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UniProtKB - Q99828 (CIB1_HUMAN)

Entry version 204 (25 May 2022)
Sequence version 4 (20 Mar 2007)
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Protein

Calcium and integrin-binding protein 1

Gene

CIB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.

1 Publication

(Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs).

1 Publication

Miscellaneous

The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi116Calcium 1PROSITE-ProRule annotation1
Metal bindingi118Calcium 1PROSITE-ProRule annotation1
Metal bindingi120Calcium 1PROSITE-ProRule annotation1
Metal bindingi122Calcium 1PROSITE-ProRule annotation1
Metal bindingi127Calcium 1PROSITE-ProRule annotation1
Metal bindingi161Calcium 2PROSITE-ProRule annotation1
Metal bindingi163Calcium 2PROSITE-ProRule annotation1
Metal bindingi165Calcium 2PROSITE-ProRule annotation1
Metal bindingi167Calcium 2PROSITE-ProRule annotation1
Metal bindingi172Calcium 2PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAngiogenesis, Apoptosis, Cell adhesion, Cell cycle, Cell division, Differentiation, Spermatogenesis
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q99828

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q99828

SIGNOR Signaling Network Open Resource

More...SIGNORi		Q99828

Protein family/group databases

Transport Classification Database

More...TCDBi		8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Calcium and integrin-binding protein 1
Short name:
CIB
Alternative name(s):
Calcium- and integrin-binding protein
Short name:
CIBP
Calmyrin
DNA-PKcs-interacting protein
Kinase-interacting protein
Short name:
KIP
SNK-interacting protein 2-28
Short name:
SIP2-28
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CIB1
Synonyms:CIB, KIP, PRKDCIP
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:16920, CIB1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		602293, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q99828

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000185043

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Epidermodysplasia verruciformis 3 (EV3)1 Publication
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV3 inheritance is autosomal recessive.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_08178472 – 191Missing in EV3; absence of CIB1 protein in homozygous patient cells. 1 PublicationAdd BLAST120

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi2G → A: Inhibits translocation to the plasma membrane. Increased apoptosis after TNF stimulation. 1 Publication1
Mutagenesisi78S → A: Loss of phosphorylation by PKD/PRKD2; in isoform 2. 1 Publication1
Mutagenesisi78S → E: Phosphomimetic; promotes tumor growth by an indirect mechanism; in isoform 2. 1 Publication1
Mutagenesisi114 – 117IFDF → AAAA: Loss of binding to ITGAV. 1 Publication4
Mutagenesisi115F → A: Loss of binding to ITGA2B. 1 Publication1
Mutagenesisi127D → N: Cytoplasmic localization. 1 Publication1
Mutagenesisi131L → A or T: Loss of binding to ITGA2B. 1 Publication1
Mutagenesisi152 – 153LI → AA: Loss of binding to ITGA2B. 1 Publication2
Mutagenesisi153I → A: Loss of binding to ITGA2B. 1 Publication1
Mutagenesisi167T → A: No effect on phosphorylation by PKD/PRKD2; in isoform 2. 1 Publication1
Mutagenesisi172E → Q: Cytoplasmic localization. 1 Publication1
Mutagenesisi173F → A: Loss of binding to ITGA2B. 3 Publications1
Mutagenesisi173F → A: Loss of binding to ITGA2B. Does not inhibit interaction with PAK1. 3 Publications1

Organism-specific databases

DisGeNET

More...DisGeNETi		10519

MalaCards human disease database

More...MalaCardsi		CIB1
MIMi618267, phenotype

Open Targets

More...OpenTargetsi		ENSG00000185043

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		302, Epidermodysplasia verruciformis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA38423

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q99828, Tbio

Chemistry databases

Drug and drug target database

More...DrugBanki		DB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CIB1

Domain mapping of disease mutations (DMDM)

More...DMDMi		134047806

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000735312 – 191Calcium and integrin-binding protein 1Add BLAST190

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi2N-myristoyl glycine1 Publication1
Isoform 2 (identifier: Q99828-2)
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei118Phosphoserine1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylation of isoform 2 at Ser-118 by PRKD2 increases its ability to stimulate tumor angiogenesis.1 Publication

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q99828

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q99828

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q99828

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q99828

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q99828

PeptideAtlas

More...PeptideAtlasi		Q99828

PRoteomics IDEntifications database

More...PRIDEi		Q99828

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		78493 [Q99828-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q99828

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q99828

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed. Expressed in the epidermis, hair follicles and keratinocytes (PubMed:30068544). Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level).6 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during breast cancer progression.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000185043, Expressed in bronchial epithelial cell and 234 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q99828, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q99828, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000185043, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

Interacts with MYO1C.

Interacts (via C-terminal region) with PPP3R1 and CACNA1C; the interactions increase upon cardiomyocytes hypertrophy (By similarity).

Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3).

Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent.

Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain).

Interacts with PLK3; the interaction inhibits PLK3 kinase activity.

Interacts with PSEN2.

Interacts (via C-terminus) with F8.

Interacts with NBR1 (via C-terminus).

Interacts with FEZ1 (via C-terminus).

Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation.

Interacts with IFI6; the interaction is direct (PubMed:15685448).

Interacts with BCL2 (PubMed:15685448).

Interacts with ITPR3; the interaction occurs in a calcium-dependent manner.

Interacts with PTK2/FAK1.

Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2.

Isoform 2 interacts with PRKD2 (via N-terminal AP-rich region), PTK2/FAK1 and PAK1.

Interacts with TAS1R2 (via C-terminus); the interaction is independent of the myristoylation state of CIB1.

Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition.

Interacts with SPHK1, the interaction occurs in a calcium-dependent manner.

Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner.

Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner.

Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.

Interacts with ITGA5 and ITGAV.

Interacts and forms a complex with TMC6 and TMC8 (PubMed:30068544).

By similarity33 Publications

(Microbial infection) Interacts with human papillomavirus 4/HPV4 protein E8, human papillomavirus 5/HPV5 protein E1, and human papillomavirus 16/HPV16 proteins E2 and E5.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		115774, 78 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q99828

Database of interacting proteins

More...DIPi		DIP-31260N

Protein interaction database and analysis system

More...IntActi		Q99828, 41 interactors

Molecular INTeraction database

More...MINTi		Q99828

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q99828, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1191
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

AlphaFold Protein Structure Database

More...AlphaFoldDBi		Q99828

Biological Magnetic Resonance Data Bank

More...BMRBi		Q99828

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q99828

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q99828

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini103 – 138EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini148 – 183EF-hand 2PROSITE-ProRule annotationAdd BLAST36

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The EF-hands may also bind magnesium ions in the presence of high Mg2+ levels and low Ca2+ levels.

Keywords - Domaini

Repeat

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158927

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_061288_6_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q99828

Identification of Orthologs from Complete Genome Data

More...OMAi		GHNRNAK

Database of Orthologous Groups

More...OrthoDBi		1271942at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q99828

TreeFam database of animal gene trees

More...TreeFami		TF313865

Family and domain databases

Conserved Domains Database

More...CDDi		cd00051, EFh, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF13499, EF-hand_7, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00054, EFh, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47473, SSF47473, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q99828-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRSVESSLR 
        60         70         80         90        100
AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD 
       110        120        130        140        150
TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK 
       160        170        180        190 
QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L
Length:191
Mass (Da):21,703
Last modified:March 20, 2007 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9AA19A0DE7AA1E05
GO
Isoform 2 (identifier: Q99828-2) [UniParc]FASTAAdd to basket
Also known as: CIB1a

The sequence of this isoform differs from the canonical sequence as follows:
     29-29: L → LSVYVVLAPHLVDNEQQARSGNEHTGRPIAENTDSSPLSTR

Show »
Length:231
Mass (Da):26,032
Checksum:i0D38C53F1478119E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A3B3ISY8A0A3B3ISY8_HUMAN
Calcium and integrin-binding protei...
CIB1
43Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti136T → M in CAG33236 (Ref. 6) Curated1
Sequence conflicti171S → F in AEZ06077 (PubMed:23503467).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01956544S → T3 PublicationsCorresponds to variant dbSNP:rs3210935Ensembl.1
Natural variantiVAR_08178472 – 191Missing in EV3; absence of CIB1 protein in homozygous patient cells. 1 PublicationAdd BLAST120
Natural variantiVAR_048636106I → T. Corresponds to variant dbSNP:rs11551250Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05374029L → LSVYVVLAPHLVDNEQQARS GNEHTGRPIAENTDSSPLST R in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U82226 mRNA Translation: AAC51106.1
U85611 mRNA Translation: AAB53387.1
AB021866 Genomic DNA Translation: BAA36281.1
JQ246073 mRNA Translation: AEZ06077.1
U83236 mRNA Translation: AAB39758.1
CR456955 mRNA Translation: CAG33236.1
AB451276 mRNA Translation: BAG70090.1
AB451406 mRNA Translation: BAG70220.1
CH471101 Genomic DNA Translation: EAX02090.1
BC000846 mRNA Translation: AAH00846.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS10360.1 [Q99828-1]
CCDS73781.1 [Q99828-2]

NCBI Reference Sequences

More...RefSeqi		NP_001264693.1, NM_001277764.1 [Q99828-2]
NP_006375.2, NM_006384.3 [Q99828-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000328649.11; ENSP00000333873.6; ENSG00000185043.12
ENST00000612800.1; ENSP00000479860.1; ENSG00000185043.12 [Q99828-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		10519

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:10519

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000328649.11; ENSP00000333873.6; NM_006384.4; NP_006375.2

UCSC genome browser

More...UCSCi		uc002bpb.5, human [Q99828-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U82226 mRNA Translation: AAC51106.1
U85611 mRNA Translation: AAB53387.1
AB021866 Genomic DNA Translation: BAA36281.1
JQ246073 mRNA Translation: AEZ06077.1
U83236 mRNA Translation: AAB39758.1
CR456955 mRNA Translation: CAG33236.1
AB451276 mRNA Translation: BAG70090.1
AB451406 mRNA Translation: BAG70220.1
CH471101 Genomic DNA Translation: EAX02090.1
BC000846 mRNA Translation: AAH00846.1
CCDSiCCDS10360.1 [Q99828-1]
CCDS73781.1 [Q99828-2]
RefSeqiNP_001264693.1, NM_001277764.1 [Q99828-2]
NP_006375.2, NM_006384.3 [Q99828-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1DGUNMR-A9-191[»]
1DGVNMR-A9-191[»]
1XO5X-ray1.99A/B9-191[»]
1Y1AX-ray2.30A/B9-191[»]
2L4HNMR-A1-191[»]
2L4INMR-A1-191[»]
2LM5NMR-A1-191[»]
6OCXX-ray1.90A/B/C/D1-191[»]
6OD0X-ray2.15A/B1-191[»]
AlphaFoldDBiQ99828
BMRBiQ99828
SMRiQ99828
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi115774, 78 interactors
CORUMiQ99828
DIPiDIP-31260N
IntActiQ99828, 41 interactors
MINTiQ99828

Chemistry databases

DrugBankiDB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

Protein family/group databases

TCDBi8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family

PTM databases

iPTMnetiQ99828
PhosphoSitePlusiQ99828

Genetic variation databases

BioMutaiCIB1
DMDMi134047806

Proteomic databases

EPDiQ99828
jPOSTiQ99828
MassIVEiQ99828
MaxQBiQ99828
PaxDbiQ99828
PeptideAtlasiQ99828
PRIDEiQ99828
ProteomicsDBi78493 [Q99828-1]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		28761, 390 antibodies from 34 providers

The DNASU plasmid repository

More...DNASUi		10519

Genome annotation databases

EnsembliENST00000328649.11; ENSP00000333873.6; ENSG00000185043.12
ENST00000612800.1; ENSP00000479860.1; ENSG00000185043.12 [Q99828-2]
GeneIDi10519
KEGGihsa:10519
MANE-SelectiENST00000328649.11; ENSP00000333873.6; NM_006384.4; NP_006375.2
UCSCiuc002bpb.5, human [Q99828-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		10519
DisGeNETi10519

GeneCards: human genes, protein and diseases

More...GeneCardsi		CIB1
HGNCiHGNC:16920, CIB1
HPAiENSG00000185043, Low tissue specificity
MalaCardsiCIB1
MIMi602293, gene
618267, phenotype
neXtProtiNX_Q99828
OpenTargetsiENSG00000185043
Orphaneti302, Epidermodysplasia verruciformis
PharmGKBiPA38423
VEuPathDBiHostDB:ENSG00000185043

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000158927
HOGENOMiCLU_061288_6_1_1
InParanoidiQ99828
OMAiGHNRNAK
OrthoDBi1271942at2759
PhylomeDBiQ99828
TreeFamiTF313865

Enzyme and pathway databases

PathwayCommonsiQ99828
SignaLinkiQ99828
SIGNORiQ99828

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		10519, 15 hits in 1085 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CIB1, human
EvolutionaryTraceiQ99828

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		CIB1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		10519
PharosiQ99828, Tbio

Protein Ontology

More...PROi		PR:Q99828
RNActiQ99828, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000185043, Expressed in bronchial epithelial cell and 234 other tissues
ExpressionAtlasiQ99828, baseline and differential
GenevisibleiQ99828, HS

Family and domain databases

CDDicd00051, EFh, 1 hit
InterProiView protein in InterPro
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
PfamiView protein in Pfam
PF13499, EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054, EFh, 2 hits
SUPFAMiSSF47473, SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCIB1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q99828
Secondary accession number(s): B5BU40
, H6WJF3, O00693, O00735, Q6IB49, Q96J54, Q99971
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 20, 2007
Last modified: May 25, 2022
This is version 204 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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