BAG1

Functionⁱ

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877). Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406). Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).5 Publications

GO - Molecular functionⁱ

adenyl-nucleotide exchange factor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 24318877
chaperone binding Source: InterPro
ubiquitin protein ligase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
cell surface receptor signaling pathway
Source: ProtInc
Traceable author statementⁱ
- 8947043
chaperone cofactor-dependent protein refolding
Source: UniProtKB
Inferred from direct assayⁱ
- 12853476
negative regulation of apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 8947043
regulation of cellular response to heat Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Chaperone
Biological process	Apoptosis

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response
SIGNORⁱ	Q99933

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BAG family molecular chaperone regulator 1 Short name: BAG-1 Alternative name(s): Bcl-2-associated athanogene 1
Gene namesⁱ	Name:BAG1 Synonyms:HAP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000107262.17
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:937 BAG1
MIMⁱ	601497 gene
neXtProtⁱ	NX_Q99933

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	308 – 309	RK → AA: Significant loss of interaction with HSPA8. 1 Publication		2

Organism-specific databases

DisGeNET More...DisGeNETⁱ	573
Open Targets More...OpenTargetsⁱ	ENSG00000107262
PharmGKBⁱ	PA25237

Polymorphism and mutation databases

BioMutaⁱ	BAG1
DMDMⁱ	296439462

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000088865	1 – 345	BAG family molecular chaperone regulator 1Add BLAST		345

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	223	PhosphoserineCombined sources		1

Post-translational modificationⁱ

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.Curated

Keywords - PTMⁱ

Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	Q99933
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99933
PaxDbⁱ	Q99933
PeptideAtlas More...PeptideAtlasⁱ	Q99933
PRIDEⁱ	Q99933
ProteomicsDBⁱ	78526 78527 [Q99933-2] 78528 [Q99933-3] 78529 [Q99933-4]

PTM databases

iPTMnetⁱ	Q99933
PhosphoSitePlusⁱ	Q99933

Expressionⁱ

Tissue specificityⁱ

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).1 Publication

Inductionⁱ

Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000107262 Expressed in 230 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_BAG1
ExpressionAtlasⁱ	Q99933 baseline and differential
Genevisibleⁱ	Q99933 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB002486 HPA018121

HPAⁱ

CAB002486
HPA018121

Interactionⁱ

Subunit structureⁱ

Homodimer. Forms a heteromeric complex with HSP70/HSC70 (PubMed:9305631). Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70 (PubMed:27474739, PubMed:24318877, PubMed:9305631, PubMed:9679980). Interacts with NR3C1 (PubMed:10477749). Interacts with the N-terminal region of STK19 (PubMed:15986447). Interacts with PPP1R15A (PubMed:12724406). Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2 (PubMed:9305631). Interacts with SIAH1 (PubMed:9582267). Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877). Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877). Interacts with SIAH2 (By similarity).By similarity9 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
	Q53FC7	2	EBI-1030678,EBI-9356749
	Q96BE0	2	EBI-1030678,EBI-9356686
HSPA8	P11142	13	EBI-1030678,EBI-351896
HSPA8	Q96IS6	5	EBI-1030678,EBI-10289199
PSMD2	Q13200	7	EBI-1030678,EBI-357648
STUB1	Q9UNE7	2	EBI-1030678,EBI-357085
TRIM23	P36406	5	EBI-1030678,EBI-740098
TRIM27	P14373	6	EBI-1030678,EBI-719493

GO - Molecular functionⁱ

chaperone binding Source: InterPro
ubiquitin protein ligase binding
Source: ARUK-UCL
Inferred from physical interactionⁱ
- 16207813

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107049, 143 interactors
CORUMⁱ	Q99933
Database of interacting proteins More...DIPⁱ	DIP-3341N
IntActⁱ	Q99933, 40 interactors
Molecular INTeraction database More...MINTⁱ	Q99933
STRINGⁱ	9606.ENSP00000420514

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	144 – 149	Combined sources	6
Beta strandⁱ	151 – 159	Combined sources	9
Beta strandⁱ	163 – 167	Combined sources	5
Helixⁱ	170 – 180	Combined sources	11
Turnⁱ	185 – 187	Combined sources	3
Beta strandⁱ	189 – 192	Combined sources	4
Beta strandⁱ	195 – 197	Combined sources	3
Beta strandⁱ	200 – 203	Combined sources	4
Helixⁱ	204 – 207	Combined sources	4
Beta strandⁱ	211 – 219	Combined sources	9
Helixⁱ	224 – 259	Combined sources	36
Beta strandⁱ	260 – 262	Combined sources	3
Helixⁱ	264 – 272	Combined sources	9
Helixⁱ	275 – 292	Combined sources	18
Helixⁱ	302 – 327	Combined sources	26

Show more details

3D structure databases

ProteinModelPortalⁱ	Q99933
SMRⁱ	Q99933
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99933

EvolutionaryTraceⁱ

Q99933

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Repeatⁱ	96 – 101	1	6
Repeatⁱ	102 – 107	2	6
Repeatⁱ	108 – 113	3	6
Repeatⁱ	114 – 119	4	6
Repeatⁱ	120 – 125	5	6
Repeatⁱ	126 – 131	6	6
Repeatⁱ	132 – 137	7	6
Domainⁱ	144 – 224	Ubiquitin-likePROSITE-ProRule annotationAdd BLAST	81
Domainⁱ	246 – 326	BAGPROSITE-ProRule annotationAdd BLAST	81

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	96 – 137	7 X 6 AA tandem repeat of E-E-X(4)Add BLAST	42
Regionⁱ	172 – 219	Interaction with HSPA8Add BLAST	48
Regionⁱ	216 – 345	Interaction with PPP1R15A1 PublicationAdd BLAST	130

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	4 – 82	Arg-richAdd BLAST		79

Keywords - Domainⁱ

Repeat

Phylogenomic databases

eggNOGⁱ	ENOG410IHYI Eukaryota ENOG4111SUG LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00450000040296
HOVERGENⁱ	HBG000236
InParanoidⁱ	Q99933
KEGG Orthology (KO) More...KOⁱ	K09555
PhylomeDBⁱ	Q99933

Family and domain databases

Gene3Dⁱ	1.20.58.120, 1 hit
InterProⁱ	View protein in InterPro IPR017093 BAG-1 IPR036533 BAG_dom_sf IPR003103 BAG_domain IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
PANTHERⁱ	PTHR12329:SF16 PTHR12329:SF16, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02179 BAG, 1 hit PF00240 ubiquitin, 1 hit
SMARTⁱ	View protein in SMART SM00264 BAG, 1 hit SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit SSF63491 SSF63491, 1 hit
PROSITEⁱ	View protein in PROSITE PS51035 BAG, 1 hit PS50053 UBIQUITIN_2, 1 hit

Sequences (4+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 4 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: Q99933-1) [UniParc]FASTA Add to basket

Also known as: BAG-1L, p50

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR 
        60         70         80         90        100
STASGHDRPT RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW 
       110        120        130        140        150
SEEATQSEEA TQGEEMNRSQ EVTRDEESTR SEEVTREEMA AAGLTVTVTH 
       160        170        180        190        200
SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV IGVPQSFQKL IFKGKSLKEM 
       210        220        230        240        250
ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV EKIADQLEEL 
       260        270        280        290        300
NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN 
       310        320        330        340 
FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE

Length:345

Mass (Da):38,779

Last modified:May 18, 2010 - v4

Checksum:ⁱ8B40EF078C66335F

GO

Isoform 2 (identifier: Q99933-2) [UniParc]FASTA Add to basket

Also known as: BAG1V, HAPV

The sequence of this isoform differs from the canonical sequence as follows:
302-345: KDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE → PTLTLVLNEK

« Hide

        10         20         30         40         50
MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR 
        60         70         80         90        100
STASGHDRPT RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW 
       110        120        130        140        150
SEEATQSEEA TQGEEMNRSQ EVTRDEESTR SEEVTREEMA AAGLTVTVTH 
       160        170        180        190        200
SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV IGVPQSFQKL IFKGKSLKEM 
       210        220        230        240        250
ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV EKIADQLEEL 
       260        270        280        290        300
NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN 
       310 
FPTLTLVLNE K

Note: Produced by alternative splicing.

Show »

Length:311

Mass (Da):34,866

Checksum:ⁱ1F94BA55E21694D3

GO

Isoform 3 (identifier: Q99933-3) [UniParc]FASTA Add to basket

Also known as: BAG-1M, RAP46

The sequence of this isoform differs from the canonical sequence as follows:
1-71: Missing.

« Hide

        10         20         30         40         50
MKKKTRRRST RSEELTRSEE LTLSEEATWS EEATQSEEAT QGEEMNRSQE 
        60         70         80         90        100
VTRDEESTRS EEVTREEMAA AGLTVTVTHS NEKHDLHVTS QQGSSEPVVQ 
       110        120        130        140        150
DLAQVVEEVI GVPQSFQKLI FKGKSLKEME TPLSALGIQD GCRVMLIGKK 
       160        170        180        190        200
NSPQEEVELK KLKHLEKSVE KIADQLEELN KELTGIQQGF LPKDLQAEAL 
       210        220        230        240        250
CKLDRRVKAT IEQFMKILEE IDTLILPENF KDSRLKRKGL VKKVQAFLAE 
       260        270 
CDTVEQNICQ ETERLQSTNF ALAE

Note: Produced by alternative initiation at Met-72 of isoform 1.

Show »

Length:274

Mass (Da):31,117

Checksum:ⁱC13E200ED63A2CF0

GO

Isoform 4 (identifier: Q99933-4) [UniParc]FASTA Add to basket

Also known as: BAG-1, p32

The sequence of this isoform differs from the canonical sequence as follows:
1-115: Missing.

« Hide

        10         20         30         40         50
MNRSQEVTRD EESTRSEEVT REEMAAAGLT VTVTHSNEKH DLHVTSQQGS 
        60         70         80         90        100
SEPVVQDLAQ VVEEVIGVPQ SFQKLIFKGK SLKEMETPLS ALGIQDGCRV 
       110        120        130        140        150
MLIGKKNSPQ EEVELKKLKH LEKSVEKIAD QLEELNKELT GIQQGFLPKD 
       160        170        180        190        200
LQAEALCKLD RRVKATIEQF MKILEEIDTL ILPENFKDSR LKRKGLVKKV 
       210        220        230
QAFLAECDTV EQNICQETER LQSTNFALAE

Note: Produced by alternative initiation at Met-116 of isoform 1.

Show »

Length:230

Mass (Da):25,989

Checksum:ⁱD4B34A8F54DE684D

GO

Computationally mapped potential isoform sequencesⁱ

There are 6 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

C9JYK5	C9JYK5_HUMAN	BAG family molecular chaperone regu... BAG family molecular chaperone regulator 1	BAG1	150	Annotation score:
A0A0U1RR89	A0A0U1RR89_HUMAN	BAG family molecular chaperone regu... BAG family molecular chaperone regulator 1	BAG1	63	Annotation score:
J3QTA2	J3QTA2_HUMAN	BAG family molecular chaperone regu... BAG family molecular chaperone regulator 1	BAG1	345	Annotation score:
F1LLU6	F1LLU6_HUMAN	BAG family molecular chaperone regu... BAG family molecular chaperone regulator 1	BAG1	160	Annotation score:
A0A0U1RQD7	A0A0U1RQD7_HUMAN	BAG family molecular chaperone regu... BAG family molecular chaperone regulator 1	BAG1	94	Annotation score:
C9J9Y9	C9J9Y9_HUMAN	BAG family molecular chaperone regu... BAG family molecular chaperone regulator 1	BAG1	48	Annotation score:

Sequence cautionⁱ

The sequence AAD11467 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence AAD25045 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence BAD96469 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated

The sequence CAA84624 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence EAW58515 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	45	G → R in AAC34258 (PubMed:8812483).Curated	1
Sequence conflictⁱ	45	G → R in BAD96469 (Ref. 5) Curated	1
Sequence conflictⁱ	45	G → R in AAH01936 (PubMed:15489334).Curated	1
Sequence conflictⁱ	45	G → R in AAH14774 (PubMed:15489334).Curated	1
Sequence conflictⁱ	79	R → F in AAD11467 (PubMed:8812483).Curated	1
Sequence conflictⁱ	84	E → K in AAD11467 (PubMed:8812483).Curated	1
Sequence conflictⁱ	90	E → K in AAD11467 (PubMed:8812483).Curated	1
Sequence conflictⁱ	245	D → N in AAD11467 (PubMed:8812483).Curated	1
Sequence conflictⁱ	293	D → H in AAD11467 (PubMed:8812483).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_038394	1 – 115	Missing in isoform 4. CuratedAdd BLAST	115
Alternative sequenceⁱVSP_038395	1 – 71	Missing in isoform 3. CuratedAdd BLAST	71
Alternative sequenceⁱVSP_000453	302 – 345	KDSRL…FALAE → PTLTLVLNEK in isoform 2. 1 PublicationAdd BLAST	44

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35491 mRNA Translation: CAA84624.1 Different initiation. U46917 mRNA Translation: AAD11467.1 Different initiation. AF022224 mRNA Translation: AAC34258.1 AF116273 mRNA Translation: AAD25045.1 Different initiation. AK222749 mRNA Translation: BAD96469.1 Different initiation. AL161445 Genomic DNA No translation available. AL356472 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58514.1 CH471071 Genomic DNA Translation: EAW58515.1 Sequence problems. BC001936 mRNA Translation: AAH01936.2 BC014774 mRNA Translation: AAH14774.2
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS35004.1 [Q99933-1] CCDS55301.1 [Q99933-4]
NCBI Reference Sequences More...RefSeqⁱ	NP_001165886.1, NM_001172415.1 [Q99933-4] NP_004314.5, NM_004323.5
UniGeneⁱ	Hs.377484

Genome annotation databases

Ensemblⁱ	ENST00000379704; ENSP00000369026; ENSG00000107262 [Q99933-4] ENST00000641048; ENSP00000493185; ENSG00000107262 [Q99933-1] ENST00000643906; ENSP00000493589; ENSG00000107262 [Q99933-1]
GeneIDⁱ	573
KEGGⁱ	hsa:573
UCSC genome browser More...UCSCⁱ	uc064sos.1 human [Q99933-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99933	Isoform 4 of BAG family molecular chaperone regulator 1		HUMAN		230	UniRef100_Q99933
BCL2-associated athanogene isoform 1 (Fragment)		HUMAN		274
Isoform 3 of BAG family molecular chaperone regulator 1		HUMAN		274
UPI000022D8EF		HUMAN		207

Protein	Similar proteins		Species	Score	Length	Source
Q99933	Isoform 4 of BAG family molecular chaperone regulator 1		HUMAN		230	UniRef90_Q99933
Uncharacterized protein		PAPAN		347
Uncharacterized protein		MACNE		347
Uncharacterized protein		MACFA		60
BCL2 associated athanogene 1		GORGO		345
+35
Q99933-2	BAG1 isoform 5		PANTR		230	UniRef90_Q99933-2
BAG family molecular chaperone regulator 1 (Fragment)		HUMAN		150
BAG1 isoform 10 (Fragment)		PONAB		150
UPI0008F4FF50		GORGO		286
BAG1 isoform 2 (Fragment)		PANTR		351
+4

Protein	Similar proteins		Species	Score	Length	Source
Q99933	Isoform 4 of BAG family molecular chaperone regulator 1		HUMAN		230	UniRef50_Q99933
Uncharacterized protein		PAPAN		347
Uncharacterized protein		MACNE		347
Uncharacterized protein		MACFA		60
BCL2 associated athanogene 1		PONAB		345
+92

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35491 mRNA Translation: CAA84624.1 Different initiation. U46917 mRNA Translation: AAD11467.1 Different initiation. AF022224 mRNA Translation: AAC34258.1 AF116273 mRNA Translation: AAD25045.1 Different initiation. AK222749 mRNA Translation: BAD96469.1 Different initiation. AL161445 Genomic DNA No translation available. AL356472 Genomic DNA No translation available. CH471071 Genomic DNA Translation: EAW58514.1 CH471071 Genomic DNA Translation: EAW58515.1 Sequence problems. BC001936 mRNA Translation: AAH01936.2 BC014774 mRNA Translation: AAH14774.2
CCDSⁱ	CCDS35004.1 [Q99933-1] CCDS55301.1 [Q99933-4]
RefSeqⁱ	NP_001165886.1, NM_001172415.1 [Q99933-4] NP_004314.5, NM_004323.5
UniGeneⁱ	Hs.377484

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1HX1	X-ray	1.90	B	222-334	[»]
	1WXV	NMR	-	A	144-222	[»]
	3FZF	X-ray	2.20	B	222-334	[»]
	3FZH	X-ray	2.00	B	222-334	[»]
	3FZK	X-ray	2.10	B	222-334	[»]
	3FZL	X-ray	2.20	B	222-334	[»]
	3FZM	X-ray	2.30	B	222-334	[»]
	3LDQ	X-ray	1.90	B	222-334	[»]
	3M3Z	X-ray	2.10	B	222-334	[»]
	5AQF	X-ray	1.88	B/D	222-334	[»]
	5AQG	X-ray	2.24	B/D/F	222-334	[»]
	5AQH	X-ray	2.00	B	222-334	[»]
	5AQI	X-ray	1.98	B/D	222-334	[»]
	5AQJ	X-ray	1.96	B/D/F	222-334	[»]
	5AQK	X-ray	2.09	B	222-334	[»]
	5AQL	X-ray	1.69	B/D	222-334	[»]
	5AQM	X-ray	1.63	B/D	222-334	[»]
	5AQN	X-ray	2.45	B/D/F	222-334	[»]
	5AQO	X-ray	2.12	B/D/F	222-334	[»]
	5AQP	X-ray	2.08	B/D/F	222-334	[»]
	5AQQ	X-ray	2.72	B/D/F	222-334	[»]
	5AQR	X-ray	1.91	B/D/F	222-334	[»]
	5AQS	X-ray	2.00	B/D	222-334	[»]
	5AQT	X-ray	1.90	B	222-334	[»]
	5AQU	X-ray	1.92	B	222-334	[»]
	5AQV	X-ray	1.75	B	222-334	[»]
ProteinModelPortalⁱ	Q99933
SMRⁱ	Q99933
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107049, 143 interactors
CORUMⁱ	Q99933
DIPⁱ	DIP-3341N
IntActⁱ	Q99933, 40 interactors
MINTⁱ	Q99933
STRINGⁱ	9606.ENSP00000420514

PTM databases

iPTMnetⁱ	Q99933
PhosphoSitePlusⁱ	Q99933

Polymorphism and mutation databases

BioMutaⁱ	BAG1
DMDMⁱ	296439462

Proteomic databases

EPDⁱ	Q99933
MaxQBⁱ	Q99933
PaxDbⁱ	Q99933
PeptideAtlasⁱ	Q99933
PRIDEⁱ	Q99933
ProteomicsDBⁱ	78526 78527 [Q99933-2] 78528 [Q99933-3] 78529 [Q99933-4]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	573
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000379704; ENSP00000369026; ENSG00000107262 [Q99933-4] ENST00000641048; ENSP00000493185; ENSG00000107262 [Q99933-1] ENST00000643906; ENSP00000493589; ENSG00000107262 [Q99933-1]
GeneIDⁱ	573
KEGGⁱ	hsa:573
UCSCⁱ	uc064sos.1 human [Q99933-1]

Organism-specific databases

CTDⁱ	573
DisGeNETⁱ	573
EuPathDBⁱ	HostDB:ENSG00000107262.17
GeneCardsⁱ	BAG1
HGNCⁱ	HGNC:937 BAG1
HPAⁱ	CAB002486 HPA018121
MIMⁱ	601497 gene
neXtProtⁱ	NX_Q99933
OpenTargetsⁱ	ENSG00000107262
PharmGKBⁱ	PA25237
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHYI Eukaryota ENOG4111SUG LUCA
GeneTreeⁱ	ENSGT00450000040296
HOVERGENⁱ	HBG000236
InParanoidⁱ	Q99933
KOⁱ	K09555
PhylomeDBⁱ	Q99933

Enzyme and pathway databases

Reactomeⁱ	R-HSA-3371453 Regulation of HSF1-mediated heat shock response
SIGNORⁱ	Q99933

Miscellaneous databases

ChiTaRSⁱ	BAG1 human
EvolutionaryTraceⁱ	Q99933
GeneWikiⁱ	BAG1
GenomeRNAiⁱ	573
Protein Ontology More...PROⁱ	PR:Q99933
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000107262 Expressed in 230 organ(s), highest expression level in palpebral conjunctiva
CleanExⁱ	HS_BAG1
ExpressionAtlasⁱ	Q99933 baseline and differential
Genevisibleⁱ	Q99933 HS

Family and domain databases

Gene3Dⁱ	1.20.58.120, 1 hit
InterProⁱ	View protein in InterPro IPR017093 BAG-1 IPR036533 BAG_dom_sf IPR003103 BAG_domain IPR029071 Ubiquitin-like_domsf IPR000626 Ubiquitin_dom
PANTHERⁱ	PTHR12329:SF16 PTHR12329:SF16, 1 hit
Pfamⁱ	View protein in Pfam PF02179 BAG, 1 hit PF00240 ubiquitin, 1 hit
SMARTⁱ	View protein in SMART SM00264 BAG, 1 hit SM00213 UBQ, 1 hit
SUPFAMⁱ	SSF54236 SSF54236, 1 hit SSF63491 SSF63491, 1 hit
PROSITEⁱ	View protein in PROSITE PS51035 BAG, 1 hit PS50053 UBIQUITIN_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	BAG1_HUMAN
Accessionⁱ	Q99933Primary (citable) accession number: Q99933 Secondary accession number(s): O75315 Q9Y2V4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	May 18, 2010
	Last modified:	September 12, 2018
	This is version 190 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - Q99933 (BAG1_HUMAN)

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BAG family molecular chaperone regulator 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

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Nucleus

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Nucleus

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Keywords - Cellular componenti

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Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

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GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

Phylogenomic databases

Family and domain databases

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Experimental Info

Alternative sequence

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Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

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Protein-protein interaction databases

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Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Sequence cautionⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ