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UniProtKB - Q99873 (ANM1_HUMAN)

Entry version 189 (07 Apr 2021)
Sequence version 3 (28 Mar 2018)
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Protein

Protein arginine N-methyltransferase 1

Gene

PRMT1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4 and SERBP1 (PubMed:10749851, PubMed:16879614, PubMed:26876602). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-4' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity. Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789).15 Publications

Caution

A paper showing that PRMT1-mediated arginine methylation of PIAS1 regulates STAT1 signaling has been retracted, because some of the data was found to be deliberately falsified.2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

By BTG1, BTG2 and ILF3.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1 µM for AdoMet1 Publication
  2. KM=4.2 µM for H41 Publication
  1. Vmax=1.2 nmol/min/mg enzyme toward AdoMet1 Publication
  2. Vmax=1.24 nmol/min/mg enzyme toward H41 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei63S-adenosyl-L-methionineBy similarity1
Binding sitei72S-adenosyl-L-methionineBy similarity1
Binding sitei96S-adenosyl-L-methionine; via carbonyl oxygenBy similarity1
Binding sitei118S-adenosyl-L-methionineBy similarity1
Binding sitei147S-adenosyl-L-methionineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei162By similarity1
Active sitei171By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05019-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.1.1.126, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99873

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-3214858, RMTs methylate histone arginines
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9018519, Estrogen-dependent gene expression

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		Q99873

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99873

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99873

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein arginine N-methyltransferase 1Curated (EC:2.1.1.3195 Publications)
Alternative name(s):
Histone-arginine N-methyltransferase PRMT1
Interferon receptor 1-bound protein 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:PRMT1Imported
Synonyms:HMT2, HRMT1L22 Publications, IR1B4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5187, PRMT1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602950, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99873

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000126457.21

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi92V → A: Loss of FOXO1 methylation, its nuclear retention, and transcriptional activity. 1 Publication1
Mutagenesisi93L → A: Loss of FOXO1 methylation, its nuclear retention, and transcriptional activity. 1 Publication1
Mutagenesisi94D → A: Loss of FOXO1 methylation, its nuclear retention, and transcriptional activity. 1 Publication1
Mutagenesisi280Y → A: No effect on S-adenosyl-L-methionine binding but reduced EWS protein methylation; when associated with A-322 and A-359. No effect on homodimerization but loss of homooligomerization; when associated with A-322 and A-359. 1 Publication1
Mutagenesisi322Y → A: No effect on S-adenosyl-L-methionine binding but reduced EWS protein methylation; when associated with A-280 and A-359. No effect on homodimerization but loss of homooligomerization; when associated with A-280 and A-359. 1 Publication1
Mutagenesisi359L → A: No effect on S-adenosyl-L-methionine binding but reduced EWS protein methylation; when associated with A-280 and A-322. No effect on homodimerization but loss of homooligomerization; when associated with A-280 and A-322. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3276

Open Targets

More...OpenTargetsi		ENSG00000126457

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29461

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99873, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5524

Drug and drug target database

More...DrugBanki		DB01752, S-adenosyl-L-homocysteine

DrugCentral

More...DrugCentrali		Q99873

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		1252

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		PRMT1

Domain mapping of disease mutations (DMDM)

More...DMDMi		161789011

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002123211 – 371Protein arginine N-methyltransferase 1Add BLAST371

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei134N6-succinyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki145Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei228N6-acetyllysineBy similarity1
Modified residuei233N6-acetyllysineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei307PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Polyubiquitinated at Lys-145 by the SCF(FBXL17) complex, leading to its subsequent degradation. Ubiquitination is regulated by acetylation at Lys-228 and Lys-233.By similarity
Acetylation at Lys-228 and Lys-233 regulates ubiquitination by the SCF(FBXL17) complex. Acetylated at Lys-233 by p300/EP300. Deacetylated at Lys-228 and Lys-233 by SIRT1.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99873

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99873

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99873

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99873

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99873

PeptideAtlas

More...PeptideAtlasi		Q99873

PRoteomics IDEntifications database

More...PRIDEi		Q99873

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		33891
44996
78511 [Q99873-1]
78512 [Q99873-2]
78513 [Q99873-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99873

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99873

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q99873

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed (PubMed:11097842). Expressed strongly in colorectal cancer cells (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000126457, Expressed in embryo and 230 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99873, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99873, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000126457, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:16879614, PubMed:26876602). Homooctamer; individual homodimers associates to form a homooctamer (PubMed:26876602). Individual homodimers can associate to form a homohexamer. Heterodimer with PRMT8.

Interacts with BTG1, BTG2, NFATC2IP and IFNAR1 (By similarity).

Interacts with and methylates CHTOP, thereby enabling the interaction of CHTOP with the 5FMC complex (PubMed:25284789).

Interacts with ILF3 and SUPT5H.

Interacts with and methylates FOXO1, leading to the nuclear retention of FOXO1 and the stimulation of FOXO1 transcriptional activity. Methylation of FOXO1 is increased upon oxidative stress.

Interacts with and probably methylates ATXN2L (PubMed:25748791).

Component of the methylosome, a 20S complex containing at least CLNS1A/pICln, PRMT5/SKB1, WDR77/MEP50, PRMT1 and ERH (PubMed:25284789).

Interacts with DHX9 (via RGG region) (PubMed:15084609).

Interacts (via N-terminus) with HABP4 (PubMed:16879614).

By similarity10 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109512, 314 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q99873

Database of interacting proteins

More...DIPi		DIP-30878N

Protein interaction database and analysis system

More...IntActi		Q99873, 119 interactors

Molecular INTeraction database

More...MINTi		Q99873

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000406162

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		Q99873

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99873, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1371
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99873

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini50 – 361SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd BLAST312

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1499, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000154700

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99873

Identification of Orthologs from Complete Genome Data

More...OMAi		TCHANSK

Database of Orthologous Groups

More...OrthoDBi		840669at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99873

TreeFam database of animal gene trees

More...TreeFami		TF300608

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR025799, Arg_MeTrfase
IPR041698, Methyltransf_25
IPR029063, SAM-dependent_MTases

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13649, Methyltransf_25, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53335, SSF53335, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 8 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99873-1) [UniParc]FASTAAdd to basket
Also known as: V2

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAEAANCI MENFVATLAN GMSLQPPLEE VSCGQAESSE KPNAEDMTSK 
        60         70         80         90        100
DYYFDSYAHF GIHEEMLKDE VRTLTYRNSM FHNRHLFKDK VVLDVGSGTG 
       110        120        130        140        150
ILCMFAAKAG ARKVIGIECS SISDYAVKIV KANKLDHVVT IIKGKVEEVE 
       160        170        180        190        200
LPVEKVDIII SEWMGYCLFY ESMLNTVLYA RDKWLAPDGL IFPDRATLYV 
       210        220        230        240        250
TAIEDRQYKD YKIHWWENVY GFDMSCIKDV AIKEPLVDVV DPKQLVTNAC 
       260        270        280        290        300
LIKEVDIYTV KVEDLTFTSP FCLQVKRNDY VHALVAYFNI EFTRCHKRTG 
       310        320        330        340        350
FSTSPESPYT HWKQTVFYME DYLTVKTGEE IFGTIGMRPN AKNNRDLDFT 
       360        370 
IDLDFKGQLC ELSCSTDYRM R
Length:371
Mass (Da):42,462
Last modified:March 28, 2018 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i544349801B0E1396
GO
Isoform 2 (identifier: Q99873-2) [UniParc]FASTAAdd to basket
Also known as: V3

The sequence of this isoform differs from the canonical sequence as follows:
     1-29: MAAAEAANCIMENFVATLANGMSLQPPLE → MVGVA

Show »
Length:347
Mass (Da):39,929
Checksum:i2546A25EF744E265
GO
Isoform 3 (identifier: Q99873-3) [UniParc]FASTAAdd to basket
Also known as: V1

The sequence of this isoform differs from the canonical sequence as follows:
     11-30: MENFVATLANGMSLQPPLEE → ME

Show »
Length:353
Mass (Da):40,548
Checksum:i1704BA3762F3E264
GO
Isoform 4 (identifier: Q99873-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     13-30: Missing.
     186-253: Missing.

Show »
Length:285
Mass (Da):32,693
Checksum:i7D985F187D73F7E3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YDE4H0YDE4_HUMAN
Protein arginine N-methyltransferas...
PRMT1
238Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMW9E9PMW9_HUMAN
Protein arginine N-methyltransferas...
PRMT1
110Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PKG1E9PKG1_HUMAN
Protein arginine N-methyltransferas...
PRMT1
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ98E9PQ98_HUMAN
Protein arginine N-methyltransferas...
PRMT1
205Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIX6E9PIX6_HUMAN
Protein arginine N-methyltransferas...
PRMT1
207Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNR9E9PNR9_HUMAN
Protein arginine N-methyltransferas...
PRMT1
160Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PMZ2E9PMZ2_HUMAN
Protein arginine N-methyltransferas...
PRMT1
63Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PIE2E9PIE2_HUMAN
Protein arginine N-methyltransferas...
PRMT1
54Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF62894 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAF62895 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI09283 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence AAI09284 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAA11029 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA71764 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA71765 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti118E → V in CAA71763 (PubMed:9545638).Curated1
Sequence conflicti118E → V in CAA71764 (PubMed:9545638).Curated1
Sequence conflicti118E → V in CAA71765 (PubMed:9545638).Curated1
Sequence conflicti118E → V in BAA11029 (PubMed:8675017).Curated1
Sequence conflicti157 – 185DIIIS…RDKWL → ASSSASGWATASSTSPCSTP CSMPGTSV in BAA11029 (PubMed:8675017).CuratedAdd BLAST29
Sequence conflicti212K → E in BAG65435 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03750188K → M. Corresponds to variant dbSNP:rs1804486Ensembl.1
Natural variantiVAR_037502168L → F. Corresponds to variant dbSNP:rs11673683Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0052081 – 29MAAAE…QPPLE → MVGVA in isoform 2. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_00520911 – 30MENFV…PPLEE → ME in isoform 3. 2 PublicationsAdd BLAST20
Alternative sequenceiVSP_05941913 – 30Missing in isoform 4. Add BLAST18
Alternative sequenceiVSP_059420186 – 253Missing in isoform 4. Add BLAST68

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Y10805 mRNA Translation: CAA71763.1
Y10806 mRNA Translation: CAA71764.1 Different initiation.
Y10807 mRNA Translation: CAA71765.1 Different initiation.
D66904 mRNA Translation: BAA11029.1 Different initiation.
AF222689 Genomic DNA Translation: AAF62893.1
AF222689 Genomic DNA Translation: AAF62894.1 Different initiation.
AF222689 Genomic DNA Translation: AAF62895.1 Different initiation.
AK304660 mRNA Translation: BAG65435.1
CR407608 mRNA Translation: CAG28536.1
AC011495 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52521.1
CH471177 Genomic DNA Translation: EAW52519.1
BC019268 mRNA Translation: AAH19268.2
BC109282 mRNA Translation: AAI09283.2 Different initiation.
BC109283 mRNA Translation: AAI09284.2 Different initiation.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS42592.1 [Q99873-3]
CCDS46145.1 [Q99873-1]
CCDS74425.1 [Q99873-5]

NCBI Reference Sequences

More...RefSeqi		NP_001193971.1, NM_001207042.2 [Q99873-5]
NP_001527.3, NM_001536.5 [Q99873-1]
NP_938074.2, NM_198318.4 [Q99873-3]
XP_016882223.1, XM_017026734.1 [Q99873-2]
XP_016882224.1, XM_017026735.1 [Q99873-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000391851; ENSP00000375724; ENSG00000126457 [Q99873-3]
ENST00000454376; ENSP00000406162; ENSG00000126457 [Q99873-1]
ENST00000610806; ENSP00000484505; ENSG00000126457 [Q99873-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3276

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3276

UCSC genome browser

More...UCSCi		uc002ppe.4, human [Q99873-1]
uc010enf.3, human

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y10805 mRNA Translation: CAA71763.1
Y10806 mRNA Translation: CAA71764.1 Different initiation.
Y10807 mRNA Translation: CAA71765.1 Different initiation.
D66904 mRNA Translation: BAA11029.1 Different initiation.
AF222689 Genomic DNA Translation: AAF62893.1
AF222689 Genomic DNA Translation: AAF62894.1 Different initiation.
AF222689 Genomic DNA Translation: AAF62895.1 Different initiation.
AK304660 mRNA Translation: BAG65435.1
CR407608 mRNA Translation: CAG28536.1
AC011495 Genomic DNA No translation available.
CH471177 Genomic DNA Translation: EAW52521.1
CH471177 Genomic DNA Translation: EAW52519.1
BC019268 mRNA Translation: AAH19268.2
BC109282 mRNA Translation: AAI09283.2 Different initiation.
BC109283 mRNA Translation: AAI09284.2 Different initiation.
CCDSiCCDS42592.1 [Q99873-3]
CCDS46145.1 [Q99873-1]
CCDS74425.1 [Q99873-5]
RefSeqiNP_001193971.1, NM_001207042.2 [Q99873-5]
NP_001527.3, NM_001536.5 [Q99873-1]
NP_938074.2, NM_198318.4 [Q99873-3]
XP_016882223.1, XM_017026734.1 [Q99873-2]
XP_016882224.1, XM_017026735.1 [Q99873-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6NT2X-ray2.48A/B/C/D1-371[»]
SMRiQ99873
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109512, 314 interactors
CORUMiQ99873
DIPiDIP-30878N
IntActiQ99873, 119 interactors
MINTiQ99873
STRINGi9606.ENSP00000406162

Chemistry databases

BindingDBiQ99873
ChEMBLiCHEMBL5524
DrugBankiDB01752, S-adenosyl-L-homocysteine
DrugCentraliQ99873
GuidetoPHARMACOLOGYi1252

PTM databases

iPTMnetiQ99873
PhosphoSitePlusiQ99873
SwissPalmiQ99873

Genetic variation databases

BioMutaiPRMT1
DMDMi161789011

Proteomic databases

EPDiQ99873
jPOSTiQ99873
MassIVEiQ99873
MaxQBiQ99873
PaxDbiQ99873
PeptideAtlasiQ99873
PRIDEiQ99873
ProteomicsDBi33891
44996
78511 [Q99873-1]
78512 [Q99873-2]
78513 [Q99873-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		18668, 531 antibodies

The DNASU plasmid repository

More...DNASUi		3276

Genome annotation databases

EnsembliENST00000391851; ENSP00000375724; ENSG00000126457 [Q99873-3]
ENST00000454376; ENSP00000406162; ENSG00000126457 [Q99873-1]
ENST00000610806; ENSP00000484505; ENSG00000126457 [Q99873-5]
GeneIDi3276
KEGGihsa:3276
UCSCiuc002ppe.4, human [Q99873-1]
uc010enf.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3276
DisGeNETi3276

GeneCards: human genes, protein and diseases

More...GeneCardsi		PRMT1
HGNCiHGNC:5187, PRMT1
HPAiENSG00000126457, Low tissue specificity
MIMi602950, gene
neXtProtiNX_Q99873
OpenTargetsiENSG00000126457
PharmGKBiPA29461
VEuPathDBiHostDB:ENSG00000126457.21

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1499, Eukaryota
GeneTreeiENSGT00940000154700
InParanoidiQ99873
OMAiTCHANSK
OrthoDBi840669at2759
PhylomeDBiQ99873
TreeFamiTF300608

Enzyme and pathway databases

BioCyciMetaCyc:HS05019-MONOMER
BRENDAi2.1.1.126, 2681
PathwayCommonsiQ99873
ReactomeiR-HSA-3214858, RMTs methylate histone arginines
R-HSA-6804114, TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest
R-HSA-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-HSA-9009391, Extra-nuclear estrogen signaling
R-HSA-9018519, Estrogen-dependent gene expression
SABIO-RKiQ99873
SignaLinkiQ99873
SIGNORiQ99873

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3276, 748 hits in 1001 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		PRMT1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		PRMT1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3276
PharosiQ99873, Tchem

Protein Ontology

More...PROi		PR:Q99873
RNActiQ99873, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000126457, Expressed in embryo and 230 other tissues
ExpressionAtlasiQ99873, baseline and differential
GenevisibleiQ99873, HS

Family and domain databases

InterProiView protein in InterPro
IPR025799, Arg_MeTrfase
IPR041698, Methyltransf_25
IPR029063, SAM-dependent_MTases
PfamiView protein in Pfam
PF13649, Methyltransf_25, 1 hit
SUPFAMiSSF53335, SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51678, SAM_MT_PRMT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiANM1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99873
Secondary accession number(s): A0A087X1W2
, B4E3C3, G5E9B6, H7C2I1, Q15529, Q2VP93, Q6LEU5, Q8WUW5, Q99872, Q99874, Q9NZ04, Q9NZ05, Q9NZ06
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 28, 2018
Last modified: April 7, 2021
This is version 189 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families
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