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Protein

Probable rRNA-processing protein EBP2

Gene

EBNA1BP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the processing of the 27S pre-rRNA.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Probable rRNA-processing protein EBP2
Alternative name(s):
EBNA1-binding protein 2
Nucleolar protein p40
Gene namesi
Name:EBNA1BP2
Synonyms:EBP2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117395.10
HGNCiHGNC:15531 EBNA1BP2
MIMi614443 gene
neXtProtiNX_Q99848

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10969
OpenTargetsiENSG00000117395
PharmGKBiPA27586

Polymorphism and mutation databases

BioMutaiEBNA1BP2
DMDMi116241344

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001199931 – 306Probable rRNA-processing protein EBP2Add BLAST306

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei3PhosphothreonineCombined sources1
Modified residuei7PhosphoserineCombined sources1
Modified residuei9PhosphoserineCombined sources1
Modified residuei11PhosphoserineCombined sources1
Modified residuei13PhosphoserineCombined sources1
Modified residuei16PhosphoserineCombined sources1
Cross-linki94Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki179Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki218Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei264PhosphoserineCombined sources1
Modified residuei270PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ99848
MaxQBiQ99848
PaxDbiQ99848
PeptideAtlasiQ99848
PRIDEiQ99848
ProteomicsDBi78504

2D gel databases

SWISS-2DPAGEiQ99848

PTM databases

iPTMnetiQ99848
PhosphoSitePlusiQ99848
SwissPalmiQ99848

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000117395
CleanExiHS_EBNA1BP2
ExpressionAtlasiQ99848 baseline and differential
GenevisibleiQ99848 HS

Organism-specific databases

HPAiHPA026512
HPA028277

Interactioni

Subunit structurei

Specifically interacts with EBV EBNA1. The EBNA1-EBP2 interaction is important for the stable segregation of EBV episomes during cell division (PubMed:10074103). Interacts with WDR46.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
EBNA1P032112EBI-1048111,EBI-996522From Epstein-Barr virus (strain B95-8).

Protein-protein interaction databases

BioGridi116166, 141 interactors
CORUMiQ99848
IntActiQ99848, 42 interactors
MINTiQ99848
STRINGi9606.ENSP00000407323

Structurei

3D structure databases

ProteinModelPortaliQ99848
SMRiQ99848
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili138 – 169Sequence analysisAdd BLAST32

Sequence similaritiesi

Belongs to the EBP2 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3080 Eukaryota
ENOG410YYHN LUCA
GeneTreeiENSGT00390000014984
HOGENOMiHOG000231281
HOVERGENiHBG031528
InParanoidiQ99848
KOiK14823
PhylomeDBiQ99848

Family and domain databases

InterProiView protein in InterPro
IPR008610 Ebp2
PANTHERiPTHR13028 PTHR13028, 1 hit
PfamiView protein in Pfam
PF05890 Ebp2, 1 hit

Sequencei

Sequence statusi: Complete.

Q99848-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDTPPLSDSE SESDESLVTD RELQDAFSRG LLKPGLNVVL EGPKKAVNDV
60 70 80 90 100
NGLKQCLAEF KRDLEWVERL DVTLGPVPEI GGSEAPAPQN KDQKAVDPED
110 120 130 140 150
DFQREMSFYR QAQAAVLAVL PRLHQLKVPT KRPTDYFAEM AKSDLQMQKI
160 170 180 190 200
RQKLQTKQAA MERSEKAKQL RALRKYGKKV QTEVLQKRQQ EKAHMMNAIK
210 220 230 240 250
KYQKGFSDKL DFLEGDQKPL AQRKKAGAKG QQMRKGPSAK RRYKNQKFGF
260 270 280 290 300
GGKKKGSKWN TRESYDDVSS FRAKTAHGRG LKRPGKKGSN KRPGKRTREK

MKNRTH
Length:306
Mass (Da):34,852
Last modified:October 17, 2006 - v2
Checksum:i1212FC2E9442FA2E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147M → V in AAB46731 (PubMed:11327720).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024437223R → H. Corresponds to variant dbSNP:rs7163Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U86602 mRNA Translation: AAB46731.1
BC009175 mRNA Translation: AAH09175.1
CCDSiCCDS478.1
PIRiJC7687
RefSeqiNP_001153408.1, NM_001159936.1
NP_006815.2, NM_006824.2
UniGeneiHs.346868

Genome annotation databases

EnsembliENST00000236051; ENSP00000236051; ENSG00000117395
GeneIDi10969
KEGGihsa:10969
UCSCiuc001cin.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiEBP2_HUMAN
AccessioniPrimary (citable) accession number: Q99848
Secondary accession number(s): Q96A66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: October 17, 2006
Last modified: July 18, 2018
This is version 163 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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