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Protein

T-complex protein 1 subunit eta

Gene

CCT7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC
R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC
R-HSA-390450 Folding of actin by CCT/TriC
R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding

Names & Taxonomyi

Protein namesi
Recommended name:
T-complex protein 1 subunit eta
Short name:
TCP-1-eta
Alternative name(s):
CCT-eta
HIV-1 Nef-interacting protein
Cleaved into the following chain:
Gene namesi
Name:CCT7
Synonyms:CCTH, NIP7-1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135624.15
HGNCiHGNC:1622 CCT7
MIMi605140 gene
neXtProtiNX_Q99832

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi10574
MalaCardsiCCT7
OpenTargetsiENSG00000135624
PharmGKBiPA26185

Polymorphism and mutation databases

BioMutaiCCT7
DMDMi3041738

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001283651 – 543T-complex protein 1 subunit etaAdd BLAST543
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00004343912 – 543T-complex protein 1 subunit eta, N-terminally processedAdd BLAST542

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1 Publication1
Modified residuei67N6-acetyllysineCombined sources1
Modified residuei250N6-acetyllysineBy similarity1
Modified residuei320N6-acetyllysineCombined sources1
Cross-linki430Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei535Omega-N-methylarginineCombined sources1
Isoform 3 (identifier: Q99832-3)
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Ubl conjugation

Proteomic databases

EPDiQ99832
MaxQBiQ99832
PaxDbiQ99832
PeptideAtlasiQ99832
PRIDEiQ99832
ProteomicsDBi78495
78496 [Q99832-2]
78497 [Q99832-3]
78498 [Q99832-4]

2D gel databases

REPRODUCTION-2DPAGEiIPI00018465

PTM databases

iPTMnetiQ99832
PhosphoSitePlusiQ99832
SwissPalmiQ99832

Expressioni

Gene expression databases

BgeeiENSG00000135624
CleanExiHS_CCT7
ExpressionAtlasiQ99832 baseline and differential
GenevisibleiQ99832 HS

Organism-specific databases

HPAiHPA008425

Interactioni

Subunit structurei

Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115825, 265 interactors
CORUMiQ99832
DIPiDIP-51608N
IntActiQ99832, 126 interactors
MINTiQ99832
STRINGi9606.ENSP00000258091

Structurei

3D structure databases

ProteinModelPortaliQ99832
SMRiQ99832
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TCP-1 chaperonin family.Curated

Phylogenomic databases

eggNOGiKOG0360 Eukaryota
COG0459 LUCA
GeneTreeiENSGT00550000074832
HOGENOMiHOG000226730
HOVERGENiHBG001052
InParanoidiQ99832
KOiK09499
OMAiQGCPNAK
OrthoDBiEOG091G05UO
PhylomeDBiQ99832
TreeFamiTF105641

Family and domain databases

CDDicd03340 TCP1_eta, 1 hit
Gene3Di1.10.560.10, 2 hits
3.30.260.10, 2 hits
3.50.7.10, 1 hit
InterProiView protein in InterPro
IPR012720 Chap_CCT_eta
IPR017998 Chaperone_TCP-1
IPR002194 Chaperonin_TCP-1_CS
IPR002423 Cpn60/TCP-1
IPR027409 GroEL-like_apical_dom_sf
IPR027413 GROEL-like_equatorial_sf
IPR027410 TCP-1-like_intermed_sf
PANTHERiPTHR11353:SF22 PTHR11353:SF22, 1 hit
PfamiView protein in Pfam
PF00118 Cpn60_TCP1, 1 hit
PRINTSiPR00304 TCOMPLEXTCP1
SUPFAMiSSF48592 SSF48592, 2 hits
SSF52029 SSF52029, 1 hit
SSF54849 SSF54849, 2 hits
TIGRFAMsiTIGR02345 chap_CCT_eta, 1 hit
PROSITEiView protein in PROSITE
PS00750 TCP1_1, 1 hit
PS00751 TCP1_2, 1 hit
PS00995 TCP1_3, 1 hit

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q99832-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMPTPVILLK EGTDSSQGIP QLVSNISACQ VIAEAVRTTL GPRGMDKLIV
60 70 80 90 100
DGRGKATISN DGATILKLLD VVHPAAKTLV DIAKSQDAEV GDGTTSVTLL
110 120 130 140 150
AAEFLKQVKP YVEEGLHPQI IIRAFRTATQ LAVNKIKEIA VTVKKADKVE
160 170 180 190 200
QRKLLEKCAM TALSSKLISQ QKAFFAKMVV DAVMMLDDLL QLKMIGIKKV
210 220 230 240 250
QGGALEDSQL VAGVAFKKTF SYAGFEMQPK KYHNPKIALL NVELELKAEK
260 270 280 290 300
DNAEIRVHTV EDYQAIVDAE WNILYDKLEK IHHSGAKVVL SKLPIGDVAT
310 320 330 340 350
QYFADRDMFC AGRVPEEDLK RTMMACGGSI QTSVNALSAD VLGRCQVFEE
360 370 380 390 400
TQIGGERYNF FTGCPKAKTC TFILRGGAEQ FMEETERSLH DAIMIVRRAI
410 420 430 440 450
KNDSVVAGGG AIEMELSKYL RDYSRTIPGK QQLLIGAYAK ALEIIPRQLC
460 470 480 490 500
DNAGFDATNI LNKLRARHAQ GGTWYGVDIN NEDIADNFEA FVWEPAMVRI
510 520 530 540
NALTAASEAA CLIVSVDETI KNPRSTVDAP TAAGRGRGRG RPH
Length:543
Mass (Da):59,367
Last modified:July 15, 1998 - v2
Checksum:i9F1E33FA80E6238E
GO
Isoform 2 (identifier: Q99832-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-89: Missing.
     90-206: Missing.

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):37,499
Checksum:iBA74E59CE7977306
GO
Isoform 3 (identifier: Q99832-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-44: Missing.

Note: No experimental confirmation available.Combined sources
Show »
Length:499
Mass (Da):54,804
Checksum:i19F19C1820F6A80A
GO
Isoform 4 (identifier: Q99832-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3-89: Missing.

Note: No experimental confirmation available.
Show »
Length:456
Mass (Da):50,352
Checksum:iAD52175094D0BD23
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti282 – 283HH → RQ in AAB41437 (Ref. 8) Curated2
Sequence conflicti293L → P in AAB41437 (Ref. 8) Curated1
Sequence conflicti336A → P in AAB41437 (Ref. 8) Curated1
Sequence conflicti364C → L in AAB41437 (Ref. 8) Curated1
Sequence conflicti374 – 376LRG → SPC in AAB41437 (Ref. 8) Curated3
Sequence conflicti407A → P in AAB41437 (Ref. 8) Curated1
Sequence conflicti411A → P in AAB41437 (Ref. 8) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052269259T → A. Corresponds to variant dbSNP:rs2231427Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0435721 – 44Missing in isoform 3. 1 PublicationAdd BLAST44
Alternative sequenceiVSP_0435733 – 89Missing in isoform 2 and isoform 4. 1 PublicationAdd BLAST87
Alternative sequenceiVSP_04357490 – 206Missing in isoform 2. 1 PublicationAdd BLAST117

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF026292 mRNA Translation: AAC96011.1
CR536511 mRNA Translation: CAG38749.1
AK291961 mRNA Translation: BAF84650.1
AK293597 mRNA Translation: BAH11543.1
AK297846 mRNA Translation: BAH12675.1
AK298153 mRNA Translation: BAH12733.1
AC010913 Genomic DNA Translation: AAX88902.1
CH471053 Genomic DNA Translation: EAW99739.1
CH471053 Genomic DNA Translation: EAW99740.1
BC019296 mRNA Translation: AAH19296.1
BC088351 mRNA Translation: AAH88351.1
U83843 mRNA Translation: AAB41437.1
CCDSiCCDS42696.1 [Q99832-2]
CCDS46336.1 [Q99832-1]
CCDS54366.1 [Q99832-4]
CCDS54367.1 [Q99832-3]
RefSeqiNP_001009570.1, NM_001009570.2 [Q99832-2]
NP_001159756.1, NM_001166284.1 [Q99832-4]
NP_001159757.1, NM_001166285.1 [Q99832-3]
NP_006420.1, NM_006429.3 [Q99832-1]
XP_011530780.1, XM_011532478.2 [Q99832-3]
XP_011530781.1, XM_011532479.1 [Q99832-3]
UniGeneiHs.368149

Genome annotation databases

EnsembliENST00000258091; ENSP00000258091; ENSG00000135624 [Q99832-1]
ENST00000398422; ENSP00000381456; ENSG00000135624 [Q99832-2]
ENST00000539919; ENSP00000437824; ENSG00000135624 [Q99832-3]
ENST00000540468; ENSP00000442058; ENSG00000135624 [Q99832-4]
GeneIDi10574
KEGGihsa:10574
UCSCiuc002siz.4 human [Q99832-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCPH_HUMAN
AccessioniPrimary (citable) accession number: Q99832
Secondary accession number(s): A8K7E6
, A8MWI8, B7WNW9, B7Z4T9, B7Z4Z7, O14871, Q6FI26
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1998
Last modified: June 20, 2018
This is version 183 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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