UniProtKB - Q99873 (ANM1_HUMAN)
Protein arginine N-methyltransferase 1
PRMT1
Functioni
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP and MAP3K5/ASK1 (PubMed:10749851, PubMed:16879614, PubMed:26876602, PubMed:22095282, PubMed:26575292, PubMed:18951090, PubMed:25284789).
Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292).
Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity (PubMed:18951090).
Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789).
Methylates MAP3K5/ASK1 at 'Arg-78' and 'Arg-80' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (PubMed:22095282).
Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).
Plays a role in regulating alternative splicing in the heart (By similarity).
By similarity16 PublicationsCaution
Catalytic activityi
- L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H+ + Nω,Nω-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine6 PublicationsEC:2.1.1.3196 Publications
Activity regulationi
Kineticsi
- KM=1 µM for AdoMet1 Publication
- KM=4.2 µM for H41 Publication
- Vmax=1.2 nmol/min/mg enzyme toward AdoMet1 Publication
- Vmax=1.24 nmol/min/mg enzyme toward H41 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 63 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 72 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 96 | S-adenosyl-L-methionine; via carbonyl oxygenBy similarity | 1 | |
Binding sitei | 118 | S-adenosyl-L-methionineBy similarity | 1 | |
Binding sitei | 147 | S-adenosyl-L-methionineBy similarity | 1 | |
Active sitei | 162 | By similarity | 1 | |
Active sitei | 171 | By similarity | 1 |
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- histone methyltransferase activity Source: UniProtKB
- histone methyltransferase activity (H4-R3 specific) Source: UniProtKB
- identical protein binding Source: UniProtKB
- methyl-CpG binding Source: UniProtKB
- methyltransferase activity Source: ProtInc
- mitogen-activated protein kinase p38 binding Source: BHF-UCL
- N-methyltransferase activity Source: UniProtKB
- protein-arginine N-methyltransferase activity Source: MGI
- protein-arginine omega-N asymmetric methyltransferase activity Source: UniProtKB
- protein-arginine omega-N monomethyltransferase activity Source: UniProtKB
- protein methyltransferase activity Source: UniProtKB
- RNA binding Source: UniProtKB
- S-adenosyl-L-methionine binding Source: UniProtKB
GO - Biological processi
- cardiac muscle tissue development Source: UniProtKB
- cell surface receptor signaling pathway Source: ProtInc
- histone H4-R3 methylation Source: UniProtKB
- histone methylation Source: UniProtKB
- in utero embryonic development Source: Ensembl
- negative regulation of JNK cascade Source: UniProtKB
- negative regulation of megakaryocyte differentiation Source: UniProtKB
- neuron projection development Source: UniProtKB
- peptidyl-arginine methylation Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of erythrocyte differentiation Source: BHF-UCL
- positive regulation of hemoglobin biosynthetic process Source: BHF-UCL
- positive regulation of p38MAPK cascade Source: BHF-UCL
- protein homooligomerization Source: UniProtKB
- protein methylation Source: UniProtKB
- regulation of megakaryocyte differentiation Source: UniProtKB
- RNA splicing Source: UniProtKB
- viral protein processing Source: Reactome
Keywordsi
Molecular function | Methyltransferase, Transferase |
Ligand | S-adenosyl-L-methionine |
Enzyme and pathway databases
BRENDAi | 2.1.1.319, 2681 |
PathwayCommonsi | Q99873 |
Reactomei | R-HSA-3214858, RMTs methylate histone arginines R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9694631, Maturation of nucleoprotein |
SABIO-RKi | Q99873 |
SignaLinki | Q99873 |
SIGNORi | Q99873 |
Names & Taxonomyi
Protein namesi | Recommended name: Protein arginine N-methyltransferase 1Curated (EC:2.1.1.3196 Publications)Alternative name(s): Histone-arginine N-methyltransferase PRMT1 Interferon receptor 1-bound protein 4 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5187, PRMT1 |
MIMi | 602950, gene |
neXtProti | NX_Q99873 |
VEuPathDBi | HostDB:ENSG00000126457 |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
- Nucleus 3 Publications
- nucleoplasm By similarity
Note: Mostly found in the cytoplasm. Colocalizes with CHTOP within the nucleus. Low levels detected also in the chromatin fraction (By similarity).By similarity
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: MGI
Other locations
- cytoplasm Source: UniProtKB
- methylosome Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 92 | V → A: Loss of FOXO1 methylation, its nuclear retention, and transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 93 | L → A: Loss of FOXO1 methylation, its nuclear retention, and transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 94 | D → A: Loss of FOXO1 methylation, its nuclear retention, and transcriptional activity. 1 Publication | 1 | |
Mutagenesisi | 280 | Y → A: No effect on S-adenosyl-L-methionine binding but reduced EWS protein methylation; when associated with A-322 and A-359. No effect on homodimerization but loss of homooligomerization; when associated with A-322 and A-359. 1 Publication | 1 | |
Mutagenesisi | 322 | Y → A: No effect on S-adenosyl-L-methionine binding but reduced EWS protein methylation; when associated with A-280 and A-359. No effect on homodimerization but loss of homooligomerization; when associated with A-280 and A-359. 1 Publication | 1 | |
Mutagenesisi | 359 | L → A: No effect on S-adenosyl-L-methionine binding but reduced EWS protein methylation; when associated with A-280 and A-322. No effect on homodimerization but loss of homooligomerization; when associated with A-280 and A-322. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3276 |
OpenTargetsi | ENSG00000126457 |
PharmGKBi | PA29461 |
Miscellaneous databases
Pharosi | Q99873, Tchem |
Chemistry databases
ChEMBLi | CHEMBL5524 |
DrugBanki | DB01752, S-adenosyl-L-homocysteine |
DrugCentrali | Q99873 |
GuidetoPHARMACOLOGYi | 1252 |
Genetic variation databases
BioMutai | PRMT1 |
DMDMi | 161789011 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000212321 | 1 – 371 | Protein arginine N-methyltransferase 1Add BLAST | 371 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 134 | N6-succinyllysineBy similarity | 1 | |
Cross-linki | 145 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity | ||
Modified residuei | 228 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 233 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 304 | PhosphoserineCombined sources | 1 | |
Modified residuei | 307 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q99873 |
jPOSTi | Q99873 |
MassIVEi | Q99873 |
MaxQBi | Q99873 |
PaxDbi | Q99873 |
PeptideAtlasi | Q99873 |
PRIDEi | Q99873 |
ProteomicsDBi | 33891 44996 78511 [Q99873-1] 78512 [Q99873-2] 78513 [Q99873-3] |
PTM databases
GlyGeni | Q99873, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99873 |
PhosphoSitePlusi | Q99873 |
SwissPalmi | Q99873 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000126457, Expressed in embryo and 231 other tissues |
ExpressionAtlasi | Q99873, baseline and differential |
Genevisiblei | Q99873, HS |
Organism-specific databases
HPAi | ENSG00000126457, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (PubMed:16879614, PubMed:26876602). Homooctamer; individual homodimers associates to form a homooctamer (PubMed:26876602). Individual homodimers can associate to form a homohexamer. Heterodimer with PRMT8.
Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity).
Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (PubMed:25284789).
Interacts with ILF3 and SUPT5H.
Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress.
Interacts with and probably methylates ATXN2L (PubMed:25748791).
Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789).
Interacts with DHX9 (via RGG region) (PubMed:15084609).
Interacts (via N-terminus) with HABP4 (PubMed:16879614).
Interacts with MAP3K5/ASK1; the interaction results in MAP3K5 methylation by PRMT1 which inhibits MAP3K5 activation (PubMed:22095282).
Interacts with TRIM48; the interaction results in ubiquitination of PRMT1 by TRIM48, leading to PRMT1 proteasomal degradation and activation of MAP3K5 (PubMed:29186683).
By similarity12 PublicationsBinary interactionsi
Q99873
Isoform 2 [Q99873-2]
With | #Exp. | IntAct |
---|---|---|
DR1 [Q01658] | 3 | EBI-16399024,EBI-750300 |
PRMT1 - isoform 3 [Q99873-3]
GO - Molecular functioni
- enzyme binding Source: UniProtKB
- identical protein binding Source: UniProtKB
- mitogen-activated protein kinase p38 binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109512, 330 interactors |
CORUMi | Q99873 |
DIPi | DIP-30878N |
IntActi | Q99873, 131 interactors |
MINTi | Q99873 |
STRINGi | 9606.ENSP00000406162 |
Chemistry databases
BindingDBi | Q99873 |
Miscellaneous databases
RNActi | Q99873, protein |
Structurei
Secondary structure
3D structure databases
AlphaFoldDBi | Q99873 |
SMRi | Q99873 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 50 – 361 | SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST | 312 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1499, Eukaryota |
GeneTreei | ENSGT00940000154700 |
InParanoidi | Q99873 |
OMAi | TTDRMEV |
OrthoDBi | 840669at2759 |
PhylomeDBi | Q99873 |
TreeFami | TF300608 |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR025799, Arg_MeTrfase IPR041698, Methyltransf_25 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR11006, PTHR11006, 1 hit |
Pfami | View protein in Pfam PF13649, Methyltransf_25, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678, SAM_MT_PRMT, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK
60 70 80 90 100
DYYFDSYAHF GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG
110 120 130 140 150
ILCMFAAKAG ARKVIGIECS SISDYAVKIV KANKLDHVVT IIKGKVEEVE
160 170 180 190 200
LPVEKVDIII SEWMGYCLFY ESMLNTVLYA RDKWLAPDGL IFPDRATLYV
210 220 230 240 250
TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV DPKQLVTNAC
260 270 280 290 300
LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG
310 320 330 340 350
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT
360 370
IDLDFKGQLC ELSCSTDYRM R
Computationally mapped potential isoform sequencesi
There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH0YDE4 | H0YDE4_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 238 | Annotation score: | ||
E9PKG1 | E9PKG1_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 325 | Annotation score: | ||
E9PQ98 | E9PQ98_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 205 | Annotation score: | ||
E9PIX6 | E9PIX6_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 207 | Annotation score: | ||
E9PNR9 | E9PNR9_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 160 | Annotation score: | ||
E9PMW9 | E9PMW9_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 110 | Annotation score: | ||
E9PMZ2 | E9PMZ2_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 63 | Annotation score: | ||
E9PIE2 | E9PIE2_HUMAN | Protein arginine N-methyltransferas... | PRMT1 | 54 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 118 | E → V in CAA71763 (PubMed:9545638).Curated | 1 | |
Sequence conflicti | 118 | E → V in CAA71764 (PubMed:9545638).Curated | 1 | |
Sequence conflicti | 118 | E → V in CAA71765 (PubMed:9545638).Curated | 1 | |
Sequence conflicti | 118 | E → V in BAA11029 (PubMed:8675017).Curated | 1 | |
Sequence conflicti | 157 – 185 | DIIIS…RDKWL → ASSSASGWATASSTSPCSTP CSMPGTSV in BAA11029 (PubMed:8675017).CuratedAdd BLAST | 29 | |
Sequence conflicti | 212 | K → E in BAG65435 (PubMed:14702039).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_037501 | 88 | K → M. Corresponds to variant dbSNP:rs1804486Ensembl. | 1 | |
Natural variantiVAR_037502 | 168 | L → F. Corresponds to variant dbSNP:rs11673683Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_005208 | 1 – 29 | MAAAE…QPPLE → MVGVA in isoform 2. 1 PublicationAdd BLAST | 29 | |
Alternative sequenceiVSP_005209 | 11 – 30 | MENFV…PPLEE → ME in isoform 3. 2 PublicationsAdd BLAST | 20 | |
Alternative sequenceiVSP_059419 | 13 – 30 | Missing in isoform 4. Add BLAST | 18 | |
Alternative sequenceiVSP_059420 | 186 – 253 | Missing in isoform 4. Add BLAST | 68 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10805 mRNA Translation: CAA71763.1 Y10806 mRNA Translation: CAA71764.1 Different initiation. Y10807 mRNA Translation: CAA71765.1 Different initiation. D66904 mRNA Translation: BAA11029.1 Different initiation. AF222689 Genomic DNA Translation: AAF62893.1 AF222689 Genomic DNA Translation: AAF62894.1 Different initiation. AF222689 Genomic DNA Translation: AAF62895.1 Different initiation. AK304660 mRNA Translation: BAG65435.1 CR407608 mRNA Translation: CAG28536.1 AC011495 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52521.1 CH471177 Genomic DNA Translation: EAW52519.1 BC019268 mRNA Translation: AAH19268.2 BC109282 mRNA Translation: AAI09283.2 Different initiation. BC109283 mRNA Translation: AAI09284.2 Different initiation. |
CCDSi | CCDS42592.1 [Q99873-3] CCDS46145.1 [Q99873-1] CCDS74425.1 [Q99873-5] |
RefSeqi | NP_001193971.1, NM_001207042.2 [Q99873-5] NP_001527.3, NM_001536.5 [Q99873-1] NP_938074.2, NM_198318.4 [Q99873-3] XP_016882223.1, XM_017026734.1 [Q99873-2] XP_016882224.1, XM_017026735.1 [Q99873-2] |
Genome annotation databases
Ensembli | ENST00000391851.8; ENSP00000375724.4; ENSG00000126457.22 [Q99873-3] ENST00000454376.7; ENSP00000406162.2; ENSG00000126457.22 ENST00000610806.4; ENSP00000484505.1; ENSG00000126457.22 [Q99873-5] |
GeneIDi | 3276 |
KEGGi | hsa:3276 |
MANE-Selecti | ENST00000454376.7; ENSP00000406162.2; NM_001536.6; NP_001527.3 |
UCSCi | uc002ppe.4, human [Q99873-1] uc010enf.3, human |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y10805 mRNA Translation: CAA71763.1 Y10806 mRNA Translation: CAA71764.1 Different initiation. Y10807 mRNA Translation: CAA71765.1 Different initiation. D66904 mRNA Translation: BAA11029.1 Different initiation. AF222689 Genomic DNA Translation: AAF62893.1 AF222689 Genomic DNA Translation: AAF62894.1 Different initiation. AF222689 Genomic DNA Translation: AAF62895.1 Different initiation. AK304660 mRNA Translation: BAG65435.1 CR407608 mRNA Translation: CAG28536.1 AC011495 Genomic DNA No translation available. CH471177 Genomic DNA Translation: EAW52521.1 CH471177 Genomic DNA Translation: EAW52519.1 BC019268 mRNA Translation: AAH19268.2 BC109282 mRNA Translation: AAI09283.2 Different initiation. BC109283 mRNA Translation: AAI09284.2 Different initiation. |
CCDSi | CCDS42592.1 [Q99873-3] CCDS46145.1 [Q99873-1] CCDS74425.1 [Q99873-5] |
RefSeqi | NP_001193971.1, NM_001207042.2 [Q99873-5] NP_001527.3, NM_001536.5 [Q99873-1] NP_938074.2, NM_198318.4 [Q99873-3] XP_016882223.1, XM_017026734.1 [Q99873-2] XP_016882224.1, XM_017026735.1 [Q99873-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6NT2 | X-ray | 2.48 | A/B/C/D | 1-371 | [»] | |
AlphaFoldDBi | Q99873 | |||||
SMRi | Q99873 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109512, 330 interactors |
CORUMi | Q99873 |
DIPi | DIP-30878N |
IntActi | Q99873, 131 interactors |
MINTi | Q99873 |
STRINGi | 9606.ENSP00000406162 |
Chemistry databases
BindingDBi | Q99873 |
ChEMBLi | CHEMBL5524 |
DrugBanki | DB01752, S-adenosyl-L-homocysteine |
DrugCentrali | Q99873 |
GuidetoPHARMACOLOGYi | 1252 |
PTM databases
GlyGeni | Q99873, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99873 |
PhosphoSitePlusi | Q99873 |
SwissPalmi | Q99873 |
Genetic variation databases
BioMutai | PRMT1 |
DMDMi | 161789011 |
Proteomic databases
EPDi | Q99873 |
jPOSTi | Q99873 |
MassIVEi | Q99873 |
MaxQBi | Q99873 |
PaxDbi | Q99873 |
PeptideAtlasi | Q99873 |
PRIDEi | Q99873 |
ProteomicsDBi | 33891 44996 78511 [Q99873-1] 78512 [Q99873-2] 78513 [Q99873-3] |
Protocols and materials databases
Antibodypediai | 18668, 546 antibodies from 40 providers |
DNASUi | 3276 |
Genome annotation databases
Ensembli | ENST00000391851.8; ENSP00000375724.4; ENSG00000126457.22 [Q99873-3] ENST00000454376.7; ENSP00000406162.2; ENSG00000126457.22 ENST00000610806.4; ENSP00000484505.1; ENSG00000126457.22 [Q99873-5] |
GeneIDi | 3276 |
KEGGi | hsa:3276 |
MANE-Selecti | ENST00000454376.7; ENSP00000406162.2; NM_001536.6; NP_001527.3 |
UCSCi | uc002ppe.4, human [Q99873-1] uc010enf.3, human |
Organism-specific databases
CTDi | 3276 |
DisGeNETi | 3276 |
GeneCardsi | PRMT1 |
HGNCi | HGNC:5187, PRMT1 |
HPAi | ENSG00000126457, Low tissue specificity |
MIMi | 602950, gene |
neXtProti | NX_Q99873 |
OpenTargetsi | ENSG00000126457 |
PharmGKBi | PA29461 |
VEuPathDBi | HostDB:ENSG00000126457 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1499, Eukaryota |
GeneTreei | ENSGT00940000154700 |
InParanoidi | Q99873 |
OMAi | TTDRMEV |
OrthoDBi | 840669at2759 |
PhylomeDBi | Q99873 |
TreeFami | TF300608 |
Enzyme and pathway databases
BRENDAi | 2.1.1.319, 2681 |
PathwayCommonsi | Q99873 |
Reactomei | R-HSA-3214858, RMTs methylate histone arginines R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-HSA-9009391, Extra-nuclear estrogen signaling R-HSA-9018519, Estrogen-dependent gene expression R-HSA-9694631, Maturation of nucleoprotein |
SABIO-RKi | Q99873 |
SignaLinki | Q99873 |
SIGNORi | Q99873 |
Miscellaneous databases
BioGRID-ORCSi | 3276, 777 hits in 1100 CRISPR screens |
ChiTaRSi | PRMT1, human |
GeneWikii | PRMT1 |
GenomeRNAii | 3276 |
Pharosi | Q99873, Tchem |
PROi | PR:Q99873 |
RNActi | Q99873, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000126457, Expressed in embryo and 231 other tissues |
ExpressionAtlasi | Q99873, baseline and differential |
Genevisiblei | Q99873, HS |
Family and domain databases
Gene3Di | 3.40.50.150, 1 hit |
InterProi | View protein in InterPro IPR025799, Arg_MeTrfase IPR041698, Methyltransf_25 IPR029063, SAM-dependent_MTases |
PANTHERi | PTHR11006, PTHR11006, 1 hit |
Pfami | View protein in Pfam PF13649, Methyltransf_25, 1 hit |
SUPFAMi | SSF53335, SSF53335, 1 hit |
PROSITEi | View protein in PROSITE PS51678, SAM_MT_PRMT, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ANM1_HUMAN | |
Accessioni | Q99873Primary (citable) accession number: Q99873 Secondary accession number(s): A0A087X1W2 Q9NZ06 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 28, 2018 | |
Last modified: | May 25, 2022 | |
This is version 193 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families