CIB1

Functionⁱ

Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells.

Isoform 2:

Plays a regulatory role in angiogenesis and tumor growth by mediating PKD/PRKD2-induced vascular endothelial growth factor A (VEGFA) secretion.1 Publication

(Microbial infection) Involved in keratinocyte-intrinsic immunity to human beta-papillomaviruses (HPVs).1 Publication

Miscellaneous

The binding of either calcium or magnesium significantly increases the structural stability of the protein in comparison to apo-CIB (calcium- and magnesium-free form).1 Publication

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Calcium bindingⁱ	116 – 127	1Add BLAST		12
Calcium bindingⁱ	161 – 172	2Add BLAST		12

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

Complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Angiogenesis, Apoptosis, Cell adhesion, Cell cycle, Cell division, Differentiation, Spermatogenesis
Ligand	Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

PathwayCommonsⁱ	Q99828
SIGNORⁱ	Q99828

Protein family/group databases

TCDBⁱ	8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family

TCDBⁱ

8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Calcium and integrin-binding protein 1 Short name: CIB Alternative name(s): Calcium- and integrin-binding protein Short name: CIBP Calmyrin DNA-PKcs-interacting protein Kinase-interacting protein Short name: KIP SNK-interacting protein 2-28 Short name: SIP2-28
Gene namesⁱ	Name:CIB1 Synonyms:CIB, KIP, PRKDCIP
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 15

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:16920, CIB1
MIMⁱ	602293, gene
neXtProtⁱ	NX_Q99828
VEuPathDBⁱ	HostDB:ENSG00000185043.10

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Epidermodysplasia verruciformis 3 (EV3)1 Publication

The disease is caused by variants affecting the gene represented in this entry.

Disease descriptionA form of epidermodysplasia verruciformis, a rare genodermatosis associated with a high risk of skin carcinoma that results from an abnormal susceptibility to infection by specific human papillomaviruses, including the oncogenic HPV5. Infection leads to the early development of disseminated flat wart-like and pityriasis versicolor-like skin lesions. Cutaneous Bowen's carcinomas in situ and invasive squamous cell carcinomas develop in about half of the patients, mainly on sun-exposed skin areas. EV3 inheritance is autosomal recessive.

Related information in OMIM

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_081784	72 – 191	Missing in EV3; absence of CIB1 protein in homozygous patient cells. 1 PublicationAdd BLAST		120

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	2	G → A: Inhibits translocation to the plasma membrane. Increased apoptosis after TNF stimulation. 1 Publication	1
Mutagenesisⁱ	78	S → A: Loss of phosphorylation by PKD/PRKD2; in isoform 2. 1 Publication	1
Mutagenesisⁱ	78	S → E: Phosphomimetic; promotes tumor growth by an indirect mechanism; in isoform 2. 1 Publication	1
Mutagenesisⁱ	114 – 117	IFDF → AAAA: Loss of binding to ITGAV. 1 Publication	4
Mutagenesisⁱ	115	F → A: Loss of binding to ITGA2B. 1 Publication	1
Mutagenesisⁱ	127	D → N: Cytoplasmic localization. 1 Publication	1
Mutagenesisⁱ	131	L → A or T: Loss of binding to ITGA2B. 1 Publication	1
Mutagenesisⁱ	152 – 153	LI → AA: Loss of binding to ITGA2B. 1 Publication	2
Mutagenesisⁱ	153	I → A: Loss of binding to ITGA2B. 1 Publication	1
Mutagenesisⁱ	167	T → A: No effect on phosphorylation by PKD/PRKD2; in isoform 2. 1 Publication	1
Mutagenesisⁱ	172	E → Q: Cytoplasmic localization. 1 Publication	1
Mutagenesisⁱ	173	F → A: Loss of binding to ITGA2B. 3 Publications	1
Mutagenesisⁱ	173	F → A: Loss of binding to ITGA2B. Does not inhibit interaction with PAK1. 3 Publications	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	10519
MalaCards human disease database More...MalaCardsⁱ	CIB1
MIMⁱ	618267, phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000185043
Orphanetⁱ	302, Epidermodysplasia verruciformis
PharmGKBⁱ	PA38423

Miscellaneous databases

Pharosⁱ	Q99828, Tbio

Pharosⁱ

Q99828, Tbio

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate

DrugBankⁱ

DB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

Genetic variation databases

BioMutaⁱ	CIB1
DMDMⁱ	134047806

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed
ChainⁱPRO_0000073531	2 – 191	Calcium and integrin-binding protein 1Add BLAST		190

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Lipidationⁱ	2	N-myristoyl glycine1 Publication	1
Isoform 2 (identifier: Q99828-2)
Modified residueⁱ	118	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Phosphorylation of isoform 2 at Ser-118 by PRKD2 increases its ability to stimulate tumor angiogenesis.1 Publication

Keywords - PTMⁱ

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDⁱ	Q99828
jPOSTⁱ	Q99828
MassIVEⁱ	Q99828
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q99828
PaxDbⁱ	Q99828
PeptideAtlas More...PeptideAtlasⁱ	Q99828
PRIDEⁱ	Q99828
ProteomicsDBⁱ	78493 [Q99828-1]

PTM databases

iPTMnetⁱ	Q99828
PhosphoSitePlusⁱ	Q99828

Expressionⁱ

Tissue specificityⁱ

Ubiquitously expressed. Expressed in the epidermis, hair follicles and keratinocytes (PubMed:30068544). Detected in platelets and in cell lines of megakaryocytic and erythrocytic lineages. Both isoform 1 and isoform 2 are detected in various cancer cell lines, with isoform 2 being the predominant form (at protein level).6 Publications

Inductionⁱ

Up-regulated during breast cancer progression.

Gene expression databases

Bgeeⁱ	ENSG00000185043, Expressed in bronchial epithelial cell and 233 other tissues
ExpressionAtlasⁱ	Q99828, baseline and differential
Genevisibleⁱ	Q99828, HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	ENSG00000185043, Low tissue specificity

HPAⁱ

ENSG00000185043, Low tissue specificity

Interactionⁱ

Subunit structureⁱ

Monomer.

Interacts with MYO1C.

Interacts (via C-terminal region) with PPP3R1 and CACNA1C; the interactions increase upon cardiomyocytes hypertrophy (By similarity).

Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3).

Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent.

Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain).

Interacts with PLK3; the interaction inhibits PLK3 kinase activity.

Interacts with PSEN2.

Interacts (via C-terminus) with F8.

Interacts with NBR1 (via C-terminus).

Interacts with FEZ1 (via C-terminus).

Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation.

Interacts with IFI6; the interaction is direct (PubMed:15685448).

Interacts with BCL2 (PubMed:15685448).

Interacts with ITPR3; the interaction occurs in a calcium-dependent manner.

Interacts with PTK2/FAK1.

Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2.

Isoform 2 interacts with PRKD2 (via N-terminal AP-rich region), PTK2/FAK1 and PAK1.

Interacts with TAS1R2 (via C-terminus); the interaction is independent of the myristoylation state of CIB1.

Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition.

Interacts with SPHK1, the interaction occurs in a calcium-dependent manner.

Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner.

Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner.

Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.

Interacts with ITGA5 and ITGAV.

Interacts and forms a complex with TMC6 and TMC8 (PubMed:30068544).

By similarity33 Publications

(Microbial infection) Interacts with human papillomavirus 4/HPV4 protein E8, human papillomavirus 5/HPV5 protein E1, and human papillomavirus 16/HPV16 proteins E2 and E5.

1 Publication

Binary interactionsⁱ

Hide details

Q99828

With	#Exp.	IntAct
CALCB [P10092]	3	EBI-372594,EBI-12883326
CD27 [P26842]	7	EBI-372594,EBI-520729
CEACAM6 [P40199]	3	EBI-372594,EBI-4314501
EIF4G1 - isoform 9 [Q04637-9]	7	EBI-372594,EBI-12012124
ELAPOR1 - isoform 3 [Q6UXG2-3]	3	EBI-372594,EBI-12920100
FUCA1 [P04066]	3	EBI-372594,EBI-2512153
GLIS3 - isoform 2 [Q8NEA6-2]	5	EBI-372594,EBI-12232117
ICAM1 [P05362]	3	EBI-372594,EBI-1035358
KAT5 [Q92993]	3	EBI-372594,EBI-399080
LMO3 - isoform 4 [Q8TAP4-4]	3	EBI-372594,EBI-11742507
LSS [P48449]	3	EBI-372594,EBI-3930711
MAP3K5 [Q99683]	7	EBI-372594,EBI-476263
NCK2 [O43639]	3	EBI-372594,EBI-713635
NME4 [O00746]	3	EBI-372594,EBI-744871
ONECUT3 [O60422]	3	EBI-372594,EBI-17431136
PAX7 - isoform 2 [P23759-2]	3	EBI-372594,EBI-12859446
SCAF1 [Q9H7N4]	5	EBI-372594,EBI-1222181
SETDB1 - isoform 2 [Q15047-2]	3	EBI-372594,EBI-9090795
SPRED1 [Q7Z699]	3	EBI-372594,EBI-5235340
SSX7 [Q7RTT5]	5	EBI-372594,EBI-12879730
TMEM95 [Q3KNT9]	3	EBI-372594,EBI-12892569
TSGA10IP [Q3SY00]	3	EBI-372594,EBI-10241197
WASL [O00401]	7	EBI-372594,EBI-957615
YWHAG [P61981]	3	EBI-372594,EBI-359832
ZBTB49 [Q6ZSB9]	3	EBI-372594,EBI-2859943

GO - Molecular functionⁱ

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGRIDⁱ	115774, 44 interactors
CORUMⁱ	Q99828
Database of interacting proteins More...DIPⁱ	DIP-31260N
IntActⁱ	Q99828, 41 interactors
Molecular INTeraction database More...MINTⁱ	Q99828

Miscellaneous databases

RNActⁱ	Q99828, protein

RNActⁱ

Q99828, protein

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	14 – 16	Combined sources	3
Turnⁱ	18 – 20	Combined sources	3
Helixⁱ	24 – 35	Combined sources	12
Helixⁱ	40 – 42	Combined sources	3
Helixⁱ	45 – 48	Combined sources	4
Turnⁱ	49 – 51	Combined sources	3
Helixⁱ	55 – 58	Combined sources	4
Helixⁱ	62 – 65	Combined sources	4
Helixⁱ	70 – 77	Combined sources	8
Beta strandⁱ	81 – 86	Combined sources	6
Helixⁱ	88 – 98	Combined sources	11
Helixⁱ	104 – 115	Combined sources	12
Beta strandⁱ	120 – 123	Combined sources	4
Helixⁱ	125 – 136	Combined sources	12
Beta strandⁱ	137 – 139	Combined sources	3
Helixⁱ	146 – 160	Combined sources	15
Beta strandⁱ	165 – 168	Combined sources	4
Helixⁱ	170 – 178	Combined sources	9
Helixⁱ	181 – 190	Combined sources	10

Show more details

3D structure databases

BMRBⁱ	Q99828
SMRⁱ	Q99828
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q99828

EvolutionaryTraceⁱ

Q99828

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	103 – 138	EF-hand 1PROSITE-ProRule annotationAdd BLAST		36
Domainⁱ	148 – 183	EF-hand 2PROSITE-ProRule annotationAdd BLAST		36

Domainⁱ

The EF-hands may also bind magnesium ions in the presence of high Mg²⁺ levels and low Ca²⁺ levels.

Keywords - Domainⁱ

Repeat

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00940000158927
HOGENOMⁱ	CLU_061288_6_1_1
InParanoidⁱ	Q99828
OMAⁱ	DERNHPN
Database of Orthologous Groups More...OrthoDBⁱ	1271942at2759
PhylomeDBⁱ	Q99828
TreeFamⁱ	TF313865

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00051, EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF13499, EF-hand_7, 1 hit
SMARTⁱ	View protein in SMART SM00054, EFh, 2 hits
SUPFAMⁱ	SSF47473, SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: Q99828-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the canonicalⁱ sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRSVESSLR 
        60         70         80         90        100
AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD 
       110        120        130        140        150
TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK 
       160        170        180        190 
QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L

Length:191

Mass (Da):21,703

Last modified:March 20, 2007 - v4

Checksum:ⁱ9AA19A0DE7AA1E05

GO

Isoform 2 (identifier: Q99828-2) [UniParc]FASTA Add to basket

Also known as: CIB1a

The sequence of this isoform differs from the canonical sequence as follows:
29-29: L → LSVYVVLAPHLVDNEQQARSGNEHTGRPIAENTDSSPLSTR

« Hide

        10         20         30         40         50
MGGSGSRLSK ELLAEYQDLT FLTKQEILLS VYVVLAPHLV DNEQQARSGN 
        60         70         80         90        100
EHTGRPIAEN TDSSPLSTRA HRRFCELLPQ EQRSVESSLR AQVPFEQILS 
       110        120        130        140        150
LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD TATPDIKSHY 
       160        170        180        190        200
AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK QLIDNILEES 
       210        220        230 
DIDRDGTINL SEFQHVISRS PDFASSFKIV L

Show »

Length:231

Mass (Da):26,032

Checksum:ⁱ0D38C53F1478119E

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	A0A3B3ISY8	A0A3B3ISY8_HUMAN		Calcium and integrin-binding protei... Calcium and integrin-binding protein 1	CIB1	43	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	136	T → M in CAG33236 (Ref. 6) Curated		1
Sequence conflictⁱ	171	S → F in AEZ06077 (PubMed:23503467).Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_019565	44	S → T3 PublicationsCorresponds to variant dbSNP:rs3210935Ensembl.	1
Natural variantⁱVAR_081784	72 – 191	Missing in EV3; absence of CIB1 protein in homozygous patient cells. 1 PublicationAdd BLAST	120
Natural variantⁱVAR_048636	106	I → T. Corresponds to variant dbSNP:rs11551250Ensembl.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_053740	29	L → LSVYVVLAPHLVDNEQQARS GNEHTGRPIAENTDSSPLST R in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U82226 mRNA Translation: AAC51106.1 U85611 mRNA Translation: AAB53387.1 AB021866 Genomic DNA Translation: BAA36281.1 JQ246073 mRNA Translation: AEZ06077.1 U83236 mRNA Translation: AAB39758.1 CR456955 mRNA Translation: CAG33236.1 AB451276 mRNA Translation: BAG70090.1 AB451406 mRNA Translation: BAG70220.1 CH471101 Genomic DNA Translation: EAX02090.1 BC000846 mRNA Translation: AAH00846.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS10360.1 [Q99828-1] CCDS73781.1 [Q99828-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001264693.1, NM_001277764.1 [Q99828-2] NP_006375.2, NM_006384.3 [Q99828-1]

Genome annotation databases

Ensemblⁱ	ENST00000328649; ENSP00000333873; ENSG00000185043 [Q99828-1] ENST00000612800; ENSP00000479860; ENSG00000185043 [Q99828-2]
GeneIDⁱ	10519
KEGGⁱ	hsa:10519
UCSC genome browser More...UCSCⁱ	uc002bpb.5, human [Q99828-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q99828	Testicular secretory protein Li 9		HUMAN		191	UniRef100_Q99828
CIB1 isoform 1		PANTR		191
Calcium and integrin binding 1		GORGO		191
+2

Protein	Similar proteins		Species	Score	Length	Source
Q99828	Testicular secretory protein Li 9		HUMAN		191	UniRef90_Q99828
CIB1 isoform 1		PANTR		191
Calcium and integrin binding 1		GORGO		191
Uncharacterized protein		OTOGA		191
+3
Q99828-2	CIB1 isoform 2		PANTR		231	UniRef90_Q99828-2
Uncharacterized protein		MACFA		231
Uncharacterized protein		MACNE		231
Uncharacterized protein		CERAT		231
Uncharacterized protein		RHIBE		231
+3

Protein	Similar proteins		Species	Score	Length	Source
Q99828	Calcium and integrin-binding protein 1		MOUSE		191	UniRef50_Q99828
Testicular secretory protein Li 9		HUMAN		191
CIB1 isoform 1		PANTR		191
Calcium and integrin binding 1		GORGO		191
Uncharacterized protein		OTOGA		191
+414
Q99828-2	Calcium and integrin-binding protein 1		RAT		191	UniRef50_Q99828-2
Calcium and integrin-binding protein 1		BOVIN		191
Calcium and integrin-binding protein 1		SHEEP		191
Uncharacterized protein		RHIBE		231
Uncharacterized protein		COLAP		231
+68

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U82226 mRNA Translation: AAC51106.1 U85611 mRNA Translation: AAB53387.1 AB021866 Genomic DNA Translation: BAA36281.1 JQ246073 mRNA Translation: AEZ06077.1 U83236 mRNA Translation: AAB39758.1 CR456955 mRNA Translation: CAG33236.1 AB451276 mRNA Translation: BAG70090.1 AB451406 mRNA Translation: BAG70220.1 CH471101 Genomic DNA Translation: EAX02090.1 BC000846 mRNA Translation: AAH00846.1
CCDSⁱ	CCDS10360.1 [Q99828-1] CCDS73781.1 [Q99828-2]
RefSeqⁱ	NP_001264693.1, NM_001277764.1 [Q99828-2] NP_006375.2, NM_006384.3 [Q99828-1]

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1DGU	NMR	-	A	9-191	[»]
	1DGV	NMR	-	A	9-191	[»]
	1XO5	X-ray	1.99	A/B	9-191	[»]
	1Y1A	X-ray	2.30	A/B	9-191	[»]
	2L4H	NMR	-	A	1-191	[»]
	2L4I	NMR	-	A	1-191	[»]
	2LM5	NMR	-	A	1-191	[»]
	6OCX	X-ray	1.90	A/B/C/D	1-191	[»]
	6OD0	X-ray	2.15	A/B	1-191	[»]
BMRBⁱ	Q99828
SMRⁱ	Q99828
ModBaseⁱ	Search...
PDBe-KBⁱ	Search...

Protein-protein interaction databases

BioGRIDⁱ	115774, 44 interactors
CORUMⁱ	Q99828
DIPⁱ	DIP-31260N
IntActⁱ	Q99828, 41 interactors
MINTⁱ	Q99828

Chemistry databases

DrugBankⁱ	DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate

DrugBankⁱ

DB11093, Calcium citrate
DB11348, Calcium Phosphate
DB14481, Calcium phosphate dihydrate

Protein family/group databases

TCDBⁱ	8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family

TCDBⁱ

8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family

PTM databases

iPTMnetⁱ	Q99828
PhosphoSitePlusⁱ	Q99828

Genetic variation databases

BioMutaⁱ	CIB1
DMDMⁱ	134047806

Proteomic databases

EPDⁱ	Q99828
jPOSTⁱ	Q99828
MassIVEⁱ	Q99828
MaxQBⁱ	Q99828
PaxDbⁱ	Q99828
PeptideAtlasⁱ	Q99828
PRIDEⁱ	Q99828
ProteomicsDBⁱ	78493 [Q99828-1]

Protocols and materials databases

Antibodypediaⁱ	28761, 383 antibodies
The DNASU plasmid repository More...DNASUⁱ	10519

Genome annotation databases

Ensemblⁱ	ENST00000328649; ENSP00000333873; ENSG00000185043 [Q99828-1] ENST00000612800; ENSP00000479860; ENSG00000185043 [Q99828-2]
GeneIDⁱ	10519
KEGGⁱ	hsa:10519
UCSCⁱ	uc002bpb.5, human [Q99828-1]

Organism-specific databases

CTDⁱ	10519
DisGeNETⁱ	10519
GeneCardsⁱ	CIB1
HGNCⁱ	HGNC:16920, CIB1
HPAⁱ	ENSG00000185043, Low tissue specificity
MalaCardsⁱ	CIB1
MIMⁱ	602293, gene 618267, phenotype
neXtProtⁱ	NX_Q99828
OpenTargetsⁱ	ENSG00000185043
Orphanetⁱ	302, Epidermodysplasia verruciformis
PharmGKBⁱ	PA38423
VEuPathDBⁱ	HostDB:ENSG00000185043.10
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

GeneTreeⁱ	ENSGT00940000158927
HOGENOMⁱ	CLU_061288_6_1_1
InParanoidⁱ	Q99828
OMAⁱ	DERNHPN
OrthoDBⁱ	1271942at2759
PhylomeDBⁱ	Q99828
TreeFamⁱ	TF313865

Enzyme and pathway databases

PathwayCommonsⁱ	Q99828
SIGNORⁱ	Q99828

Miscellaneous databases

BioGRID-ORCSⁱ	10519, 5 hits in 996 CRISPR screens
ChiTaRSⁱ	CIB1, human
EvolutionaryTraceⁱ	Q99828
GeneWikiⁱ	CIB1
GenomeRNAiⁱ	10519
Pharosⁱ	Q99828, Tbio
Protein Ontology More...PROⁱ	PR:Q99828
RNActⁱ	Q99828, protein
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000185043, Expressed in bronchial epithelial cell and 233 other tissues
ExpressionAtlasⁱ	Q99828, baseline and differential
Genevisibleⁱ	Q99828, HS

Family and domain databases

CDDⁱ	cd00051, EFh, 1 hit
InterProⁱ	View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom
Pfamⁱ	View protein in Pfam PF13499, EF-hand_7, 1 hit
SMARTⁱ	View protein in SMART SM00054, EFh, 2 hits
SUPFAMⁱ	SSF47473, SSF47473, 1 hit
PROSITEⁱ	View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CIB1_HUMAN
Accessionⁱ	Q99828Primary (citable) accession number: Q99828 Secondary accession number(s): B5BU40 Q99971
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	March 20, 2007
	Last modified:	April 7, 2021
	This is version 200 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Reference proteome

Documents

Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM
Human entries with genetic variants
List of human entries with genetic variants
Human variants curated from literature reports
Index of human variants curated from literature reports
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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UniProtKB - Q99828 (CIB1_HUMAN)

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Calcium and integrin-binding protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Keywords - PTMi

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Q99828

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ