltransferase, 1 hit
SMARTiView protein in SMART
SM00563 PlsC, 1 hit
TIGRFAMsiTIGR00530 AGP_acyltrn, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPLCA_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99943
Secondary accession number(s): A2BFI5, Q5BL03
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 1, 1998
Last modified: June 17, 2020
This is version 178 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again