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Protein

Smoothened homolog

Gene

SMO

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7, GLI2 and GLI3 in the cilia (PubMed:19592253). Interacts with DLG5 at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • drug binding Source: UniProtKB
  • G protein-coupled receptor activity Source: UniProtKB-KW
  • patched binding Source: BHF-UCL

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein, G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO

SignaLink: a signaling pathway resource with multi-layered regulatory networks

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SignaLinki
Q99835

SIGNOR Signaling Network Open Resource

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SIGNORi
Q99835

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.16.4 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Smoothened homolog
Short name:
SMO
Alternative name(s):
Protein Gx
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SMO
Synonyms:SMOH
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000128602.9

Human Gene Nomenclature Database

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HGNCi
HGNC:11119 SMO

Online Mendelian Inheritance in Man (OMIM)

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MIMi
601500 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q99835

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 233ExtracellularSequence analysisAdd BLAST206
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei234 – 254Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini255 – 262CytoplasmicSequence analysis8
Transmembranei263 – 283Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini284 – 314ExtracellularSequence analysisAdd BLAST31
Transmembranei315 – 335Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini336 – 358CytoplasmicSequence analysisAdd BLAST23
Transmembranei359 – 379Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini380 – 402ExtracellularSequence analysisAdd BLAST23
Transmembranei403 – 423Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini424 – 451CytoplasmicSequence analysisAdd BLAST28
Transmembranei452 – 472Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini473 – 524ExtracellularSequence analysisAdd BLAST52
Transmembranei525 – 545Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini546 – 787CytoplasmicSequence analysisAdd BLAST242

Keywords - Cellular componenti

Cell projection, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Curry-Jones syndrome (CRJS)2 Publications
The disease is caused by mutations affecting the gene represented in this entry. 8 individuals have been identified with the disease-causing mutation Phe-412 and all were mosaic. The mutation could not be reliably detected in blood, greatest success rates were obtained with affected tissues obtained by invasive procedures. It is thought that the mutation has arisen postzygotically early during embryonic development (PubMed:27236920). This mutation has also been identified in ameloblastoma, medulloblastoma, meningioma, and basal cell carcinoma, and has been reported as the oncogenic driver in some of these tumors (PubMed:24859340).2 Publications
Disease descriptionA multisystem disorder characterized by patchy skin lesions, polysyndactyly, diverse cerebral malformations, unicoronal craniosynostosis, iris colobomas, microphthalmia, and intestinal malrotation with myofibromas or hamartomas.
See also OMIM:601707
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_077087412L → F in CRJS; constitutive activation of the smoothened signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs879255280EnsemblClinVar.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6608

MalaCards human disease database

More...
MalaCardsi
SMO
MIMi601707 phenotype

Open Targets

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OpenTargetsi
ENSG00000128602

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
1553 Curry-Jones syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35968

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL5971

Drug and drug target database

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DrugBanki
DB01047 Fluocinonide
DB06786 Halcinonide
DB09143 Sonidegib
DB08828 Vismodegib

IUPHAR/BPS Guide to PHARMACOLOGY

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GuidetoPHARMACOLOGYi
239

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SMO

Domain mapping of disease mutations (DMDM)

More...
DMDMi
6226142

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001301528 – 787Smoothened homologAdd BLAST760

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi35N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi70 ↔ 134PROSITE-ProRule annotation
Disulfide bondi78 ↔ 127PROSITE-ProRule annotation
Disulfide bondi118 ↔ 154PROSITE-ProRule annotation
Disulfide bondi147 ↔ 169PROSITE-ProRule annotation
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi193 ↔ 213PROSITE-ProRule annotation1 Publication
Disulfide bondi217 ↔ 295PROSITE-ProRule annotation1 Publication
Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi314 ↔ 390PROSITE-ProRule annotation1 Publication
Disulfide bondi490 ↔ 507PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q99835

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q99835

PeptideAtlas

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PeptideAtlasi
Q99835

PRoteomics IDEntifications database

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PRIDEi
Q99835

ProteomicsDB human proteome resource

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ProteomicsDBi
78499

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q99835

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
Q99835

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000128602 Expressed in 181 organ(s), highest expression level in left ovary

CleanEx database of gene expression profiles

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CleanExi
HS_SMO

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q99835 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q99835 HS

Organism-specific databases

Human Protein Atlas

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HPAi
CAB011446

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (PubMed:23636324). Interacts with ARRB2 (By similarity). Interacts with KIF7 (PubMed:19592253). Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (PubMed:22072986). Interacts with DLG5 and SDCBP (By similarity). Interacts with GAS8/DRC4 (PubMed:21659505).By similarity4 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112492, 8 interactors

Database of interacting proteins

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DIPi
DIP-34574N

Protein interaction database and analysis system

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IntActi
Q99835, 7 interactors

Molecular INTeraction database

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MINTi
Q99835

STRING: functional protein association networks

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STRINGi
9606.ENSP00000249373

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
Q99835

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1787
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JKVX-ray2.45A/B190-555[»]
4N4WX-ray2.80A190-555[»]
4O9RX-ray3.20A190-433[»]
A441-555[»]
4QIMX-ray2.61A190-433[»]
A441-555[»]
4QINX-ray2.60A190-433[»]
A441-555[»]
5L7DX-ray3.20A/B32-428[»]
A/B443-555[»]
5L7IX-ray3.30A/B32-428[»]
A/B443-555[»]
5V56X-ray2.90A/B53-437[»]
A/B444-558[»]
5V57X-ray3.00A/B58-437[»]
A/B444-558[»]

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q99835

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q99835

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini65 – 181FZPROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni538 – 569Interaction with BBS5 and BBS71 PublicationAdd BLAST32
Regioni581 – 593Interaction with DLG5By similarityAdd BLAST13

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3577 Eukaryota
ENOG410XRC8 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157206

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000252964

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG000352

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q99835

KEGG Orthology (KO)

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KOi
K06226

Identification of Orthologs from Complete Genome Data

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OMAi
KNSNRYP

Database of Orthologous Groups

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OrthoDBi
385042at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q99835

TreeFam database of animal gene trees

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TreeFami
TF106460

Family and domain databases

Conserved Domains Database

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CDDi
cd15030 7tmF_SMO_homolog, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.2000.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
IPR026544 SMO
IPR035683 SMO_7TM

The PANTHER Classification System

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PANTHERi
PTHR11309 PTHR11309, 1 hit
PTHR11309:SF35 PTHR11309:SF35, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00489 FRIZZLED

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF63501 SSF63501, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q99835-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR
60 70 80 90 100
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE
110 120 130 140 150
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT
160 170 180 190 200
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT
210 220 230 240 250
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA
260 270 280 290 300
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT
310 320 330 340 350
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY
360 370 380 390 400
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR
410 420 430 440 450
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML
460 470 480 490 500
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT
510 520 530 540 550
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC
560 570 580 590 600
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV
610 620 630 640 650
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE
660 670 680 690 700
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST
710 720 730 740 750
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP
760 770 780
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF
Length:787
Mass (Da):86,397
Last modified:May 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8B4C459B34D13F83
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C509H7C509_HUMAN
Smoothened homolog
SMO
151Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C5S9H7C5S9_HUMAN
Smoothened homolog
SMO
70Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_077087412L → F in CRJS; constitutive activation of the smoothened signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs879255280EnsemblClinVar.1
Natural variantiVAR_037891473D → H. Corresponds to variant dbSNP:rs17710891EnsemblClinVar.1
Natural variantiVAR_007848535W → L in basal cell carcinoma and ameloblastoma samples; somatic mutation; constitutive activation of the smoothened signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs121918347EnsemblClinVar.1
Natural variantiVAR_007849562R → Q in basal cell carcinoma samples; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918348EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
U84401 mRNA Translation: AAB41788.1
AF114821, AF114819, AF114820 Genomic DNA Translation: AAD17202.1
AF120103 mRNA Translation: AAF31757.1
AF071494 mRNA Translation: AAC24863.1
CH236950 Genomic DNA Translation: EAL24102.1
CH471070 Genomic DNA Translation: EAW83715.1
BC009989 mRNA Translation: AAH09989.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS5811.1

NCBI Reference Sequences

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RefSeqi
NP_005622.1, NM_005631.4

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.437846

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000249373; ENSP00000249373; ENSG00000128602

Database of genes from NCBI RefSeq genomes

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GeneIDi
6608

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6608

UCSC genome browser

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UCSCi
uc003vor.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U84401 mRNA Translation: AAB41788.1
AF114821, AF114819, AF114820 Genomic DNA Translation: AAD17202.1
AF120103 mRNA Translation: AAF31757.1
AF071494 mRNA Translation: AAC24863.1
CH236950 Genomic DNA Translation: EAL24102.1
CH471070 Genomic DNA Translation: EAW83715.1
BC009989 mRNA Translation: AAH09989.1
CCDSiCCDS5811.1
RefSeqiNP_005622.1, NM_005631.4
UniGeneiHs.437846

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4JKVX-ray2.45A/B190-555[»]
4N4WX-ray2.80A190-555[»]
4O9RX-ray3.20A190-433[»]
A441-555[»]
4QIMX-ray2.61A190-433[»]
A441-555[»]
4QINX-ray2.60A190-433[»]
A441-555[»]
5L7DX-ray3.20A/B32-428[»]
A/B443-555[»]
5L7IX-ray3.30A/B32-428[»]
A/B443-555[»]
5V56X-ray2.90A/B53-437[»]
A/B444-558[»]
5V57X-ray3.00A/B58-437[»]
A/B444-558[»]
ProteinModelPortaliQ99835
SMRiQ99835
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112492, 8 interactors
DIPiDIP-34574N
IntActiQ99835, 7 interactors
MINTiQ99835
STRINGi9606.ENSP00000249373

Chemistry databases

BindingDBiQ99835
ChEMBLiCHEMBL5971
DrugBankiDB01047 Fluocinonide
DB06786 Halcinonide
DB09143 Sonidegib
DB08828 Vismodegib
GuidetoPHARMACOLOGYi239

Protein family/group databases

TCDBi9.A.14.16.4 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

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GPCRDBi
Search...

PTM databases

iPTMnetiQ99835
PhosphoSitePlusiQ99835

Polymorphism and mutation databases

BioMutaiSMO
DMDMi6226142

Proteomic databases

EPDiQ99835
PaxDbiQ99835
PeptideAtlasiQ99835
PRIDEiQ99835
ProteomicsDBi78499

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6608
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000249373; ENSP00000249373; ENSG00000128602
GeneIDi6608
KEGGihsa:6608
UCSCiuc003vor.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6608
DisGeNETi6608
EuPathDBiHostDB:ENSG00000128602.9

GeneCards: human genes, protein and diseases

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GeneCardsi
SMO
HGNCiHGNC:11119 SMO
HPAiCAB011446
MalaCardsiSMO
MIMi601500 gene
601707 phenotype
neXtProtiNX_Q99835
OpenTargetsiENSG00000128602
Orphaneti1553 Curry-Jones syndrome
PharmGKBiPA35968

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG3577 Eukaryota
ENOG410XRC8 LUCA
GeneTreeiENSGT00940000157206
HOGENOMiHOG000252964
HOVERGENiHBG000352
InParanoidiQ99835
KOiK06226
OMAiKNSNRYP
OrthoDBi385042at2759
PhylomeDBiQ99835
TreeFamiTF106460

Enzyme and pathway databases

ReactomeiR-HSA-373080 Class B/2 (Secretin family receptors)
R-HSA-5610787 Hedgehog 'off' state
R-HSA-5620922 BBSome-mediated cargo-targeting to cilium
R-HSA-5632684 Hedgehog 'on' state
R-HSA-5635838 Activation of SMO
SignaLinkiQ99835
SIGNORiQ99835

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SMO human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Smoothened

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6608

Protein Ontology

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PROi
PR:Q99835

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000128602 Expressed in 181 organ(s), highest expression level in left ovary
CleanExiHS_SMO
ExpressionAtlasiQ99835 baseline and differential
GenevisibleiQ99835 HS

Family and domain databases

CDDicd15030 7tmF_SMO_homolog, 1 hit
Gene3Di1.10.2000.10, 1 hit
InterProiView protein in InterPro
IPR015526 Frizzled/SFRP
IPR000539 Frizzled/Smoothened_TM
IPR020067 Frizzled_dom
IPR036790 Frizzled_dom_sf
IPR017981 GPCR_2-like
IPR026544 SMO
IPR035683 SMO_7TM
PANTHERiPTHR11309 PTHR11309, 1 hit
PTHR11309:SF35 PTHR11309:SF35, 1 hit
PfamiView protein in Pfam
PF01534 Frizzled, 1 hit
PF01392 Fz, 1 hit
PRINTSiPR00489 FRIZZLED
SMARTiView protein in SMART
SM00063 FRI, 1 hit
SM01330 Frizzled, 1 hit
SUPFAMiSSF63501 SSF63501, 1 hit
PROSITEiView protein in PROSITE
PS50038 FZ, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSMO_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99835
Secondary accession number(s): A4D1K5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: May 1, 1997
Last modified: January 16, 2019
This is version 189 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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