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UniProtKB - Q99941 (ATF6B_HUMAN)

Entry version 198 (02 Dec 2020)
Sequence version 2 (23 Jan 2002)
Previous versions | rss
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Protein

Cyclic AMP-dependent transcription factor ATF-6 beta

Gene

ATF6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Precursor of the transcription factor form (Processed cyclic AMP-dependent transcription factor ATF-6 beta), which is embedded in the endoplasmic reticulum membrane (PubMed:11256944). Endoplasmic reticulum stress promotes processing of this form, releasing the transcription factor form that translocates into the nucleus, where it activates transcription of genes involved in the unfolded protein response (UPR) (PubMed:11256944).1 Publication
Transcription factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress (PubMed:11256944). Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN9CCAC[GA]-3') when NF-Y is bound to ERSE (PubMed:11256944).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei410Important for cleavage by MBTPS2By similarity1
Sitei413Important for cleavage by MBTPS2By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation, Unfolded protein response

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99941

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99941

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-6 beta
Short name:
cAMP-dependent transcription factor ATF-6 beta
Alternative name(s):
Activating transcription factor 6 beta
Short name:
ATF6-beta
Protein G13
cAMP response element-binding protein-related protein
Short name:
Creb-rp
cAMP-responsive element-binding protein-like 1
Cleaved into the following chain:
Processed cyclic AMP-dependent transcription factor ATF-6 beta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATF6B
Synonyms:CREBL1, G13
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000213676.10

Human Gene Nomenclature Database

More...HGNCi		HGNC:2349, ATF6B

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		600984, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99941

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini2 – 396CytoplasmicSequence analysisAdd BLAST395
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei397 – 417Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini418 – 703LumenalSequence analysisAdd BLAST286

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		1388

Open Targets

More...OpenTargetsi		ENSG00000213676

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA164716250

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99941, Tbio

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ATF6B

Domain mapping of disease mutations (DMDM)

More...DMDMi		20137431

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000765902 – 703Cyclic AMP-dependent transcription factor ATF-6 betaAdd BLAST702
ChainiPRO_00002962012 – ?Processed cyclic AMP-dependent transcription factor ATF-6 beta

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi476N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi610N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication
During unfolded protein response, a fragment of approximately 60 kDa containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 (MBTPS1, S1P) and site-2 (MBTPS2, S2P) proteases.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei440 – 441Cleavage; by MBTPS1By similarity2

Keywords - PTMi

Acetylation, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99941

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99941

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99941

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99941

PeptideAtlas

More...PeptideAtlasi		Q99941

PRoteomics IDEntifications database

More...PRIDEi		Q99941

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78531 [Q99941-1]
78532 [Q99941-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q99941, 6 sites, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99941

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99941

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000213676, Expressed in cerebellar vermis and 152 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99941, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99941, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000213676, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer and heterodimer with ATF6-alpha. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC).

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107778, 42 interactors

Protein interaction database and analysis system

More...IntActi		Q99941, 20 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000364349

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99941, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99941

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini325 – 388bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2 – 86Transcription activationAdd BLAST85
Regioni327 – 347Basic motifPROSITE-ProRule annotationAdd BLAST21
Regioni350 – 357Leucine-zipperPROSITE-ProRule annotation8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi96 – 105Poly-Ser10

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The basic domain functions as a nuclear localization signal.1 Publication
The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4343, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160798

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026136_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99941

Identification of Orthologs from Complete Genome Data

More...OMAi		PPQLFRC

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99941

TreeFam database of animal gene trees

More...TreeFami		TF316079

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029809, ATF6B
IPR004827, bZIP

The PANTHER Classification System

More...PANTHERi		PTHR46164:SF2, PTHR46164:SF2, 2 hits

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00170, bZIP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00338, BRLZ, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 2 (identifier: Q99941-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR 
        60         70         80         90        100
CPEQDVPFDG SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL 
       110        120        130        140        150
SSESSRLSTE PSSEALGVGE VLHVKTESLA PPLCLLGDDP TSSFETVQIN 
       160        170        180        190        200
VIPTSDDSSD VQTKIEPVSP CSSVNSEASL LSADSSSQAF IGEEVLEVKT 
       210        220        230        240        250
ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR KPPLQPKPVV 
       260        270        280        290        300
LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP 
       310        320        330        340        350
RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL 
       360        370        380        390        400
QGLEARLQAV LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI 
       410        420        430        440        450
MVFLLFIAFN FGPVSISEPP SAPISPRMNK GEPQPRRHLL GFSEQEPVQG 
       460        470        480        490        500
VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF PGGAKELLLR DLDQLFLSSD 
       510        520        530        540        550
CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS QPRKKSPPVK 
       560        570        580        590        600
AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD 
       610        620        630        640        650
HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM 
       660        670        680        690        700
DTRVIHIKTS TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL 

NHP
Length:703
Mass (Da):76,709
Last modified:January 23, 2002 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB04C7B23E7D83F82
GO
Isoform 1 (identifier: Q99941-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     28-31: GLQN → D

Show »
Length:700
Mass (Da):76,412
Checksum:i54C077BF95309216
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0Y7D7H0Y7D7_HUMAN
Cyclic AMP-dependent transcription ...
ATF6B
627Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JIM1A0A0G2JIM1_HUMAN
Cyclic AMP-dependent transcription ...
ATF6B
142Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC50888 differs from that shown. Reason: Frameshift.Curated
The sequence AAG14898 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3E → D in CAA66664 (PubMed:8870652).Curated1
Sequence conflicti329 – 330QQ → HE in CAA66664 (PubMed:8870652).Curated2
Sequence conflicti520V → D in AAC50888 (PubMed:8923003).Curated1
Sequence conflicti600D → G in AAA97438 (PubMed:8586413).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_00059328 – 31GLQN → D in isoform 1. 1 Publication4

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U31903 mRNA Translation: AAA97438.1
X98053 Genomic DNA Translation: CAA66663.1
X98054 mRNA Translation: CAA66664.1
U89337 Genomic DNA Translation: AAB47487.1
AL049547 Genomic DNA Translation: CAB89295.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
CR753803 Genomic DNA No translation available.
CR925796 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03581.1
CH471081 Genomic DNA Translation: EAX03583.1
U52694 Genomic DNA Translation: AAG14900.1
U52696 mRNA Translation: AAC50888.1 Frameshift.
U52693 Genomic DNA Translation: AAG14898.1 Frameshift.
U52701 mRNA Translation: AAC50883.1 Sequence problems.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4737.1 [Q99941-1]
CCDS47408.1 [Q99941-2]

NCBI Reference Sequences

More...RefSeqi		NP_001129625.1, NM_001136153.1 [Q99941-2]
NP_004372.3, NM_004381.4 [Q99941-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000293709; ENSP00000293709; ENSG00000168468 [Q99941-1]
ENST00000375201; ENSP00000364347; ENSG00000213676 [Q99941-2]
ENST00000375203; ENSP00000364349; ENSG00000213676 [Q99941-1]
ENST00000383156; ENSP00000372642; ENSG00000168468 [Q99941-2]
ENST00000425571; ENSP00000404814; ENSG00000228628 [Q99941-1]
ENST00000427136; ENSP00000404725; ENSG00000234539 [Q99941-1]
ENST00000435768; ENSP00000399764; ENSG00000228628 [Q99941-2]
ENST00000439240; ENSP00000391131; ENSG00000234539 [Q99941-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1388

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1388

UCSC genome browser

More...UCSCi		uc003nzn.4, human [Q99941-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31903 mRNA Translation: AAA97438.1
X98053 Genomic DNA Translation: CAA66663.1
X98054 mRNA Translation: CAA66664.1
U89337 Genomic DNA Translation: AAB47487.1
AL049547 Genomic DNA Translation: CAB89295.1
AL662828 Genomic DNA No translation available.
AL662884 Genomic DNA No translation available.
CR753803 Genomic DNA No translation available.
CR925796 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03581.1
CH471081 Genomic DNA Translation: EAX03583.1
U52694 Genomic DNA Translation: AAG14900.1
U52696 mRNA Translation: AAC50888.1 Frameshift.
U52693 Genomic DNA Translation: AAG14898.1 Frameshift.
U52701 mRNA Translation: AAC50883.1 Sequence problems.
CCDSiCCDS4737.1 [Q99941-1]
CCDS47408.1 [Q99941-2]
RefSeqiNP_001129625.1, NM_001136153.1 [Q99941-2]
NP_004372.3, NM_004381.4 [Q99941-1]

3D structure databases

SMRiQ99941
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi107778, 42 interactors
IntActiQ99941, 20 interactors
STRINGi9606.ENSP00000364349

PTM databases

GlyGeniQ99941, 6 sites, 1 O-linked glycan (1 site)
iPTMnetiQ99941
PhosphoSitePlusiQ99941

Polymorphism and mutation databases

BioMutaiATF6B
DMDMi20137431

Proteomic databases

jPOSTiQ99941
MassIVEiQ99941
MaxQBiQ99941
PaxDbiQ99941
PeptideAtlasiQ99941
PRIDEiQ99941
ProteomicsDBi78531 [Q99941-1]
78532 [Q99941-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49313, 210 antibodies
7841, 6 antibodies

The DNASU plasmid repository

More...DNASUi		1388

Genome annotation databases

EnsembliENST00000293709; ENSP00000293709; ENSG00000168468 [Q99941-1]
ENST00000375201; ENSP00000364347; ENSG00000213676 [Q99941-2]
ENST00000375203; ENSP00000364349; ENSG00000213676 [Q99941-1]
ENST00000383156; ENSP00000372642; ENSG00000168468 [Q99941-2]
ENST00000425571; ENSP00000404814; ENSG00000228628 [Q99941-1]
ENST00000427136; ENSP00000404725; ENSG00000234539 [Q99941-1]
ENST00000435768; ENSP00000399764; ENSG00000228628 [Q99941-2]
ENST00000439240; ENSP00000391131; ENSG00000234539 [Q99941-2]
GeneIDi1388
KEGGihsa:1388
UCSCiuc003nzn.4, human [Q99941-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1388
DisGeNETi1388
EuPathDBiHostDB:ENSG00000213676.10

GeneCards: human genes, protein and diseases

More...GeneCardsi		ATF6B
HGNCiHGNC:2349, ATF6B
HPAiENSG00000213676, Low tissue specificity
MIMi600984, gene
neXtProtiNX_Q99941
OpenTargetsiENSG00000213676
PharmGKBiPA164716250

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG4343, Eukaryota
GeneTreeiENSGT00940000160798
HOGENOMiCLU_026136_0_0_1
InParanoidiQ99941
OMAiPPQLFRC
PhylomeDBiQ99941
TreeFamiTF316079

Enzyme and pathway databases

PathwayCommonsiQ99941
SIGNORiQ99941

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1388, 13 hits in 870 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ATF6B, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CREBL1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1388
PharosiQ99941, Tbio

Protein Ontology

More...PROi		PR:Q99941
RNActiQ99941, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000213676, Expressed in cerebellar vermis and 152 other tissues
ExpressionAtlasiQ99941, baseline and differential
GenevisibleiQ99941, HS

Family and domain databases

InterProiView protein in InterPro
IPR029809, ATF6B
IPR004827, bZIP
PANTHERiPTHR46164:SF2, PTHR46164:SF2, 2 hits
PfamiView protein in Pfam
PF00170, bZIP_1, 1 hit
SMARTiView protein in SMART
SM00338, BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217, BZIP, 1 hit
PS00036, BZIP_BASIC, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATF6B_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99941
Secondary accession number(s): B0UYX6
, Q13269, Q14343, Q14345, Q5SSW7, Q99635, Q99637, Q9H3V9, Q9H3W1, Q9NPL0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: December 2, 2020
This is version 198 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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