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Protein

Chymotrypsin-C

Gene

CTRC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulates activation and degradation of trypsinogens and procarboxypeptidases by targeting specific cleavage sites within their zymogen precursors. Has chymotrypsin-type protease activity and hypocalcemic activity.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

  • Preferential cleavage: Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa. EC:3.4.21.2

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei74Charge relay systemBy similarity1
Active sitei121Charge relay systemBy similarity1
Active sitei216Charge relay systemBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • cobalamin metabolic process Source: Reactome
  • proteolysis Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

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BRENDAi
3.4.21.2 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Protein family/group databases

MEROPS protease database

More...
MEROPSi
S01.157

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Chymotrypsin-C (EC:3.4.21.2)
Alternative name(s):
Caldecrin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CTRC
Synonyms:CLCR
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000162438.11

Human Gene Nomenclature Database

More...
HGNCi
HGNC:2523 CTRC

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601405 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99895

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Pancreatitis, hereditary (PCTT)4 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry. Loss-of-function CTRC variants predispose to pancreatitis by diminishing its protective trypsin-degrading activity (PubMed:18059268). They cause loss of function by one or more of three mechanisms: reduced secretion, catalytic defect and increased degradation by trypsin (PubMed:22942235).2 Publications
Disease descriptionA disease characterized by pancreas inflammation, permanent destruction of the pancreatic parenchyma, maldigestion, and severe abdominal pain attacks.
See also OMIM:167800
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_07052232G → V in PCTT; associated with disease susceptibility; highly reduced catalytic efficiency. 1 Publication1
Natural variantiVAR_04352073A → T in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion. 4 PublicationsCorresponds to variant dbSNP:rs515726209EnsemblClinVar.1
Natural variantiVAR_070526155C → Y in PCTT; associated with susceptibility to disease; the mutant is not secreted. 2 Publications1
Natural variantiVAR_070528178Q → R in PCTT; associated with disease susceptibility; impaired catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs200678111EnsemblClinVar.1
Natural variantiVAR_043522217G → R in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion and loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs202058123EnsemblClinVar.1
Natural variantiVAR_043523217G → S in PCTT; associated with susceptibility to disease; reduced protein secretion; impaired catalytic activity. 3 PublicationsCorresponds to variant dbSNP:rs202058123EnsemblClinVar.1
Natural variantiVAR_043527235V → I in PCTT; associated with susceptibility to disease; slightly reduced activity. 4 PublicationsCorresponds to variant dbSNP:rs140993290EnsemblClinVar.1
Natural variantiVAR_070536247 – 254Missing in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity. 2 Publications8
Natural variantiVAR_043528249P → L in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs142560329EnsemblClinVar.1
Natural variantiVAR_070538250V → E in PCTT; associated with disease susceptibility; results in altered enzyme specificity and loss of activity. 1 Publication1
Natural variantiVAR_043529254R → W in PCTT; associated with susceptibility to disease; results in reduced secretion; normal activity; the mutant undergoes proteolytic degradation during trypsin-mediated activation. 5 PublicationsCorresponds to variant dbSNP:rs121909293EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
11330

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
CTRC

MalaCards human disease database

More...
MalaCardsi
CTRC
MIMi167800 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000162438

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
676 Hereditary chronic pancreatitis
103918 Tropical pancreatitis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA27024

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2386

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
2341

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CTRC

Domain mapping of disease mutations (DMDM)

More...
DMDMi
14194504

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 16Sequence analysisAdd BLAST16
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_000002771317 – 29Activation peptideAdd BLAST13
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000002771430 – 268Chymotrypsin-CAdd BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi17 ↔ 141PROSITE-ProRule annotation1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi52N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi59 ↔ 75PROSITE-ProRule annotation1 Publication
Disulfide bondi155 ↔ 222PROSITE-ProRule annotation1 Publication
Disulfide bondi186 ↔ 202PROSITE-ProRule annotation1 Publication
Disulfide bondi212 ↔ 243PROSITE-ProRule annotation1 Publication
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99895

PeptideAtlas

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PeptideAtlasi
Q99895

PRoteomics IDEntifications database

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PRIDEi
Q99895

ProteomicsDB human proteome resource

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ProteomicsDBi
78519

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Pancreas.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000162438 Expressed in 106 organ(s), highest expression level in body of pancreas

CleanEx database of gene expression profiles

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CleanExi
HS_CTRC

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99895 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99895 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA046920

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
KRTAP10-7P604093EBI-10295404,EBI-10172290

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
116458, 6 interactors

Protein interaction database and analysis system

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IntActi
Q99895, 13 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000365116

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q99895

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1268
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99895

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99895

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini30 – 267Peptidase S1PROSITE-ProRule annotationAdd BLAST238

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase S1 family. Elastase subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3627 Eukaryota
COG5640 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000153216

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000251820

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG013304

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99895

KEGG Orthology (KO)

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KOi
K01311

Identification of Orthologs from Complete Genome Data

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OMAi
VDTIHVH

Database of Orthologous Groups

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OrthoDBi
EOG091G0DF7

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99895

TreeFam database of animal gene trees

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TreeFami
TF330455

Family and domain databases

Conserved Domains Database

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CDDi
cd00190 Tryp_SPc, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER

Pfam protein domain database

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Pfami
View protein in Pfam
PF00089 Trypsin, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00722 CHYMOTRYPSIN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00020 Tryp_SPc, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50494 SSF50494, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q99895-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLGITVLAAL LACASSCGVP SFPPNLSARV VGGEDARPHS WPWQISLQYL
60 70 80 90 100
KNDTWRHTCG GTLIASNFVL TAAHCISNTR TYRVAVGKNN LEVEDEEGSL
110 120 130 140 150
FVGVDTIHVH KRWNALLLRN DIALIKLAEH VELSDTIQVA CLPEKDSLLP
160 170 180 190 200
KDYPCYVTGW GRLWTNGPIA DKLQQGLQPV VDHATCSRID WWGFRVKKTM
210 220 230 240 250
VCAGGDGVIS ACNGDSGGPL NCQLENGSWE VFGIVSFGSR RGCNTRKKPV
260
VYTRVSAYID WINEKMQL
Length:268
Mass (Da):29,484
Last modified:June 1, 2001 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i460BF33B4A96516F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q68DR9Q68DR9_HUMAN
Chymotrypsin-C
CTRC DKFZp779K0837
69Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti16S → T in AAB47104 (PubMed:8635596).Curated1
Sequence conflicti52N → D in CAA74031 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07052018G → R Found in a patient with chronic pancreatitis; unknown pathological significance; catalytic activity comparable to that of wild type; the mutant undergoes proteolytic degradation during trypsin-mediated activation. 1 PublicationCorresponds to variant dbSNP:rs200576965EnsemblClinVar.1
Natural variantiVAR_07052129R → Q Found in patients with chronic pancreatitis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs772024986Ensembl.1
Natural variantiVAR_07052232G → V in PCTT; associated with disease susceptibility; highly reduced catalytic efficiency. 1 Publication1
Natural variantiVAR_04351635D → H1 Publication1
Natural variantiVAR_04351735D → N1 PublicationCorresponds to variant dbSNP:rs184977421Ensembl.1
Natural variantiVAR_07052335D → Y Found in a patient with chronic pancreatitis; unknown pathological significance; catalytic activity comparable to that of wild type. 1 Publication1
Natural variantiVAR_04351837R → Q Rare variant; results in normal secretion and activity. 1 PublicationCorresponds to variant dbSNP:rs145868278EnsemblClinVar.1
Natural variantiVAR_04351948Q → R Rare variant that may be associated with susceptibility to pancreatitis; results in markedly reduced protein secretion. 3 PublicationsCorresponds to variant dbSNP:rs536812916Ensembl.1
Natural variantiVAR_07052461G → R Found in a patient with chronic pancreatitis; unknown pathological significance; the mutant is not secreted. 1 PublicationCorresponds to variant dbSNP:rs769482036Ensembl.1
Natural variantiVAR_04352073A → T in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion. 4 PublicationsCorresponds to variant dbSNP:rs515726209EnsemblClinVar.1
Natural variantiVAR_01092880R → W1 PublicationCorresponds to variant dbSNP:rs779643710Ensembl.1
Natural variantiVAR_070525151K → N Found in a patient with chronic pancreatitis; unknown pathological significance. 1
Natural variantiVAR_070526155C → Y in PCTT; associated with susceptibility to disease; the mutant is not secreted. 2 Publications1
Natural variantiVAR_070527162R → H Rare variant; found in a patient with chronic pancreatitis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs775404479Ensembl.1
Natural variantiVAR_043521172K → E3 PublicationsCorresponds to variant dbSNP:rs34949635EnsemblClinVar.1
Natural variantiVAR_070528178Q → R in PCTT; associated with disease susceptibility; impaired catalytic activity. 1 PublicationCorresponds to variant dbSNP:rs200678111EnsemblClinVar.1
Natural variantiVAR_070529200M → V Rare variant; found in a patient with chronic pancreatitis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs146235499Ensembl.1
Natural variantiVAR_070530209I → M1 Publication1
Natural variantiVAR_043522217G → R in PCTT; associated with susceptibility to disease; results in markedly reduced protein secretion and loss of activity. 3 PublicationsCorresponds to variant dbSNP:rs202058123EnsemblClinVar.1
Natural variantiVAR_043523217G → S in PCTT; associated with susceptibility to disease; reduced protein secretion; impaired catalytic activity. 3 PublicationsCorresponds to variant dbSNP:rs202058123EnsemblClinVar.1
Natural variantiVAR_043524218G → S1 Publication1
Natural variantiVAR_043525220L → R Rare variant; results in impaired protein secretion. 2 Publications1
Natural variantiVAR_043526225E → A1 PublicationCorresponds to variant dbSNP:rs201486613EnsemblClinVar.1
Natural variantiVAR_070531225E → K Found in a patient with chronic pancreatitis; unknown pathological significance. 1 Publication1
Natural variantiVAR_070532227G → S1 PublicationCorresponds to variant dbSNP:rs567745213Ensembl.1
Natural variantiVAR_043527235V → I in PCTT; associated with susceptibility to disease; slightly reduced activity. 4 PublicationsCorresponds to variant dbSNP:rs140993290EnsemblClinVar.1
Natural variantiVAR_070533239S → A Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication1
Natural variantiVAR_070534239S → C Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication1
Natural variantiVAR_070535246R → C1 PublicationCorresponds to variant dbSNP:rs200412314EnsemblClinVar.1
Natural variantiVAR_070536247 – 254Missing in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity. 2 Publications8
Natural variantiVAR_070537247K → E Found in patients with chronic pancreatitis; unknown pathological significance. 1 Publication1
Natural variantiVAR_043528249P → L in PCTT; associated with disease susceptibility; results in reduced protein secretion and loss of activity. 2 PublicationsCorresponds to variant dbSNP:rs142560329EnsemblClinVar.1
Natural variantiVAR_070538250V → E in PCTT; associated with disease susceptibility; results in altered enzyme specificity and loss of activity. 1 Publication1
Natural variantiVAR_070539254R → Q Found in a patient with chronic pancreatitis; unknown pathological significance; mutant protein secretion, activity and trypsin-mediated degradation are comparable to those of wild-type. 2 PublicationsCorresponds to variant dbSNP:rs755811899EnsemblClinVar.1
Natural variantiVAR_043529254R → W in PCTT; associated with susceptibility to disease; results in reduced secretion; normal activity; the mutant undergoes proteolytic degradation during trypsin-mediated activation. 5 PublicationsCorresponds to variant dbSNP:rs121909293EnsemblClinVar.1
Natural variantiVAR_070540257A → T Found in patients with chronic pancreatitis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs200406696Ensembl.1
Natural variantiVAR_043530260D → N1 PublicationCorresponds to variant dbSNP:rs540753875Ensembl.1
Natural variantiVAR_070541263N → S Found in a patient with chronic pancreatitis; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs769975164Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
S82198 mRNA Translation: AAB47104.2 Sequence problems.
AK289447 mRNA Translation: BAF82136.1
AL031283 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51726.1
BC015118 mRNA Translation: AAH15118.1
Y13697 mRNA Translation: CAA74031.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS156.1

Protein sequence database of the Protein Information Resource

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PIRi
S68825
S68826

NCBI Reference Sequences

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RefSeqi
NP_009203.2, NM_007272.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.631869

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000375949; ENSP00000365116; ENSG00000162438

Database of genes from NCBI RefSeq genomes

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GeneIDi
11330

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:11330

UCSC genome browser

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UCSCi
uc001awi.2 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S82198 mRNA Translation: AAB47104.2 Sequence problems.
AK289447 mRNA Translation: BAF82136.1
AL031283 Genomic DNA No translation available.
CH471167 Genomic DNA Translation: EAW51726.1
BC015118 mRNA Translation: AAH15118.1
Y13697 mRNA Translation: CAA74031.1
CCDSiCCDS156.1
PIRiS68825
S68826
RefSeqiNP_009203.2, NM_007272.2
UniGeneiHs.631869

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4H4FX-ray1.90A30-268[»]
Q17-26[»]
ProteinModelPortaliQ99895
SMRiQ99895
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116458, 6 interactors
IntActiQ99895, 13 interactors
STRINGi9606.ENSP00000365116

Chemistry databases

BindingDBiQ99895
ChEMBLiCHEMBL2386
GuidetoPHARMACOLOGYi2341

Protein family/group databases

MEROPSiS01.157

Polymorphism and mutation databases

BioMutaiCTRC
DMDMi14194504

Proteomic databases

PaxDbiQ99895
PeptideAtlasiQ99895
PRIDEiQ99895
ProteomicsDBi78519

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375949; ENSP00000365116; ENSG00000162438
GeneIDi11330
KEGGihsa:11330
UCSCiuc001awi.2 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
11330
DisGeNETi11330
EuPathDBiHostDB:ENSG00000162438.11

GeneCards: human genes, protein and diseases

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GeneCardsi
CTRC
GeneReviewsiCTRC
HGNCiHGNC:2523 CTRC
HPAiHPA046920
MalaCardsiCTRC
MIMi167800 phenotype
601405 gene
neXtProtiNX_Q99895
OpenTargetsiENSG00000162438
Orphaneti676 Hereditary chronic pancreatitis
103918 Tropical pancreatitis
PharmGKBiPA27024

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00940000153216
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ99895
KOiK01311
OMAiVDTIHVH
OrthoDBiEOG091G0DF7
PhylomeDBiQ99895
TreeFamiTF330455

Enzyme and pathway databases

BRENDAi3.4.21.2 2681
ReactomeiR-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
CTRC human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Chymotrypsin-C

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
11330

Protein Ontology

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PROi
PR:Q99895

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000162438 Expressed in 106 organ(s), highest expression level in body of pancreas
CleanExiHS_CTRC
ExpressionAtlasiQ99895 baseline and differential
GenevisibleiQ99895 HS

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCTRC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99895
Secondary accession number(s): A8K082, O00765, Q9NUH5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: December 5, 2018
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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