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UniProtKB - Q99933 (BAG1_HUMAN)

Entry version 211 (23 Feb 2022)
Sequence version 4 (18 May 2010)
Previous versions | rss
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Protein

BAG family molecular chaperone regulator 1

Gene

BAG1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:27474739, PubMed:9873016, PubMed:24318877).

Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity (PubMed:12724406).

Markedly increases the anti-cell death function of BCL2 induced by various stimuli (PubMed:9305631).

5 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChaperone
Biological processApoptosis

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99933

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3371453, Regulation of HSF1-mediated heat shock response

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99933

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99933

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
BAG family molecular chaperone regulator 1
Short name:
BAG-1
Alternative name(s):
Bcl-2-associated athanogene 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:BAG1
Synonyms:HAP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:937, BAG1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601497, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99933

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000107262

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi308 – 309RK → AA: Significant loss of interaction with HSPA8. 1 Publication2

Organism-specific databases

DisGeNET

More...DisGeNETi		573

Open Targets

More...OpenTargetsi		ENSG00000107262

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA25237

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99933, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB07045, (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		BAG1

Domain mapping of disease mutations (DMDM)

More...DMDMi		296439462

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000888651 – 345BAG family molecular chaperone regulator 1Add BLAST345

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei223PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.Curated

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99933

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99933

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99933

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99933

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99933

PeptideAtlas

More...PeptideAtlasi		Q99933

PRoteomics IDEntifications database

More...PRIDEi		Q99933

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78526 [Q99933-1]
78527 [Q99933-2]
78528 [Q99933-3]
78529 [Q99933-4]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q99933, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99933

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99933

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 4 is the most abundantly expressed isoform. It is ubiquitously expressed throughout most tissues, except the liver, colon, breast and uterine myometrium. Isoform 1 is expressed in the ovary and testis. Isoform 4 is expressed in several types of tumor cell lines, and at consistently high levels in leukemia and lymphoma cell lines. Isoform 1 is expressed in the prostate, breast and leukemia cell lines. Isoform 3 is the least abundant isoform in tumor cell lines (at protein level).1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during differentiation of bladder epithelial cells and down-regulated during differentiation of prostate epithelium.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000107262, Expressed in palpebral conjunctiva and 245 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99933, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99933, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000107262, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Forms a heteromeric complex with HSP70/HSC70 (PubMed:9305631). Binds to the ATPase domain of HSP/HSC70 chaperones. Isoform 1, isoform 3 and isoform 4 but not isoform 2 interact with HSPA8/HSC70 (PubMed:27474739, PubMed:24318877, PubMed:9305631, PubMed:9679980).

Interacts with NR3C1 (PubMed:10477749).

Interacts with the N-terminal region of STK19 (PubMed:15986447).

Interacts with PPP1R15A (PubMed:12724406).

Interacts with BCL2 in an ATP-dependent manner. Isoform 2 does not interact with BCL2 (PubMed:9305631).

Interacts with SIAH1 (PubMed:9582267).

Interacts with HSPA8 (via NBD) (PubMed:27474739, PubMed:24318877).

Interacts with HSPA1A (via NBD) and HSPA1B (via NBD) (PubMed:24318877).

Interacts with SIAH2 (By similarity).

By similarity9 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		107049, 154 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q99933

Database of interacting proteins

More...DIPi		DIP-3341N

Protein interaction database and analysis system

More...IntActi		Q99933, 57 interactors

Molecular INTeraction database

More...MINTi		Q99933

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000420514

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99933, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1345
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99933

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99933

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati96 – 10116
Repeati102 – 10726
Repeati108 – 11336
Repeati114 – 11946
Repeati120 – 12556
Repeati126 – 13166
Repeati132 – 13776
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 224Ubiquitin-likePROSITE-ProRule annotationAdd BLAST81
Domaini246 – 326BAGPROSITE-ProRule annotationAdd BLAST81

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 137DisorderedSequence analysisAdd BLAST137
Regioni96 – 1377 X 6 AA tandem repeat of E-E-X(4)Add BLAST42
Regioni172 – 219Interaction with HSPA8Add BLAST48
Regioni216 – 345Interaction with PPP1R15A1 PublicationAdd BLAST130

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 29Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi98 – 113Polar residuesSequence analysisAdd BLAST16
Compositional biasi114 – 137Basic and acidic residuesSequence analysisAdd BLAST24

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502RN5W, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00450000040296

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_055378_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99933

Identification of Orthologs from Complete Genome Data

More...OMAi		NFSDCRM

Database of Orthologous Groups

More...OrthoDBi		1450573at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99933

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.58.120, 1 hit

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID00495

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR017093, BAG-1
IPR039773, BAG_chaperone_regulator
IPR036533, BAG_dom_sf
IPR003103, BAG_domain
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...PANTHERi		PTHR12329, PTHR12329, 1 hit
PTHR12329:SF16, PTHR12329:SF16, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02179, BAG, 1 hit
PF00240, ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00264, BAG, 1 hit
SM00213, UBQ, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF54236, SSF54236, 1 hit
SSF63491, SSF63491, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51035, BAG, 1 hit
PS50053, UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

This entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99933-1) [UniParc]FASTAAdd to basket
Also known as: BAG-1L, p50

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAQRGGARRP RGDRERLGSR LRALRPGREP RQSEPPAQRG PPPSGRPPAR 
        60         70         80         90        100
STASGHDRPT RGAAAGARRP RMKKKTRRRS TRSEELTRSE ELTLSEEATW 
       110        120        130        140        150
SEEATQSEEA TQGEEMNRSQ EVTRDEESTR SEEVTREEMA AAGLTVTVTH 
       160        170        180        190        200
SNEKHDLHVT SQQGSSEPVV QDLAQVVEEV IGVPQSFQKL IFKGKSLKEM 
       210        220        230        240        250
ETPLSALGIQ DGCRVMLIGK KNSPQEEVEL KKLKHLEKSV EKIADQLEEL 
       260        270        280        290        300
NKELTGIQQG FLPKDLQAEA LCKLDRRVKA TIEQFMKILE EIDTLILPEN 
       310        320        330        340 
FKDSRLKRKG LVKKVQAFLA ECDTVEQNIC QETERLQSTN FALAE
Length:345
Mass (Da):38,779
Last modified:May 18, 2010 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B40EF078C66335F
GO
Isoform 2 (identifier: Q99933-2) [UniParc]FASTAAdd to basket
Also known as: BAG1V, HAPV

The sequence of this isoform differs from the canonical sequence as follows:
     302-345: KDSRLKRKGLVKKVQAFLAECDTVEQNICQETERLQSTNFALAE → PTLTLVLNEK

Note: Produced by alternative splicing.Curated
Show »
Length:311
Mass (Da):34,866
Checksum:i1F94BA55E21694D3
GO
Isoform 3 (identifier: Q99933-3) [UniParc]FASTAAdd to basket
Also known as: BAG-1M, RAP46

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.

Note: Produced by alternative initiation at Met-72 of isoform 1.Curated
Show »
Length:274
Mass (Da):31,117
Checksum:iC13E200ED63A2CF0
GO
Isoform 4 (identifier: Q99933-4) [UniParc]FASTAAdd to basket
Also known as: BAG-1, p32

The sequence of this isoform differs from the canonical sequence as follows:
     1-115: Missing.

Note: Produced by alternative initiation at Met-116 of isoform 1.Curated
Show »
Length:230
Mass (Da):25,989
Checksum:iD4B34A8F54DE684D
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3QTA2J3QTA2_HUMAN
BAG family molecular chaperone regu...
BAG1
345Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JYK5C9JYK5_HUMAN
BAG family molecular chaperone regu...
BAG1
150Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9J9Y9C9J9Y9_HUMAN
BAG family molecular chaperone regu...
BAG1
48Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RR89A0A0U1RR89_HUMAN
BAG family molecular chaperone regu...
BAG1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0U1RQD7A0A0U1RQD7_HUMAN
BAG family molecular chaperone regu...
BAG1
94Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1LLU6F1LLU6_HUMAN
BAG family molecular chaperone regu...
BAG1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAD11467 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAD25045 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD96469 differs from that shown. Unusual initiator. The initiator methionine is coded by a non-canonical CTG leucine codon.Curated
The sequence CAA84624 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence EAW58515 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti45G → R in AAC34258 (PubMed:8812483).Curated1
Sequence conflicti45G → R in BAD96469 (Ref. 5) Curated1
Sequence conflicti45G → R in AAH01936 (PubMed:15489334).Curated1
Sequence conflicti45G → R in AAH14774 (PubMed:15489334).Curated1
Sequence conflicti79R → F in AAD11467 (PubMed:8812483).Curated1
Sequence conflicti84E → K in AAD11467 (PubMed:8812483).Curated1
Sequence conflicti90E → K in AAD11467 (PubMed:8812483).Curated1
Sequence conflicti245D → N in AAD11467 (PubMed:8812483).Curated1
Sequence conflicti293D → H in AAD11467 (PubMed:8812483).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0383941 – 115Missing in isoform 4. CuratedAdd BLAST115
Alternative sequenceiVSP_0383951 – 71Missing in isoform 3. CuratedAdd BLAST71
Alternative sequenceiVSP_000453302 – 345KDSRL…FALAE → PTLTLVLNEK in isoform 2. 1 PublicationAdd BLAST44

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z35491 mRNA Translation: CAA84624.1 Different initiation.
U46917 mRNA Translation: AAD11467.1 Different initiation.
AF022224 mRNA Translation: AAC34258.1
AF116273 mRNA Translation: AAD25045.1 Different initiation.
AK222749 mRNA Translation: BAD96469.1 Different initiation.
AL161445 Genomic DNA No translation available.
AL356472 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58514.1
CH471071 Genomic DNA Translation: EAW58515.1 Sequence problems.
BC001936 mRNA Translation: AAH01936.2
BC014774 mRNA Translation: AAH14774.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS35004.1 [Q99933-1]
CCDS55301.1 [Q99933-4]

NCBI Reference Sequences

More...RefSeqi		NP_001165886.1, NM_001172415.1 [Q99933-4]
NP_004314.5, NM_004323.5 [Q99933-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000379704; ENSP00000369026; ENSG00000107262 [Q99933-4]
ENST00000634734; ENSP00000489189; ENSG00000107262

Database of genes from NCBI RefSeq genomes

More...GeneIDi		573

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:573

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000634734.3; ENSP00000489189.2; NM_004323.6; NP_004314.6

UCSC genome browser

More...UCSCi		uc064sos.1, human [Q99933-1]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35491 mRNA Translation: CAA84624.1 Different initiation.
U46917 mRNA Translation: AAD11467.1 Different initiation.
AF022224 mRNA Translation: AAC34258.1
AF116273 mRNA Translation: AAD25045.1 Different initiation.
AK222749 mRNA Translation: BAD96469.1 Different initiation.
AL161445 Genomic DNA No translation available.
AL356472 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58514.1
CH471071 Genomic DNA Translation: EAW58515.1 Sequence problems.
BC001936 mRNA Translation: AAH01936.2
BC014774 mRNA Translation: AAH14774.2
CCDSiCCDS35004.1 [Q99933-1]
CCDS55301.1 [Q99933-4]
RefSeqiNP_001165886.1, NM_001172415.1 [Q99933-4]
NP_004314.5, NM_004323.5 [Q99933-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1HX1X-ray1.90B222-334[»]
1WXVNMR-A144-222[»]
3FZFX-ray2.20B222-334[»]
3FZHX-ray2.00B222-334[»]
3FZKX-ray2.10B222-334[»]
3FZLX-ray2.20B222-334[»]
3FZMX-ray2.30B222-334[»]
3LDQX-ray1.90B222-334[»]
3M3ZX-ray2.10B222-334[»]
5AQFX-ray1.88B/D222-334[»]
5AQGX-ray2.24B/D/F222-334[»]
5AQHX-ray2.00B222-334[»]
5AQIX-ray1.98B/D222-334[»]
5AQJX-ray1.96B/D/F222-334[»]
5AQKX-ray2.09B222-334[»]
5AQLX-ray1.69B/D222-334[»]
5AQMX-ray1.63B/D222-334[»]
5AQNX-ray2.45B/D/F222-334[»]
5AQOX-ray2.12B/D/F222-334[»]
5AQPX-ray2.08B/D/F222-334[»]
5AQQX-ray2.72B/D/F222-334[»]
5AQRX-ray1.91B/D/F222-334[»]
5AQSX-ray2.00B/D222-334[»]
5AQTX-ray1.90B222-334[»]
5AQUX-ray1.92B222-334[»]
5AQVX-ray1.75B222-334[»]
SMRiQ99933
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi107049, 154 interactors
CORUMiQ99933
DIPiDIP-3341N
IntActiQ99933, 57 interactors
MINTiQ99933
STRINGi9606.ENSP00000420514

Chemistry databases

DrugBankiDB07045, (2R,3R,4S,5R)-2-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol

PTM databases

GlyGeniQ99933, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ99933
PhosphoSitePlusiQ99933

Genetic variation databases

BioMutaiBAG1
DMDMi296439462

Proteomic databases

EPDiQ99933
jPOSTiQ99933
MassIVEiQ99933
MaxQBiQ99933
PaxDbiQ99933
PeptideAtlasiQ99933
PRIDEiQ99933
ProteomicsDBi78526 [Q99933-1]
78527 [Q99933-2]
78528 [Q99933-3]
78529 [Q99933-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2968, 536 antibodies from 41 providers

The DNASU plasmid repository

More...DNASUi		573

Genome annotation databases

EnsembliENST00000379704; ENSP00000369026; ENSG00000107262 [Q99933-4]
ENST00000634734; ENSP00000489189; ENSG00000107262
GeneIDi573
KEGGihsa:573
MANE-SelectiENST00000634734.3; ENSP00000489189.2; NM_004323.6; NP_004314.6
UCSCiuc064sos.1, human [Q99933-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		573
DisGeNETi573

GeneCards: human genes, protein and diseases

More...GeneCardsi		BAG1
HGNCiHGNC:937, BAG1
HPAiENSG00000107262, Low tissue specificity
MIMi601497, gene
neXtProtiNX_Q99933
OpenTargetsiENSG00000107262
PharmGKBiPA25237
VEuPathDBiHostDB:ENSG00000107262

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502RN5W, Eukaryota
GeneTreeiENSGT00450000040296
HOGENOMiCLU_055378_0_1_1
InParanoidiQ99933
OMAiNFSDCRM
OrthoDBi1450573at2759
PhylomeDBiQ99933

Enzyme and pathway databases

PathwayCommonsiQ99933
ReactomeiR-HSA-3371453, Regulation of HSF1-mediated heat shock response
SignaLinkiQ99933
SIGNORiQ99933

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		573, 9 hits in 1052 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		BAG1, human
EvolutionaryTraceiQ99933

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		BAG1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		573
PharosiQ99933, Tbio

Protein Ontology

More...PROi		PR:Q99933
RNActiQ99933, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000107262, Expressed in palpebral conjunctiva and 245 other tissues
ExpressionAtlasiQ99933, baseline and differential
GenevisibleiQ99933, HS

Family and domain databases

Gene3Di1.20.58.120, 1 hit
IDEALiIID00495
InterProiView protein in InterPro
IPR017093, BAG-1
IPR039773, BAG_chaperone_regulator
IPR036533, BAG_dom_sf
IPR003103, BAG_domain
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR12329, PTHR12329, 1 hit
PTHR12329:SF16, PTHR12329:SF16, 1 hit
PfamiView protein in Pfam
PF02179, BAG, 1 hit
PF00240, ubiquitin, 1 hit
SMARTiView protein in SMART
SM00264, BAG, 1 hit
SM00213, UBQ, 1 hit
SUPFAMiSSF54236, SSF54236, 1 hit
SSF63491, SSF63491, 1 hit
PROSITEiView protein in PROSITE
PS51035, BAG, 1 hit
PS50053, UBIQUITIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiBAG1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99933
Secondary accession number(s): O75315
, Q14414, Q53H32, Q5VZE8, Q5VZE9, Q5VZF0, Q96TG2, Q9Y2V4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: February 23, 2022
This is version 211 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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