UniProtKB - Q99941 (ATF6B_HUMAN)
Cyclic AMP-dependent transcription factor ATF-6 beta
ATF6B
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 410 | Important for cleavage by MBTPS2By similarity | 1 | |
Sitei | 413 | Important for cleavage by MBTPS2By similarity | 1 |
GO - Molecular functioni
- cAMP response element binding Source: InterPro
- DNA-binding transcription factor activity Source: ParkinsonsUK-UCL
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
- sequence-specific double-stranded DNA binding Source: ARUK-UCL
- transcription regulatory region sequence-specific DNA binding Source: ParkinsonsUK-UCL
GO - Biological processi
- ATF6-mediated unfolded protein response Source: ParkinsonsUK-UCL
- negative regulation of ATF6-mediated unfolded protein response Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: NTNU_SB
- positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: ParkinsonsUK-UCL
- signal transduction Source: ProtInc
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation, Unfolded protein response |
Enzyme and pathway databases
PathwayCommonsi | Q99941 |
SIGNORi | Q99941 |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic AMP-dependent transcription factor ATF-6 betaShort name: cAMP-dependent transcription factor ATF-6 beta Alternative name(s): Activating transcription factor 6 beta Short name: ATF6-beta Protein G13 cAMP response element-binding protein-related protein Short name: Creb-rp cAMP-responsive element-binding protein-like 1 Cleaved into the following chain: |
Gene namesi | Name:ATF6B Synonyms:CREBL1, G13 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000213676.10 |
HGNCi | HGNC:2349, ATF6B |
MIMi | 600984, gene |
neXtProti | NX_Q99941 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 1 Publication; Single-pass type II membrane protein Sequence analysis
Nucleus
- Nucleus 1 Publication
Note: Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.1 Publication
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: ParkinsonsUK-UCL
- integral component of endoplasmic reticulum membrane Source: ParkinsonsUK-UCL
Golgi apparatus
- Golgi apparatus Source: ParkinsonsUK-UCL
Nucleus
- nuclear chromatin Source: NTNU_SB
- nucleus Source: ParkinsonsUK-UCL
Other locations
- protein-DNA complex Source: ParkinsonsUK-UCL
- RNA polymerase II transcription regulator complex Source: NTNU_SB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 396 | CytoplasmicSequence analysisAdd BLAST | 395 | |
Transmembranei | 397 – 417 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 418 – 703 | LumenalSequence analysisAdd BLAST | 286 |
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 1388 |
OpenTargetsi | ENSG00000213676 |
PharmGKBi | PA164716250 |
Miscellaneous databases
Pharosi | Q99941, Tbio |
Polymorphism and mutation databases
BioMutai | ATF6B |
DMDMi | 20137431 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources | |||
ChainiPRO_0000076590 | 2 – 703 | Cyclic AMP-dependent transcription factor ATF-6 betaAdd BLAST | 702 | |
ChainiPRO_0000296201 | 2 – ? | Processed cyclic AMP-dependent transcription factor ATF-6 beta |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources | 1 | |
Glycosylationi | 476 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 505 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 610 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 627 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 676 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 440 – 441 | Cleavage; by MBTPS1By similarity | 2 |
Keywords - PTMi
Acetylation, GlycoproteinProteomic databases
jPOSTi | Q99941 |
MassIVEi | Q99941 |
MaxQBi | Q99941 |
PaxDbi | Q99941 |
PeptideAtlasi | Q99941 |
PRIDEi | Q99941 |
ProteomicsDBi | 78531 [Q99941-1] 78532 [Q99941-2] |
PTM databases
GlyGeni | Q99941, 6 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q99941 |
PhosphoSitePlusi | Q99941 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000213676, Expressed in cerebellar vermis and 152 other tissues |
ExpressionAtlasi | Q99941, baseline and differential |
Genevisiblei | Q99941, HS |
Organism-specific databases
HPAi | ENSG00000213676, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).
1 PublicationBinary interactionsi
Q99941
With | #Exp. | IntAct |
---|---|---|
Non-structural protein 4B (PRO_0000037575) from Hepatitis C virus genotype 1a (isolate H77). | 5 | EBI-2841031,EBI-8763498 |
Protein-protein interaction databases
BioGRIDi | 107778, 42 interactors |
IntActi | Q99941, 20 interactors |
STRINGi | 9606.ENSP00000364349 |
Miscellaneous databases
RNActi | Q99941, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 325 – 388 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 2 – 86 | Transcription activationAdd BLAST | 85 | |
Regioni | 327 – 347 | Basic motifPROSITE-ProRule annotationAdd BLAST | 21 | |
Regioni | 350 – 357 | Leucine-zipperPROSITE-ProRule annotation | 8 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 96 – 105 | Poly-Ser | 10 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4343, Eukaryota |
GeneTreei | ENSGT00940000160798 |
HOGENOMi | CLU_026136_0_0_1 |
InParanoidi | Q99941 |
OMAi | PPQLFRC |
PhylomeDBi | Q99941 |
TreeFami | TF316079 |
Family and domain databases
InterProi | View protein in InterPro IPR029809, ATF6B IPR004827, bZIP |
PANTHERi | PTHR46164:SF2, PTHR46164:SF2, 2 hits |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR
60 70 80 90 100
CPEQDVPFDG SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL
110 120 130 140 150
SSESSRLSTE PSSEALGVGE VLHVKTESLA PPLCLLGDDP TSSFETVQIN
160 170 180 190 200
VIPTSDDSSD VQTKIEPVSP CSSVNSEASL LSADSSSQAF IGEEVLEVKT
210 220 230 240 250
ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR KPPLQPKPVV
260 270 280 290 300
LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP
310 320 330 340 350
RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL
360 370 380 390 400
QGLEARLQAV LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI
410 420 430 440 450
MVFLLFIAFN FGPVSISEPP SAPISPRMNK GEPQPRRHLL GFSEQEPVQG
460 470 480 490 500
VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF PGGAKELLLR DLDQLFLSSD
510 520 530 540 550
CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS QPRKKSPPVK
560 570 580 590 600
AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD
610 620 630 640 650
HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM
660 670 680 690 700
DTRVIHIKTS TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL
NHP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0Y7D7 | H0Y7D7_HUMAN | Cyclic AMP-dependent transcription ... | ATF6B | 627 | Annotation score: | ||
A0A0G2JIM1 | A0A0G2JIM1_HUMAN | Cyclic AMP-dependent transcription ... | ATF6B | 142 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 3 | E → D in CAA66664 (PubMed:8870652).Curated | 1 | |
Sequence conflicti | 329 – 330 | QQ → HE in CAA66664 (PubMed:8870652).Curated | 2 | |
Sequence conflicti | 520 | V → D in AAC50888 (PubMed:8923003).Curated | 1 | |
Sequence conflicti | 600 | D → G in AAA97438 (PubMed:8586413).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_000593 | 28 – 31 | GLQN → D in isoform 1. 1 Publication | 4 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31903 mRNA Translation: AAA97438.1 X98053 Genomic DNA Translation: CAA66663.1 X98054 mRNA Translation: CAA66664.1 U89337 Genomic DNA Translation: AAB47487.1 AL049547 Genomic DNA Translation: CAB89295.1 AL662828 Genomic DNA No translation available. AL662884 Genomic DNA No translation available. CR753803 Genomic DNA No translation available. CR925796 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03581.1 CH471081 Genomic DNA Translation: EAX03583.1 U52694 Genomic DNA Translation: AAG14900.1 U52696 mRNA Translation: AAC50888.1 Frameshift. U52693 Genomic DNA Translation: AAG14898.1 Frameshift. U52701 mRNA Translation: AAC50883.1 Sequence problems. |
CCDSi | CCDS4737.1 [Q99941-1] CCDS47408.1 [Q99941-2] |
RefSeqi | NP_001129625.1, NM_001136153.1 [Q99941-2] NP_004372.3, NM_004381.4 [Q99941-1] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31903 mRNA Translation: AAA97438.1 X98053 Genomic DNA Translation: CAA66663.1 X98054 mRNA Translation: CAA66664.1 U89337 Genomic DNA Translation: AAB47487.1 AL049547 Genomic DNA Translation: CAB89295.1 AL662828 Genomic DNA No translation available. AL662884 Genomic DNA No translation available. CR753803 Genomic DNA No translation available. CR925796 Genomic DNA No translation available. CH471081 Genomic DNA Translation: EAX03581.1 CH471081 Genomic DNA Translation: EAX03583.1 U52694 Genomic DNA Translation: AAG14900.1 U52696 mRNA Translation: AAC50888.1 Frameshift. U52693 Genomic DNA Translation: AAG14898.1 Frameshift. U52701 mRNA Translation: AAC50883.1 Sequence problems. |
CCDSi | CCDS4737.1 [Q99941-1] CCDS47408.1 [Q99941-2] |
RefSeqi | NP_001129625.1, NM_001136153.1 [Q99941-2] NP_004372.3, NM_004381.4 [Q99941-1] |
3D structure databases
SMRi | Q99941 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107778, 42 interactors |
IntActi | Q99941, 20 interactors |
STRINGi | 9606.ENSP00000364349 |
PTM databases
GlyGeni | Q99941, 6 sites, 1 O-linked glycan (1 site) |
iPTMneti | Q99941 |
PhosphoSitePlusi | Q99941 |
Polymorphism and mutation databases
BioMutai | ATF6B |
DMDMi | 20137431 |
Proteomic databases
jPOSTi | Q99941 |
MassIVEi | Q99941 |
MaxQBi | Q99941 |
PaxDbi | Q99941 |
PeptideAtlasi | Q99941 |
PRIDEi | Q99941 |
ProteomicsDBi | 78531 [Q99941-1] 78532 [Q99941-2] |
Protocols and materials databases
Antibodypediai | 49313, 210 antibodies 7841, 6 antibodies |
DNASUi | 1388 |
Genome annotation databases
Organism-specific databases
CTDi | 1388 |
DisGeNETi | 1388 |
EuPathDBi | HostDB:ENSG00000213676.10 |
GeneCardsi | ATF6B |
HGNCi | HGNC:2349, ATF6B |
HPAi | ENSG00000213676, Low tissue specificity |
MIMi | 600984, gene |
neXtProti | NX_Q99941 |
OpenTargetsi | ENSG00000213676 |
PharmGKBi | PA164716250 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG4343, Eukaryota |
GeneTreei | ENSGT00940000160798 |
HOGENOMi | CLU_026136_0_0_1 |
InParanoidi | Q99941 |
OMAi | PPQLFRC |
PhylomeDBi | Q99941 |
TreeFami | TF316079 |
Enzyme and pathway databases
PathwayCommonsi | Q99941 |
SIGNORi | Q99941 |
Miscellaneous databases
BioGRID-ORCSi | 1388, 13 hits in 870 CRISPR screens |
ChiTaRSi | ATF6B, human |
GeneWikii | CREBL1 |
GenomeRNAii | 1388 |
Pharosi | Q99941, Tbio |
PROi | PR:Q99941 |
RNActi | Q99941, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000213676, Expressed in cerebellar vermis and 152 other tissues |
ExpressionAtlasi | Q99941, baseline and differential |
Genevisiblei | Q99941, HS |
Family and domain databases
InterProi | View protein in InterPro IPR029809, ATF6B IPR004827, bZIP |
PANTHERi | PTHR46164:SF2, PTHR46164:SF2, 2 hits |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATF6B_HUMAN | |
Accessioni | Q99941Primary (citable) accession number: Q99941 Secondary accession number(s): B0UYX6 Q9NPL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 23, 2002 |
Last sequence update: | January 23, 2002 | |
Last modified: | December 2, 2020 | |
This is version 198 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families