UniProtKB - Q99835 (SMO_HUMAN)
Smoothened homolog
SMO
Functioni
GO - Molecular functioni
- drug binding Source: UniProtKB
- G protein-coupled receptor activity Source: UniProtKB-KW
- patched binding Source: BHF-UCL
GO - Biological processi
- anterior/posterior pattern specification Source: Ensembl
- astrocyte activation Source: Ensembl
- atrial septum morphogenesis Source: Ensembl
- cell fate specification Source: Ensembl
- cellular response to cholesterol Source: BHF-UCL
- central nervous system development Source: GO_Central
- central nervous system neuron differentiation Source: Ensembl
- cerebellar cortex morphogenesis Source: Ensembl
- cerebral cortex development Source: Ensembl
- commissural neuron axon guidance Source: GO_Central
- dentate gyrus development Source: Ensembl
- detection of cell density by contact stimulus involved in contact inhibition Source: BHF-UCL
- determination of left/right asymmetry in lateral mesoderm Source: BHF-UCL
- dorsal/ventral neural tube patterning Source: Ensembl
- epithelial-mesenchymal cell signaling Source: Ensembl
- forebrain morphogenesis Source: BHF-UCL
- hair follicle morphogenesis Source: Ensembl
- heart looping Source: BHF-UCL
- homeostasis of number of cells within a tissue Source: Ensembl
- in utero embryonic development Source: Ensembl
- left/right axis specification Source: Ensembl
- mammary gland epithelial cell differentiation Source: Ensembl
- mesenchymal to epithelial transition involved in metanephric renal vesicle formation Source: UniProtKB
- midgut development Source: BHF-UCL
- multicellular organism growth Source: Ensembl
- myoblast migration Source: Ensembl
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of DNA binding Source: UniProtKB
- negative regulation of epithelial cell differentiation Source: Ensembl
- negative regulation of gene expression Source: UniProtKB
- negative regulation of hair follicle development Source: Ensembl
- negative regulation of transcription by RNA polymerase II Source: Ensembl
- neural crest cell migration Source: Ensembl
- odontogenesis of dentin-containing tooth Source: Ensembl
- osteoblast differentiation Source: Ensembl
- pancreas morphogenesis Source: Ensembl
- positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
- positive regulation of cell migration Source: ARUK-UCL
- positive regulation of epithelial cell proliferation Source: Ensembl
- positive regulation of gene expression Source: ARUK-UCL
- positive regulation of hh target transcription factor activity Source: BHF-UCL
- positive regulation of mesenchymal cell proliferation Source: Ensembl
- positive regulation of multicellular organism growth Source: Ensembl
- positive regulation of neuroblast proliferation Source: Ensembl
- positive regulation of organ growth Source: Ensembl
- positive regulation of protein import into nucleus Source: Ensembl
- positive regulation of smoothened signaling pathway Source: GO_Central
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- protein localization to nucleus Source: Ensembl
- protein stabilization Source: Ensembl
- regulation of heart morphogenesis Source: BHF-UCL
- regulation of stem cell population maintenance Source: Ensembl
- renal system development Source: UniProtKB
- skeletal muscle fiber development Source: Ensembl
- smoothened signaling pathway Source: UniProtKB
- smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation Source: Ensembl
- smoothened signaling pathway involved in ventral spinal cord patterning Source: Ensembl
- somite development Source: BHF-UCL
- thalamus development Source: Ensembl
- type B pancreatic cell development Source: Ensembl
- vasculogenesis Source: Ensembl
- ventral midline determination Source: BHF-UCL
Keywordsi
Molecular function | Developmental protein, G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-5610787 Hedgehog 'off' state R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-5632684 Hedgehog 'on' state R-HSA-5635838 Activation of SMO |
SignaLinki | Q99835 |
SIGNORi | Q99835 |
Protein family/group databases
TCDBi | 9.A.14.16.4 the g-protein-coupled receptor (gpcr) family |
Names & Taxonomyi
Protein namesi | Recommended name: Smoothened homologShort name: SMO Alternative name(s): Protein Gx |
Gene namesi | Name:SMO Synonyms:SMOH |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11119 SMO |
MIMi | 601500 gene |
neXtProti | NX_Q99835 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Multi-pass membrane protein 1 Publication
- cilium 1 Publication
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Plasma Membrane
- ciliary membrane Source: Reactome
- plasma membrane Source: UniProtKB
Other locations
- ciliary tip Source: Reactome
- cilium Source: UniProtKB
- dendrite Source: GO_Central
- endocytic vesicle membrane Source: Reactome
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: BHF-UCL
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 28 – 233 | ExtracellularSequence analysisAdd BLAST | 206 | |
Transmembranei | 234 – 254 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 255 – 262 | CytoplasmicSequence analysis | 8 | |
Transmembranei | 263 – 283 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 284 – 314 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 315 – 335 | Helical; Name=3Sequence analysisAdd BLAST | 21 | |
Topological domaini | 336 – 358 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 359 – 379 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 380 – 402 | ExtracellularSequence analysisAdd BLAST | 23 | |
Transmembranei | 403 – 423 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 424 – 451 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 452 – 472 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 473 – 524 | ExtracellularSequence analysisAdd BLAST | 52 | |
Transmembranei | 525 – 545 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 546 – 787 | CytoplasmicSequence analysisAdd BLAST | 242 |
Keywords - Cellular componenti
Cell projection, MembranePathology & Biotechi
Involvement in diseasei
Curry-Jones syndrome (CRJS)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077087 | 412 | L → F in CRJS; constitutive activation of the smoothened signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs879255280EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease mutationOrganism-specific databases
DisGeNETi | 6608 |
MalaCardsi | SMO |
MIMi | 601707 phenotype |
OpenTargetsi | ENSG00000128602 |
Orphaneti | 1553 Curry-Jones syndrome |
PharmGKBi | PA35968 |
Miscellaneous databases
Pharosi | Q99835 |
Chemistry databases
ChEMBLi | CHEMBL5971 |
DrugBanki | DB01047 Fluocinonide DB11978 Glasdegib DB06786 Halcinonide DB09143 Sonidegib DB08828 Vismodegib |
DrugCentrali | Q99835 |
GuidetoPHARMACOLOGYi | 239 |
Polymorphism and mutation databases
BioMutai | SMO |
DMDMi | 6226142 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 27 | Sequence analysisAdd BLAST | 27 | |
ChainiPRO_0000013015 | 28 – 787 | Smoothened homologAdd BLAST | 760 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 35 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 70 ↔ 134 | PROSITE-ProRule annotation | ||
Disulfide bondi | 78 ↔ 127 | PROSITE-ProRule annotation | ||
Disulfide bondi | 118 ↔ 154 | PROSITE-ProRule annotation | ||
Disulfide bondi | 147 ↔ 169 | PROSITE-ProRule annotation | ||
Glycosylationi | 188 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 193 ↔ 213 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 217 ↔ 295 | PROSITE-ProRule annotation1 Publication | ||
Glycosylationi | 309 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 314 ↔ 390 | PROSITE-ProRule annotation1 Publication | ||
Disulfide bondi | 490 ↔ 507 | PROSITE-ProRule annotation1 Publication |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
EPDi | Q99835 |
MassIVEi | Q99835 |
PaxDbi | Q99835 |
PeptideAtlasi | Q99835 |
PRIDEi | Q99835 |
ProteomicsDBi | 78499 |
PTM databases
GlyConnecti | 2079 |
iPTMneti | Q99835 |
PhosphoSitePlusi | Q99835 |
Expressioni
Gene expression databases
Bgeei | ENSG00000128602 Expressed in 181 organ(s), highest expression level in left ovary |
ExpressionAtlasi | Q99835 baseline and differential |
Genevisiblei | Q99835 HS |
Organism-specific databases
HPAi | CAB011446 |
Interactioni
Subunit structurei
Homodimer (PubMed:23636324).
Interacts with ARRB2 (By similarity).
Interacts with KIF7 (PubMed:19592253).
Interacts with BBS5 and BBS7; the interactions are indicative for the association of SMO with the BBsome complex to facilitate ciliary localization of SMO (PubMed:22072986).
Interacts with DLG5 and SDCBP (By similarity).
Interacts with GAS8/DRC4 (PubMed:21659505).
By similarity4 PublicationsGO - Molecular functioni
- patched binding Source: BHF-UCL
Protein-protein interaction databases
BioGridi | 112492, 8 interactors |
DIPi | DIP-34574N |
IntActi | Q99835, 34 interactors |
MINTi | Q99835 |
STRINGi | 9606.ENSP00000249373 |
Chemistry databases
BindingDBi | Q99835 |
Structurei
Secondary structure
3D structure databases
SMRi | Q99835 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 65 – 181 | FZPROSITE-ProRule annotationAdd BLAST | 117 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 538 – 569 | Interaction with BBS5 and BBS71 PublicationAdd BLAST | 32 | |
Regioni | 581 – 593 | Interaction with DLG5By similarityAdd BLAST | 13 |
Sequence similaritiesi
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3577 Eukaryota ENOG410XRC8 LUCA |
GeneTreei | ENSGT00940000157206 |
HOGENOMi | HOG000252964 |
InParanoidi | Q99835 |
KOi | K06226 |
OMAi | DMHAYIA |
OrthoDBi | 385042at2759 |
PhylomeDBi | Q99835 |
TreeFami | TF106460 |
Family and domain databases
CDDi | cd07451 CRD_SMO, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526 Frizzled/SFRP IPR000539 Frizzled/Smoothened_TM IPR020067 Frizzled_dom IPR036790 Frizzled_dom_sf IPR017981 GPCR_2-like IPR026544 SMO IPR041771 SMO_CRD |
PANTHERi | PTHR11309 PTHR11309, 1 hit PTHR11309:SF35 PTHR11309:SF35, 1 hit |
Pfami | View protein in Pfam PF01534 Frizzled, 1 hit PF01392 Fz, 1 hit |
PRINTSi | PR00489 FRIZZLED |
SMARTi | View protein in SMART SM00063 FRI, 1 hit SM01330 Frizzled, 1 hit |
SUPFAMi | SSF63501 SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038 FZ, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAAARPARGP ELPLLGLLLL LLLGDPGRGA ASSGNATGPG PRSAGGSARR
60 70 80 90 100
SAAVTGPPPP LSHCGRAAPC EPLRYNVCLG SVLPYGATST LLAGDSDSQE
110 120 130 140 150
EAHGKLVLWS GLRNAPRCWA VIQPLLCAVY MPKCENDRVE LPSRTLCQAT
160 170 180 190 200
RGPCAIVERE RGWPDFLRCT PDRFPEGCTN EVQNIKFNSS GQCEVPLVRT
210 220 230 240 250
DNPKSWYEDV EGCGIQCQNP LFTEAEHQDM HSYIAAFGAV TGLCTLFTLA
260 270 280 290 300
TFVADWRNSN RYPAVILFYV NACFFVGSIG WLAQFMDGAR REIVCRADGT
310 320 330 340 350
MRLGEPTSNE TLSCVIIFVI VYYALMAGVV WFVVLTYAWH TSFKALGTTY
360 370 380 390 400
QPLSGKTSYF HLLTWSLPFV LTVAILAVAQ VDGDSVSGIC FVGYKNYRYR
410 420 430 440 450
AGFVLAPIGL VLIVGGYFLI RGVMTLFSIK SNHPGLLSEK AASKINETML
460 470 480 490 500
RLGIFGFLAF GFVLITFSCH FYDFFNQAEW ERSFRDYVLC QANVTIGLPT
510 520 530 540 550
KQPIPDCEIK NRPSLLVEKI NLFAMFGTGI AMSTWVWTKA TLLIWRRTWC
560 570 580 590 600
RLTGQSDDEP KRIKKSKMIA KAFSKRHELL QNPGQELSFS MHTVSHDGPV
610 620 630 640 650
AGLAFDLNEP SADVSSAWAQ HVTKMVARRG AILPQDISVT PVATPVPPEE
660 670 680 690 700
QANLWLVEAE ISPELQKRLG RKKKRRKRKK EVCPLAPPPE LHPPAPAPST
710 720 730 740 750
IPRLPQLPRQ KCLVAAGAWG AGDSCRQGAW TLVSNPFCPE PSPPQDPFLP
760 770 780
SAPAPVAWAH GRRQGLGPIH SRTNLMDTEL MDADSDF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C509 | H7C509_HUMAN | Smoothened homolog | SMO | 151 | Annotation score: | ||
H7C5S9 | H7C5S9_HUMAN | Smoothened homolog | SMO | 70 | Annotation score: | ||
A0A590UJE7 | A0A590UJE7_HUMAN | Smoothened homolog | SMO | 111 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_077087 | 412 | L → F in CRJS; constitutive activation of the smoothened signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs879255280EnsemblClinVar. | 1 | |
Natural variantiVAR_037891 | 473 | D → H. Corresponds to variant dbSNP:rs17710891EnsemblClinVar. | 1 | |
Natural variantiVAR_007848 | 535 | W → L in basal cell carcinoma and ameloblastoma samples; somatic mutation; constitutive activation of the smoothened signaling pathway. 2 PublicationsCorresponds to variant dbSNP:rs121918347EnsemblClinVar. | 1 | |
Natural variantiVAR_007849 | 562 | R → Q in basal cell carcinoma samples; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs121918348EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U84401 mRNA Translation: AAB41788.1 AF114821, AF114819, AF114820 Genomic DNA Translation: AAD17202.1 AF120103 mRNA Translation: AAF31757.1 AF071494 mRNA Translation: AAC24863.1 CH236950 Genomic DNA Translation: EAL24102.1 CH471070 Genomic DNA Translation: EAW83715.1 BC009989 mRNA Translation: AAH09989.1 |
CCDSi | CCDS5811.1 |
RefSeqi | NP_005622.1, NM_005631.4 |
Genome annotation databases
Ensembli | ENST00000249373; ENSP00000249373; ENSG00000128602 |
GeneIDi | 6608 |
KEGGi | hsa:6608 |
UCSCi | uc003vor.4 human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U84401 mRNA Translation: AAB41788.1 AF114821, AF114819, AF114820 Genomic DNA Translation: AAD17202.1 AF120103 mRNA Translation: AAF31757.1 AF071494 mRNA Translation: AAC24863.1 CH236950 Genomic DNA Translation: EAL24102.1 CH471070 Genomic DNA Translation: EAW83715.1 BC009989 mRNA Translation: AAH09989.1 |
CCDSi | CCDS5811.1 |
RefSeqi | NP_005622.1, NM_005631.4 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JKV | X-ray | 2.45 | A/B | 190-555 | [»] | |
4N4W | X-ray | 2.80 | A | 190-555 | [»] | |
4O9R | X-ray | 3.20 | A | 190-433 | [»] | |
A | 441-555 | [»] | ||||
4QIM | X-ray | 2.61 | A | 190-433 | [»] | |
A | 441-555 | [»] | ||||
4QIN | X-ray | 2.60 | A | 190-433 | [»] | |
A | 441-555 | [»] | ||||
5L7D | X-ray | 3.20 | A/B | 32-428 | [»] | |
A/B | 443-555 | [»] | ||||
5L7I | X-ray | 3.30 | A/B | 32-428 | [»] | |
A/B | 443-555 | [»] | ||||
5V56 | X-ray | 2.90 | A/B | 53-437 | [»] | |
A/B | 444-558 | [»] | ||||
5V57 | X-ray | 3.00 | A/B | 58-437 | [»] | |
A/B | 444-558 | [»] | ||||
6OT0 | electron microscopy | 3.90 | R | 1-555 | [»] | |
SMRi | Q99835 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 112492, 8 interactors |
DIPi | DIP-34574N |
IntActi | Q99835, 34 interactors |
MINTi | Q99835 |
STRINGi | 9606.ENSP00000249373 |
Chemistry databases
BindingDBi | Q99835 |
ChEMBLi | CHEMBL5971 |
DrugBanki | DB01047 Fluocinonide DB11978 Glasdegib DB06786 Halcinonide DB09143 Sonidegib DB08828 Vismodegib |
DrugCentrali | Q99835 |
GuidetoPHARMACOLOGYi | 239 |
Protein family/group databases
TCDBi | 9.A.14.16.4 the g-protein-coupled receptor (gpcr) family |
GPCRDBi | Search... |
PTM databases
GlyConnecti | 2079 |
iPTMneti | Q99835 |
PhosphoSitePlusi | Q99835 |
Polymorphism and mutation databases
BioMutai | SMO |
DMDMi | 6226142 |
Proteomic databases
EPDi | Q99835 |
MassIVEi | Q99835 |
PaxDbi | Q99835 |
PeptideAtlasi | Q99835 |
PRIDEi | Q99835 |
ProteomicsDBi | 78499 |
Protocols and materials databases
DNASUi | 6608 |
Genome annotation databases
Ensembli | ENST00000249373; ENSP00000249373; ENSG00000128602 |
GeneIDi | 6608 |
KEGGi | hsa:6608 |
UCSCi | uc003vor.4 human |
Organism-specific databases
CTDi | 6608 |
DisGeNETi | 6608 |
GeneCardsi | SMO |
HGNCi | HGNC:11119 SMO |
HPAi | CAB011446 |
MalaCardsi | SMO |
MIMi | 601500 gene 601707 phenotype |
neXtProti | NX_Q99835 |
OpenTargetsi | ENSG00000128602 |
Orphaneti | 1553 Curry-Jones syndrome |
PharmGKBi | PA35968 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3577 Eukaryota ENOG410XRC8 LUCA |
GeneTreei | ENSGT00940000157206 |
HOGENOMi | HOG000252964 |
InParanoidi | Q99835 |
KOi | K06226 |
OMAi | DMHAYIA |
OrthoDBi | 385042at2759 |
PhylomeDBi | Q99835 |
TreeFami | TF106460 |
Enzyme and pathway databases
Reactomei | R-HSA-373080 Class B/2 (Secretin family receptors) R-HSA-5610787 Hedgehog 'off' state R-HSA-5620922 BBSome-mediated cargo-targeting to cilium R-HSA-5632684 Hedgehog 'on' state R-HSA-5635838 Activation of SMO |
SignaLinki | Q99835 |
SIGNORi | Q99835 |
Miscellaneous databases
ChiTaRSi | SMO human |
GeneWikii | Smoothened |
GenomeRNAii | 6608 |
Pharosi | Q99835 |
PROi | PR:Q99835 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000128602 Expressed in 181 organ(s), highest expression level in left ovary |
ExpressionAtlasi | Q99835 baseline and differential |
Genevisiblei | Q99835 HS |
Family and domain databases
CDDi | cd07451 CRD_SMO, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526 Frizzled/SFRP IPR000539 Frizzled/Smoothened_TM IPR020067 Frizzled_dom IPR036790 Frizzled_dom_sf IPR017981 GPCR_2-like IPR026544 SMO IPR041771 SMO_CRD |
PANTHERi | PTHR11309 PTHR11309, 1 hit PTHR11309:SF35 PTHR11309:SF35, 1 hit |
Pfami | View protein in Pfam PF01534 Frizzled, 1 hit PF01392 Fz, 1 hit |
PRINTSi | PR00489 FRIZZLED |
SMARTi | View protein in SMART SM00063 FRI, 1 hit SM01330 Frizzled, 1 hit |
SUPFAMi | SSF63501 SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038 FZ, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SMO_HUMAN | |
Accessioni | Q99835Primary (citable) accession number: Q99835 Secondary accession number(s): A4D1K5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 30, 2000 |
Last sequence update: | May 1, 1997 | |
Last modified: | October 16, 2019 | |
This is version 195 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Reference proteomeDocuments
- Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references