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Protein

Gamma-aminobutyric acid receptor subunit gamma-3

Gene

GABRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Miscellaneous

This subunit carries the benzodiazepine binding site.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChloride channel, Ion channel
Biological processIon transport, Transport
LigandChloride

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Names & Taxonomyi

Protein namesi
Recommended name:
Gamma-aminobutyric acid receptor subunit gamma-3
Alternative name(s):
GABA(A) receptor subunit gamma-3
Gene namesi
Name:GABRG3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

EuPathDBiHostDB:ENSG00000182256.12
HGNCiHGNC:4088 GABRG3
MIMi600233 gene
neXtProtiNX_Q99928

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 254ExtracellularCuratedAdd BLAST237
Transmembranei255 – 277HelicalCuratedAdd BLAST23
Transmembranei281 – 303HelicalCuratedAdd BLAST23
Transmembranei315 – 337HelicalCuratedAdd BLAST23
Topological domaini338 – 443CytoplasmicCuratedAdd BLAST106
Transmembranei444 – 467HelicalCuratedAdd BLAST24

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi2567
GeneReviewsiGABRG3
OpenTargetsiENSG00000182256
PharmGKBiPA28502

Chemistry databases

ChEMBLiCHEMBL3885577
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB06579 Adipiplon
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB00690 Flurazepam
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

Polymorphism and mutation databases

BioMutaiGABRG3
DMDMi13959689

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Sequence analysisAdd BLAST17
ChainiPRO_000000048118 – 467Gamma-aminobutyric acid receptor subunit gamma-3Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi110N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi171 ↔ 185By similarity
Glycosylationi228N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

May be palmitoylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ99928
PRIDEiQ99928
ProteomicsDBi78522

PTM databases

iPTMnetiQ99928
PhosphoSitePlusiQ99928

Expressioni

Gene expression databases

BgeeiENSG00000182256 Expressed in 66 organ(s), highest expression level in corpus callosum
CleanExiHS_GABRG3
ExpressionAtlasiQ99928 baseline and differential
GenevisibleiQ99928 HS

Organism-specific databases

HPAiHPA054010

Interactioni

Subunit structurei

Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho.

Protein-protein interaction databases

BioGridi108841, 1 interactor
STRINGi9606.ENSP00000331912

Structurei

3D structure databases

ProteinModelPortaliQ99928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiQ99928
KOiK05186
OMAiRIHIDIS
OrthoDBiEOG091G0805
PhylomeDBiQ99928
TreeFamiTF315453

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR005440 GABBAg3_rcpt
IPR005437 GABBAg_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01620 GABAARGAMMA
PR01623 GABAARGAMMA3
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99928-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAPKLLLLLC LFSGLHARSR KVEEDEYEDS SSNQKWVLAP KSQDTDVTLI
60 70 80 90 100
LNKLLREYDK KLRPDIGIKP TVIDVDIYVN SIGPVSSINM EYQIDIFFAQ
110 120 130 140 150
TWTDSRLRFN STMKILTLNS NMVGLIWIPD TIFRNSKTAE AHWITTPNQL
160 170 180 190 200
LRIWNDGKIL YTLRLTINAE CQLQLHNFPM DEHSCPLIFS SYGYPKEEMI
210 220 230 240 250
YRWRKNSVEA ADQKSWRLYQ FDFMGLRNTT EIVTTSAGDY VVMTIYFELS
260 270 280 290 300
RRMGYFTIQT YIPCILTVVL SWVSFWIKKD ATPARTALGI TTVLTMTTLS
310 320 330 340 350
TIARKSLPRV SYVTAMDLFV TVCFLFVFAA LMEYATLNYY SSCRKPTTTK
360 370 380 390 400
KTTSLLHPDS SRWIPERISL QAPSNYSLLD MRPPPTAMIT LNNSVYWQEF
410 420 430 440 450
EDTCVYECLD GKDCQSFFCC YEECKSGSWR KGRIHIDILE LDSYSRVFFP
460
TSFLLFNLVY WVGYLYL
Length:467
Mass (Da):54,289
Last modified:May 4, 2001 - v2
Checksum:i1B22D145166438D6
GO
Isoform 2 (identifier: Q99928-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-253: DYVVMTIYFELSRRM → RNLLKEAQLSKAREA
     254-467: Missing.

Note: No experimental confirmation available.
Show »
Length:253
Mass (Da):29,402
Checksum:iBB0AE39434EE015F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MR73A0A0A0MR73_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
288Annotation score:
H0YJP1H0YJP1_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
258Annotation score:
H7BZQ0H7BZQ0_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
169Annotation score:
H0YJ81H0YJ81_HUMAN
Gamma-aminobutyric acid receptor su...
GABRG3
38Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti172Q → R in BC045709 (PubMed:15489334).Curated1
Sequence conflicti386T → P in AAB39369 (PubMed:8719414).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033957352T → A Found in a patient with MRT52; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs2066712Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_047543239 – 253DYVVM…LSRRM → RNLLKEAQLSKAREA in isoform 2. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_047544254 – 467Missing in isoform 2. 1 PublicationAdd BLAST214

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82769 mRNA Translation: AAB39369.1
AF269144
, AF269135, AF269136, AF269137, AF269138, AF269139, AF269140, AF269141, AF269142, AF269143 Genomic DNA Translation: AAF99698.1
AC104002 Genomic DNA No translation available.
AC127511 Genomic DNA No translation available.
AC135326 Genomic DNA No translation available.
AC136896 Genomic DNA No translation available.
AC144833 Genomic DNA No translation available.
AC145436 Genomic DNA No translation available.
EU606049 Genomic DNA No translation available.
CH471151 Genomic DNA Translation: EAW57658.1
BC045709 mRNA No translation available.
AH009226 Genomic DNA Translation: AAF63215.1
CCDSiCCDS45195.1 [Q99928-1]
CCDS59251.1 [Q99928-2]
RefSeqiNP_001257802.1, NM_001270873.1 [Q99928-2]
NP_150092.2, NM_033223.4 [Q99928-1]
UniGeneiHs.569475

Genome annotation databases

EnsembliENST00000555083; ENSP00000452244; ENSG00000182256 [Q99928-2]
ENST00000615808; ENSP00000479113; ENSG00000182256 [Q99928-1]
GeneIDi2567
KEGGihsa:2567
UCSCiuc001zbf.5 human [Q99928-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Protein Spotlight

Forbidden fruit - Issue 56 of March 2005

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82769 mRNA Translation: AAB39369.1
AF269144
, AF269135, AF269136, AF269137, AF269138, AF269139, AF269140, AF269141, AF269142, AF269143 Genomic DNA Translation: AAF99698.1
AC104002 Genomic DNA No translation available.
AC127511 Genomic DNA No translation available.
AC135326 Genomic DNA No translation available.
AC136896 Genomic DNA No translation available.
AC144833 Genomic DNA No translation available.
AC145436 Genomic DNA No translation available.
EU606049 Genomic DNA No translation available.
CH471151 Genomic DNA Translation: EAW57658.1
BC045709 mRNA No translation available.
AH009226 Genomic DNA Translation: AAF63215.1
CCDSiCCDS45195.1 [Q99928-1]
CCDS59251.1 [Q99928-2]
RefSeqiNP_001257802.1, NM_001270873.1 [Q99928-2]
NP_150092.2, NM_033223.4 [Q99928-1]
UniGeneiHs.569475

3D structure databases

ProteinModelPortaliQ99928
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108841, 1 interactor
STRINGi9606.ENSP00000331912

Chemistry databases

ChEMBLiCHEMBL3885577
DrugBankiDB00659 Acamprosate
DB00546 Adinazolam
DB06579 Adipiplon
DB00404 Alprazolam
DB00543 Amoxapine
DB01558 Bromazepam
DB00237 Butabarbital
DB00241 Butalbital
DB00475 Chlordiazepoxide
DB01594 Cinolazepam
DB00349 Clobazam
DB01068 Clonazepam
DB00628 Clorazepate
DB01559 Clotiazepam
DB01189 Desflurane
DB00829 Diazepam
DB00228 Enflurane
DB01049 Ergoloid mesylate
DB01215 Estazolam
DB00402 Eszopiclone
DB00898 Ethanol
DB00189 Ethchlorvynol
DB00292 Etomidate
DB01567 Fludiazepam
DB01205 Flumazenil
DB00690 Flurazepam
DB01437 Glutethimide
DB00801 Halazepam
DB01159 Halothane
DB00753 Isoflurane
DB00186 Lorazepam
DB00371 Meprobamate
DB00463 Metharbital
DB01028 Methoxyflurane
DB01107 Methyprylon
DB00683 Midazolam
DB01595 Nitrazepam
DB00334 Olanzapine
DB00842 Oxazepam
DB00312 Pentobarbital
DB01708 Prasterone
DB01588 Prazepam
DB00794 Primidone
DB00818 Propofol
DB01589 Quazepam
DB01236 Sevoflurane
DB00306 Talbutal
DB00231 Temazepam
DB11582 Thiocolchicoside
DB00273 Topiramate
DB00897 Triazolam

PTM databases

iPTMnetiQ99928
PhosphoSitePlusiQ99928

Polymorphism and mutation databases

BioMutaiGABRG3
DMDMi13959689

Proteomic databases

PaxDbiQ99928
PRIDEiQ99928
ProteomicsDBi78522

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555083; ENSP00000452244; ENSG00000182256 [Q99928-2]
ENST00000615808; ENSP00000479113; ENSG00000182256 [Q99928-1]
GeneIDi2567
KEGGihsa:2567
UCSCiuc001zbf.5 human [Q99928-1]

Organism-specific databases

CTDi2567
DisGeNETi2567
EuPathDBiHostDB:ENSG00000182256.12
GeneCardsiGABRG3
GeneReviewsiGABRG3
H-InvDBiHIX0026811
HGNCiHGNC:4088 GABRG3
HPAiHPA054010
MIMi600233 gene
neXtProtiNX_Q99928
OpenTargetsiENSG00000182256
PharmGKBiPA28502
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3642 Eukaryota
ENOG410XNQG LUCA
GeneTreeiENSGT00760000119010
HOGENOMiHOG000231337
HOVERGENiHBG051707
InParanoidiQ99928
KOiK05186
OMAiRIHIDIS
OrthoDBiEOG091G0805
PhylomeDBiQ99928
TreeFamiTF315453

Enzyme and pathway databases

ReactomeiR-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission
R-HSA-977441 GABA A receptor activation

Miscellaneous databases

ChiTaRSiGABRG3 human
GeneWikiiGABRG3
GenomeRNAii2567
PROiPR:Q99928
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000182256 Expressed in 66 organ(s), highest expression level in corpus callosum
CleanExiHS_GABRG3
ExpressionAtlasiQ99928 baseline and differential
GenevisibleiQ99928 HS

Family and domain databases

Gene3Di2.70.170.10, 1 hit
InterProiView protein in InterPro
IPR006028 GABAA/Glycine_rcpt
IPR005440 GABBAg3_rcpt
IPR005437 GABBAg_rcpt
IPR006202 Neur_chan_lig-bd
IPR036734 Neur_chan_lig-bd_sf
IPR006201 Neur_channel
IPR036719 Neuro-gated_channel_TM_sf
IPR006029 Neurotrans-gated_channel_TM
IPR018000 Neurotransmitter_ion_chnl_CS
PANTHERiPTHR18945 PTHR18945, 1 hit
PfamiView protein in Pfam
PF02931 Neur_chan_LBD, 1 hit
PF02932 Neur_chan_memb, 1 hit
PRINTSiPR00253 GABAARECEPTR
PR01620 GABAARGAMMA
PR01623 GABAARGAMMA3
PR00252 NRIONCHANNEL
SUPFAMiSSF63712 SSF63712, 1 hit
SSF90112 SSF90112, 1 hit
TIGRFAMsiTIGR00860 LIC, 1 hit
PROSITEiView protein in PROSITE
PS00236 NEUROTR_ION_CHANNEL, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBRG3_HUMAN
AccessioniPrimary (citable) accession number: Q99928
Secondary accession number(s): G3V594, Q9HD46, Q9NYT2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 4, 2001
Last modified: November 7, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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