UniProtKB - Q99836 (MYD88_HUMAN)
Myeloid differentiation primary response protein MyD88
MYD88
Functioni
GO - Molecular functioni
- death receptor binding Source: ProtInc
- identical protein binding Source: IntAct
- interleukin-1 receptor binding Source: Ensembl
- protein self-association Source: AgBase
- TIR domain binding Source: BHF-UCL
- Toll binding Source: Ensembl
- Toll-like receptor binding Source: GO_Central
GO - Biological processi
- 3'-UTR-mediated mRNA stabilization Source: BHF-UCL
- apoptotic process Source: AgBase
- cell surface receptor signaling pathway Source: ProtInc
- cellular response to lipopolysaccharide Source: ARUK-UCL
- cellular response to mechanical stimulus Source: UniProtKB
- cellular response to oxidised low-density lipoprotein particle stimulus Source: ARUK-UCL
- defense response to bacterium Source: BHF-UCL
- defense response to Gram-positive bacterium Source: UniProtKB
- defense response to protozoan Source: ARUK-UCL
- establishment of endothelial intestinal barrier Source: Ensembl
- immunoglobulin mediated immune response Source: Ensembl
- induced systemic resistance Source: Ensembl
- innate immune response Source: GO_Central
- interleukin-1-mediated signaling pathway Source: Reactome
- JNK cascade Source: Ensembl
- leukocyte activation involved in inflammatory response Source: Ensembl
- lipopolysaccharide-mediated signaling pathway Source: Ensembl
- MyD88-dependent toll-like receptor signaling pathway Source: Reactome
- negative regulation of apoptotic process Source: Reactome
- neutrophil activation involved in immune response Source: Ensembl
- neutrophil-mediated killing of bacterium Source: Ensembl
- phagocytosis Source: UniProtKB
- positive regulation of chemokine production Source: Ensembl
- positive regulation of cytokine production involved in inflammatory response Source: BHF-UCL
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
- positive regulation of interleukin-17 production Source: BHF-UCL
- positive regulation of interleukin-23 production Source: BHF-UCL
- positive regulation of interleukin-6 production Source: BHF-UCL
- positive regulation of interleukin-8 production Source: BHF-UCL
- positive regulation of JNK cascade Source: Ensembl
- positive regulation of lymphocyte proliferation Source: Ensembl
- positive regulation of NF-kappaB transcription factor activity Source: AgBase
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of tumor necrosis factor production Source: Ensembl
- positive regulation of type I interferon production Source: BHF-UCL
- regulation of chemokine (C-X-C motif) ligand 1 production Source: Ensembl
- regulation of chemokine (C-X-C motif) ligand 2 production Source: Ensembl
- regulation of inflammatory response Source: BHF-UCL
- regulation of neutrophil migration Source: Ensembl
- response to interleukin-1 Source: BHF-UCL
- response to molecule of fungal origin Source: Ensembl
- response to peptidoglycan Source: Ensembl
- response to virus Source: Ensembl
- signal transduction Source: ProtInc
- toll-like receptor 9 signaling pathway Source: Reactome
- toll-like receptor signaling pathway Source: Reactome
- Toll signaling pathway Source: GO_Central
- type I interferon signaling pathway Source: BHF-UCL
Keywordsi
Biological process | Immunity, Inflammatory response, Innate immunity |
Enzyme and pathway databases
PathwayCommonsi | Q99836 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1257604, PIP3 activates AKT signaling R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-209543, p75NTR recruits signalling complexes R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5602680, MyD88 deficiency (TLR5) R-HSA-5603037, IRAK4 deficiency (TLR5) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9020702, Interleukin-1 signaling R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155, MyD88 dependent cascade initiated on endosome R-HSA-975871, MyD88 cascade initiated on plasma membrane |
SignaLinki | Q99836 |
SIGNORi | Q99836 |
Names & Taxonomyi
Protein namesi | Recommended name: Myeloid differentiation primary response protein MyD88 |
Gene namesi | Name:MYD88Imported |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7562, MYD88 |
MIMi | 602170, gene |
neXtProti | NX_Q99836 |
VEuPathDBi | HostDB:ENSG00000172936.12 |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Endosome
- endosome membrane Source: Reactome
Nucleus
- nucleus Source: AgBase
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: AgBase
- postsynaptic density Source: Ensembl
- protein-containing complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Immunodeficiency 68 (IMD68)4 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072894 | 52 | Missing in IMD68; loss of NF-kappa-B complex activation. 2 Publications | 1 | |
Natural variantiVAR_047953 | 93 | L → P in IMD68; results in a loss of function; loss of NF-kappa-B complex activation. 3 PublicationsCorresponds to variant dbSNP:rs137853065EnsemblClinVar. | 1 | |
Natural variantiVAR_047954 | 196 | R → C in IMD68; results in a loss of function; decreases NF-kappa-B complex activation. 4 PublicationsCorresponds to variant dbSNP:rs137853064EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 179 | I → N in Pococurante (Poc); abolished MYD88-dependent sensing of most Toll-like receptor (TLR) ligands. 1 Publication | 1 | |
Mutagenesisi | 196 | R → A: Reduced interaction with TIRAP, and strongly reduced activity. Strongly reduced interaction with TIRAP; when associated with A-288. 1 Publication | 1 | |
Mutagenesisi | 197 | D → A: Slightly reduced activity. 1 Publication | 1 | |
Mutagenesisi | 203 | C → S: Abolished interaction with E.coli TcpC without affecting ability to promote Toll-like receptor (TLR)-mediated cytokine production; when associated with S-280. 1 Publication | 1 | |
Mutagenesisi | 217 | R → A: Strongly reduced activity. 1 Publication | 1 | |
Mutagenesisi | 280 | C → S: Abolished interaction with E.coli TcpC without affecting ability to promote Toll-like receptor (TLR)-mediated cytokine production; when associated with S-203. 1 Publication | 1 | |
Mutagenesisi | 282 | K → A: Slightly reduced activity. 1 Publication | 1 | |
Mutagenesisi | 288 | R → A: Slightly reduced activity, and reduced interaction with TIRAP. Strongly reduced interaction with TIRAP; when associated with A-196. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 4615 |
MalaCardsi | MYD88 |
MIMi | 612260, phenotype |
OpenTargetsi | ENSG00000172936 |
Orphaneti | 183713, Bacterial susceptibility due to TLR signaling pathway deficiency 33226, Waldenstroem macroglobulinemia |
PharmGKBi | PA31361 |
Miscellaneous databases
Pharosi | Q99836, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5919 |
Genetic variation databases
BioMutai | MYD88 |
DMDMi | 18202671 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000096666 | 1 – 296 | Myeloid differentiation primary response protein MyD88Add BLAST | 296 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 244 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q99836 |
jPOSTi | Q99836 |
MassIVEi | Q99836 |
MaxQBi | Q99836 |
PaxDbi | Q99836 |
PeptideAtlasi | Q99836 |
PRIDEi | Q99836 |
ProteomicsDBi | 78500 [Q99836-1] 78501 [Q99836-2] 78502 [Q99836-3] 78503 [Q99836-4] |
TopDownProteomicsi | Q99836-4 [Q99836-4] |
PTM databases
iPTMneti | Q99836 |
PhosphoSitePlusi | Q99836 |
SwissPalmi | Q99836 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000172936, Expressed in blood and 233 other tissues |
ExpressionAtlasi | Q99836, baseline and differential |
Organism-specific databases
HPAi | ENSG00000172936, Tissue enhanced (blood) |
Interactioni
Subunit structurei
Homodimer. Also forms heterodimers with TIRAP. Binds to TLR2, TLR4, TLR5, IRAK1, IRAK2 and IRAK4 via their respective TIR domains.
Interacts with IL18R1.
Interacts with BMX, IL1RL1, IKBKE and IRF7.
Interacts with LRRFIP1 and LRRFIP2; this interaction positively regulates Toll-like receptor (TLR) signaling in response to agonist.
Interacts with FLII. LRRFIP1 and LRRFIP2 compete with FLII for MYD88-binding.
Interacts with IRF1. Upon IL1B treatment, forms a complex with PELI1, IRAK1, IRAK4 and TRAF6; this complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation. Direct binding of SMAD6 to PELI1 prevents the complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression. May interact with PIK3AP1.
Interacts (via TIR domain) with DHX9 (via H2A and OB-fold regions); this interaction is direct (PubMed:20696886).
Interacts with OTUD4 deubiquitinase; the interaction is direct (PubMed:29395066).
15 Publications(Microbial infection) In case of infection, interacts with uropathogenic E.coli protein TcpC; suppressing Toll-like receptor (TLR)-mediated cytokine production.
1 Publication(Microbial infection) In case of infection, interacts with uropathogenic E.faecalis protein TcpF; suppressing Toll-like receptor (TLR)-mediated cytokine production.
1 PublicationBinary interactionsi
Hide detailsQ99836
Isoform 1 [Q99836-1]
With | #Exp. | IntAct |
---|---|---|
CYTH2 [Q99418] | 3 | EBI-15855480,EBI-448974 |
IRAK4 [Q9NWZ3] | 9 | EBI-15855480,EBI-448378 |
GO - Molecular functioni
- death receptor binding Source: ProtInc
- identical protein binding Source: IntAct
- interleukin-1 receptor binding Source: Ensembl
- protein self-association Source: AgBase
- TIR domain binding Source: BHF-UCL
- Toll binding Source: Ensembl
- Toll-like receptor binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 110700, 73 interactors |
DIPi | DIP-31349N |
IntActi | Q99836, 46 interactors |
MINTi | Q99836 |
STRINGi | 9606.ENSP00000401399 |
Miscellaneous databases
RNActi | Q99836, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q99836 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99836 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 54 – 109 | DeathPROSITE-ProRule annotationAdd BLAST | 56 | |
Domaini | 159 – 293 | TIRPROSITE-ProRule annotationAdd BLAST | 135 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 155 | Intermediate domainBy similarityAdd BLAST | 46 |
Domaini
Phylogenomic databases
eggNOGi | ENOG502QWKI, Eukaryota |
GeneTreei | ENSGT00510000048324 |
HOGENOMi | CLU_116540_0_0_1 |
InParanoidi | Q99836 |
PhylomeDBi | Q99836 |
TreeFami | TF326264 |
Family and domain databases
CDDi | cd08312, Death_MyD88, 1 hit |
Gene3Di | 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR034249, MyD88_Death IPR017281, Myelin_different_resp_MyD88 IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR15079, PTHR15079, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037756, MyD88, 1 hit |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS50104, TIR, 1 hit |
s (6+)i Sequence
Sequence statusi: Complete.
This entry describes 6 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 6 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAGGPGAGS AAPVSSTSSL PLAALNMRVR RRLSLFLNVR TQVAADWTAL
60 70 80 90 100
AEEMDFEYLE IRQLETQADP TGRLLDAWQG RPGASVGRLL ELLTKLGRDD
110 120 130 140 150
VLLELGPSIE EDCQKYILKQ QQEEAEKPLQ VAAVDSSVPR TAELAGITTL
160 170 180 190 200
DDPLGHMPER FDAFICYCPS DIQFVQEMIR QLEQTNYRLK LCVSDRDVLP
210 220 230 240 250
GTCVWSIASE LIEKRCRRMV VVVSDDYLQS KECDFQTKFA LSLSPGAHQK
260 270 280 290
RLIPIKYKAM KKEFPSILRF ITVCDYTNPC TKSWFWTRLA KALSLP
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MSI9 | A0A0A0MSI9_HUMAN | Myeloid differentiation primary res... | MYD88 | 264 | Annotation score: | ||
A0A494C0J8 | A0A494C0J8_HUMAN | Myeloid differentiation primary res... | MYD88 | 245 | Annotation score: | ||
A0A3B3ITY3 | A0A3B3ITY3_HUMAN | Myeloid differentiation primary res... | MYD88 | 159 | Annotation score: | ||
A0A3F2YP85 | A0A3F2YP85_HUMAN | Myeloid differentiation primary res... | MYD88 | 204 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 190 | K → T in BI524129 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 223 – 224 | VS → WL in BI524129 (PubMed:15489334).Curated | 2 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_072893 | 34 | S → Y Rare variant; unknown pathological significance; loss of NF-kappa-B complex activation; loss of interaction with IRAK4; reduces homooligomerization. 2 PublicationsCorresponds to variant dbSNP:rs1319438Ensembl. | 1 | |
Natural variantiVAR_073252 | 39 | V → M Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs770387646Ensembl. | 1 | |
Natural variantiVAR_072894 | 52 | Missing in IMD68; loss of NF-kappa-B complex activation. 2 Publications | 1 | |
Natural variantiVAR_047953 | 93 | L → P in IMD68; results in a loss of function; loss of NF-kappa-B complex activation. 3 PublicationsCorresponds to variant dbSNP:rs137853065EnsemblClinVar. | 1 | |
Natural variantiVAR_072895 | 98 | R → C Found in hematological malignancies; somatic mutation; unknown pathological significance; loss of NF-kappa-B complex activation; loss of interaction with IRAK4; reduces homooligomerization. 3 PublicationsCorresponds to variant dbSNP:rs199396Ensembl. | 1 | |
Natural variantiVAR_073253 | 136 | S → G Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_073254 | 136 | S → I Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_072896 | 178 | M → I Found in hematological malignancies; somatic mutation; unknown pathological significance; no effect on NF-kappaB complex activation. 2 PublicationsCorresponds to variant dbSNP:rs41285117Ensembl. | 1 | |
Natural variantiVAR_047954 | 196 | R → C in IMD68; results in a loss of function; decreases NF-kappa-B complex activation. 4 PublicationsCorresponds to variant dbSNP:rs137853064EnsemblClinVar. | 1 | |
Natural variantiVAR_073255 | 204 | V → F Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 PublicationCorresponds to variant dbSNP:rs776995408Ensembl. | 1 | |
Natural variantiVAR_073256 | 205 | W → R Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_073257 | 206 | S → C Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_073258 | 207 | I → T Found in hematological malignancies; somatic mutation; unknown pathological significance. 1 Publication | 1 | |
Natural variantiVAR_073259 | 209 | S → R Found in hematological malignancies; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation. 1 Publication | 1 | |
Natural variantiVAR_073260 | 219 | M → T Found in hematological malignancies; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation. 1 Publication | 1 | |
Natural variantiVAR_073261 | 230 | S → N Found in hematological malignancies; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation. 1 PublicationCorresponds to variant dbSNP:rs1353791431Ensembl. | 1 | |
Natural variantiVAR_073262 | 252 | L → P Found in hematological malignancies; common mutation in Waldenstroem macroglobulinemia; somatic mutation; unknown pathological significance; constitutively activates NF-kappaB complex activation; gain-of-function mutation; does not affect interaction with IRAK4. 3 PublicationsCorresponds to variant dbSNP:rs387907272EnsemblClinVar. | 1 | |
Natural variantiVAR_073263 | 281 | T → P Found in hematological malignancies; somatic mutation; unknown pathological significance; no effect on NF-kappaB complex activation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053764 | 1 – 22 | MAAGG…SSLPL → M in isoform 5. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_038887 | 110 – 154 | Missing in isoform 2. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_043498 | 110 | E → G in isoform 4. 1 Publication | 1 | |
Alternative sequenceiVSP_043499 | 111 – 155 | Missing in isoform 4. 1 PublicationAdd BLAST | 45 | |
Alternative sequenceiVSP_043500 | 156 – 296 | HMPER…ALSLP → AAGWWWLSLMITCRARNVTS RPNLHSASLQVPIRSD in isoform 3 and isoform 4. 1 PublicationAdd BLAST | 141 | |
Alternative sequenceiVSP_053765 | 215 | R → RLARRPRGG in isoform 6. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70451 mRNA Translation: AAB49967.1 U84408 mRNA Translation: AAC50954.1 AB446470 mRNA Translation: BAG55247.1 BT007376 mRNA Translation: AAP36040.1 AK296570 mRNA Translation: BAG59190.1 AK296716 mRNA Translation: BAG59306.1 AK298650 mRNA Translation: BAG60822.1 Different initiation. AK298666 mRNA Translation: BAG60834.1 Different initiation. AP006309 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64521.1 Sequence problems. BC013589 mRNA Translation: AAH13589.1 BI524129 mRNA No translation available. |
CCDSi | CCDS2674.2 [Q99836-1] CCDS54565.1 [Q99836-6] CCDS54566.1 [Q99836-3] CCDS54567.1 [Q99836-2] CCDS54568.1 [Q99836-4] |
RefSeqi | NP_001166037.1, NM_001172566.1 [Q99836-4] NP_001166039.1, NM_001172568.1 [Q99836-2] NP_001166040.1, NM_001172569.1 [Q99836-3] NP_002459.2, NM_002468.4 [Q99836-1] |
Genome annotation databases
Ensembli | ENST00000396334; ENSP00000379625; ENSG00000172936 [Q99836-1] ENST00000417037; ENSP00000401399; ENSG00000172936 [Q99836-2] ENST00000421516; ENSP00000391753; ENSG00000172936 [Q99836-6] ENST00000650112; ENSP00000497991; ENSG00000172936 [Q99836-4] ENST00000650905; ENSP00000498360; ENSG00000172936 [Q99836-1] ENST00000651800; ENSP00000499012; ENSG00000172936 [Q99836-3] |
GeneIDi | 4615 |
KEGGi | hsa:4615 |
UCSCi | uc011ayj.3, human [Q99836-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U70451 mRNA Translation: AAB49967.1 U84408 mRNA Translation: AAC50954.1 AB446470 mRNA Translation: BAG55247.1 BT007376 mRNA Translation: AAP36040.1 AK296570 mRNA Translation: BAG59190.1 AK296716 mRNA Translation: BAG59306.1 AK298650 mRNA Translation: BAG60822.1 Different initiation. AK298666 mRNA Translation: BAG60834.1 Different initiation. AP006309 Genomic DNA No translation available. CH471055 Genomic DNA Translation: EAW64521.1 Sequence problems. BC013589 mRNA Translation: AAH13589.1 BI524129 mRNA No translation available. |
CCDSi | CCDS2674.2 [Q99836-1] CCDS54565.1 [Q99836-6] CCDS54566.1 [Q99836-3] CCDS54567.1 [Q99836-2] CCDS54568.1 [Q99836-4] |
RefSeqi | NP_001166037.1, NM_001172566.1 [Q99836-4] NP_001166039.1, NM_001172568.1 [Q99836-2] NP_001166040.1, NM_001172569.1 [Q99836-3] NP_002459.2, NM_002468.4 [Q99836-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2JS7 | NMR | - | A | 146-296 | [»] | |
2Z5V | NMR | - | A | 148-296 | [»] | |
3MOP | X-ray | 3.40 | A/B/C/D/E/F | 20-117 | [»] | |
4DOM | X-ray | 1.80 | A | 157-296 | [»] | |
4EO7 | X-ray | 1.45 | A | 157-296 | [»] | |
6I3N | electron microscopy | 3.10 | A/B/C/D/E/F/G/H/I/J/K/L/M | 1-151 | [»] | |
SMRi | Q99836 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110700, 73 interactors |
DIPi | DIP-31349N |
IntActi | Q99836, 46 interactors |
MINTi | Q99836 |
STRINGi | 9606.ENSP00000401399 |
Chemistry databases
ChEMBLi | CHEMBL5919 |
PTM databases
iPTMneti | Q99836 |
PhosphoSitePlusi | Q99836 |
SwissPalmi | Q99836 |
Genetic variation databases
BioMutai | MYD88 |
DMDMi | 18202671 |
Proteomic databases
EPDi | Q99836 |
jPOSTi | Q99836 |
MassIVEi | Q99836 |
MaxQBi | Q99836 |
PaxDbi | Q99836 |
PeptideAtlasi | Q99836 |
PRIDEi | Q99836 |
ProteomicsDBi | 78500 [Q99836-1] 78501 [Q99836-2] 78502 [Q99836-3] 78503 [Q99836-4] |
TopDownProteomicsi | Q99836-4 [Q99836-4] |
Protocols and materials databases
Antibodypediai | 3965, 943 antibodies |
DNASUi | 4615 |
Genome annotation databases
Ensembli | ENST00000396334; ENSP00000379625; ENSG00000172936 [Q99836-1] ENST00000417037; ENSP00000401399; ENSG00000172936 [Q99836-2] ENST00000421516; ENSP00000391753; ENSG00000172936 [Q99836-6] ENST00000650112; ENSP00000497991; ENSG00000172936 [Q99836-4] ENST00000650905; ENSP00000498360; ENSG00000172936 [Q99836-1] ENST00000651800; ENSP00000499012; ENSG00000172936 [Q99836-3] |
GeneIDi | 4615 |
KEGGi | hsa:4615 |
UCSCi | uc011ayj.3, human [Q99836-1] |
Organism-specific databases
CTDi | 4615 |
DisGeNETi | 4615 |
GeneCardsi | MYD88 |
HGNCi | HGNC:7562, MYD88 |
HPAi | ENSG00000172936, Tissue enhanced (blood) |
MalaCardsi | MYD88 |
MIMi | 602170, gene 612260, phenotype |
neXtProti | NX_Q99836 |
OpenTargetsi | ENSG00000172936 |
Orphaneti | 183713, Bacterial susceptibility due to TLR signaling pathway deficiency 33226, Waldenstroem macroglobulinemia |
PharmGKBi | PA31361 |
VEuPathDBi | HostDB:ENSG00000172936.12 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QWKI, Eukaryota |
GeneTreei | ENSGT00510000048324 |
HOGENOMi | CLU_116540_0_0_1 |
InParanoidi | Q99836 |
PhylomeDBi | Q99836 |
TreeFami | TF326264 |
Enzyme and pathway databases
PathwayCommonsi | Q99836 |
Reactomei | R-HSA-1236974, ER-Phagosome pathway R-HSA-1257604, PIP3 activates AKT signaling R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-1810476, RIP-mediated NFkB activation via ZBP1 R-HSA-209543, p75NTR recruits signalling complexes R-HSA-3134963, DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-5602498, MyD88 deficiency (TLR2/4) R-HSA-5602680, MyD88 deficiency (TLR5) R-HSA-5603037, IRAK4 deficiency (TLR5) R-HSA-5603041, IRAK4 deficiency (TLR2/4) R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-9020702, Interleukin-1 signaling R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975155, MyD88 dependent cascade initiated on endosome R-HSA-975871, MyD88 cascade initiated on plasma membrane |
SignaLinki | Q99836 |
SIGNORi | Q99836 |
Miscellaneous databases
BioGRID-ORCSi | 4615, 18 hits in 995 CRISPR screens |
ChiTaRSi | MYD88, human |
EvolutionaryTracei | Q99836 |
GeneWikii | MYD88 |
GenomeRNAii | 4615 |
Pharosi | Q99836, Tbio |
PROi | PR:Q99836 |
RNActi | Q99836, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172936, Expressed in blood and 233 other tissues |
ExpressionAtlasi | Q99836, baseline and differential |
Family and domain databases
CDDi | cd08312, Death_MyD88, 1 hit |
Gene3Di | 3.40.50.10140, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR034249, MyD88_Death IPR017281, Myelin_different_resp_MyD88 IPR000157, TIR_dom IPR035897, Toll_tir_struct_dom_sf |
PANTHERi | PTHR15079, PTHR15079, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF01582, TIR, 1 hit |
PIRSFi | PIRSF037756, MyD88, 1 hit |
SMARTi | View protein in SMART SM00005, DEATH, 1 hit SM00255, TIR, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF52200, SSF52200, 1 hit |
PROSITEi | View protein in PROSITE PS50017, DEATH_DOMAIN, 1 hit PS50104, TIR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | MYD88_HUMAN | |
Accessioni | Q99836Primary (citable) accession number: Q99836 Secondary accession number(s): B4DKH8 Q53XS7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | May 1, 1997 | |
Last modified: | April 7, 2021 | |
This is version 207 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references