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Protein

AT-rich interactive domain-containing protein 3A

Gene

ARID3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor which may be involved in the control of cell cycle progression by the RB1/E2F1 pathway and in B-cell differentiation.2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Names & Taxonomyi

Protein namesi
Recommended name:
AT-rich interactive domain-containing protein 3A
Short name:
ARID domain-containing protein 3A
Alternative name(s):
B-cell regulator of IgH transcription
Short name:
Bright
Dead ringer-like protein 1
E2F-binding protein 1
Gene namesi
Name:ARID3A
Synonyms:DRIL1, DRIL3, DRX, E2FBP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000116017.10
HGNCiHGNC:3031 ARID3A
MIMi603265 gene
neXtProtiNX_Q99856

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi325Y → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi461K → A: Abolishes nuclear targeting. 1 Publication1
Mutagenesisi527G → A or P: Impairs DNA-binding but not self-association. 1 Publication1
Mutagenesisi530Y → A: Impairs DNA-binding but not self-association. 1 Publication1
Mutagenesisi530Y → F: No effect on DNA-binding. 1 Publication1
Mutagenesisi532G → A: Impairs DNA-binding. 1 Publication1
Mutagenesisi534L → A: Impairs DNA-binding. 1 Publication1

Organism-specific databases

DisGeNETi1820
OpenTargetsiENSG00000116017
PharmGKBiPA27485

Polymorphism and mutation databases

BioMutaiARID3A
DMDMi12230034

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002005781 – 593AT-rich interactive domain-containing protein 3AAdd BLAST593

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei77PhosphoserineCombined sources1
Modified residuei81PhosphoserineCombined sources1
Modified residuei88PhosphoserineCombined sources1
Modified residuei98PhosphothreonineCombined sources1
Modified residuei101PhosphoserineCombined sources1
Modified residuei119PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei362PhosphoserineCombined sources1
Cross-linki398Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki399Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki452Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki462Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99856
MaxQBiQ99856
PaxDbiQ99856
PeptideAtlasiQ99856
PRIDEiQ99856
ProteomicsDBi78506

PTM databases

iPTMnetiQ99856
PhosphoSitePlusiQ99856
SwissPalmiQ99856

Expressioni

Tissue specificityi

Widely expressed, with highest expression in skeletal muscle, thalamus, and colon.

Inductioni

By p53/TP53 following DNA damage.1 Publication

Gene expression databases

BgeeiENSG00000116017 Expressed in 140 organ(s), highest expression level in blood
CleanExiHS_ARID3A
ExpressionAtlasiQ99856 baseline and differential
GenevisibleiQ99856 HS

Organism-specific databases

HPAiHPA004793
HPA076330

Interactioni

Subunit structurei

Homodimer. Heterodimer with ARID3B. Interacts with E2F1. Interacts with GTF2I and BTK.3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi108154, 33 interactors
IntActiQ99856, 24 interactors
MINTiQ99856
STRINGi9606.ENSP00000263620

Structurei

Secondary structure

1593
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ99856
SMRiQ99856
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ99856

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini238 – 330ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini444 – 541REKLESPROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni119 – 156AcidicAdd BLAST38
Regioni445 – 488Important for nuclear localizationBy similarityAdd BLAST44
Regioni490 – 513HomodimerizationAdd BLAST24
Regioni537 – 557Important for cytoplasmic localizationBy similarityAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi67 – 70Poly-Ala4
Compositional biasi89 – 157Glu-richAdd BLAST69
Compositional biasi424 – 445Ala-richAdd BLAST22
Compositional biasi550 – 579Gly-richAdd BLAST30

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00550000074575
HOGENOMiHOG000236281
HOVERGENiHBG050574
InParanoidiQ99856
OMAiMKPKWEE
OrthoDBiEOG091G16XQ
PhylomeDBiQ99856
TreeFamiTF320364

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR023334 REKLES_domain
PfamiView protein in Pfam
PF01388 ARID, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51486 REKLES, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99856-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLQAVMETL LQRQQRARQE LEARQQLPPD PPAAPPGRAR AAPDEDREPE
60 70 80 90 100
SARMQRAQMA ALAAMRAAAA GLGHPASPGG SEDGPPGSEE EDAAREGTPG
110 120 130 140 150
SPGRGREGPG EEHFEDMASD EDMKPKWEEE EMEEDLGEDE EEEEEDYEDE
160 170 180 190 200
EEEEDEEGLG PPGPASLGTT ALFPRKAQPP QAFRGDGVPR VLGGQERPGP
210 220 230 240 250
GPAHPGGAAH VAPQLQPPDH GDWTYEEQFK QLYELDGDPK RKEFLDDLFS
260 270 280 290 300
FMQKRGTPVN RIPIMAKQVL DLFMLYVLVT EKGGLVEVIN KKLWREITKG
310 320 330 340 350
LNLPTSITSA AFTLRTQYMK YLYPYECEKR GLSNPNELQA AIDSNRREGR
360 370 380 390 400
RQSFGGSLFA YSPGGAHGML SSPKLPVSSL GLAASTNGSS ITPAPKIKKE
410 420 430 440 450
EDSAIPITVP GRLPVSLAGH PVVAAQAAAV QAAAAQAAVA AQAAALEQLR
460 470 480 490 500
EKLESAEPPE KKMALVADEQ QRLMQRALQQ NFLAMAAQLP MSIRINSQAS
510 520 530 540 550
ESRQDSAVNL TGTNGSNSIS MSVEINGIMY TGVLFAQPPA PTPTSAPNKG
560 570 580 590
GGGGGGSSSN AGGRGGNTGT SGGQAGPAGL STPSTSTSNN SLP
Length:593
Mass (Da):62,889
Last modified:January 1, 1998 - v2
Checksum:i4D09131E168A2880
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7EJ04K7EJ04_HUMAN
AT-rich interactive domain-containi...
ARID3A
338Annotation score:
H0YFY1H0YFY1_HUMAN
AT-rich interactive domain-containi...
ARID3A
96Annotation score:

Sequence cautioni

The sequence AAW30734 differs from that shown. Reason: Frameshift at position 498.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti423V → S in AAN74028 (PubMed:9780002).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03320336P → H1 PublicationCorresponds to variant dbSNP:rs17857499Ensembl.1
Natural variantiVAR_033204320K → E1 PublicationCorresponds to variant dbSNP:rs17857501Ensembl.1
Natural variantiVAR_033205556G → S2 PublicationsCorresponds to variant dbSNP:rs1051505Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88047 mRNA Translation: AAC32888.1
AF039850
, AF039844, AF039845, AF039846, AF039847, AF039848, AF039849 Genomic DNA Translation: AAC69994.1
AY152547 mRNA Translation: AAN74028.1
AY845638 mRNA Translation: AAW30734.1 Frameshift.
AC005391 Genomic DNA Translation: AAC28918.1
AC005379 Genomic DNA Translation: AAC28499.1
BC033163 mRNA Translation: AAH33163.1
BC060828 mRNA Translation: AAH60828.1
CCDSiCCDS12050.1
RefSeqiNP_005215.1, NM_005224.2
XP_005259570.1, XM_005259513.4
XP_005259571.1, XM_005259514.4
XP_016881934.1, XM_017026445.1
UniGeneiHs.501296
Hs.660769

Genome annotation databases

EnsembliENST00000263620; ENSP00000263620; ENSG00000116017
GeneIDi1820
KEGGihsa:1820
UCSCiuc002lql.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88047 mRNA Translation: AAC32888.1
AF039850
, AF039844, AF039845, AF039846, AF039847, AF039848, AF039849 Genomic DNA Translation: AAC69994.1
AY152547 mRNA Translation: AAN74028.1
AY845638 mRNA Translation: AAW30734.1 Frameshift.
AC005391 Genomic DNA Translation: AAC28918.1
AC005379 Genomic DNA Translation: AAC28499.1
BC033163 mRNA Translation: AAH33163.1
BC060828 mRNA Translation: AAH60828.1
CCDSiCCDS12050.1
RefSeqiNP_005215.1, NM_005224.2
XP_005259570.1, XM_005259513.4
XP_005259571.1, XM_005259514.4
XP_016881934.1, XM_017026445.1
UniGeneiHs.501296
Hs.660769

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2KK0NMR-A218-351[»]
4LJXX-ray2.21A/B216-351[»]
ProteinModelPortaliQ99856
SMRiQ99856
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108154, 33 interactors
IntActiQ99856, 24 interactors
MINTiQ99856
STRINGi9606.ENSP00000263620

PTM databases

iPTMnetiQ99856
PhosphoSitePlusiQ99856
SwissPalmiQ99856

Polymorphism and mutation databases

BioMutaiARID3A
DMDMi12230034

Proteomic databases

EPDiQ99856
MaxQBiQ99856
PaxDbiQ99856
PeptideAtlasiQ99856
PRIDEiQ99856
ProteomicsDBi78506

Protocols and materials databases

DNASUi1820
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263620; ENSP00000263620; ENSG00000116017
GeneIDi1820
KEGGihsa:1820
UCSCiuc002lql.4 human

Organism-specific databases

CTDi1820
DisGeNETi1820
EuPathDBiHostDB:ENSG00000116017.10
GeneCardsiARID3A
HGNCiHGNC:3031 ARID3A
HPAiHPA004793
HPA076330
MIMi603265 gene
neXtProtiNX_Q99856
OpenTargetsiENSG00000116017
PharmGKBiPA27485
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2744 Eukaryota
ENOG410Y2AP LUCA
GeneTreeiENSGT00550000074575
HOGENOMiHOG000236281
HOVERGENiHBG050574
InParanoidiQ99856
OMAiMKPKWEE
OrthoDBiEOG091G16XQ
PhylomeDBiQ99856
TreeFamiTF320364

Enzyme and pathway databases

ReactomeiR-HSA-6804116 TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest

Miscellaneous databases

EvolutionaryTraceiQ99856
GeneWikiiARID3A
GenomeRNAii1820
PROiPR:Q99856
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116017 Expressed in 140 organ(s), highest expression level in blood
CleanExiHS_ARID3A
ExpressionAtlasiQ99856 baseline and differential
GenevisibleiQ99856 HS

Family and domain databases

Gene3Di1.10.150.60, 1 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR023334 REKLES_domain
PfamiView protein in Pfam
PF01388 ARID, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51486 REKLES, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARI3A_HUMAN
AccessioniPrimary (citable) accession number: Q99856
Secondary accession number(s): Q5I858
, Q6P9C6, Q8IZA7, Q8N4Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: January 1, 1998
Last modified: November 7, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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