UniProtKB - Q99828 (CIB1_HUMAN)
Calcium and integrin-binding protein 1
CIB1
Functioni
Miscellaneous
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Calcium bindingi | 116 – 127 | 1Add BLAST | 12 | |
Calcium bindingi | 161 – 172 | 2Add BLAST | 12 |
GO - Molecular functioni
- calcium-dependent protein kinase inhibitor activity Source: CACAO
- calcium ion binding Source: HGNC-UCL
- ion channel binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein kinase binding Source: Ensembl
- protein-membrane adaptor activity Source: BHF-UCL
- protein serine/threonine kinase inhibitor activity Source: CACAO
- small GTPase binding Source: UniProtKB
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- apoptotic process Source: HGNC-UCL
- cell adhesion Source: ProtInc
- cell division Source: UniProtKB-KW
- cellular response to DNA damage stimulus Source: HGNC-UCL
- cellular response to growth factor stimulus Source: UniProtKB
- cellular response to nerve growth factor stimulus Source: UniProtKB
- cellular response to tumor necrosis factor Source: UniProtKB
- cytoplasmic microtubule organization Source: UniProtKB
- double-strand break repair Source: ProtInc
- endomitotic cell cycle Source: UniProtKB
- extrinsic apoptotic signaling pathway Source: BHF-UCL
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of megakaryocyte differentiation Source: UniProtKB
- negative regulation of microtubule depolymerization Source: UniProtKB
- negative regulation of neuron projection development Source: UniProtKB
- negative regulation of protein kinase B signaling Source: UniProtKB
- negative regulation of protein phosphorylation Source: UniProtKB
- platelet formation Source: UniProtKB
- positive regulation of calcineurin-NFAT signaling cascade Source: BHF-UCL
- positive regulation of catalytic activity Source: UniProtKB
- positive regulation of cell adhesion mediated by integrin Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of cell-matrix adhesion Source: UniProtKB
- positive regulation of cell migration Source: UniProtKB
- positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
- positive regulation of male germ cell proliferation Source: UniProtKB
- positive regulation of NF-kappaB transcription factor activity Source: UniProtKB
- positive regulation of protein localization to plasma membrane Source: BHF-UCL
- positive regulation of protein phosphorylation Source: UniProtKB
- positive regulation of protein serine/threonine kinase activity Source: UniProtKB
- positive regulation of protein targeting to membrane Source: UniProtKB
- positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
- regulation of cell division Source: UniProtKB
- regulation of cell population proliferation Source: UniProtKB
- response to ischemia Source: UniProtKB
- spermatid development Source: UniProtKB
- thrombopoietin-mediated signaling pathway Source: UniProtKB
Keywordsi
Biological process | Angiogenesis, Apoptosis, Cell adhesion, Cell cycle, Cell division, Differentiation, Spermatogenesis |
Ligand | Calcium, Magnesium, Metal-binding |
Enzyme and pathway databases
PathwayCommonsi | Q99828 |
SIGNORi | Q99828 |
Protein family/group databases
TCDBi | 8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family |
Names & Taxonomyi
Protein namesi | Recommended name: Calcium and integrin-binding protein 1Short name: CIB Alternative name(s): Calcium- and integrin-binding protein Short name: CIBP Calmyrin DNA-PKcs-interacting protein Kinase-interacting protein Short name: KIP SNK-interacting protein 2-28 Short name: SIP2-28 |
Gene namesi | Name:CIB1 Synonyms:CIB, KIP, PRKDCIP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16920, CIB1 |
MIMi | 602293, gene |
neXtProti | NX_Q99828 |
VEuPathDBi | HostDB:ENSG00000185043.10 |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
- Nucleus 1 Publication
Cytoskeleton
Plasma membrane
Other locations
- Membrane ; Lipid-anchor
- filopodium tip
- growth cone 1 Publication
- lamellipodium 1 Publication
- perinuclear region
- neuron projection 1 Publication
- Perikaryon 1 Publication
Note: Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in the hypertrophic heart (By similarity). Colocalized with NBR1 to the perinuclear region. Colocalizes with TAS1R2 in apical regions of taste receptor cells. Colocalized with RAC3 in the perinuclear area and at the cell periphery. Colocalized with PAK1 within membrane ruffles during cell spreading upon readhesion to fibronectin. Redistributed to the cytoskeleton upon platelet aggregation. Translocates from the cytosol to the plasma membrane in a calcium-dependent manner. Colocalized with PLK3 at centrosomes in ductal breast carcinoma cells.By similarity
Golgi apparatus
- trans-Golgi network 1 Publication
Other locations
- perinuclear region 1 Publication
Cytoskeleton
- centrosome Source: UniProtKB
Endoplasmic reticulum
- endoplasmic reticulum Source: HGNC-UCL
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Plasma Membrane
- apical plasma membrane Source: UniProtKB-SubCell
- plasma membrane Source: UniProtKB
- ruffle membrane Source: UniProtKB-SubCell
- sarcolemma Source: BHF-UCL
Other locations
- cell periphery Source: UniProtKB
- cytoplasm Source: UniProtKB
- dendrite Source: Ensembl
- filopodium tip Source: UniProtKB
- growth cone Source: UniProtKB
- lamellipodium Source: UniProtKB
- membrane Source: HGNC-UCL
- neuron projection Source: UniProtKB
- neuronal cell body Source: UniProtKB
- perikaryon Source: UniProtKB-SubCell
- perinuclear region of cytoplasm Source: UniProtKB
- vesicle Source: UniProtKB
Keywords - Cellular componenti
Cell membrane, Cell projection, Cytoplasm, Cytoskeleton, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Involvement in diseasei
Epidermodysplasia verruciformis 3 (EV3)1 Publication
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_081784 | 72 – 191 | Missing in EV3; absence of CIB1 protein in homozygous patient cells. 1 PublicationAdd BLAST | 120 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 2 | G → A: Inhibits translocation to the plasma membrane. Increased apoptosis after TNF stimulation. 1 Publication | 1 | |
Mutagenesisi | 78 | S → A: Loss of phosphorylation by PKD/PRKD2; in isoform 2. 1 Publication | 1 | |
Mutagenesisi | 78 | S → E: Phosphomimetic; promotes tumor growth by an indirect mechanism; in isoform 2. 1 Publication | 1 | |
Mutagenesisi | 114 – 117 | IFDF → AAAA: Loss of binding to ITGAV. 1 Publication | 4 | |
Mutagenesisi | 115 | F → A: Loss of binding to ITGA2B. 1 Publication | 1 | |
Mutagenesisi | 127 | D → N: Cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 131 | L → A or T: Loss of binding to ITGA2B. 1 Publication | 1 | |
Mutagenesisi | 152 – 153 | LI → AA: Loss of binding to ITGA2B. 1 Publication | 2 | |
Mutagenesisi | 153 | I → A: Loss of binding to ITGA2B. 1 Publication | 1 | |
Mutagenesisi | 167 | T → A: No effect on phosphorylation by PKD/PRKD2; in isoform 2. 1 Publication | 1 | |
Mutagenesisi | 172 | E → Q: Cytoplasmic localization. 1 Publication | 1 | |
Mutagenesisi | 173 | F → A: Loss of binding to ITGA2B. 3 Publications | 1 | |
Mutagenesisi | 173 | F → A: Loss of binding to ITGA2B. Does not inhibit interaction with PAK1. 3 Publications | 1 |
Organism-specific databases
DisGeNETi | 10519 |
MalaCardsi | CIB1 |
MIMi | 618267, phenotype |
OpenTargetsi | ENSG00000185043 |
Orphaneti | 302, Epidermodysplasia verruciformis |
PharmGKBi | PA38423 |
Miscellaneous databases
Pharosi | Q99828, Tbio |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
Genetic variation databases
BioMutai | CIB1 |
DMDMi | 134047806 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed | |||
ChainiPRO_0000073531 | 2 – 191 | Calcium and integrin-binding protein 1Add BLAST | 190 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length | |
---|---|---|---|---|---|
Lipidationi | 2 | N-myristoyl glycine1 Publication | 1 | ||
Isoform 2 (identifier: Q99828-2) | |||||
Modified residuei | 118 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
Lipoprotein, Myristate, PhosphoproteinProteomic databases
EPDi | Q99828 |
jPOSTi | Q99828 |
MassIVEi | Q99828 |
MaxQBi | Q99828 |
PaxDbi | Q99828 |
PeptideAtlasi | Q99828 |
PRIDEi | Q99828 |
ProteomicsDBi | 78493 [Q99828-1] |
PTM databases
iPTMneti | Q99828 |
PhosphoSitePlusi | Q99828 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSG00000185043, Expressed in bronchial epithelial cell and 233 other tissues |
ExpressionAtlasi | Q99828, baseline and differential |
Genevisiblei | Q99828, HS |
Organism-specific databases
HPAi | ENSG00000185043, Low tissue specificity |
Interactioni
Subunit structurei
Monomer.
Interacts with MYO1C.
Interacts (via C-terminal region) with PPP3R1 and CACNA1C; the interactions increase upon cardiomyocytes hypertrophy (By similarity).
Interacts with the heterodimeric integrin alpha-IIb/beta3 (ITGA2B-ITGB3).
Interacts with ITGA2B (via cytoplasmic domain); the interaction is direct and calcium-dependent.
Interacts with the protein kinases PLK2/SNK and PRKDC (via the region immediately upstream of the kinase domain).
Interacts with PLK3; the interaction inhibits PLK3 kinase activity.
Interacts with PSEN2.
Interacts (via C-terminus) with F8.
Interacts with NBR1 (via C-terminus).
Interacts with FEZ1 (via C-terminus).
Interacts with UBR5 (via C-terminus); the interaction is sensitive to DNA damage, and may target CIB1 for ubiquitin-mediated degradation.
Interacts with IFI6; the interaction is direct (PubMed:15685448).
Interacts with BCL2 (PubMed:15685448).
Interacts with ITPR3; the interaction occurs in a calcium-dependent manner.
Interacts with PTK2/FAK1.
Interacts with MAP3K5; the interaction inhibits MAP3K5 activation by phosphorylation, and its subsequent interaction with TRAF2.
Isoform 2 interacts with PRKD2 (via N-terminal AP-rich region), PTK2/FAK1 and PAK1.
Interacts with TAS1R2 (via C-terminus); the interaction is independent of the myristoylation state of CIB1.
Interacts (via C-terminal region) with STMN2 (via the N-terminal region); the interaction is direct, occurs in a calcium-dependent manner and attenuates the STMN2-induced neurite outgrowth inhibition.
Interacts with SPHK1, the interaction occurs in a calcium-dependent manner.
Interacts with ITGA2B (via C-terminal cytoplasmic tail); the interaction occurs upon platelet aggregation and is stabilized/increased in a calcium and magnesium-dependent manner.
Interacts with PAK1 (via N-terminal region); the interaction is direct and occurs in a calcium-dependent manner.
Interacts with RAC3 (via C-terminal region); the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion.
Interacts with ITGA5 and ITGAV.
Interacts and forms a complex with TMC6 and TMC8 (PubMed:30068544).
By similarity33 Publications(Microbial infection) Interacts with human papillomavirus 4/HPV4 protein E8, human papillomavirus 5/HPV5 protein E1, and human papillomavirus 16/HPV16 proteins E2 and E5.
1 PublicationBinary interactionsi
Hide detailsQ99828
GO - Molecular functioni
- ion channel binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- protein kinase binding Source: Ensembl
- small GTPase binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 115774, 44 interactors |
CORUMi | Q99828 |
DIPi | DIP-31260N |
IntActi | Q99828, 41 interactors |
MINTi | Q99828 |
Miscellaneous databases
RNActi | Q99828, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q99828 |
SMRi | Q99828 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q99828 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 103 – 138 | EF-hand 1PROSITE-ProRule annotationAdd BLAST | 36 | |
Domaini | 148 – 183 | EF-hand 2PROSITE-ProRule annotationAdd BLAST | 36 |
Domaini
Keywords - Domaini
RepeatPhylogenomic databases
GeneTreei | ENSGT00940000158927 |
HOGENOMi | CLU_061288_6_1_1 |
InParanoidi | Q99828 |
OMAi | DERNHPN |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q99828 |
TreeFami | TF313865 |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGGSGSRLSK ELLAEYQDLT FLTKQEILLA HRRFCELLPQ EQRSVESSLR
60 70 80 90 100
AQVPFEQILS LPELKANPFK ERICRVFSTS PAKDSLSFED FLDLLSVFSD
110 120 130 140 150
TATPDIKSHY AFRIFDFDDD GTLNREDLSR LVNCLTGEGE DTRLSASEMK
160 170 180 190
QLIDNILEES DIDRDGTINL SEFQHVISRS PDFASSFKIV L
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ISY8 | A0A3B3ISY8_HUMAN | Calcium and integrin-binding protei... | CIB1 | 43 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 136 | T → M in CAG33236 (Ref. 6) Curated | 1 | |
Sequence conflicti | 171 | S → F in AEZ06077 (PubMed:23503467).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_019565 | 44 | S → T3 PublicationsCorresponds to variant dbSNP:rs3210935Ensembl. | 1 | |
Natural variantiVAR_081784 | 72 – 191 | Missing in EV3; absence of CIB1 protein in homozygous patient cells. 1 PublicationAdd BLAST | 120 | |
Natural variantiVAR_048636 | 106 | I → T. Corresponds to variant dbSNP:rs11551250Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053740 | 29 | L → LSVYVVLAPHLVDNEQQARS GNEHTGRPIAENTDSSPLST R in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82226 mRNA Translation: AAC51106.1 U85611 mRNA Translation: AAB53387.1 AB021866 Genomic DNA Translation: BAA36281.1 JQ246073 mRNA Translation: AEZ06077.1 U83236 mRNA Translation: AAB39758.1 CR456955 mRNA Translation: CAG33236.1 AB451276 mRNA Translation: BAG70090.1 AB451406 mRNA Translation: BAG70220.1 CH471101 Genomic DNA Translation: EAX02090.1 BC000846 mRNA Translation: AAH00846.1 |
CCDSi | CCDS10360.1 [Q99828-1] CCDS73781.1 [Q99828-2] |
RefSeqi | NP_001264693.1, NM_001277764.1 [Q99828-2] NP_006375.2, NM_006384.3 [Q99828-1] |
Genome annotation databases
Ensembli | ENST00000328649; ENSP00000333873; ENSG00000185043 [Q99828-1] ENST00000612800; ENSP00000479860; ENSG00000185043 [Q99828-2] |
GeneIDi | 10519 |
KEGGi | hsa:10519 |
UCSCi | uc002bpb.5, human [Q99828-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U82226 mRNA Translation: AAC51106.1 U85611 mRNA Translation: AAB53387.1 AB021866 Genomic DNA Translation: BAA36281.1 JQ246073 mRNA Translation: AEZ06077.1 U83236 mRNA Translation: AAB39758.1 CR456955 mRNA Translation: CAG33236.1 AB451276 mRNA Translation: BAG70090.1 AB451406 mRNA Translation: BAG70220.1 CH471101 Genomic DNA Translation: EAX02090.1 BC000846 mRNA Translation: AAH00846.1 |
CCDSi | CCDS10360.1 [Q99828-1] CCDS73781.1 [Q99828-2] |
RefSeqi | NP_001264693.1, NM_001277764.1 [Q99828-2] NP_006375.2, NM_006384.3 [Q99828-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1DGU | NMR | - | A | 9-191 | [»] | |
1DGV | NMR | - | A | 9-191 | [»] | |
1XO5 | X-ray | 1.99 | A/B | 9-191 | [»] | |
1Y1A | X-ray | 2.30 | A/B | 9-191 | [»] | |
2L4H | NMR | - | A | 1-191 | [»] | |
2L4I | NMR | - | A | 1-191 | [»] | |
2LM5 | NMR | - | A | 1-191 | [»] | |
6OCX | X-ray | 1.90 | A/B/C/D | 1-191 | [»] | |
6OD0 | X-ray | 2.15 | A/B | 1-191 | [»] | |
BMRBi | Q99828 | |||||
SMRi | Q99828 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 115774, 44 interactors |
CORUMi | Q99828 |
DIPi | DIP-31260N |
IntActi | Q99828, 41 interactors |
MINTi | Q99828 |
Chemistry databases
DrugBanki | DB11093, Calcium citrate DB11348, Calcium Phosphate DB14481, Calcium phosphate dihydrate |
Protein family/group databases
TCDBi | 8.A.82.1.9, the calmodulin calcium binding protein (calmodulin) family |
PTM databases
iPTMneti | Q99828 |
PhosphoSitePlusi | Q99828 |
Genetic variation databases
BioMutai | CIB1 |
DMDMi | 134047806 |
Proteomic databases
EPDi | Q99828 |
jPOSTi | Q99828 |
MassIVEi | Q99828 |
MaxQBi | Q99828 |
PaxDbi | Q99828 |
PeptideAtlasi | Q99828 |
PRIDEi | Q99828 |
ProteomicsDBi | 78493 [Q99828-1] |
Protocols and materials databases
Antibodypediai | 28761, 383 antibodies |
DNASUi | 10519 |
Genome annotation databases
Ensembli | ENST00000328649; ENSP00000333873; ENSG00000185043 [Q99828-1] ENST00000612800; ENSP00000479860; ENSG00000185043 [Q99828-2] |
GeneIDi | 10519 |
KEGGi | hsa:10519 |
UCSCi | uc002bpb.5, human [Q99828-1] |
Organism-specific databases
CTDi | 10519 |
DisGeNETi | 10519 |
GeneCardsi | CIB1 |
HGNCi | HGNC:16920, CIB1 |
HPAi | ENSG00000185043, Low tissue specificity |
MalaCardsi | CIB1 |
MIMi | 602293, gene 618267, phenotype |
neXtProti | NX_Q99828 |
OpenTargetsi | ENSG00000185043 |
Orphaneti | 302, Epidermodysplasia verruciformis |
PharmGKBi | PA38423 |
VEuPathDBi | HostDB:ENSG00000185043.10 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000158927 |
HOGENOMi | CLU_061288_6_1_1 |
InParanoidi | Q99828 |
OMAi | DERNHPN |
OrthoDBi | 1271942at2759 |
PhylomeDBi | Q99828 |
TreeFami | TF313865 |
Enzyme and pathway databases
PathwayCommonsi | Q99828 |
SIGNORi | Q99828 |
Miscellaneous databases
BioGRID-ORCSi | 10519, 5 hits in 996 CRISPR screens |
ChiTaRSi | CIB1, human |
EvolutionaryTracei | Q99828 |
GeneWikii | CIB1 |
GenomeRNAii | 10519 |
Pharosi | Q99828, Tbio |
PROi | PR:Q99828 |
RNActi | Q99828, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185043, Expressed in bronchial epithelial cell and 233 other tissues |
ExpressionAtlasi | Q99828, baseline and differential |
Genevisiblei | Q99828, HS |
Family and domain databases
CDDi | cd00051, EFh, 1 hit |
InterProi | View protein in InterPro IPR011992, EF-hand-dom_pair IPR018247, EF_Hand_1_Ca_BS IPR002048, EF_hand_dom |
Pfami | View protein in Pfam PF13499, EF-hand_7, 1 hit |
SMARTi | View protein in SMART SM00054, EFh, 2 hits |
SUPFAMi | SSF47473, SSF47473, 1 hit |
PROSITEi | View protein in PROSITE PS00018, EF_HAND_1, 2 hits PS50222, EF_HAND_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CIB1_HUMAN | |
Accessioni | Q99828Primary (citable) accession number: Q99828 Secondary accession number(s): B5BU40 Q99971 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | March 20, 2007 | |
Last modified: | April 7, 2021 | |
This is version 200 of the entry and version 4 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references