UniProtKB - Q99865 (SPI2A_HUMAN)
Protein
Spindlin-2A
Gene
SPIN2A
Organism
Homo sapiens (Human)
Status
Functioni
May be involved in the regulation of cell cycle progression (By similarity). Exhibits H3K4me3-binding activity (PubMed:29061846).By similarity1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 169 | Histone H3K4me3 and H3R8me2aBy similarity | 1 | |
Binding sitei | 176 | Histone H3K4me3 and H3R8me2aBy similarity | 1 | |
Binding sitei | 180 | Histone H3K4me3 and H3R8me2aBy similarity | 1 |
GO - Molecular functioni
- methylated histone binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- gamete generation Source: InterPro
- regulation of cell cycle Source: InterPro
- regulation of transcription, DNA-templated Source: GO_Central
Keywordsi
Biological process | Cell cycle |
Enzyme and pathway databases
PathwayCommonsi | Q99865 |
Names & Taxonomyi
Protein namesi | Recommended name: Spindlin-2AAlternative name(s): Protein DXF34 Spindlin-like protein 2A Short name: SPIN-2 Short name: SPIN-2A |
Gene namesi | Name:SPIN2A Synonyms:DXF34, SPIN2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20694, SPIN2A |
MIMi | 300621, gene |
neXtProti | NX_Q99865 |
VEuPathDBi | HostDB:ENSG00000147059.8 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 54466 |
OpenTargetsi | ENSG00000147059 |
PharmGKBi | PA144596490 |
Miscellaneous databases
Pharosi | Q99865, Tdark |
Genetic variation databases
BioMutai | SPIN2A |
DMDMi | 116242797 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000181371 | 1 – 258 | Spindlin-2AAdd BLAST | 258 |
Proteomic databases
EPDi | Q99865 |
jPOSTi | Q99865 |
MassIVEi | Q99865 |
MaxQBi | Q99865 |
PaxDbi | Q99865 |
PeptideAtlasi | Q99865 |
PRIDEi | Q99865 |
ProteomicsDBi | 78507 |
PTM databases
iPTMneti | Q99865 |
PhosphoSitePlusi | Q99865 |
Expressioni
Gene expression databases
Bgeei | ENSG00000147059, Expressed in sural nerve and 109 other tissues |
ExpressionAtlasi | Q99865, baseline and differential |
Genevisiblei | Q99865, HS |
Organism-specific databases
HPAi | ENSG00000147059, Low tissue specificity |
Interactioni
Subunit structurei
Interacts with C11orf84/SPINDOC (PubMed:29061846).
1 PublicationGO - Molecular functioni
- methylated histone binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 119972, 8 interactors |
IntActi | Q99865, 1 interactor |
STRINGi | 9606.ENSP00000364043 |
Miscellaneous databases
RNActi | Q99865, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 50 – 99 | Tudor-like domain 1Sequence analysisAdd BLAST | 50 | |
Regioni | 129 – 178 | Tudor-like domain 2Sequence analysisAdd BLAST | 50 | |
Regioni | 138 | Histone H3K4me3 and H3R8me2a bindingBy similarity | 1 | |
Regioni | 210 – 255 | Tudor-like domain 3Sequence analysisAdd BLAST | 46 | |
Regioni | 246 – 248 | Histone H3K4me3 and H3R8me2a bindingBy similarity | 3 |
Sequence similaritiesi
Belongs to the SPIN/STSY family.Curated
Phylogenomic databases
eggNOGi | ENOG502QRYD, Eukaryota |
GeneTreei | ENSGT00950000182925 |
HOGENOMi | CLU_068595_0_0_1 |
InParanoidi | Q99865 |
OMAi | HHTISTN |
OrthoDBi | 1027563at2759 |
PhylomeDBi | Q99865 |
TreeFami | TF332665 |
Family and domain databases
Gene3Di | 2.80.10.70, 1 hit |
InterProi | View protein in InterPro IPR029564, SPIN-2 IPR003671, SPIN/Ssty IPR042567, SPIN/Ssty_sf |
PANTHERi | PTHR10405, PTHR10405, 1 hit PTHR10405:SF13, PTHR10405:SF13, 1 hit |
Pfami | View protein in Pfam PF02513, Spin-Ssty, 3 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q99865-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKTPNAQEAE GQQTRAAAGR ATGSANMTKK KVSQKKQRGR PSSQPRRNIV
60 70 80 90 100
GCRISHGWKE GDEPITQWKG TVLDQVPINP SLYLVKYDGI DCVYGLELHR
110 120 130 140 150
DERVLSLKIL SDRVASSHIS DANLANTIIG KAVEHMFEGE HGSKDEWRGM
160 170 180 190 200
VLAQAPIMKA WFYITYEKDP VLYMYQLLDD YKEGDLRIMP ESSESPPTER
210 220 230 240 250
EPGGVVDGLI GKHVEYTKED GSKRIGMVIH QVETKPSVYF IKFDDDFHIY
VYDLVKKS
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A087X074 | A0A087X074_HUMAN | Spindlin-2A | SPIN2A | 157 | Annotation score: |
Sequence cautioni
The sequence CAA70988 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 46 | R → C in CAA70988 (PubMed:9271673).Curated | 1 | |
Sequence conflicti | 46 | R → C in AAH71694 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09858 mRNA Translation: CAA70988.1 Frameshift. AL022157 Genomic DNA No translation available. BC071694 mRNA Translation: AAH71694.1 |
CCDSi | CCDS35312.1 |
RefSeqi | NP_061876.3, NM_019003.3 XP_005262073.3, XM_005262016.4 XP_005262074.3, XM_005262017.4 XP_005262076.1, XM_005262019.3 XP_016885087.1, XM_017029598.1 |
Genome annotation databases
Ensembli | ENST00000374906; ENSP00000364041; ENSG00000147059 ENST00000374908; ENSP00000364043; ENSG00000147059 |
GeneIDi | 54466 |
KEGGi | hsa:54466 |
UCSCi | uc004dvb.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09858 mRNA Translation: CAA70988.1 Frameshift. AL022157 Genomic DNA No translation available. BC071694 mRNA Translation: AAH71694.1 |
CCDSi | CCDS35312.1 |
RefSeqi | NP_061876.3, NM_019003.3 XP_005262073.3, XM_005262016.4 XP_005262074.3, XM_005262017.4 XP_005262076.1, XM_005262019.3 XP_016885087.1, XM_017029598.1 |
3D structure databases
SMRi | Q99865 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 119972, 8 interactors |
IntActi | Q99865, 1 interactor |
STRINGi | 9606.ENSP00000364043 |
PTM databases
iPTMneti | Q99865 |
PhosphoSitePlusi | Q99865 |
Genetic variation databases
BioMutai | SPIN2A |
DMDMi | 116242797 |
Proteomic databases
EPDi | Q99865 |
jPOSTi | Q99865 |
MassIVEi | Q99865 |
MaxQBi | Q99865 |
PaxDbi | Q99865 |
PeptideAtlasi | Q99865 |
PRIDEi | Q99865 |
ProteomicsDBi | 78507 |
Protocols and materials databases
Antibodypediai | 55479, 52 antibodies |
DNASUi | 54466 |
Genome annotation databases
Ensembli | ENST00000374906; ENSP00000364041; ENSG00000147059 ENST00000374908; ENSP00000364043; ENSG00000147059 |
GeneIDi | 54466 |
KEGGi | hsa:54466 |
UCSCi | uc004dvb.3, human |
Organism-specific databases
CTDi | 54466 |
DisGeNETi | 54466 |
GeneCardsi | SPIN2A |
HGNCi | HGNC:20694, SPIN2A |
HPAi | ENSG00000147059, Low tissue specificity |
MIMi | 300621, gene |
neXtProti | NX_Q99865 |
OpenTargetsi | ENSG00000147059 |
PharmGKBi | PA144596490 |
VEuPathDBi | HostDB:ENSG00000147059.8 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QRYD, Eukaryota |
GeneTreei | ENSGT00950000182925 |
HOGENOMi | CLU_068595_0_0_1 |
InParanoidi | Q99865 |
OMAi | HHTISTN |
OrthoDBi | 1027563at2759 |
PhylomeDBi | Q99865 |
TreeFami | TF332665 |
Enzyme and pathway databases
PathwayCommonsi | Q99865 |
Miscellaneous databases
BioGRID-ORCSi | 54466, 25 hits in 467 CRISPR screens |
GenomeRNAii | 54466 |
Pharosi | Q99865, Tdark |
PROi | PR:Q99865 |
RNActi | Q99865, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000147059, Expressed in sural nerve and 109 other tissues |
ExpressionAtlasi | Q99865, baseline and differential |
Genevisiblei | Q99865, HS |
Family and domain databases
Gene3Di | 2.80.10.70, 1 hit |
InterProi | View protein in InterPro IPR029564, SPIN-2 IPR003671, SPIN/Ssty IPR042567, SPIN/Ssty_sf |
PANTHERi | PTHR10405, PTHR10405, 1 hit PTHR10405:SF13, PTHR10405:SF13, 1 hit |
Pfami | View protein in Pfam PF02513, Spin-Ssty, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SPI2A_HUMAN | |
Accessioni | Q99865Primary (citable) accession number: Q99865 Secondary accession number(s): O75650, Q6IPW2, Q9UJJ0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | October 17, 2006 | |
Last modified: | February 10, 2021 | |
This is version 154 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families