Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
The new UniProt website is here! Take me to UniProt BETA

UniProtKB - Q99856 (ARI3A_HUMAN)

Entry version 187 (25 May 2022)
Sequence version 2 (01 Jan 1998)
Previous versions | rss
Add a publicationFeedback
Protein

AT-rich interactive domain-containing protein 3A

Gene

ARID3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99856

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99856

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3A
Short name:
ARID domain-containing protein 3A
Alternative name(s):
B-cell regulator of IgH transcription
Short name:
Bright
Dead ringer-like protein 1
E2F-binding protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARID3A
Synonyms:DRIL1, DRIL3, DRX, E2FBP1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:3031, ARID3A

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		603265, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99856

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000116017

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi325Y → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi461K → A: Abolishes nuclear targeting. 1 Publication1
Mutagenesisi527G → A or P: Impairs DNA-binding but not self-association. 1 Publication1
Mutagenesisi530Y → A: Impairs DNA-binding but not self-association. 1 Publication1
Mutagenesisi530Y → F: No effect on DNA-binding. 1 Publication1
Mutagenesisi532G → A: Impairs DNA-binding. 1 Publication1
Mutagenesisi534L → A: Impairs DNA-binding. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1820

Open Targets

More...OpenTargetsi		ENSG00000116017

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA27485

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99856, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		ARID3A

Domain mapping of disease mutations (DMDM)

More...DMDMi		12230034

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002005781 – 593AT-rich interactive domain-containing protein 3AAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei98PhosphothreonineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki398Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99856

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99856

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99856

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99856

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99856

PeptideAtlas

More...PeptideAtlasi		Q99856

PRoteomics IDEntifications database

More...PRIDEi		Q99856

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78506

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q99856, 1 site, 1 O-linked glycan (1 site)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99856

MetOSite database of methionine sulfoxide sites

More...MetOSitei		Q99856

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99856

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q99856

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By p53/TP53 following DNA damage.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000116017, Expressed in colon and 155 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99856, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99856, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000116017, Tissue enhanced (placenta, testis)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer. Heterodimer with ARID3B.

Interacts with E2F1.

Interacts with GTF2I and BTK.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		108154, 68 interactors

Protein interaction database and analysis system

More...IntActi		Q99856, 73 interactors

Molecular INTeraction database

More...MINTi		Q99856

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000263620

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99856, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99856

Biological Magnetic Resonance Data Bank

More...BMRBi		Q99856

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99856

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99856

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini238 – 330ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini444 – 541REKLESPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni14 – 222DisorderedSequence analysisAdd BLAST209
Regioni119 – 156AcidicAdd BLAST38
Regioni445 – 488Important for nuclear localizationBy similarityAdd BLAST44
Regioni490 – 513HomodimerizationAdd BLAST24
Regioni497 – 516DisorderedSequence analysisAdd BLAST20
Regioni537 – 557Important for cytoplasmic localizationBy similarityAdd BLAST21
Regioni539 – 593DisorderedSequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi106 – 125Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi126 – 159Acidic residuesSequence analysisAdd BLAST34
Compositional biasi551 – 593Polar residuesSequence analysisAdd BLAST43

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2744, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160899

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_026952_3_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99856

Identification of Orthologs from Complete Genome Data

More...OMAi		MKPKWEE

Database of Orthologous Groups

More...OrthoDBi		1347369at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99856

TreeFam database of animal gene trees

More...TreeFami		TF320364

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.150.60, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR045147, ARI3A/B/C
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR023334, REKLES_domain

The PANTHER Classification System

More...PANTHERi		PTHR15348, PTHR15348, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01388, ARID, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00501, BRIGHT, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF46774, SSF46774, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51011, ARID, 1 hit
PS51486, REKLES, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99856-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE 
        60         70         80         90        100
SARMQRAQMA ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG 
       110        120        130        140        150
SPGRGREGPG EEHFEDMASD EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE 
       160        170        180        190        200
EEEEDEEGLG PPGPASLGTT ALFPRKAQPP QAFRGDGVPR VLGGQERPGP 
       210        220        230        240        250
GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK RKEFLDDLFS 
       260        270        280        290        300
FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG 
       310        320        330        340        350
LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR 
       360        370        380        390        400
RQSFGGSLFA YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE 
       410        420        430        440        450
EDSAIPITVP GRLPVSLAGH PVVAAQAAAV QAAAAQAAVA AQAAALEQLR 
       460        470        480        490        500
EKLESAEPPE KKMALVADEQ QRLMQRALQQ NFLAMAAQLP MSIRINSQAS 
       510        520        530        540        550
ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA PTPTSAPNKG 
       560        570        580        590 
GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP
Length:593
Mass (Da):62,889
Last modified:January 1, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4D09131E168A2880
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJ04K7EJ04_HUMAN
AT-rich interactive domain-containi...
ARID3A
338Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YFY1H0YFY1_HUMAN
AT-rich interactive domain-containi...
ARID3A
96Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAW30734 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti423V → S in AAN74028 (PubMed:9780002).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03320336P → H1 PublicationCorresponds to variant dbSNP:rs17857499Ensembl.1
Natural variantiVAR_033204320K → E1 PublicationCorresponds to variant dbSNP:rs17857501Ensembl.1
Natural variantiVAR_033205556G → S2 PublicationsCorresponds to variant dbSNP:rs1051505Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U88047 mRNA Translation: AAC32888.1
AF039850 AF039849 Genomic DNA Translation: AAC69994.1
AY152547 mRNA Translation: AAN74028.1
AY845638 mRNA Translation: AAW30734.1 Frameshift.
AC005391 Genomic DNA Translation: AAC28918.1
AC005379 Genomic DNA Translation: AAC28499.1
BC033163 mRNA Translation: AAH33163.1
BC060828 mRNA Translation: AAH60828.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12050.1

NCBI Reference Sequences

More...RefSeqi		NP_005215.1, NM_005224.2
XP_005259570.1, XM_005259513.4
XP_005259571.1, XM_005259514.4
XP_016881934.1, XM_017026445.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000263620.8; ENSP00000263620.2; ENSG00000116017.11

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1820

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1820

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000263620.8; ENSP00000263620.2; NM_005224.3; NP_005215.1

UCSC genome browser

More...UCSCi		uc002lql.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88047 mRNA Translation: AAC32888.1
AF039850 AF039849 Genomic DNA Translation: AAC69994.1
AY152547 mRNA Translation: AAN74028.1
AY845638 mRNA Translation: AAW30734.1 Frameshift.
AC005391 Genomic DNA Translation: AAC28918.1
AC005379 Genomic DNA Translation: AAC28499.1
BC033163 mRNA Translation: AAH33163.1
BC060828 mRNA Translation: AAH60828.1
CCDSiCCDS12050.1
RefSeqiNP_005215.1, NM_005224.2
XP_005259570.1, XM_005259513.4
XP_005259571.1, XM_005259514.4
XP_016881934.1, XM_017026445.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KK0NMR-A218-351[»]
4LJXX-ray2.21A/B216-351[»]
AlphaFoldDBiQ99856
BMRBiQ99856
SMRiQ99856
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi108154, 68 interactors
IntActiQ99856, 73 interactors
MINTiQ99856
STRINGi9606.ENSP00000263620

PTM databases

GlyGeniQ99856, 1 site, 1 O-linked glycan (1 site)
iPTMnetiQ99856
MetOSiteiQ99856
PhosphoSitePlusiQ99856
SwissPalmiQ99856

Genetic variation databases

BioMutaiARID3A
DMDMi12230034

Proteomic databases

EPDiQ99856
jPOSTiQ99856
MassIVEiQ99856
MaxQBiQ99856
PaxDbiQ99856
PeptideAtlasiQ99856
PRIDEiQ99856
ProteomicsDBi78506

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		Q99856, 2 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		1435, 284 antibodies from 33 providers

The DNASU plasmid repository

More...DNASUi		1820

Genome annotation databases

EnsembliENST00000263620.8; ENSP00000263620.2; ENSG00000116017.11
GeneIDi1820
KEGGihsa:1820
MANE-SelectiENST00000263620.8; ENSP00000263620.2; NM_005224.3; NP_005215.1
UCSCiuc002lql.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1820
DisGeNETi1820

GeneCards: human genes, protein and diseases

More...GeneCardsi		ARID3A
HGNCiHGNC:3031, ARID3A
HPAiENSG00000116017, Tissue enhanced (placenta, testis)
MIMi603265, gene
neXtProtiNX_Q99856
OpenTargetsiENSG00000116017
PharmGKBiPA27485
VEuPathDBiHostDB:ENSG00000116017

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2744, Eukaryota
GeneTreeiENSGT00940000160899
HOGENOMiCLU_026952_3_0_1
InParanoidiQ99856
OMAiMKPKWEE
OrthoDBi1347369at2759
PhylomeDBiQ99856
TreeFamiTF320364

Enzyme and pathway databases

PathwayCommonsiQ99856
ReactomeiR-HSA-6804116, TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
SignaLinkiQ99856

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		1820, 175 hits in 1104 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		ARID3A, human
EvolutionaryTraceiQ99856

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		ARID3A

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1820
PharosiQ99856, Tbio

Protein Ontology

More...PROi		PR:Q99856
RNActiQ99856, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000116017, Expressed in colon and 155 other tissues
ExpressionAtlasiQ99856, baseline and differential
GenevisibleiQ99856, HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR045147, ARI3A/B/C
IPR001606, ARID_dom
IPR036431, ARID_dom_sf
IPR023334, REKLES_domain
PANTHERiPTHR15348, PTHR15348, 1 hit
PfamiView protein in Pfam
PF01388, ARID, 1 hit
SMARTiView protein in SMART
SM00501, BRIGHT, 1 hit
SUPFAMiSSF46774, SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011, ARID, 1 hit
PS51486, REKLES, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARI3A_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99856
Secondary accession number(s): Q5I858
, Q6P9C6, Q8IZA7, Q8N4Z3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: May 25, 2022
This is version 187 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again