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UniProtKB - Q99856 (ARI3A_HUMAN)
Protein
AT-rich interactive domain-containing protein 3A
Gene
ARID3A
Organism
Homo sapiens (Human)
Status
Functioni
Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.
2 PublicationsGO - Molecular functioni
- chromatin binding Source: Ensembl
- DNA binding Source: GO_Central
- identical protein binding Source: Ensembl
- transcription coregulator activity Source: Ensembl
GO - Biological processi
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | Q99856 |
Reactomei | R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
SignaLinki | Q99856 |
Names & Taxonomyi
Protein namesi | Recommended name: AT-rich interactive domain-containing protein 3AShort name: ARID domain-containing protein 3A Alternative name(s): B-cell regulator of IgH transcription Short name: Bright Dead ringer-like protein 1 E2F-binding protein 1 |
Gene namesi | Name:ARID3A Synonyms:DRIL1, DRIL3, DRX, E2FBP1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:3031, ARID3A |
MIMi | 603265, gene |
neXtProti | NX_Q99856 |
VEuPathDBi | HostDB:ENSG00000116017 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- membrane raft Source: MGI
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 325 | Y → A: Abolishes DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 461 | K → A: Abolishes nuclear targeting. 1 Publication | 1 | |
Mutagenesisi | 527 | G → A or P: Impairs DNA-binding but not self-association. 1 Publication | 1 | |
Mutagenesisi | 530 | Y → A: Impairs DNA-binding but not self-association. 1 Publication | 1 | |
Mutagenesisi | 530 | Y → F: No effect on DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 532 | G → A: Impairs DNA-binding. 1 Publication | 1 | |
Mutagenesisi | 534 | L → A: Impairs DNA-binding. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1820 |
OpenTargetsi | ENSG00000116017 |
PharmGKBi | PA27485 |
Miscellaneous databases
Pharosi | Q99856, Tbio |
Genetic variation databases
BioMutai | ARID3A |
DMDMi | 12230034 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000200578 | 1 – 593 | AT-rich interactive domain-containing protein 3AAdd BLAST | 593 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 77 | PhosphoserineCombined sources | 1 | |
Modified residuei | 81 | PhosphoserineCombined sources | 1 | |
Modified residuei | 88 | PhosphoserineCombined sources | 1 | |
Modified residuei | 98 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 101 | PhosphoserineCombined sources | 1 | |
Modified residuei | 119 | PhosphoserineCombined sources | 1 | |
Modified residuei | 353 | PhosphoserineCombined sources | 1 | |
Modified residuei | 362 | PhosphoserineCombined sources | 1 | |
Cross-linki | 398 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 399 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 452 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources | ||
Cross-linki | 462 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q99856 |
jPOSTi | Q99856 |
MassIVEi | Q99856 |
MaxQBi | Q99856 |
PaxDbi | Q99856 |
PeptideAtlasi | Q99856 |
PRIDEi | Q99856 |
ProteomicsDBi | 78506 |
PTM databases
GlyGeni | Q99856, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99856 |
MetOSitei | Q99856 |
PhosphoSitePlusi | Q99856 |
SwissPalmi | Q99856 |
Expressioni
Tissue specificityi
Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.
Inductioni
By p53/TP53 following DNA damage.1 Publication
Gene expression databases
Bgeei | ENSG00000116017, Expressed in colon and 155 other tissues |
ExpressionAtlasi | Q99856, baseline and differential |
Genevisiblei | Q99856, HS |
Organism-specific databases
HPAi | ENSG00000116017, Tissue enhanced (placenta, testis) |
Interactioni
Subunit structurei
Homodimer. Heterodimer with ARID3B.
Interacts with E2F1.
Interacts with GTF2I and BTK.
3 PublicationsBinary interactionsi
Q99856
GO - Molecular functioni
- identical protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 108154, 68 interactors |
IntActi | Q99856, 73 interactors |
MINTi | Q99856 |
STRINGi | 9606.ENSP00000263620 |
Miscellaneous databases
RNActi | Q99856, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | Q99856 |
BMRBi | Q99856 |
SMRi | Q99856 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99856 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 238 – 330 | ARIDPROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 444 – 541 | REKLESPROSITE-ProRule annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 14 – 222 | DisorderedSequence analysisAdd BLAST | 209 | |
Regioni | 119 – 156 | AcidicAdd BLAST | 38 | |
Regioni | 445 – 488 | Important for nuclear localizationBy similarityAdd BLAST | 44 | |
Regioni | 490 – 513 | HomodimerizationAdd BLAST | 24 | |
Regioni | 497 – 516 | DisorderedSequence analysisAdd BLAST | 20 | |
Regioni | 537 – 557 | Important for cytoplasmic localizationBy similarityAdd BLAST | 21 | |
Regioni | 539 – 593 | DisorderedSequence analysisAdd BLAST | 55 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 106 – 125 | Basic and acidic residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 126 – 159 | Acidic residuesSequence analysisAdd BLAST | 34 | |
Compositional biasi | 551 – 593 | Polar residuesSequence analysisAdd BLAST | 43 |
Phylogenomic databases
eggNOGi | KOG2744, Eukaryota |
GeneTreei | ENSGT00940000160899 |
HOGENOMi | CLU_026952_3_0_1 |
InParanoidi | Q99856 |
OMAi | MKPKWEE |
OrthoDBi | 1347369at2759 |
PhylomeDBi | Q99856 |
TreeFami | TF320364 |
Family and domain databases
Gene3Di | 1.10.150.60, 1 hit |
InterProi | View protein in InterPro IPR045147, ARI3A/B/C IPR001606, ARID_dom IPR036431, ARID_dom_sf IPR023334, REKLES_domain |
PANTHERi | PTHR15348, PTHR15348, 1 hit |
Pfami | View protein in Pfam PF01388, ARID, 1 hit |
SMARTi | View protein in SMART SM00501, BRIGHT, 1 hit |
SUPFAMi | SSF46774, SSF46774, 1 hit |
PROSITEi | View protein in PROSITE PS51011, ARID, 1 hit PS51486, REKLES, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q99856-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE
60 70 80 90 100
SARMQRAQMA ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG
110 120 130 140 150
SPGRGREGPG EEHFEDMASD EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE
160 170 180 190 200
EEEEDEEGLG PPGPASLGTT ALFPRKAQPP QAFRGDGVPR VLGGQERPGP
210 220 230 240 250
GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK RKEFLDDLFS
260 270 280 290 300
FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG
310 320 330 340 350
LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR
360 370 380 390 400
RQSFGGSLFA YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE
410 420 430 440 450
EDSAIPITVP GRLPVSLAGH PVVAAQAAAV QAAAAQAAVA AQAAALEQLR
460 470 480 490 500
EKLESAEPPE KKMALVADEQ QRLMQRALQQ NFLAMAAQLP MSIRINSQAS
510 520 530 540 550
ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA PTPTSAPNKG
560 570 580 590
GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketK7EJ04 | K7EJ04_HUMAN | AT-rich interactive domain-containi... | ARID3A | 338 | Annotation score: | ||
H0YFY1 | H0YFY1_HUMAN | AT-rich interactive domain-containi... | ARID3A | 96 | Annotation score: |
Sequence cautioni
The sequence AAW30734 differs from that shown. Reason: Frameshift.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 423 | V → S in AAN74028 (PubMed:9780002).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_033203 | 36 | P → H1 PublicationCorresponds to variant dbSNP:rs17857499Ensembl. | 1 | |
Natural variantiVAR_033204 | 320 | K → E1 PublicationCorresponds to variant dbSNP:rs17857501Ensembl. | 1 | |
Natural variantiVAR_033205 | 556 | G → S2 PublicationsCorresponds to variant dbSNP:rs1051505Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88047 mRNA Translation: AAC32888.1 AF039850 , AF039844, AF039845, AF039846, AF039847, AF039848, AF039849 Genomic DNA Translation: AAC69994.1 AY152547 mRNA Translation: AAN74028.1 AY845638 mRNA Translation: AAW30734.1 Frameshift. AC005391 Genomic DNA Translation: AAC28918.1 AC005379 Genomic DNA Translation: AAC28499.1 BC033163 mRNA Translation: AAH33163.1 BC060828 mRNA Translation: AAH60828.1 |
CCDSi | CCDS12050.1 |
RefSeqi | NP_005215.1, NM_005224.2 XP_005259570.1, XM_005259513.4 XP_005259571.1, XM_005259514.4 XP_016881934.1, XM_017026445.1 |
Genome annotation databases
Ensembli | ENST00000263620.8; ENSP00000263620.2; ENSG00000116017.11 |
GeneIDi | 1820 |
KEGGi | hsa:1820 |
MANE-Selecti | ENST00000263620.8; ENSP00000263620.2; NM_005224.3; NP_005215.1 |
UCSCi | uc002lql.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U88047 mRNA Translation: AAC32888.1 AF039850 , AF039844, AF039845, AF039846, AF039847, AF039848, AF039849 Genomic DNA Translation: AAC69994.1 AY152547 mRNA Translation: AAN74028.1 AY845638 mRNA Translation: AAW30734.1 Frameshift. AC005391 Genomic DNA Translation: AAC28918.1 AC005379 Genomic DNA Translation: AAC28499.1 BC033163 mRNA Translation: AAH33163.1 BC060828 mRNA Translation: AAH60828.1 |
CCDSi | CCDS12050.1 |
RefSeqi | NP_005215.1, NM_005224.2 XP_005259570.1, XM_005259513.4 XP_005259571.1, XM_005259514.4 XP_016881934.1, XM_017026445.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2KK0 | NMR | - | A | 218-351 | [»] | |
4LJX | X-ray | 2.21 | A/B | 216-351 | [»] | |
AlphaFoldDBi | Q99856 | |||||
BMRBi | Q99856 | |||||
SMRi | Q99856 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 108154, 68 interactors |
IntActi | Q99856, 73 interactors |
MINTi | Q99856 |
STRINGi | 9606.ENSP00000263620 |
PTM databases
GlyGeni | Q99856, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | Q99856 |
MetOSitei | Q99856 |
PhosphoSitePlusi | Q99856 |
SwissPalmi | Q99856 |
Genetic variation databases
BioMutai | ARID3A |
DMDMi | 12230034 |
Proteomic databases
EPDi | Q99856 |
jPOSTi | Q99856 |
MassIVEi | Q99856 |
MaxQBi | Q99856 |
PaxDbi | Q99856 |
PeptideAtlasi | Q99856 |
PRIDEi | Q99856 |
ProteomicsDBi | 78506 |
Protocols and materials databases
ABCDi | Q99856, 2 sequenced antibodies |
Antibodypediai | 1435, 284 antibodies from 33 providers |
DNASUi | 1820 |
Genome annotation databases
Ensembli | ENST00000263620.8; ENSP00000263620.2; ENSG00000116017.11 |
GeneIDi | 1820 |
KEGGi | hsa:1820 |
MANE-Selecti | ENST00000263620.8; ENSP00000263620.2; NM_005224.3; NP_005215.1 |
UCSCi | uc002lql.4, human |
Organism-specific databases
CTDi | 1820 |
DisGeNETi | 1820 |
GeneCardsi | ARID3A |
HGNCi | HGNC:3031, ARID3A |
HPAi | ENSG00000116017, Tissue enhanced (placenta, testis) |
MIMi | 603265, gene |
neXtProti | NX_Q99856 |
OpenTargetsi | ENSG00000116017 |
PharmGKBi | PA27485 |
VEuPathDBi | HostDB:ENSG00000116017 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2744, Eukaryota |
GeneTreei | ENSGT00940000160899 |
HOGENOMi | CLU_026952_3_0_1 |
InParanoidi | Q99856 |
OMAi | MKPKWEE |
OrthoDBi | 1347369at2759 |
PhylomeDBi | Q99856 |
TreeFami | TF320364 |
Enzyme and pathway databases
PathwayCommonsi | Q99856 |
Reactomei | R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
SignaLinki | Q99856 |
Miscellaneous databases
BioGRID-ORCSi | 1820, 175 hits in 1104 CRISPR screens |
ChiTaRSi | ARID3A, human |
EvolutionaryTracei | Q99856 |
GeneWikii | ARID3A |
GenomeRNAii | 1820 |
Pharosi | Q99856, Tbio |
PROi | PR:Q99856 |
RNActi | Q99856, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000116017, Expressed in colon and 155 other tissues |
ExpressionAtlasi | Q99856, baseline and differential |
Genevisiblei | Q99856, HS |
Family and domain databases
Gene3Di | 1.10.150.60, 1 hit |
InterProi | View protein in InterPro IPR045147, ARI3A/B/C IPR001606, ARID_dom IPR036431, ARID_dom_sf IPR023334, REKLES_domain |
PANTHERi | PTHR15348, PTHR15348, 1 hit |
Pfami | View protein in Pfam PF01388, ARID, 1 hit |
SMARTi | View protein in SMART SM00501, BRIGHT, 1 hit |
SUPFAMi | SSF46774, SSF46774, 1 hit |
PROSITEi | View protein in PROSITE PS51011, ARID, 1 hit PS51486, REKLES, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ARI3A_HUMAN | |
Accessioni | Q99856Primary (citable) accession number: Q99856 Secondary accession number(s): Q5I858 Q8N4Z3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 11, 2001 |
Last sequence update: | January 1, 1998 | |
Last modified: | May 25, 2022 | |
This is version 187 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references